Efficacy of the oral fluorouracil pro-drug capecitabine in cancer treatment: a review

scientific article published on 27 August 2008

Efficacy of the oral fluorouracil pro-drug capecitabine in cancer treatment: a review is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.3390/MOLECULES13081897
P932PMC publication ID6245068
P698PubMed publication ID18794792
P5875ResearchGate publication ID23258277

P2093author name stringJohn Kouvaris
Vassilios Kouloulias
Georgios V Koukourakis
Georgios A Zacharias
Haralabos Zabatis
Michael J Koukourakis
P2860cites workBiweekly high-dose gemcitabine alone or in combination with capecitabine in patients with metastatic pancreatic adenocarcinoma: a randomized phase II trialQ44253349
Combining capecitabine and gemcitabine in patients with advanced pancreatic carcinoma: a phase I/II trialQ44265656
Thymidine phosphorylase-mediated angiogenesis regulated by thymidine phosphorylase inhibitor in human ovarian cancer cells in vivo.Q44396415
Treatment of advanced colorectal carcinoma with oxaliplatin and capecitabine: a phase II trialQ44457418
Multicenter phase II study of oral capecitabine (Xeloda(")) in patients with metastatic breast cancer relapsing after treatment with a taxane-containing therapyQ44525923
Phase II study of capecitabine and oxaliplatin as first-line treatment in advanced colorectal cancerQ44572711
Randomized multicenter Phase II trial of two different schedules of irinotecan combined with capecitabine as first-line treatment in metastatic colorectal carcinomaQ44723860
Multicentre, phase II study evaluating capecitabine monotherapy in patients with anthracycline- and taxane-pretreated metastatic breast cancer.Q44764054
A phase II trial of capecitabine in heavily pre-treated platinum-resistant ovarian cancerQ44853139
Oral capecitabine in anthracycline- and taxane-pretreated advanced/metastatic breast cancerQ44910538
Capecitabine plus paclitaxel as front-line combination therapy for metastatic breast cancer: a multicenter phase II studyQ44936609
Preoperative concurrent radiotherapy with capecitabine before total mesorectal excision in locally advanced rectal cancerQ46507603
Results of a phase II open-label study of capecitabine in combination with irinotecan as first-line treatment for metastatic colorectal cancerQ46522138
Preoperative treatment combining capecitabine with radiation therapy in rectal cancer: a GERCOR Phase II StudyQ46640577
Phase II study of preoperative oxaliplatin, capecitabine and external beam radiotherapy in patients with rectal cancer: the RadiOxCape studyQ46747924
Capecitabine in combination with preoperative radiation therapy in locally advanced, resectable, rectal cancer: a multicentric phase II studyQ46799677
Capecitabine plus oxaliplatin (CapOx) versus capecitabine plus gemcitabine (CapGem) versus gemcitabine plus oxaliplatin (mGemOx): final results of a multicenter randomized phase II trial in advanced pancreatic cancerQ46930586
Phase II study of capecitabine (Xeloda) and concomitant boost radiotherapy in patients with locally advanced rectal cancer.Q51783229
Efficacy of intravenous continuous infusion of fluorouracil compared with bolus administration in advanced colorectal cancerQ59647361
A Phase II Study of Preoperative Capecitabine and Radiation Therapy in Patients With Rectal CancerQ60192965
Prospective randomised trial comparing fluorouracil versus doxifluridine for the treatment of advanced colorectal cancerQ70478710
Tumor inhibitory effects of a new fluorouracil derivative: 5'-deoxy-5-fluorouridineQ70529566
Relationship between fluorouracil systemic exposure and tumor response and patient survivalQ72504290
Capecitabine, an oral fluoropyrimidine carbamate with substantial activity in advanced colorectal cancer: results of a randomized phase II studyQ73544195
Antitumor activities of a novel fluoropyrimidine, N4-pentyloxycarbonyl-5'-deoxy-5-fluorocytidine (capecitabine)Q77087512
Phase II study of capecitabine single-agent therapy in patients with metastatic renal cell carcinomaQ79396495
A phase II study of second-line neoadjuvant chemotherapy with capecitabine and radiation therapy for anthracycline-resistant locally advanced breast cancerQ79721051
New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of CanadaQ27860904
Design of a novel oral fluoropyrimidine carbamate, capecitabine, which generates 5-fluorouracil selectively in tumours by enzymes concentrated in human liver and cancer tissueQ27863454
Four decades of continuing innovation with fluorouracil: current and future approaches to fluorouracil chemoradiation therapyQ30433652
Front-line treatment of inoperable or metastatic pancreatic cancer with gemcitabine and capecitabine: an intergroup, multicenter, phase II studyQ33358845
Phase II study of capecitabine with concomitant radiotherapy for patients with locally advanced pancreatic cancer: up-regulation of thymidine phosphorylaseQ33376459
Preliminary studies of a novel oral fluoropyrimidine carbamate: capecitabineQ33502454
Multicenter phase II study of capecitabine in paclitaxel-refractory metastatic breast cancerQ33855276
XELOX (capecitabine plus oxaliplatin): active first-line therapy for patients with metastatic colorectal cancerQ33978749
Capecitabine: preclinical pharmacology studiesQ34084259
Induction of thymidine phosphorylase activity and enhancement of capecitabine efficacy by taxol/taxotere in human cancer xenografts.Q34465823
Comparison of oral capecitabine versus intravenous fluorouracil plus leucovorin as first-line treatment in 605 patients with metastatic colorectal cancer: results of a randomized phase III studyQ34514696
Oral capecitabine compared with intravenous fluorouracil plus leucovorin in patients with metastatic colorectal cancer: results of a large phase III studyQ34519158
Capecitabine in the treatment of metastatic renal cell carcinoma failing immunotherapy.Q34520221
Superior survival with capecitabine plus docetaxel combination therapy in anthracycline-pretreated patients with advanced breast cancer: phase III trial resultsQ34524041
Enhanced tumorocidal effect of chemotherapy with preoperative radiotherapy for rectal cancer: preliminary results--EORTC 22921.Q34559198
Chemotherapy with preoperative radiotherapy in rectal cancerQ34570877
Preoperative radiotherapy with or without concurrent fluorouracil and leucovorin in T3-4 rectal cancers: results of FFCD 9203.Q34571372
New systemic frontline treatment for metastatic colorectal carcinomaQ35741932
Systemic chemotherapy for pancreatic cancerQ35746026
Capecitabine as a radiosensitizing agent in neoadjuvant treatment of locally advanced resectable rectal cancer: prospective phase II trialQ36147847
Controversial issues in 5-fluorouracil infusion use. Dose intensity, treatment duration, and cost comparisonsQ36356364
A phase II study of capecitabine and irinotecan in combination with concurrent pelvic radiotherapy (CapIri-RT) as neoadjuvant treatment of locally advanced rectal cancerQ36610100
Capecitabine in the treatment of metastatic renal cell carcinomaQ36621825
Randomised, phase II trial comparing oral capecitabine (Xeloda) with paclitaxel in patients with metastatic/advanced breast cancer pretreated with anthracyclines.Q36644465
A phase II trial of capecitabine (Xeloda®) in recurrent ovarian cancerQ36671560
Capecitabine in hormone-resistant metastatic prostatic carcinoma - a phase II trialQ36694859
Phase II study of capecitabine in combination with paclitaxel in patients with anthracycline-pretreated advanced/metastatic breast cancerQ36697132
Comparison of the efficacy of oral capecitabine versus bolus 5-FU in preoperative radiotherapy of locally advanced rectal cancerQ37323827
Thymidine phosphorylase expression in normal, hyperplastic and neoplastic prostates: correlation with tumour associated macrophages, infiltrating lymphocytes, and angiogenesisQ38283244
Pre-operative chemoradiotherapy with oral capecitabine in locally advanced, resectable rectal cancer.Q43654175
Randomized, open-label, phase II trial of oral capecitabine (Xeloda) vs. a reference arm of intravenous CMF (cyclophosphamide, methotrexate and 5-fluorouracil) as first-line therapy for advanced/metastatic breast cancerQ43791689
Multicenter, Phase II study of capecitabine in taxane-pretreated metastatic breast carcinoma patientsQ43824330
Phase II study of oral capecitabine in patients with advanced or metastatic pancreatic cancerQ43843462
Phase II study of capecitabine and oxaliplatin in first- and second-line treatment of advanced or metastatic colorectal cancerQ43937160
P275copyright licenseCreative Commons AttributionQ6905323
P6216copyright statuscopyrightedQ50423863
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectfluorouracilQ238512
capecitabineQ420207
deoxycytidineQ422504
neoplasmQ1216998
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)1897-1922
P577publication date2008-08-27
P1433published inMoleculesQ151332
P1476titleEfficacy of the oral fluorouracil pro-drug capecitabine in cancer treatment: a review
P478volume13

Reverse relations

cites work (P2860)
Q46865578A comparison of cardiomyocyte cytotoxic mechanisms for 5-fluorouracil and its pro-drug capecitabine.
Q34658293Bosutinib plus capecitabine for selected advanced solid tumours: results of a phase 1 dose-escalation study
Q34542467Clinical efficacy of including capecitabine in neoadjuvant chemotherapy for breast cancer: a systematic review and meta-analysis of randomized controlled trials
Q36598736Comparative effectiveness of chemotherapy in elderly patients with metastatic colorectal cancer
Q39064132Comparative in vitro evaluation of transportability and toxicity of capecitabine and its metabolites in cells derived from normal human kidney and renal cancers
Q97537783Effective Oral Administration of Antitumorigenic Nanoformulated Titanium Complex
Q37346140Effects of capecitabine treatment on the uptake of thymidine analogs using exploratory PET imaging agents: 18F-FAU, 18F-FMAU, and 18F-FLT.
Q92823869Glycosyl ortho-(1-phenylvinyl)benzoates versatile glycosyl donors for highly efficient synthesis of both O-glycosides and nucleosides
Q38803038Pharmacokinetic variations in cancer patients with liver dysfunction: applications and challenges of pharmacometabolomics
Q34337609Prodrugs: a challenge for the drug development
Q33421880Randomized study of orally administered fluorinated pyrimidines (capecitabine versus S-1) in women with metastatic or recurrent breast cancer: Japan Breast Cancer Research Network 05 Trial
Q39735268Regioselective metalation of 6-methylpurines: synthesis of fluoromethyl purines and related nucleosides for suicide gene therapy of cancer

Search more.