Regioselective metalation of 6-methylpurines: synthesis of fluoromethyl purines and related nucleosides for suicide gene therapy of cancer

scientific article

Regioselective metalation of 6-methylpurines: synthesis of fluoromethyl purines and related nucleosides for suicide gene therapy of cancer is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1080/15257770903091938
P698PubMed publication ID20183607

P2093author name stringJohn A Secrist
William B Parker
Abdalla E A Hassan
Paula W Allan
P2860cites workPhase II study of 5-fluorouracil and paclitaxel in patients with gemcitabine-refractory pancreatic cancer.Q33381016
Antitumor activity of 2-fluoro-2'-deoxyadenosine against tumors that express Escherichia coli purine nucleoside phosphorylaseQ34165621
Design, synthesis, and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methylcytidine, a potent inhibitor of hepatitis C virus replicationQ34443810
Discovery and development of clofarabine: a nucleoside analogue for treating cancerQ34571029
Fludarabine: a review of its use in non-Hodgkin's lymphomaQ34657289
Capecitabine: a reviewQ36069267
Efficacy of the oral fluorouracil pro-drug capecitabine in cancer treatment: a reviewQ37270388
Purine Nucleoside Phosphorylase from Escherichia coli and Salmonella typhimurium. Purification and Some PropertiesQ40311965
Metabolism and metabolic actions of 6-methylpurine and 2-fluoroadenine in human cellsQ41032358
Antiviral activity of clevudine [L-FMAU, (1-(2-fluoro-5-methyl-beta, L-arabinofuranosyl) uracil)] against woodchuck hepatitis virus replication and gene expression in chronically infected woodchucks (Marmota monax).Q43513121
Selective Metalation of 6-Methylpurines: Synthesis of 6-Fluoromethylpurines and Related NucleosidesQ44621881
Convenient syntheses of 6-methylpurine and related nucleosidesQ45871005
In vivo sensitization of ovarian tumors to chemotherapy by expression of E. coli purine nucleoside phosphorylase in a small fraction of cellsQ45872463
In vivo gene therapy of cancer with E. coli purine nucleoside phosphorylaseQ45883671
Synthesis and biological activity of 2-fluoro adenine and 6-methyl purine nucleoside analogs as prodrugs for suicide gene therapy of cancerQ45888002
The first synthesis and cytostatic activity of novel 6-(fluoromethyl)purine bases and nucleosidesQ46722846
Adenine as Substrate for Purine Nucleoside PhosphorylaseQ51121715
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectsuicideQ10737
gene therapyQ213901
P304page(s)642-656
P577publication date2009-05-01
P1433published inNucleosides, Nucleotides & Nucleic AcidsQ7068261
P1476titleRegioselective metalation of 6-methylpurines: synthesis of fluoromethyl purines and related nucleosides for suicide gene therapy of cancer
P478volume28