Frequency of inherited variants in the MEFV gene in myelodysplastic syndrome and acute myeloid leukemia

scientific article published on 18 February 2012

Frequency of inherited variants in the MEFV gene in myelodysplastic syndrome and acute myeloid leukemia is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S12185-012-1022-0
P698PubMed publication ID22351163

P2093author name stringSerkan Celik
Cagatay Oktenli
Ozkan Sayan
Yavuz S Sanisoglu
Osman Ipcioglu
Fatih Tangi
H Onur Ozari
Alev A Erikci
Emrah Kilicaslan
M Hakan Terekeci
P2860cites workPYPAF1, a PYRIN-containing Apaf1-like protein that assembles with ASC and regulates activation of NF-kappa BQ24292156
The PAAD/PYRIN-only protein POP1/ASC2 is a modulator of ASC-mediated nuclear-factor-kappa B and pro-caspase-1 regulationQ24298443
The PAAD/PYRIN-family protein ASC is a dual regulator of a conserved step in nuclear factor kappaB activation pathwaysQ24337186
Regulation of cryopyrin/Pypaf1 signaling by pyrin, the familial Mediterranean fever gene productQ28180120
Familial autoinflammatory diseases: genetics, pathogenesis and treatmentQ28266680
Targeting NF-kappaB in hematologic malignanciesQ28299055
Phenylarsine oxide blocks interleukin-1beta-induced activation of the nuclear transcription factor NF-kappaB, inhibits proliferation, and induces apoptosis of acute myelogenous leukemia cellsQ28373909
The PYRIN connection: novel players in innate immunity and inflammationQ30956847
Nuclear factor kB as a target for new drug development in myeloid malignanciesQ33292635
A candidate gene for familial Mediterranean feverQ34065122
Fire and ICE: the role of pyrin domain-containing proteins in inflammation and apoptosis.Q34153664
The spectrum of Familial Mediterranean Fever (FMF) mutationsQ34314032
Chromosome and molecular abnormalities in myelodysplastic syndromesQ34336409
A distinct and unique transcriptional program expressed by tumor-associated macrophages (defective NF-kappaB and enhanced IRF-3/STAT1 activation).Q34465280
NF-kappaB and FLIP in arsenic trioxide (ATO)-induced apoptosis in myelodysplastic syndromes (MDSs)Q34560200
Myelodysplastic syndromes: From pathogenesis and prognosis to treatmentQ35800910
Deregulated NF-kappaB activity in haematological malignanciesQ36541023
The involvement of IL-1 in tumorigenesis, tumor invasiveness, metastasis and tumor-host interactionsQ36624543
Apoptosis and antiapoptotic mechanisms in the progression of myelodysplastic syndromeQ36988558
Is interleukin-1 a good or bad 'guy' in tumor immunobiology and immunotherapy?Q37118170
The SPRY domain of Pyrin, mutated in familial Mediterranean fever patients, interacts with inflammasome components and inhibits proIL-1beta processingQ40146198
The rate of MEFV gene mutations in hematolymphoid neoplasmsQ40357212
High frequency of MEFV gene mutations in patients with myeloid neoplasmQ40359750
NF-kappaB constitutes a potential therapeutic target in high-risk myelodysplastic syndromeQ40362293
Increased asymmetric dimethylarginine levels in young men with familial Mediterranean fever (FMF): is it early evidence of interaction between inflammation and endothelial dysfunction in FMF?Q40409956
Familial Mediterranean fever attacks do not alter functional and morphologic tissue Doppler echocardiographic parametersQ40413693
The rate of pyrin mutations in critically ill patients with systemic inflammatory response syndrome and sepsis: a pilot study.Q40442030
Familial Mediterranean fever (FMF) in Lebanon and Jordan: a population genetics study and report of three novel mutationsQ40490090
Does immune activation continue during an attack-free period in familial Mediterranean fever?Q40521033
Targeted disruption of pyrin, the FMF protein, causes heightened sensitivity to endotoxin and a defect in macrophage apoptosisQ40562330
The gene for familial Mediterranean fever, MEFV, is expressed in early leukocyte development and is regulated in response to inflammatory mediators.Q40621671
Clinical versus genetic diagnosis of familial Mediterranean feverQ40622322
Hematopoietic-specific expression of MEFV, the gene mutated in familial Mediterranean fever, and subcellular localization of its corresponding protein, pyrin.Q40626582
Expression of constitutively active nuclear-kappa B RelA transcription factor in blasts of acute myeloid leukemiaQ42457853
Nuclear factor-kappaB is constitutively activated in primitive human acute myelogenous leukemia cellsQ43757315
Acquisition of FLT3 or N-ras mutations is frequently associated with progression of myelodysplastic syndrome to acute myeloid leukemiaQ44737477
Targeting NF-kappaB activation via pharmacologic inhibition of IKK2-induced apoptosis of human acute myeloid leukemia cells.Q45083325
Ancient Missense Mutations in a New Member of the RoRet Gene Family Are Likely to Cause Familial Mediterranean FeverQ56288694
Oncogene mutation and prognosis in the myelodysplastic syndromesQ73309760
Methylation of the p15(INK4b) gene in myelodysplastic syndromes is frequent and acquired during disease progressionQ74412911
Nuclear factor k B is activated in myelodysplastic bone marrow cellsQ74753350
Caspase 2 and caspase 3 protein levels as predictors of survival in acute myelogenous leukemiaQ77459150
Increased IkappaB kinase activity is associated with activated NF-kappaB in acute myeloid blastsQ78306906
P433issue3
P921main subjectmyelodysplastic syndromeQ954625
P304page(s)285-290
P577publication date2012-02-18
P1433published inInternational Journal of HematologyQ6051416
P1476titleFrequency of inherited variants in the MEFV gene in myelodysplastic syndrome and acute myeloid leukemia
P478volume95

Reverse relations

cites work (P2860)
Q51732335CBL mutation and MEFV single-nucleotide variant are important genetic predictors of tumor reduction in glucocorticoid-treated patients with chronic myelomonocytic leukemia.
Q52659306Chemotherapy-Colchicine Interaction in a Child with Familial Mediterranean Fever and Hodgkin Lymphoma.
Q37997663High frequency of inherited variants in the MEFV gene in patients with hematologic neoplasms: a genetic susceptibility?
Q34141506Increased frequency of Mediterranean fever gene variants in multiple myeloma
Q37068967Mortality risk factors associated with familial Mediterranean fever among a cohort of 1.25 million adolescents
Q40110559Periodic Fever, Aphthosis, Pharyngitis, and Adenitis Syndrome: Analysis of Patients From Two Geographic Areas.

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