Demonstration of an anti-hyperalgesic effect of a novel pan-Trk inhibitor PF-06273340 in a battery of human evoked pain models.

scientific article published on 27 November 2017

Demonstration of an anti-hyperalgesic effect of a novel pan-Trk inhibitor PF-06273340 in a battery of human evoked pain models. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1111/BCP.13448
P932PMC publication ID5777446
P698PubMed publication ID29178434

P50authorDonal GormanQ89413294
P2093author name stringKatrina Gore
Richard P Butt
Geert Jan Groeneveld
Justin L Hay
Peter Loudon
Pinky Dua
Guido van Amerongen
Pieter Siebenga
P2860cites workNGF induces non-inflammatory localized and lasting mechanical and thermal hypersensitivity in human skinQ57215013
Efficacy and safety of intravenous tanezumab for the symptomatic treatment of osteoarthritis: 2 randomized controlled trials versus naproxenQ85664357
Long-term safety and effectiveness of tanezumab as treatment for chronic low back painQ88095844
Neurotrophins and Neuropathic Pain: Role in PathobiologyQ28084413
The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligandsQ28603128
Local gene expression changes after UV-irradiation of human skinQ28728091
The Concise Guide to PHARMACOLOGY 2015/16: Catalytic receptorsQ30488655
Modulation of ultraviolet-induced hyperalgesia and cytokine upregulation by interleukins 10 and 13Q35042934
Antagonism of nerve growth factor-TrkA signaling and the relief of painQ35064559
Neurotrophins: mediators and modulators of pain.Q36507606
Selective inhibition of tropomyosin-receptor-kinase A (TrkA) reduces pain and joint damage in two rat models of inflammatory arthritis.Q36871346
Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task BatteryQ37087716
Treatment of chronic non-cancer painQ37894414
Brain-derived neurotrophic factor as a driving force behind neuroplasticity in neuropathic and central sensitization pain: a new therapeutic target?Q38292331
The use of baseline covariates in crossover studiesQ39128607
Exploring the role of tanezumab as a novel treatment for the relief of neuropathic painQ39195605
The Discovery of a Potent, Selective, and Peripherally Restricted Pan-Trk Inhibitor (PF-06273340) for the Treatment of PainQ39263564
Systems pharmacology of the nerve growth factor pathway: use of a systems biology model for the identification of key drug targets using sensitivity analysis and the integration of physiology and pharmacologyQ40186234
When Is Osteonecrosis Not Osteonecrosis?: Adjudication of Reported Serious Adverse Joint Events in the Tanezumab Clinical Development ProgramQ40337398
p38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesiaQ42526677
The use of a battery of pain models to detect analgesic properties of compounds: a two-part four-way crossover study.Q47942829
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)301-309
P577publication date2017-11-28
P1433published inBritish Journal of Clinical PharmacologyQ176044
P1476titleDemonstration of an anti-hyperalgesic effect of a novel pan-Trk inhibitor PF-06273340 in a battery of human evoked pain models
P478volume84

Reverse relations

cites work (P2860)
Q92644368Analgesic potential of PF-06372865, an α2/α3/α5 subtype-selective GABAA partial agonist, in humans
Q91806664Does in vitro potency predict clinical efficacious concentrations?
Q64275708Quantitative Systems Pharmacology and Empirical Models: Friends or Foes?
Q90828394The ultraviolet B inflammation model: Postinflammatory hyperpigmentation and validation of a reduced UVB exposure paradigm for inducing hyperalgesia in healthy subjects

Search more.