Differential impact of acute and prolonged cAMP agonist exposure on protein kinase A activation and human myometrium contractile activity.

scientific article published on 22 June 2016

Differential impact of acute and prolonged cAMP agonist exposure on protein kinase A activation and human myometrium contractile activity. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1113/JP272320
P932PMC publication ID5088248
P698PubMed publication ID27328735

P50authorPei F LaiQ64819608
Rachel TribeQ55875789
P2093author name stringMark R Johnson
P2860cites workCrystal structures of the catalytic domain of human soluble guanylate cyclaseQ24336722
PKA phosphorylation of the small heat-shock protein Hsp20 enhances its cardioprotective effectsQ26998509
Role of serine-threonine phosphoprotein phosphatases in smooth muscle contractilityQ27693957
Protein kinase A anchoring to the myometrial plasma membrane is required for cyclic adenosine 3',5'-monophosphate regulation of phosphatidylinositide turnoverQ28146075
Exchange protein activated by cAMP (Epac) mediates cAMP-dependent but protein kinase A-insensitive modulation of vascular ATP-sensitive potassium channelsQ28581691
Cyclic AMP signalling pathways in the regulation of uterine relaxationQ33287745
Regulation of human myometrial contractility during pregnancy and labour: are calcium homeostatic pathways important?Q34295311
Role of cyclic nucleotide-dependent actin cytoskeletal dynamics:Ca(2+)](i) and force suppression in forskolin-pretreated porcine coronary arteries.Q34674437
Human bronchial smooth muscle cells express adenylyl cyclase isoforms 2, 4, and 6 in distinct membrane microdomainsQ34715744
PKA and Epac synergistically inhibit smooth muscle cell proliferation.Q34978265
Acetylation of heat shock protein 20 (Hsp20) regulates human myometrial activityQ35311275
Phasic contractions of isolated human myometrium are associated with Rho-kinase (ROCK)-dependent phosphorylation of myosin phosphatase-targeting subunit (MYPT1).Q35920703
Phosphorylation of h1 calponin by PKC epsilon may contribute to facilitate the contraction of uterine myometrium in mice during pregnancy and laborQ36235853
Emerging targets for novel therapy of asthmaQ36941412
Epac1 and cAMP-dependent Protein Kinase Holoenzyme Have Similar cAMP Affinity, but Their cAMP Domains Have Distinct Structural Features and Cyclic Nucleotide RecognitionQ62030423
Length-Tension Relationship of Smooth Muscle of the Hog Carotid ArteryQ69597964
Comparison of the effects of forskolin and dibutyryl cyclic AMP in neuroblastoma cells: evidence that some of the actions of dibutyryl cyclic AMP are mediated by butyrateQ69841467
Expression of oxytocin receptor in human pregnant myometriumQ70983655
PACAP modulates L-type Ca2+ channel currents in vascular smooth muscle cells: involvement of PKC and PKAQ71604047
Glucocorticosteroids increase beta 2-adrenergic receptor transcription in human lungQ72492127
Down-regulation of G alpha s in human myometrium in term and preterm labor: a mechanism for parturitionQ72879125
Anchoring protein is required for cAMP-dependent stimulation of L-type Ca(2+) channels in rabbit portal veinQ73070843
Cyclic nucleotide-dependent vasorelaxation is associated with the phosphorylation of a small heat shock-related proteinQ73248301
Calcium homeostatic pathways change with gestation in human myometriumQ74206191
The differential expression of myometrial connexin-43, cyclooxygenase-1 and -2, and Gs alpha proteins in the upper and lower segments of the human uterus during pregnancy and laborQ77738517
Selective up-regulation of phosphodiesterase-4 cyclic adenosine 3',5'-monophosphate (cAMP)-specific phosphodiesterase variants by elevated cAMP content in human myometrial cells in cultureQ77932875
cAMP induces adhesion of microvascular smooth muscle cells to fibronectin via an Epac-mediated but PKA-independent mechanismQ84515021
Uterus-relaxing effect of β2-agonists in combination with phosphodiesterase inhibitors: studies on pregnant rat in vivo and on pregnant human myometrium in vitroQ84526953
Prostacyclin primes pregnant human myometrium for an enhanced contractile response in parturitionQ36972755
Cyclic AMP increases COX-2 expression via mitogen-activated kinase in human myometrial cellsQ37295519
Underpinning compartmentalised cAMP signalling through targeted cAMP breakdownQ37623201
Cyclic nucleotide-dependent relaxation pathways in vascular smooth muscle.Q37938771
cAMP regulation of airway smooth muscle functionQ38013462
Adenylate cyclase-centred microdomainsQ38237737
Protein kinase A and the exchange protein directly activated by cAMP (Epac) modulate phenotype plasticity in human airway smooth muscleQ38740008
Disruption of the cyclic AMP phosphodiesterase-4 (PDE4)-HSP20 complex attenuates the β-agonist induced hypertrophic response in cardiac myocytesQ39589356
cAMP inhibits modulation of airway smooth muscle phenotype via the exchange protein activated by cAMP (Epac) and protein kinase AQ39661770
Evidence that a protein kinase A substrate, small heat-shock protein 20, modulates myometrial relaxation in human pregnancy.Q40054018
In vitro and in vivo pharmacological characterization of ethyl-4-[trans-4-[((2S)-2-hydroxy-3-[4-hydroxy-3[(methylsulfonyl)amino]-phenoxy]propyl) amino]cyclohexyl]benzoate hydrochloride (SAR150640), a new potent and selective human beta3-adrenoceptorQ40160812
The cytosolic domains of Ca2+-sensitive adenylyl cyclases dictate their targeting to plasma membrane lipid raftsQ40485876
Evidence for inhibition by protein kinase A of receptor/G alpha(q)/phospholipase C (PLC) coupling by a mechanism not involving PLCbeta2.Q41043410
Membrane-permeant derivatives of cyclic AMP optimized for high potency, prolonged activity, or rapid reversibility.Q41437400
Effects of cyclic GMP elevation on isoprenaline-induced increase in cyclic AMP and relaxation in rat aortic smooth muscle: role of phosphodiesterase 3.Q41779255
Regulation of cAMP metabolism in mouse parotid gland by cGMP and calciumQ42466011
Involvement of protein kinase A in the regulation of intracellular free calcium and phosphoinositide turnover in rat myometriumQ42474374
Assessment of myometrial transcriptome changes associated with spontaneous human labour by high-throughput RNA-seqQ42774372
Activation of protein kinase A by dibutyryl cAMP treatment of NIH 3T3 cells inhibits proliferation but fails to induce Ser-133 phosphorylation and transcriptional activation of CREB.Q42815012
Effects of medroxyprogesterone acetate on gene expression in myometrial explants from pregnant women.Q42906456
Actin depolymerization factor/cofilin activation regulates actin polymerization and tension development in canine tracheal smooth muscleQ43225126
Cyclic AMP enhances progesterone action in human myometrial cells.Q43678571
Discrete microdomains with high concentration of cAMP in stimulated rat neonatal cardiac myocytesQ43901717
Differential expression of the adenylyl cyclase-stimulatory guanosine triphosphate-binding protein G(s)alpha in the human myometrium during pregnancy and labor involves transcriptional regulation by cyclic adenosine 3',5'-monophosphate and binding oQ44238667
Effects of L-type Ca(2+)-channel blockade, K(+)(ATP)-channel opening and nitric oxide on human uterine contractility in relation to gestational age and labourQ44329068
Inhibition of sustained smooth muscle contraction by PKA and PKG preferentially mediated by phosphorylation of RhoAQ44433192
Expression and intracellular localization of protein phosphatases 2A and 2B, protein kinase a, A-Kinase anchoring protein (AKAP79), and binding of the regulatory (RII) subunit of protein kinase a to AKAP79 in human myometriumQ44602721
Decreased myometrial beta-adrenoceptors in women receiving beta 2-adrenergic tocolytic therapy: correlation with lymphocyte beta-adrenoceptorsQ44750449
Crystal structures of the catalytic domain of phosphodiesterase 4B complexed with AMP, 8-Br-AMP, and rolipram.Q44788121
Identification and localization of prostaglandin E2 receptors in upper and lower segment human myometrium during pregnancyQ45275812
Self-limitation of intravenous tocolysis with beta2-adrenergic agonists is mediated through receptor G protein uncouplingQ45280566
Inhibitors of Phosphodiesterase 4, but Not Phosphodiesterase 3, Increase β2-Agonist-Induced Expression of Antiinflammatory Mitogen-Activated Protein Kinase Phosphatase 1 in Airway Smooth Muscle Cells.Q46038615
Differential expression of protein kinase A, AKAP79, and PP2B in pregnant human myometrial membranes prior to and during laborQ46507801
Uterine stretch and progesterone actionQ46887988
Inhibition of human airway smooth muscle cell proliferation by beta 2-adrenergic receptors and cAMP is PKA independent: evidence for EPAC involvementQ46907168
Anti-inflammatory and relaxatory effects of prostaglandin E2 in myometrial smooth muscleQ46925533
Human Myometrial Quiescence and Activation during Gestation and Parturition Involve Dramatic Changes in Expression and Activity of Particulate Type II (RIIα) Protein Kinase A HoloenzymeQ47937903
In vivo model with targeted cAMP biosensor reveals changes in receptor-microdomain communication in cardiac diseaseQ48749621
The influence of smooth muscle content and orientation in dissected human pregnant myometrial strips on contractility measurementsQ48859097
EP2 receptor activates dual G protein signaling pathways that mediate contrasting proinflammatory and relaxatory responses in term pregnant human myometrium.Q50707752
Analysis of a mutation in phosphodiesterase type 4 that alters both inhibitor activity and nucleotide selectivity.Q52578467
Labour is associated with decreased expression of the PGF2alpha receptor (PTGFR) and a novel PTGFR splice variant in human myometrium but not decidua.Q54425640
Pregnancy induces a modulation of the cAMP phosphodiesterase 4-conformers ratio in human myometrium: consequences for the utero-relaxant effect of PDE4-selective inhibitors.Q54643058
Cyclic nucleotide analogs as probes of signaling pathways.Q55049561
Expression and regulation of prostaglandin E synthase isoforms in human myometrium with labourQ58450576
P433issue21
P407language of work or nameEnglishQ1860
P1104number of pages25
P304page(s)6369-6393
P577publication date2016-08-08
P1433published inJournal of PhysiologyQ7743612
P1476titleDifferential impact of acute and prolonged cAMP agonist exposure on protein kinase A activation and human myometrium contractile activity
P478volume594