Palmitate-induced skeletal muscle insulin resistance does not require NF-κB activation

scientific article published on 5 September 2010

Palmitate-induced skeletal muscle insulin resistance does not require NF-κB activation is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1007/S00018-010-0515-3
P932PMC publication ID3056136
P698PubMed publication ID20820848
P5875ResearchGate publication ID46159269

P50authorAnnemie M W J ScholsQ48890769
Lauren M SparksQ57373184
Ronald P. MensinkQ92464699
P2093author name stringJogchum Plat
Pascal P H Hommelberg
Ramon C J Langen
Marco C J M Kelders
Denis van Beurden
Anon L M van Essen
P2860cites workIdentification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesisQ24645996
Conditional disruption of IkappaB kinase 2 fails to prevent obesity-induced insulin resistanceQ28167026
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Salicylic acid reverses phorbol 12-myristate-13-acetate (PMA)- and tumor necrosis factor alpha (TNFalpha)-induced insulin receptor substrate 1 (IRS1) serine 307 phosphorylation and insulin resistance in human embryonic kidney 293 (HEK293) cellsQ28194070
Aspirin inhibits serine phosphorylation of insulin receptor substrate 1 in tumor necrosis factor-treated cells through targeting multiple serine kinasesQ28195772
Fatty acid-induced insulin resistance in L6 myotubes is prevented by inhibition of activation and nuclear localization of nuclear factor kappa BQ28208638
Stereospecificity of the inhibition by etomoxir of fatty acid and cholesterol synthesis in isolated rat hepatocytesQ28333704
Prevention of fat-induced insulin resistance by salicylateQ28345600
Global and societal implications of the diabetes epidemicQ29614551
A central role for JNK in obesity and insulin resistanceQ29619778
Saturated, but not n-6 polyunsaturated, fatty acids induce insulin resistance: role of intramuscular accumulation of lipid metabolitesQ34476883
The anti-inflammatory natural product parthenolide from the medicinal herb Feverfew directly binds to and inhibits IkappaB kinaseQ34517140
Effect of endotoxin-induced monokines on glucose metabolism in the muscle cell line L6.Q34616369
Upregulation of myocellular DGAT1 augments triglyceride synthesis in skeletal muscle and protects against fat-induced insulin resistance.Q35785726
Inhibition of nuclear translocation of transcription factor NF-kappa B by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequenceQ36707669
An update of the enzymology and regulation of sphingomyelin metabolismQ37923512
Fatty acid-induced NF-kappaB activation and insulin resistance in skeletal muscle are chain length dependentQ39924051
The proinflammatory cytokine tumor necrosis factor-alpha increases the amount of glucose transporter-4 at the surface of muscle cells independently of changes in interleukin-6.Q40030161
CPT I overexpression protects L6E9 muscle cells from fatty acid-induced insulin resistanceQ40216131
Palmitate induces tumor necrosis factor-alpha expression in C2C12 skeletal muscle cells by a mechanism involving protein kinase C and nuclear factor-kappaB activationQ40362277
Ceramide triggers an NF-kappaB-dependent survival pathway through calpain.Q40413936
IKKbeta/NF-kappaB activation causes severe muscle wasting in miceQ40505119
Enhanced myogenic differentiation by extracellular matrix is regulated at the early stages of myogenesisQ40632317
Inhibition of carnitine palmitoyltransferase I augments sphingolipid synthesis and palmitate-induced apoptosisQ41128299
TNF-alpha stimulates glucose uptake in L6 myoblastsQ41207836
Ceramide content is increased in skeletal muscle from obese insulin-resistant humansQ42454790
Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitateQ42476162
Characterizing the effects of saturated fatty acids on insulin signaling and ceramide and diacylglycerol accumulation in 3T3-L1 adipocytes and C2C12 myotubesQ42834541
Trans fatty acid-induced NF-kappaB activation does not induce insulin resistance in cultured murine skeletal muscle cellsQ43167763
Tumor necrosis factor-alpha induces distinctive NF-kappa B signaling within human dermal fibroblastsQ43510334
Prolonged inhibition of muscle carnitine palmitoyltransferase-1 promotes intramyocellular lipid accumulation and insulin resistance in ratsQ43516811
Reducing plasma free fatty acids by acipimox improves glucose tolerance in high-fat fed miceQ43605712
Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscleQ43990155
Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alphaQ44043178
Acute lowering of circulating fatty acids improves insulin secretion in a subset of type 2 diabetes subjectsQ44251616
Palmitate, but not unsaturated fatty acids, induces the expression of interleukin-6 in human myotubes through proteasome-dependent activation of nuclear factor-kappaB.Q44804019
Relationship between insulin sensitivity and sphingomyelin signaling pathway in human skeletal muscleQ44865479
Measurement of plasma glucose, free fatty acid, lactate, and insulin for 24 h in patients with NIDDM.Q46624327
Inhibition or deletion of the lipopolysaccharide receptor Toll-like receptor-4 confers partial protection against lipid-induced insulin resistance in rodent skeletal muscleQ46865480
Local activation of the IkappaK-NF-kappaB pathway in muscle does not cause insulin resistance.Q46888842
Diet-induced muscle insulin resistance in rats is ameliorated by acute dietary lipid withdrawal or a single bout of exercise: parallel relationship between insulin stimulation of glucose uptake and suppression of long-chain fatty acyl-CoA.Q51572827
Relationship of dietary saturated fatty acids and body habitus to serum insulin concentrations: the Normative Aging Study.Q51599575
Characterization of the mitochondrial carnitine palmitoyltransferase enzyme system. I. Use of inhibitors.Q52493898
Regulation of NF-kappa B, AP-1, NFAT, and STAT1 nuclear import in T lymphocytes by noninvasive delivery of peptide carrying the nuclear localization sequence of NF-kappa B p50.Q52532775
Diet-induced obesity and acute hyperlipidemia reduce IkappaBalpha levels in rat skeletal muscle in a fiber-type dependent manner.Q53848632
Effect of etomoxiryl-CoA on different carnitine acyltransferasesQ64984286
The effect of insulin on the disposal of intravenous glucose. Results from indirect calorimetry and hepatic and femoral venous catheterizationQ70196543
Amidepsines, Inhibitors of Diacylglycerol Acyltransferase Produced by Humicola sp. FO-2942. I. Production, Isolation and Biological PropertiesQ71822311
Alterations in the expression and cellular localization of protein kinase C isozymes epsilon and theta are associated with insulin resistance in skeletal muscle of the high-fat-fed ratQ72989982
Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascadeQ77795070
Reversal of diet-induced insulin resistance with a single bout of exercise in the rat: the role of PTP1B and IRS-1 serine phosphorylationQ79156528
P433issue7
P921main subjectNF-κBQ411114
insulin resistanceQ1053470
preproinsulinQ7240673
P304page(s)1215-1225
P577publication date2010-09-05
P1433published inCellular and Molecular Life SciencesQ5058352
P1476titlePalmitate-induced skeletal muscle insulin resistance does not require NF-κB activation
P478volume68

Reverse relations

cites work (P2860)
Q36783125ANT1-mediated fatty acid-induced uncoupling as a target for improving myocellular insulin sensitivity
Q42511873Glucose Uptake Measurement and Response to Insulin Stimulation in In Vitro Cultured Human Primary Myotubes.
Q89620077Myokine Regulation of Insulin Secretion: Impact of Inflammation and Type 2 Diabetes
Q34105654Palmitoleic acid prevents palmitic acid-induced macrophage activation and consequent p38 MAPK-mediated skeletal muscle insulin resistance
Q28271295Perilipin 2 improves insulin sensitivity in skeletal muscle despite elevated intramuscular lipid levels
Q47711038Preventive effect of oleate on palmitate-induced insulin resistance in skeletal muscle and its mechanism of action
Q33683986Protectin DX ameliorates palmitate- or high-fat diet-induced insulin resistance and inflammation through an AMPK-PPARα-dependent pathway in mice
Q42247586Role for sterol regulatory element binding protein-1c activation in mediating skeletal muscle insulin resistance via repression of rat insulin receptor substrate-1 transcription
Q96127000Skeletal muscle enhancer interactions identify genes controlling whole-body metabolism
Q50507100Targeting of mitochondrial reactive oxygen species production does not avert lipid-induced insulin resistance in muscle tissue from mice.
Q45462968The Implication of PGC-1α on Fatty Acid Transport across Plasma and Mitochondrial Membranes in the Insulin Sensitive Tissues.

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