Analgesic potential of PF-06372865, an α2/α3/α5 subtype-selective GABAA partial agonist, in humans

scientific article published on 31 January 2019

Analgesic potential of PF-06372865, an α2/α3/α5 subtype-selective GABAA partial agonist, in humans is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.BJA.2018.12.006
P932PMC publication ID6676245
P698PubMed publication ID30915991

P2093author name stringRachel Gurrell
Mark Whitlock
Donal Gorman
Richard P Butt
Pieter Okkerse
Geert Jan Groeneveld
Justin L Hay
Pinky Dua
Guido van Amerongen
Pieter S Siebenga
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Genuine antihyperalgesia by systemic diazepam revealed by experiments in GABAA receptor point-mutated miceQ46193090
Pharmacology in translation; the preclinical and early clinical profile of the novel α2/3 functionally selective GABAA receptor positive allosteric modulator PF-06372865.Q46246232
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No evidence of potentiation of buprenorphine by milnacipran in healthy subjects using a nociceptive test batteryQ88374096
A randomised, placebo-controlled clinical trial with the α2/3/5 subunit selective GABAA positive allosteric modulator PF-06372865 in patients with chronic low back painQ88771965
P433issue2
P304page(s)e194-e203
P577publication date2019-01-31
P1433published inBritish Journal of AnaesthesiaQ72466
P1476titleAnalgesic potential of PF-06372865, an α2/α3/α5 subtype-selective GABAA partial agonist, in humans
P478volume123

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cites work (P2860)
Q90323235GABAergic modulation of secondary hyperalgesia: A randomized controlled 4-way crossover trial with the α2-subunit preferring GABA positive allosteric modulator, N-desmethyl-clobazam in healthy volunteers
Q92592856Progress in pain medicine: where are we now?

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