Targeting NF-kappaB in hematologic malignancies

scientific article

Targeting NF-kappaB in hematologic malignancies is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1038/SJ.CDD.4401874
P698PubMed publication ID16498458
P5875ResearchGate publication ID7279903

P50authorGuido KroemerQ19508945
Pierre FenauxQ30170095
P2093author name stringT Braun
G Carvalho
C Fabre
J Grosjean
P2860cites workA novel gene, MALT1 at 18q21, is involved in t(11;18) (q21;q21) found in low-grade B-cell lymphoma of mucosa-associated lymphoid tissueQ22010675
Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMOQ24303248
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The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphomaQ27824784
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A phase 2 study of bortezomib in relapsed, refractory myelomaQ33348702
Phase II study of proteasome inhibitor bortezomib in relapsed or refractory B-cell non-Hodgkin's lymphomaQ33364240
Phase 1 trial of the proteasome inhibitor bortezomib and pegylated liposomal doxorubicin in patients with advanced hematologic malignanciesQ33364359
Reactive oxygen signaling and MAPK activation distinguish Epstein-Barr Virus (EBV)-positive versus EBV-negative Burkitt's lymphomaQ33714992
Cellular origin of human B-cell lymphomas.Q33772424
Human T-cell leukemia virus type 1 Tax induction of NF-kappaB involves activation of the IkappaB kinase alpha (IKKalpha) and IKKbeta cellular kinasesQ33777633
Multiple mutations contribute to the oncogenicity of the retroviral oncoprotein v-RelQ33797168
Persistent activation of NF-kappaB by the tax transforming protein of HTLV-1: hijacking cellular IkappaB kinasesQ33797174
Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-kappaB signalling cascadesQ34086191
Expression of TNF receptors and related signaling molecules in the bone marrow from patients with myelodysplastic syndromesQ44394144
Effect of NF-kappaB/Rel inhibition on spontaneous vs chemotherapy-induced apoptosis in AML and normal cord blood CD34+ cellsQ44452187
Mechanisms of Bcr-Abl-mediated NF-kappaB/Rel activationQ44492984
BortezomibQ44542821
Nuclear factor-kappaB and STAT3 are constitutively active in CD138+ cells derived from multiple myeloma patients, and suppression of these transcription factors leads to apoptosisQ44834826
Targeting NF-kappaB activation via pharmacologic inhibition of IKK2-induced apoptosis of human acute myeloid leukemia cells.Q45083325
AT514, a cyclic depsipeptide from Serratia marcescens, induces apoptosis of B-chronic lymphocytic leukemia cells: interference with the Akt/NF-kappaB survival pathway.Q45296438
Enhancement of cytosine arabinoside-induced apoptosis in human myeloblastic leukemia cells by NF-kappa B/Rel- specific decoy oligodeoxynucleotidesQ45869627
Rapamycin stimulates apoptosis of childhood acute lymphoblastic leukemia cellsQ46477311
Bortezomib or high-dose dexamethasone for relapsed multiple myelomaQ46549268
The proteasome inhibitor bortezomib induces apoptosis in mantle-cell lymphoma through generation of ROS and Noxa activation independent of p53 statusQ46706369
Expression of FLIPLong and FLIPShort in bone marrow mononuclear and CD34+ cells in patients with myelodysplastic syndrome: correlation with apoptosisQ47439811
Apoptotic resistance to ionizing radiation in pediatric B-precursor acute lymphoblastic leukemia frequently involves increased NF-kappaB survival pathway signaling.Q47606126
The 4th nation-wide study of adult T-cell leukemia/lymphoma (ATL) in Japan: estimates of risk of ATL and its geographical and clinical features. The T- and B-cell Malignancy Study GroupQ50553300
Mutational analysis of the N-ras gene in acute lymphoblastic leukemia: a study of 125 Japanese pediatric casesQ50871661
Expression of IAP family proteins in myelodysplastic syndromes transforming to overt leukemia.Q52087420
The molecular signature of mediastinal large B-cell lymphoma differs from that of other diffuse large B-cell lymphomas and shares features with classical Hodgkin lymphoma.Q53931762
Variable frequencies of t(11;18)(q21;q21) in MALT lymphomas of different sites: significant association with CagA strains of H pylori in gastric MALT lymphoma.Q54780176
MALT lymphoma: from morphology to moleculesQ57369685
Molecular profiling of diffuse large B-cell lymphoma identifies robust subtypes including one characterized by host inflammatory responseQ57374967
Expression of the NF-κB targets BCL2 and BIRC5/Survivin characterizes small B-cell and aggressive B-cell lymphomas, respectivelyQ58010962
Survivin is expressed on CD40 stimulation and interfaces proliferation and apoptosis in B-cell chronic lymphocytic leukemiaQ58042064
Constitutive NF-κB/Rel Activation in Philadelphia Chromosome Positive (Ph+) Acute Lymphoblastic Leukemia (ALL)Q58414426
Quinine improves results of intensive chemotherapy (IC) in myelodysplastic syndromes (MDS) expressing P-glycoprotein (PGP). Updated results of a randomized study. Groupe Français des Myélodysplasies (GFM) and Groupe GOELAMSQ73028075
Detection by the fluorescence in situ hybridization technique of MYC translocations in paraffin-embedded lymphoma biopsy samplesQ73204017
Modulation of NF-kappa B activity and apoptosis in chronic lymphocytic leukemia B cellsQ73407146
Expression and prognostic significance of Bcl-2 family proteins in myelodysplastic syndromesQ74447420
Increased IkappaB kinase activity is associated with activated NF-kappaB in acute myeloid blastsQ78306906
Autocrine VEGF mediates the antiapoptotic effect of CD154 on CLL cellsQ81326791
Latent membrane protein 1 of Epstein-Barr virus mimics a constitutively active receptor molecule.Q34250209
Signaling pathways activated by daunorubicinQ34330164
Preferential induction of apoptosis for primary human leukemic stem cellsQ34415832
Identification of a tumor-associated mutant form of the NF-kappaB RelA gene with reduced DNA-binding and transactivating activitiesQ34417654
Classical Hodgkin lymphoma is characterized by recurrent copy number gains of the short arm of chromosome 2.Q34520814
NF-kappaB and FLIP in arsenic trioxide (ATO)-induced apoptosis in myelodysplastic syndromes (MDSs)Q34560200
Novel therapeutic approaches for multiple myelomaQ35170935
A requirement for NF-kappaB activation in Bcr-Abl-mediated transformationQ35195588
NF-kappaB/Rel-mediated regulation of apoptosis in hematologic malignancies and normal hematopoietic progenitors.Q35566335
Part I: Hodgkin's lymphoma--molecular biology of Hodgkin and Reed-Sternberg cellsQ35618780
The IKK NF-kappa B system: a treasure trove for drug developmentQ35621375
Nuclear factor-kappaB: the enemy withinQ35893620
Proteasome inhibition as a novel therapeutic target in human cancer.Q36014046
Myeloproliferative disorders: the centrosome connectionQ36233843
Properties of thalidomide and its analogues: implications for anticancer therapyQ36250757
Constitutive nuclear factor kappaB activity is required for survival of activated B cell-like diffuse large B cell lymphoma cellsQ36369816
Clonal deleterious mutations in the IkappaBalpha gene in the malignant cells in Hodgkin's lymphomaQ36375732
c-FLIP mediates resistance of Hodgkin/Reed-Sternberg cells to death receptor-induced apoptosisQ36399443
The human T-lymphotropic virus type I tax gene can cooperate with the ras oncogene to induce neoplastic transformation of cellsQ36714886
Potentiation of tumour apoptosis by human growth hormone via glutathione production and decreased NF-kappaB activityQ38306010
Identification of NF-kappa B-regulated genes induced by TNFalpha utilizing expression profiling and RNA interferenceQ38355972
NF-kappaB transcription factor induces drug resistance through MDR1 expression in cancer cellsQ38358712
Constitutive nuclear factor-kappaB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cellsQ39795545
NF-kappaB constitutes a potential therapeutic target in high-risk myelodysplastic syndromeQ40362293
Curcumin suppresses constitutive activation of AP-1 by downregulation of JunD protein in HTLV-1-infected T-cell linesQ40374653
Elevated NF-kappaB p50 complex formation and Bcl-3 expression in classical Hodgkin, anaplastic large-cell, and other peripheral T-cell lymphomasQ40381315
Constitutive NF-kappaB activation by the t(11;18)(q21;q21) product in MALT lymphoma is linked to deregulated ubiquitin ligase activityQ40422412
NFkappaB activity, function, and target-gene signatures in primary mediastinal large B-cell lymphoma and diffuse large B-cell lymphoma subtypesQ40427138
Role for the nuclear factor kappaB pathway in transforming growth factor-beta1 production in idiopathic myelofibrosis: possible relationship with FK506 binding protein 51 overexpressionQ40434394
Transcriptional activation of survivin through the NF-kappaB pathway by human T-cell leukemia virus type I tax.Q40454759
Chemosensitization by erythropoietin through inhibition of the NF-kappaB rescue pathwayQ40484626
Transcriptional activation of hTERT through the NF-kappaB pathway in HTLV-I-transformed cellsQ40540408
A sustained activation of PI3K/NF-kappaB pathway is critical for the survival of chronic lymphocytic leukemia B cells.Q40549559
Resveratrol blocks interleukin-1beta-induced activation of the nuclear transcription factor NF-kappaB, inhibits proliferation, causes S-phase arrest, and induces apoptosis of acute myeloid leukemia cellsQ40594673
Curcumin (Diferuloylmethane) Inhibits Constitutive and IL-6-Inducible STAT3 Phosphorylation in Human Multiple Myeloma CellsQ40633129
Malignant transformation of primary chicken spleen cells by human transcription factor c-RelQ40769231
Analysis of expression of nuclear factor kappa B (NF-kappa B) in multiple myeloma: downregulation of NF-kappa B induces apoptosisQ40769452
NF-kappa B as a central mediator in the induction of TGF-beta in monocytes from patients with idiopathic myelofibrosis: an inflammatory response beyond the realm of homeostasisQ40864312
B-cell lymphoma of MALT type: a review with special emphasis on diagnostic and management problems of low-grade gastric tumoursQ41694133
Blockade of the Bcr-Abl kinase activity induces apoptosis of chronic myelogenous leukemia cells by suppressing signal transducer and activator of transcription 5-dependent expression of Bcl-xLQ42139163
Expression of constitutively active nuclear-kappa B RelA transcription factor in blasts of acute myeloid leukemiaQ42457853
Oncogenic Ha-Ras-induced signaling activates NF-kappaB transcriptional activity, which is required for cellular transformationQ42795799
Inhibition of NF-kappa B activity by thalidomide through suppression of IkappaB kinase activityQ43571541
Nuclear factor-kappaB is constitutively activated in primitive human acute myelogenous leukemia cellsQ43757315
Apoptotic signaling induced by immunomodulatory thalidomide analogs in human multiple myeloma cells: therapeutic implicationsQ44010411
The function of multiple IkappaB : NF-kappaB complexes in the resistance of cancer cells to Taxol-induced apoptosisQ44134125
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectNF-κBQ411114
P304page(s)748-58
P577publication date2006-05-01
P1433published inCell Death & DifferentiationQ2943974
P1476titleTargeting NF-kappaB in hematologic malignancies
P478volume13

Reverse relations

cites work (P2860)
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