Inhibition of human airway smooth muscle cell proliferation by beta 2-adrenergic receptors and cAMP is PKA independent: evidence for EPAC involvement

scientific article published on 9 November 2007

Inhibition of human airway smooth muscle cell proliferation by beta 2-adrenergic receptors and cAMP is PKA independent: evidence for EPAC involvement is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1152/AJPLUNG.00381.2007
P698PubMed publication ID17993585
P5875ResearchGate publication ID5852448

P50authorReynold A PanettieriQ96255784
P2093author name stringMyron L Toews
Todd A Wyatt
Karen M Kassel
P433issue1
P304page(s)L131-8
P577publication date2007-11-09
P1433published inAmerican Journal of Physiology - Lung Cellular and Molecular PhysiologyQ4352992
P1476titleInhibition of human airway smooth muscle cell proliferation by beta 2-adrenergic receptors and cAMP is PKA independent: evidence for EPAC involvement
P478volume294

Reverse relations

cites work (P2860)
Q38240756A-kinase anchoring proteins: cAMP compartmentalization in neurodegenerative and obstructive pulmonary diseases
Q28730910Activation of protein kinase A and exchange protein directly activated by cAMP promotes adipocyte differentiation of human mesenchymal stem cells
Q46513009Airway smooth muscle cell tone amplifies contractile function in the presence of chronic cyclic strain
Q34421820Anti-mitogenic effects of β-agonists and PGE2 on airway smooth muscle are PKA dependent.
Q33764984Attenuation of inhibitory prostaglandin E2 signaling in human lung fibroblasts is mediated by phosphodiesterase 4.
Q54448921Beta-adrenergic signals regulate cardiac differentiation of mouse embryonic stem cells via mitogen-activated protein kinase pathways.
Q35312155Biochemical basis of asthma therapy
Q42756543Cyclic Adenosine Monophosphate-Mediated Enhancement of Vascular Endothelial Growth Factor Released by Differentiated Human Monocytic Cells: The Role of Protein Kinase A.
Q39666497Differential impact of acute and prolonged cAMP agonist exposure on protein kinase A activation and human myometrium contractile activity.
Q96817200Distinctive roles of Abi1 in regulating actin-associated proteins during human smooth muscle cell migration
Q41852828Epac as a novel effector of airway smooth muscle relaxation
Q37619293Epac1 agonist decreased inflammatory proteins in retinal endothelial cells, and loss of Epac1 increased inflammatory proteins in the retinal vasculature of mice
Q92493447Epac1 and Glycyrrhizin Both Inhibit HMGB1 Levels to Reduce Diabetes-Induced Neuronal and Vascular Damage in the Mouse Retina
Q90728342Epac1 deacetylates HMGB1 through increased IGFBP-3 and SIRT1 levels in the retinal vasculature
Q37390223Epac1 interacts with importin β1 and controls neurite outgrowth independently of cAMP and Rap1.
Q92091557Exchange protein directly activated by cAMP (Epac) protects against airway inflammation and airway remodeling in asthmatic mice
Q37968330Function and mechanisms of TSLP/TSLPR complex in asthma and COPD.
Q90725072Genome-Wide Mapping Defines a Role for C/EBPβ and c-Jun in Non-Canonical Cyclic AMP Signalling
Q42591121Inhibition of ATP release from erythrocytes: a role for EPACs and PKC.
Q52656382Intracellular cAMP Sensor EPAC: Physiology, Pathophysiology, and Therapeutics Development.
Q58722156MicroRNA miR-509 Regulates ERK1/2, the Vimentin Network, and Focal Adhesions by Targeting Plk1
Q46129094Modulation of epidermal growth factor receptor binding to human airway smooth muscle cells by glucocorticoids and beta2-adrenergic receptor agonists
Q47275656PDE8 is Expressed in Human Airway Smooth Muscle and Selectively Regulates cAMP Signaling by β2AR-AC6.
Q39793680PKA and Epac cooperate to augment bradykinin-induced interleukin-8 release from human airway smooth muscle cells
Q44614511Phosphodiesterase-4 inhibition augments human lung fibroblast vascular endothelial growth factor production induced by prostaglandin E2.
Q39990887Prostaglandin E2 inhibits specific lung fibroblast functions via selective actions of PKA and Epac-1.
Q37447476Protease-activated receptors and prostaglandins in inflammatory lung disease.
Q38740008Protein kinase A and the exchange protein directly activated by cAMP (Epac) modulate phenotype plasticity in human airway smooth muscle
Q54332300Protein kinase a-mediated cell proliferation in brown preadipocytes is independent of Erk1/2, PI3K and mTOR.
Q42839797Real time analysis of β(2)-adrenoceptor-mediated signaling kinetics in human primary airway smooth muscle cells reveals both ligand and dose dependent differences
Q46467763Role of Epac1 in mediating anti-proliferative effects of prostanoid EP(2) receptors and cAMP in human lung fibroblasts
Q91583545Role of PI3K/Akt and MEK/ERK Signalling in cAMP/Epac-Mediated Endothelial Barrier Stabilisation
Q37621296Role of the cAMP-binding protein Epac in cardiovascular physiology and pathophysiology
Q33858419Stimulation of Adenosine A2B Receptor Inhibits Endothelin-1-Induced Cardiac Fibroblast Proliferation and α-Smooth Muscle Actin Synthesis Through the cAMP/Epac/PI3K/Akt-Signaling Pathway
Q36603243Synergistic interaction between PPAR ligands and salbutamol on human bronchial smooth muscle cell proliferation
Q37632467The role of Epac proteins, novel cAMP mediators, in the regulation of immune, lung and neuronal function
Q35098055The small molecule PKA-specific cyclic AMP analogue as an inducer of osteoblast-like cells differentiation and mineralization
Q41681579Thiazolidinediones inhibit airway smooth muscle release of the chemokine CXCL10: in vitro comparison with current asthma therapies
Q39661770cAMP inhibits modulation of airway smooth muscle phenotype via the exchange protein activated by cAMP (Epac) and protein kinase A
Q38013462cAMP regulation of airway smooth muscle function
Q34044729β-Agonist-mediated relaxation of airway smooth muscle is protein kinase A-dependent.

Search more.