Neurotrophins and Neuropathic Pain: Role in Pathobiology

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Neurotrophins and Neuropathic Pain: Role in Pathobiology is …
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review articleQ7318358
scholarly articleQ13442814

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P356DOI10.3390/MOLECULES200610657
P8608Fatcat IDrelease_rdtvpsvo55as3nzzwp7cjci2ei
P3181OpenCitations bibliographic resource ID4835990
P932PMC publication ID6272404
P698PubMed publication ID26065639
P5875ResearchGate publication ID278020632

P50authorMaree SmithQ24851696
P2093author name stringNemat Khan
P2860cites workSortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signalingQ24307989
Recommendations for the pharmacological management of neuropathic pain: an overview and literature updateQ24616897
Neurotrophin-regulated signalling pathwaysQ24678332
Mechanisms of acupuncture-electroacupuncture on persistent painQ26866252
Nerve growth factor-mediated regulation of pain signalling and proposed new intervention strategies in clinical pain managementQ27011486
Neurotrophin signal transduction in the nervous systemQ27876223
Activation of phosphatidylinositol 3-kinase and protein kinase B/Akt in dorsal root ganglia and spinal cord contributes to the neuropathic pain induced by spinal nerve ligation in ratsQ80605700
NT-3 expression in spared DRG and the associated spinal laminae as well as its anterograde transport in sensory neurons following removal of adjacent DRG in catsQ80821809
The role of neurotrophins in the maintenance of the spinal cord motor neurons and the dorsal root ganglia proprioceptive sensory neuronsQ81259421
Sympathetic sprouting and changes in nociceptive sensory innervation in the glabrous skin of the rat hind paw following partial peripheral nerve injuryQ82679670
Efficacy and safety of tanezumab in the treatment of chronic low back painQ84421146
Characterization of nerve growth factor-induced mechanical and thermal hypersensitivity in ratsQ84855400
Nerve growth factor regulates the expression of brain-derived neurotrophic factor mRNA in the peripheral nervous systemQ49137091
Tanezumab reduces osteoarthritic knee pain: results of a randomized, double-blind, placebo-controlled phase III trial.Q51326054
Neuropathic pain behaviours in a chronic-relapsing model of experimental autoimmune encephalomyelitis (EAE).Q51668434
Nerve safety of tanezumab, a nerve growth factor inhibitor for pain treatment.Q51707357
Introduction of a neurotrophin-3 transgene into muscle selectively rescues proprioceptive neurons in mice lacking endogenous neurotrophin-3.Q52192540
Nerve growth factor contributes to the generation of inflammatory sensory hypersensitivity.Q52214955
NT-3, like NGF, is required for survival of sympathetic neurons, but not their precursors.Q52535261
Neurotrophins from dorsal root ganglia trigger allodynia after spinal nerve injury in rats.Q53747564
In vivo NGF deprivation reduces SNS expression and TTX-R sodium currents in IB4-negative DRG neurons.Q54104418
Role of nerve growth factor-tyrosine kinase receptor A signaling in paclitaxel-induced peripheral neuropathy in rats.Q54225222
Suppression of the p75 neurotrophin receptor in uninjured sensory neurons reduces neuropathic pain after nerve injury.Q54292334
Peripheral and Central Mechanisms of NGF-induced HyperalgesiaQ56980379
Nerve growth factor-induced hyperalgesia in the neonatal and adult ratQ56980397
Increased content and transport of substance P and calcitonin gene-related peptide in sensory nerves innervating inflamed tissue: Evidence for a regulatory function of nerve growth factor in vivoQ56990844
NGF induces non-inflammatory localized and lasting mechanical and thermal hypersensitivity in human skinQ57215013
Nerve growth factor induces mechanical allodynia associated with novel A fibre-evoked spinal reflex activity and enhanced neurokinin-1 receptor activation in the rat.Q39417487
Cannabinoid 1 receptors are expressed by nerve growth factor- and glial cell-derived neurotrophic factor-responsive primary sensory neurones.Q39598750
Proneurotrophins require endocytosis and intracellular proteolysis to induce TrkA activationQ39647271
TrkA receptor "hot spots" for binding of NT-3 as a heterologous ligandQ40144725
NGF rapidly increases membrane expression of TRPV1 heat-gated ion channels.Q40345535
Neurotrophic factors expressed in both cortex and spinal cord induce axonal plasticity after spinal cord injuryQ40630598
Neurotrophin-4, alone or heterodimerized with brain-derived neurotrophic factor, is sorted to the constitutive secretory pathwayQ40635192
Neurotrophic factor changes in the rat thick skin following chronic constriction injury of the sciatic nerveQ40762287
Developmental changes in NT3 signalling via TrkA and TrkB in embryonic neurons.Q40789379
Intrathecally injected neurotrophins and the release of substance P from the rat isolated spinal cordQ40903406
NT-3 promotes growth of lesioned adult rat sensory axons ascending in the dorsal columns of the spinal cord.Q40914375
Differential role of GDNF and NGF in the maintenance of two TTX-resistant sodium channels in adult DRG neuronsQ40958612
A role for nerve growth factor in sympathetic sprouting in rat dorsal root gangliaQ40976134
Phenotypic modification of primary sensory neurons: the role of nerve growth factor in the production of persistent painQ41055368
Plasticity of calcitonin gene related peptide neurotransmission in the spinal cord during peripheral inflammationQ41143334
Neurotrophic factors in the treatment of peripheral neuropathy.Q41159493
Endogenous levels of nerve growth factor (NGF) are altered in experimental diabetes mellitus: a possible role for NGF in the pathogenesis of diabetic neuropathyQ41197663
Neuropathic pain is constitutively suppressed in early life by anti-inflammatory neuroimmune regulationQ41581503
Neurotrophin-5: A novel neurotrophic factor that activates trk and trkBQ41658559
Trk receptors: roles in neuronal signal transductionQ27919636
Sortilin: a receptor to regulate neuronal viability and functionQ28260073
Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovaryQ28276438
Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous systemQ28505213
Lumbar transplant of neurons genetically modified to secrete brain-derived neurotrophic factor attenuates allodynia and hyperalgesia after sciatic nerve constrictionQ28571071
Brain-derived neurotrophic factor modulates nociceptive sensory inputs and NMDA-evoked responses in the rat spinal cordQ28571753
Nerve growth factor antiserum induces axotomy-like changes in neuropeptide expression in intact sympathetic and sensory neuronsQ31840674
The molecular pathophysiology of pain: abnormal expression of sodium channel genes and its contributions to hyperexcitability of primary sensory neuronsQ33735104
Trk receptors: mediators of neurotrophin actionQ33950703
Thyroid hormone activates oligodendrocyte precursors and increases a myelin-forming protein and NGF content in the spinal cord during experimental allergic encephalomyelitisQ34017385
Reduction in voltage-gated K+ channel activity in primary sensory neurons in painful diabetic neuropathy: role of brain-derived neurotrophic factorQ34071965
Understanding proneurotrophin actions: Recent advances and challengesQ34100777
Trans-synaptic shift in anion gradient in spinal lamina I neurons as a mechanism of neuropathic painQ34224419
The immunomodulator glatiramer acetate augments the expression of neurotrophic factors in brains of experimental autoimmune encephalomyelitis miceQ34245104
Central modulation of painQ34245455
Remyelination in multiple sclerosis: a new role for neurotrophins?Q34287004
Differential regulation of mRNA encoding nerve growth factor and its receptor in rat sciatic nerve during development, degeneration, and regeneration: role of macrophagesQ34374550
Are voltage-gated sodium channels on the dorsal root ganglion involved in the development of neuropathic pain?Q34639336
Neuropathic pain: redefinition and a grading system for clinical and research purposesQ34713765
Analgesic mechanism of electroacupuncture in a rat L5 spinal nerve ligation modelQ35048774
Antagonism of nerve growth factor-TrkA signaling and the relief of painQ35064559
Nerve growth factor mediates mechanical allodynia in a mouse model of type 2 diabetes.Q35184731
Induction of nerve growth factor receptor in Schwann cells after axotomyQ35609990
The role of growth factors in diabetic peripheral neuropathy.Q35661123
The function neutralizing anti-TrkA antibody MNAC13 reduces inflammatory and neuropathic painQ35669849
Interventional management of neuropathic pain: NeuPSIG recommendationsQ35794710
Regulation of Neurotrophin-3 and Interleukin-1β and Inhibition of Spinal Glial Activation Contribute to the Analgesic Effect of Electroacupuncture in Chronic Neuropathic Pain States of RatsQ35805686
Antiallodynic effects of alpha lipoic acid in an optimized RR-EAE mouse model of MS-neuropathic pain are accompanied by attenuation of upregulated BDNF-TrkB-ERK signaling in the dorsal horn of the spinal cordQ35822338
Plasticity of pain signaling: role of neurotrophic factors exemplified by acid-induced pain.Q35884832
Time-course changes of nerve growth factor, corticotropin-releasing hormone, and nitric oxide synthase isoforms and their possible role in the development of inflammatory response in experimental allergic encephalomyelitis.Q36085707
BDNF in sensory neurons and chronic painQ36413814
Differential effects of brain-derived neurotrophic factor and neurotrophin-3 on hindlimb function in paraplegic ratsQ36431214
Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptorsQ36447081
Alterations in endocannabinoid tone following chemotherapy-induced peripheral neuropathy: effects of endocannabinoid deactivation inhibitors targeting fatty-acid amide hydrolase and monoacylglycerol lipase in comparison to reference analgesics folloQ36476481
Differential influence of nerve growth factor on neuropeptide expression in vivo: a novel role in peptide suppression in adult sensory neurons.Q41664947
Effect of nerve growth factor on peptide neurons in dorsal root ganglia after taxol or cisplatin treatment and in diabetic (db/db) miceQ41665271
Neurotrophin-3 reverses nerve conduction velocity deficits in streptozotocin-diabetic rats.Q41715272
Injury Induced Activation of Extracellular Signal-Regulated Kinase (ERK) in the Rat Rostral Ventromedial Medulla (RVM) is Age Dependant and Requires the Lamina I Projection PathwayQ41772718
Differential expression of mRNAs for neurotrophins and their receptors after axotomy of the sciatic nerveQ42056826
The p75NTR signaling cascade mediates mechanical hyperalgesia induced by nerve growth factor injected into the rat hind paw.Q42078588
Nerve growth factor treatment increases stimulus-evoked release of sensory neuropeptides in the rat spinal cordQ42439525
Disruption of a single allele of the nerve growth factor gene results in atrophy of basal forebrain cholinergic neurons and memory deficitsQ42444231
CB1 cannabinoid receptor agonist prevents NGF-induced sensitization of TRPV1 in sensory neuronsQ42566809
Extensive sprouting of sensory afferents and hyperalgesia induced by conditional expression of nerve growth factor in the adult spinal cord.Q42800909
Contribution of the spinal cord BDNF to the development of neuropathic pain by activation of the NR2B-containing NMDA receptors in rats with spinal nerve ligationQ43192659
Continuous delivery of neurotrophin 3 by gene therapy has a neuroprotective effect in experimental models of diabetic and acrylamide neuropathiesQ43846708
Spinal brain-derived neurotrophic factor (BDNF) produces hyperalgesia in normal mice while antisense directed against either BDNF or trkB, prevent inflammation-induced hyperalgesiaQ44219073
Cellular mechanisms regulating activity-dependent release of native brain-derived neurotrophic factor from hippocampal neurons.Q44228549
Involvement of a spinal brain-derived neurotrophic factor/full-length TrkB pathway in the development of nerve injury-induced thermal hyperalgesia in miceQ44241806
Neurotrophin-4 mediated TrkB activation reinforces morphine-induced analgesia.Q44324995
Neurotrophin‐3 down‐regulates trkA mRNA, NGF high‐affinity binding sites, and associated phenotype in adult DRG neuronsQ44597445
Early predictors of peripheral neurotoxicity in cisplatin and paclitaxel combination chemotherapy.Q45023423
Neurotrophin-3 suppresses thermal hyperalgesia associated with neuropathic pain and attenuates transient receptor potential vanilloid receptor-1 expression in adult sensory neurons.Q45230651
Repetitive hyperbaric oxygen treatment attenuates complete Freund's adjuvant-induced pain and reduces glia-mediated neuroinflammation in the spinal cordQ45836278
Amelioration of chronic neuropathic pain after partial nerve injury by adeno-associated viral (AAV) vector-mediated over-expression of BDNF in the rat spinal cordQ45855288
Tanezumab for the Treatment of Pain from Osteoarthritis of the KneeQ46259879
Cannabinoid receptor CB2 localisation and agonist-mediated inhibition of capsaicin responses in human sensory neuronsQ46436184
Brain-derived neurotrophic factor enhances the excitability of rat sensory neurons through activation of the p75 neurotrophin receptor and the sphingomyelin pathwayQ46616468
Effects of electroacupuncture on cold allodynia in a rat model of neuropathic pain: mediation by spinal adrenergic and serotonergic receptorsQ46626488
Supraspinal brain-derived neurotrophic factor signaling: a novel mechanism for descending pain facilitation.Q46884566
Complete Freunds adjuvant-induced peripheral inflammation evokes glial activation and proinflammatory cytokine expression in the CNS.Q47249503
Direct evidence of primary afferent sprouting in distant segments following spinal cord injury in the rat: colocalization of GAP-43 and CGRP.Q47364955
Contribution of neurotrophin-3 to the neuropeptide Y-induced increase in neurite outgrowth of rat dorsal root ganglion cellsQ47734320
BDNF parabrachio-amygdaloid pathway in morphine-induced analgesia.Q47913541
Expression of nerve growth factor receptors by Schwann cells of axotomized peripheral nerves: ultrastructural location, suppression by axonal contact, and binding propertiesQ48120803
Downregulation of voltage-gated potassium channel alpha gene expression by axotomy and neurotrophins in rat dorsal root gangliaQ48128408
Reversal by NGF of cytostatic drug-induced reduction of neurite outgrowth in rat dorsal root ganglia in vitroQ48155718
Endogenous TrkB ligands suppress functional mechanosensory plasticity in the deafferented spinal cordQ48157959
Nerve growth factor administration protects against experimental diabetic sensory neuropathyQ48190313
Antinociceptive effect of brain-derived neurotrophic factor and neurotrophin-3.Q48191303
Electroacupuncture attenuates mechanical and warm allodynia through suppression of spinal glial activation in a rat model of neuropathic painQ48226606
BDNF is involved in sympathetic sprouting in the dorsal root ganglia following peripheral nerve injury in rats.Q48265811
Increased brain-derived neurotrophic factor expression in white blood cells of relapsing-remitting multiple sclerosis patientsQ48306926
Changes in spinal and supraspinal endocannabinoid levels in neuropathic ratsQ48408629
Attenuation of mechanical hyperalgesia following spinal cord injury by administration of antibodies to nerve growth factor in the rat.Q48420373
The effects of NGF and sensory nerve stimulation on collateral sprouting and gene expression in adult sensory neuronsQ48455674
Expression of mRNAs for neurotrophins (NGF, BDNF, and NT-3) and their receptors (p75NGFR, trk, trkB, and trkC) in human peripheral neuropathiesQ48477752
Nerve growth factor treatment increases brain-derived neurotrophic factor selectively in TrkA-expressing dorsal root ganglion cells and in their central terminations within the spinal cordQ48617112
Differential expression of neurotrophic factors and inflammatory cytokines by myelin basic protein-specific and other recruited T cells infiltrating the central nervous system during experimental autoimmune encephalomyelitisQ48636254
Expression of brain-derived neurotrophic factor in rat dorsal root ganglia, spinal cord and gracile nuclei in experimental models of neuropathic painQ48697972
Immune cell NT-3 expression is associated with brain atrophy in multiple sclerosis patients.Q48808347
Endogenous brain-derived neurotrophic factor is anterogradely transported in primary sensory neuronsQ48906291
Direct evidence for the involvement of brain-derived neurotrophic factor in the development of a neuropathic pain-like state in miceQ48925048
Evidence that nerve growth factor promotes the recovery of peripheral neuropathy induced in mice by cisplatin: behavioral, structural and biochemical analysisQ48940708
The secreted brain-derived neurotrophic factor precursor pro-BDNF binds to TrkB and p75NTR but not to TrkA or TrkC.Q49062410
Regulation of Trk receptors following contusion of the rat spinal cordQ49067304
BDNF: a neuromodulator in nociceptive pathways?Q57898658
ERK is sequentially activated in neurons, microglia, and astrocytes by spinal nerve ligation and contributes to mechanical allodynia in this neuropathic pain modelQ57990428
Interleukin-1 regulates synthesis of nerve growth factor in non-neuronal cells of rat sciatic nerveQ59086360
Nerve growth factor acutely sensitizes the response of adult rat sensory neurons to capsaicinQ60705124
Effects of Endogenous Neurotrophins on Sympathetic Sprouting in the Dorsal Root Ganglia and Allodynia Following Spinal Nerve InjuryQ60706886
Satellite-cell-derived nerve growth factor and neurotrophin-3 are involved in noradrenergic sprouting in the dorsal root ganglia following peripheral nerve injury in the ratQ60706906
Intrathecal NGF Administration Reduces Reactive Astrocytosis and Changes Neurotrophin Receptors Expression Pattern in a Rat Model of Neuropathic PainQ61071120
BDNF and gp145trkB in multiple sclerosis brain lesions: neuroprotective interactions between immune and neuronal cells?Q61709659
Neurotrophins giveth and they taketh awayQ64445328
Multiple sclerosis patients express increased levels of beta-nerve growth factor in cerebrospinal fluidQ67984181
Contribution of protein kinase C to central sensitization and persistent pain following tissue injuryQ68014211
Nerve growth factor prevents experimental cisplatin neuropathyQ68068322
Nerve growth factor receptors on normal and injured sensory neuronsQ69335214
Expression of neurotrophins and their receptors in sciatic nerve of experimentally diabetic ratsQ70958208
Neurotrophin‐3 reverses experimental cisplatin‐induced peripheral sensory neuropathyQ71879369
BDNF produces analgesia in the formalin test and modifies neuropeptide levels in rat brain and spinal cord areas associated with nociceptionQ71913305
trkB-like immunoreactivity in rat dorsal root ganglia following sciatic nerve injuryQ72406959
Altered neurotrophin mRNA levels in peripheral nerve and skeletal muscle of experimentally diabetic ratsQ72557687
Anatomical evidence supporting the potential for modulation by multiple neurotrophins in the majority of adult lumbar sensory neuronsQ73089927
Efficacy and safety of recombinant human nerve growth factor in patients with diabetic polyneuropathy: A randomized controlled trial. rhNGF Clinical Investigator GroupQ73135923
Neurotrophin expression by spinal motoneurons in adult and developing ratsQ73282050
Tolerability of recombinant-methionyl human neurotrophin-3 (r-metHuNT3) in healthy subjectsQ73365723
Nerve growth factor- and neurotrophin-3-induced changes in nociceptive threshold and the release of substance P from the rat isolated spinal cordQ73797605
Spinal cord injury and anti-NGF treatment results in changes in CGRP density and distribution in the dorsal horn in the ratQ73820547
Up-regulation of the TrkB receptor in mice injured by the partial ligation of the sciatic nerveQ74107179
Target tissue production and axonal transport of neurotrophin-3 are reduced in streptozotocin-diabetic ratsQ74440935
Effect of NGF and anti-NGF on neuropathic pain in rats following chronic constriction injury of the sciatic nerveQ74587113
Glial overexpression of NGF enhances neuropathic pain and adrenergic sprouting into DRG following chronic sciatic constriction in miceQ77134735
Nerve growth factor (NGF) and diabetic neuropathy in the rat: morphological investigations of the sural nerve, dorsal root ganglion, and spinal cordQ77319896
Characterization of antiallodynic actions of ALE-0540, a novel nerve growth factor receptor antagonist, in the ratQ77772586
NGF-mediated sensitization of the excitability of rat sensory neurons is prevented by a blocking antibody to the p75 neurotrophin receptorQ80382886
The neurotrophin receptor p75NTR in Schwann cells is implicated in remyelination and motor recovery after peripheral nerve injuryQ80545779
Neurotrophins: mediators and modulators of pain.Q36507606
Nerve growth factor: from the early discoveries to the potential clinical useQ36526946
BDNF but not NT-4 is required for normal flexion reflex plasticity and functionQ36540995
Selective inhibition of extracellular signal-regulated kinases 1/2 blocks nerve growth factor to brain-derived neurotrophic factor signaling and suppresses the development of and reverses already established pain behavior in ratsQ36627244
Protein kinases as potential targets for the treatment of pathological painQ36646044
Neurotrophin release by neurotrophins: implications for activity-dependent neuronal plasticity.Q36724679
Brain derived nerve growth factor induces spinal noradrenergic fiber sprouting and enhances clonidine analgesia following nerve injury in ratsQ36793984
Endocannabinoid metabolism and uptake: novel targets for neuropathic and inflammatory painQ36912778
Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificityQ36935698
TrkB.T1 contributes to neuropathic pain after spinal cord injury through regulation of cell cycle pathwaysQ37041596
The role of growth factors in the prevention and treatment of chemotherapy-induced peripheral neurotoxicityQ37239320
Biological activity of nerve growth factor precursor is dependent upon relative levels of its receptorsQ37258596
TrkB signaling is required for both the induction and maintenance of tissue and nerve injury-induced persistent painQ37289615
Involvement of TrkB- and p75(NTR)-signaling pathways in two contrasting forms of long-lasting synaptic plasticityQ37293533
The role of dorsal root ganglia activation and brain-derived neurotrophic factor in multiple sclerosis.Q37294255
Targeting nerve growth factor in pain: what is the therapeutic potential?Q37322267
Neurotrophin-3 significantly reduces sodium channel expression linked to neuropathic pain statesQ37362605
c-Fos and pERK, which is a better marker for neuronal activation and central sensitization after noxious stimulation and tissue injury?Q37412516
Treadmill exercise reduces spinal cord injury-induced apoptosis by activating the PI3K/Akt pathway in ratsQ37574857
Multiple sclerosis-induced neuropathic pain: pharmacological management and pathophysiological insights from rodent EAE modelsQ37601317
Targeting NGF pathway for developing neuroprotective therapies for multiple sclerosis and other neurological diseasesQ37894003
The neurotrophin family of neurotrophic factors: an overviewQ37988419
p75 neurotrophin receptor signaling in nervous system injury and degeneration: paradox and opportunityQ38002635
Pro-neurotrophins, sortilin, and nociceptionQ38185068
Endocannabinoids and neuropathic pain: focus on neuron-glia and endocannabinoid-neurotrophin interactionsQ38185071
Neurotrophins in the regulation of cellular survival and deathQ38199413
Mechanisms of disease: role of neurotrophins in diabetes and diabetic neuropathyQ38269667
Brain-derived neurotrophic factor as a driving force behind neuroplasticity in neuropathic and central sensitization pain: a new therapeutic target?Q38292331
A systematic review of the efficacy and general safety of antibodies to NGF in the treatment of OA of the hip or kneeQ38295106
Establishment and characterization of an optimized mouse model of multiple sclerosis-induced neuropathic pain using behavioral, pharmacologic, histologic and immunohistochemical methodsQ39128725
Selective induction of tyrosine hydroxylase and dopamine β-hydroxylase by nerve growth factor: comparison between adrenal medulla and sympathetic ganglia of adult and newborn ratsQ39164014
Exploring the role of tanezumab as a novel treatment for the relief of neuropathic painQ39195605
Acetyl-L-carnitine increases artemin level and prevents neurotrophic factor alterations during neuropathy.Q39289155
Antibodies to nerve growth factor reverse established tactile allodynia in rodent models of neuropathic pain without toleranceQ39336890
P275copyright licenseCreative Commons AttributionQ6905323
P6216copyright statuscopyrightedQ50423863
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectneuralgiaQ1136940
neuropathic painQ2798704
nerve growth factorsQ98072643
P304page(s)10657-10688
P577publication date2015-06-09
P1433published inMoleculesQ151332
P1476titleNeurotrophins and Neuropathic Pain: Role in Pathobiology
P478volume20

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cites work (P2860)
Q64093272A Novel Peptide Interfering with proBDNF-Sortilin Interaction Alleviates Chronic Inflammatory Pain
Q37592861Activation of neurotrophins in lumbar dorsal root probably contributes to neuropathic pain after spinal nerve ligation.
Q38826512Alleviation of pain in painful diabetic neuropathy
Q52331711An Inflammation-Centric View of Neurological Disease: Beyond the Neuron.
Q47994138An exploratory study of BDNF and oxidative stress marker alterations in subacute and chronic stroke patients affected by neuropathic pain
Q47159630Attenuation of the Infiltration of Angiotensin II Expressing CD3+ T-Cells and the Modulation of Nerve Growth Factor in Lumbar Dorsal Root Ganglia - A Possible Mechanism Underpinning Analgesia Produced by EMA300, An Angiotensin II Type 2 (AT2) Recept
Q60915306Bogijetong Decoction and Its Selected Formulation Are Involved in Alleviating Neuropathic Pain in a Rat Model of Chronic Constrictive Injury
Q45992958Chronic Pain After Traumatic Brain Injury: Pathophysiology and Pain Mechanisms.
Q68691896CircAnks1a in the spinal cord regulates hypersensitivity in a rodent model of neuropathic pain
Q91710271Deficits in systemic biomarkers of neuroinflammation and growth factors promoting nerve regeneration in patients with type 2 diabetes and polyneuropathy
Q48232122Demonstration of an anti-hyperalgesic effect of a novel pan-Trk inhibitor PF-06273340 in a battery of human evoked pain models.
Q90575393Dim Light at Night Exposure Induces Cold Hyperalgesia and Mechanical Allodynia in Male Mice
Q58741796Effect of PEA-OXA on neuropathic pain and functional recovery after sciatic nerve crush
Q33705029Impaired Spinal Glucocorticoid Receptor Signaling Contributes to the Attenuating Effect of Depression on Mechanical Allodynia and Thermal Hyperalgesia in Rats with Neuropathic Pain
Q88753838Involvement of the VGF-derived peptide TLQP-62 in nerve injury-induced hypersensitivity and spinal neuroplasticity
Q37701087Macrophage and nerve interaction in endometriosis
Q54981810Merestinib (LY2801653) inhibits neurotrophic receptor kinase (NTRK) and suppresses growth of NTRK fusion bearing tumors.
Q55005540Nerve Growth Factor and Pathogenesis of Leprosy: Review and Update.
Q94338265Nerve growth factor for neuropathic pain
Q90258507Nerve growth factor gene therapy improves bone marrow sensory innervation and nociceptor-mediated stem cell release in a mouse model of type 1 diabetes with limb ischaemia
Q37256159Neural Stem Cells Engineered to Express Three Therapeutic Factors Mediate Recovery from Chronic Stage CNS Autoimmunity
Q57022000Neuron activity-induced Wnt signaling up-regulates expression of brain-derived neurotrophic factor in the pain neural circuit
Q92328941Neurotrophins and neuropathic pain in patients with traumatic brain injury
Q59126105Oxycodone regulates incision-induced activation of neurotrophic factors and receptors in an acute post-surgery pain rat model
Q93042699Panax ginseng (Korea Red Ginseng) repairs diabetic sensorineural damage through promotion of the nerve growth factor pathway in diabetic zebrafish
Q33802464Peripheral inflammatory pain sensitisation is independent of mast cell activation in male mice
Q58694734Peripheral sympathetic mechanisms in orofacial pain
Q52663819Physiologic facet capsule stretch can induce pain & upregulate matrix metalloproteinase-3 in the dorsal root ganglia when preceded by a physiological mechanical or nonpainful chemical exposure.
Q89449289Polycistronic Delivery of IL-10 and NT-3 Promotes Oligodendrocyte Myelination and Functional Recovery in a Mouse Spinal Cord Injury Model
Q47985898Role of the spinal TrkB-NMDA receptor link in the BDNF-induced long-lasting mechanical hyperalgesia in the rat: A behavioural study
Q35884375SP, CGRP changes in pyridoxine induced neuropathic dogs with nerve growth factor gene therapy
Q38605796Swimming Training Reduces Neuroma Pain by Regulating Neurotrophins
Q52669750Systemic Inflammation Inhibits Serotonin Receptor 2-induced Phrenic Motor Facilitation Upstream from BDNF/TrkB Signaling.
Q33668659Targeting the Microglial Signaling Pathways: New Insights in the Modulation of Neuropathic Pain
Q36792598The Adaptor Protein CD2AP Is a Coordinator of Neurotrophin Signaling-Mediated Axon Arbor Plasticity.
Q97075152The Delayed-Onset Mechanical Pain Behavior Induced by Infant Peripheral Nerve Injury Is Accompanied by Sympathetic Sprouting in the Dorsal Root Ganglion
Q59519802Ultraschallgesteuerte Interventionen am peripheren Nervensystem
Q38660842Understanding respiratory syncytial virus (RSV) vaccine development and aspects of disease pathogenesis.
Q59792715Villainous role of estrogen in macrophage-nerve interaction in endometriosis
Q47877991WWL70 protects against chronic constriction injury-induced neuropathic pain in mice by cannabinoid receptor-independent mechanisms

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