Vitamin E δ-tocotrienol inhibits TNF-α-stimulated NF-κB activation by up-regulation of anti-inflammatory A20 via modulation of sphingolipid including elevation of intracellular dihydroceramides

scientific article published on 03 November 2018

Vitamin E δ-tocotrienol inhibits TNF-α-stimulated NF-κB activation by up-regulation of anti-inflammatory A20 via modulation of sphingolipid including elevation of intracellular dihydroceramides is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.JNUTBIO.2018.10.013
P932PMC publication ID6363855
P698PubMed publication ID30471562

P2093author name stringQing Jiang
Chao Yang
P2860cites workDe-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signallingQ24299573
ABIN-1 binds to NEMO/IKKgamma and co-operates with A20 in inhibiting NF-kappaBQ24336707
Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient miceQ24616207
Immunity, Inflammation, and CancerQ27861048
CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family membersQ28201693
Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaBQ28201706
NF-kappaB is essential for induction of CYLD, the negative regulator of NF-kappaB: evidence for a novel inducible autoregulatory feedback pathwayQ28269436
Introduction to NF-kappaB: players, pathways, perspectivesQ28271022
Gamma-tocotrienol attenuates the aberrant lipid mediator production in NLRP3 inflammasome-stimulated macrophagesQ89344758
Targeting NF-kappaB in hematologic malignanciesQ28299055
NF-kappaB functions as a tumour promoter in inflammation-associated cancerQ29614598
The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responsesQ29616349
Crosstalk in NF-κB signaling pathwaysQ29617418
Inflammation and oncogenesis: a vicious connectionQ33653294
Oncogenic activation of NF-kappaB.Q33849388
Natural forms of vitamin E: metabolism, antioxidant, and anti-inflammatory activities and their role in disease prevention and therapyQ33998131
Mutations of multiple genes cause deregulation of NF-kappaB in diffuse large B-cell lymphoma.Q34277639
δ-Tocotrienol and quercetin reduce serum levels of nitric oxide and lipid parameters in female chickensQ34646385
Vitamin E δ-tocotrienol augments the antitumor activity of gemcitabine and suppresses constitutive NF-κB activation in pancreatic cancerQ35613168
The IKK/NF-kappaB activation pathway-a target for prevention and treatment of cancerQ35687935
Inhibition of nitric oxide in LPS-stimulated macrophages of young and senescent mice by δ-tocotrienol and quercetinQ35704170
Vitamin E γ-Tocotrienol Inhibits Cytokine-Stimulated NF-κB Activation by Induction of Anti-Inflammatory A20 via Stress Adaptive Response Due to Modulation of SphingolipidsQ35762884
Gamma-tocotrienol induces apoptosis and autophagy in prostate cancer cells by increasing intracellular dihydrosphingosine and dihydroceramide.Q36052937
Sphingolipidomics: high-throughput, structure-specific, and quantitative analysis of sphingolipids by liquid chromatography tandem mass spectrometryQ36127968
Involvement of dihydroceramide desaturase in cell cycle progression in human neuroblastoma cellsQ36157119
Expression of A20 by dendritic cells preserves immune homeostasis and prevents colitis and spondyloarthritis.Q36164605
A Phase I Safety, Pharmacokinetic, and Pharmacodynamic Presurgical Trial of Vitamin E δ-tocotrienol in Patients with Pancreatic Ductal NeoplasiaQ36437690
Potential role of CYLD (Cylindromatosis) as a deubiquitinating enzyme in vascular cellsQ36482246
γ-Tocotrienol inhibits lipopolysaccharide-induced interlukin-6 and granulocyte colony-stimulating factor by suppressing C/EBPβ and NF-κB in macrophagesQ36724490
Vitamin E metabolite 13'-carboxychromanols inhibit pro-inflammatory enzymes, induce apoptosis and autophagy in human cancer cells by modulating sphingolipids and suppress colon tumor development in miceQ36902001
NFkappaB signaling in carcinogenesis and as a potential molecular target for cancer therapyQ37391444
CYLD: a tumor suppressor deubiquitinase regulating NF-kappaB activation and diverse biological processesQ37448141
The ubiquitin-editing enzyme A20 (TNFAIP3) is a central regulator of immunopathologyQ37567071
gamma-Tocopherol or combinations of vitamin E forms induce cell death in human prostate cancer cells by interrupting sphingolipid synthesisQ37707881
Return to homeostasis: downregulation of NF-κB responsesQ37902868
CYLD, A20 and OTULIN deubiquitinases in NF-κB signaling and cell death: so similar, yet so differentQ39210955
Involvement of de novo ceramide synthesis in gamma-tocopherol and gamma-tocotrienol-induced apoptosis in human breast cancer cellsQ39259261
Dihydroceramide desaturase activity is modulated by oxidative stress.Q39747371
Direct, noncatalytic mechanism of IKK inhibition by A20.Q39773165
The deubiquitinase activity of A20 is dispensable for NF-κB signaling.Q42076015
Tocotrienols promote apoptosis in human breast cancer cells by inducing poly(ADP-ribose) polymerase cleavage and inhibiting nuclear factor kappa-B activityQ45018412
A20 attenuates allergic airway inflammation in mice.Q45954119
Dihydroceramide intracellular increase in response to resveratrol treatment mediates autophagy in gastric cancer cells.Q46036649
Natural Forms of Vitamin E as Effective Agents for Cancer Prevention and TherapyQ49988596
TNF phase III signalling in tolerant cells is tightly controlled by A20 and CYLD.Q50577547
Gamma-tocotrienol profoundly alters sphingolipids in cancer cells by inhibition of dihydroceramide desaturase and possibly activation of sphingolipid hydrolysis during prolonged treatment.Q51027990
Annatto Tocotrienol Attenuates NLRP3 Inflammasome Activation in MacrophagesQ89335918
P921main subjectsphingolipidsQ410395
NF-κBQ411114
P304page(s)101-109
P577publication date2018-11-03
P1433published inJournal of Nutritional BiochemistryQ15716705
P1476titleVitamin E δ-tocotrienol inhibits TNF-α-stimulated NF-κB activation by up-regulation of anti-inflammatory A20 via modulation of sphingolipid including elevation of intracellular dihydroceramides
P478volume64

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cites work (P2860)
Q89525397Vitamin E and cancer prevention: Studies with different forms of tocopherols and tocotrienols
Q64986757Vitamin E and cancer: an update on the emerging role of γ and δ tocotrienols.

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