Sensitization of melanoma cells for death ligand-induced apoptosis by an indirubin derivative—Enhancement of both extrinsic and intrinsic apoptosis pathways

scientific article published on September 19, 2010

Sensitization of melanoma cells for death ligand-induced apoptosis by an indirubin derivative—Enhancement of both extrinsic and intrinsic apoptosis pathways is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.BCP.2010.09.010
P953full work available at URLhttps://api.elsevier.com/content/article/PII:S0006295210006933?httpAccept=text/xml
https://hal.archives-ouvertes.fr/hal-00642430/file/PEER_stage2_10.1016%252Fj.bcp.2010.09.010.pdf
https://api.elsevier.com/content/article/PII:S0006295210006933?httpAccept=text/plain
P698PubMed publication ID20858462
P5875ResearchGate publication ID46392871

P50authorJürgen EberleQ92285142
P2093author name stringManfred Kunz
Michael Plötz
Peter Langer
Anja Berger
Martin Hein
Sandra-Annika Quast
P2860cites workCleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosisQ24310597
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The Bad guy cooperates with good cop p53: Bad is transcriptionally up-regulated by p53 and forms a Bad/p53 complex at the mitochondria to induce apoptosisQ35131647
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Triptolide induces cell death independent of cellular responses to imatinib in blast crisis chronic myelogenous leukemia cells including quiescent CD34+ primitive progenitor cellsQ37369672
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Trichostatin A sensitizes human ovarian cancer cells to TRAIL-induced apoptosis by down-regulation of c-FLIPL via inhibition of EGFR pathwayQ39854847
Apo2L/TRAIL inhibits tumor growth and bone destruction in a murine model of multiple myelomaQ39874761
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Critical role of Bid and Bax in indirubin-3'-monoxime-induced apoptosis in human cancer cellsQ39996865
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Indirubin-3'-monoxime inhibits autophosphorylation of FGFR1 and stimulates ERK1/2 activity via p38 MAPK.Q40126914
Antitumor activity of novel indirubin derivatives in rat tumor modelQ40187912
Resistance of melanoma cells to TRAIL does not result from upregulation of antiapoptotic proteins by NF-kappaB but is related to downregulation of initiator caspases and DR4.Q40198109
Wogonin sensitizes resistant malignant cells to TNFalpha- and TRAIL-induced apoptosisQ40239748
Indirubin enhances tumor necrosis factor-induced apoptosis through modulation of nuclear factor-kappa B signaling pathway.Q40265640
7-Bromoindirubin-3'-oxime induces caspase-independent cell deathQ40279500
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Phase I dose-escalation study of recombinant human Apo2L/TRAIL, a dual proapoptotic receptor agonist, in patients with advanced cancerQ40359028
Antitumor effect of G3139 Bcl-2 antisense oligonucleotide is independent of its immune stimulation by CpG motifs in SCID miceQ40672841
Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinasesQ40918567
Indirubin-3'-monoxime rescues spatial memory deficits and attenuates beta-amyloid-associated neuropathology in a mouse model of Alzheimer's diseaseQ43104154
Downregulation of c-FLIP, XIAP and Mcl-1 protein as well as depletion of reduced glutathione contribute to the apoptosis induction of glycyrrhetinic acid derivatives in leukemia cellsQ43233411
XIAP inhibition of caspase-3 preserves its association with the Apaf-1 apoptosome and prevents CD95- and Bax-induced apoptosisQ44104444
Receptor-selective mutants of apoptosis-inducing ligand 2/tumor necrosis factor-related apoptosis-inducing ligand reveal a greater contribution of death receptor (DR) 5 than DR4 to apoptosis signalingQ46580419
Mitochondria in cell death.Q50550781
Apoptosis pathways and oncolytic adenoviral vectors: promising targets and tools to overcome therapy resistance of malignant melanomaQ64376859
Production of indoxyl derivatives in indole-supplemented tissue cultures of Polygonum tinctoriumQ79658488
A phase I safety and pharmacokinetic study of the death receptor 5 agonistic antibody PRO95780 in patients with advanced malignanciesQ82847250
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectapoptotic processQ14599311
P304page(s)71-81
P577publication date2010-09-19
P1433published inBiochemical PharmacologyQ864229
P1476titleSensitization of melanoma cells for death ligand-induced apoptosis by an indirubin derivative--Enhancement of both extrinsic and intrinsic apoptosis pathways
Sensitization of melanoma cells for death ligand-induced apoptosis by an indirubin derivative—Enhancement of both extrinsic and intrinsic apoptosis pathways
P478volume81

Reverse relations

cites work (P2860)
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Q26784341Indirubin and Indirubin Derivatives for Counteracting Proliferative Diseases
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