Comparison of oral capecitabine versus intravenous fluorouracil plus leucovorin as first-line treatment in 605 patients with metastatic colorectal cancer: results of a randomized phase III study

scientific article

Comparison of oral capecitabine versus intravenous fluorouracil plus leucovorin as first-line treatment in 605 patients with metastatic colorectal cancer: results of a randomized phase III study is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1200/JCO.2001.19.8.2282
P8608Fatcat IDrelease_xc7pmgyn3berfmkzwqgyfiax2y
P698PubMed publication ID11304782

P2093author name stringR Wong
J Maroun
G Batist
B Osterwalder
J Cox
P M Hoff
W Kocha
R Ansari
C Weaver
E Harrison
H U Burger
M Kuperminc
A O Wong
D Walde
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectcolorectal cancerQ188874
colorectal carcinomaQ25493920
metastatic colon cancerQ108566365
capecitabineQ420207
fluorouracilQ238512
P304page(s)2282-2292
P577publication date2001-04-01
P1433published inJournal of Clinical OncologyQ400292
P1476titleComparison of oral capecitabine versus intravenous fluorouracil plus leucovorin as first-line treatment in 605 patients with metastatic colorectal cancer: results of a randomized phase III study
P478volume19

Reverse relations

cites work (P2860)
Q5071082037th annual meeting of the American Society of Clinical Oncology. San Francisco, CA, May 12-15, 2001.
Q341802605-Fluorouracil or capecitabine in the treatment of advanced colorectal cancer: a pooled-analysis of randomized trials
Q282019375-Fluorouracil: mechanisms of action and clinical strategies
Q555150225-fluorouracil and cardiotoxicity: a review.
Q44255524A Phase I study of 9-nitrocamptothecin given concurrently with capecitabine in patients with refractory, metastatic solid tumors
Q33368148A Phase II study of capecitabine combined with gemcitabine in patients with advanced gallbladder carcinoma.
Q82758717A Phase II, open-label, randomised study to assess the efficacy and safety of the MEK1/2 inhibitor AZD6244 (ARRY-142886) versus capecitabine monotherapy in patients with colorectal cancer who have failed one or two prior chemotherapeutic regimens
Q42770955A Phase Ib pharmacokinetic study of the anti-angiogenic agent CKD-732 used in combination with capecitabine and oxaliplatin (XELOX) in metastatic colorectal cancer patients who progressed on irinotecan-based chemotherapy.
Q36070770A Phase Ib/II Study Evaluating the Combination of Weekly Docetaxel and Cisplatin Together with Capecitabine and Bevacizumab in Patients with Advanced Esophago-Gastric Cancer
Q55308824A Review of the Literature of Surgical and Nonsurgical Treatments of Invasive Squamous Cells Carcinoma.
Q46350339A case of cardiogenic shock caused by capecitabine treatment
Q34569995A case of long partial response to combination therapy of bevacizumab and capecitabine for liver metastases of rectal cancer
Q37131721A comparison between 5-fluorouracil/mitomycin and capecitabine/mitomycin in combination with radiation for anal cancer
Q44014861A dynamic model of hand-and-foot syndrome in patients receiving capecitabine
Q37225701A multicenter phase II study of the combination of oxaliplatin, irinotecan and capecitabine in the first-line treatment of metastatic colorectal cancer
Q43197898A new chemoimmunotherapy regimen (OXAFI) for advanced hepatocellular carcinoma
Q33358691A novel combination of cisplatin, irinotecan, and capecitabine in patients with advanced cancer
Q43962409A observational study of the efficacy and safety of capecitabine versus bolus infusional 5-fluorouracil in pre-operative chemoradiotherapy for locally advanced rectal cancer
Q36616386A phase I clinical and pharmacokinetic study of capecitabine (Xeloda) and irinotecan combination therapy (XELIRI) in patients with metastatic gastrointestinal tumours
Q33919101A phase I dose-escalation study of imatinib mesylate (Gleevec/STI571) plus capecitabine (Xeloda) in advanced solid tumors
Q34910416A phase I study of EKB-569 in combination with capecitabine in patients with advanced colorectal cancer
Q33973344A phase I study of an oral simulated FOLFOX with high dose capecitabine
Q33619858A phase I study of gefitinib, capecitabine, and celecoxib in patients with advanced solid tumors
Q46531270A phase I/II and pharmacokinetic study of irinotecan in combination with capecitabine as first-line therapy for advanced colorectal cancer
Q36858196A phase II study evaluating the use of concurrent mitomycin C and capecitabine in patients with advanced unresectable pseudomyxoma peritonei
Q36859180A phase II study of UFT with leucovorin administered as a twice daily schedule in the treatment of patients with metastatic colorectal cancer.
Q36694899A phase II study of capecitabine and docetaxel combination chemotherapy in patients with advanced gastric cancer
Q36097259A phase II study of capecitabine and lapatinib in advanced refractory colorectal adenocarcinoma: A Wisconsin Oncology Network study
Q44390789A phase II study of capecitabine in patients with recurrent and metastatic nasopharyngeal carcinoma pretreated with platinum-based chemotherapy
Q36614036A phase II study of capecitabine plus 3-weekly oxaliplatin as first-line therapy for patients with advanced gastric cancer
Q33399530A phase II study of capecitabine plus oxaliplatin as first-line chemotherapy in elderly patients with advanced gastric cancer
Q36105171A phase II study of capecitabine, oxaliplatin, and cetuximab with or without bevacizumab as frontline therapy for metastatic colorectal cancer. A Fox Chase extramural research study
Q36614004A phase II study of fixed-dose capecitabine and assessment of predictors of toxicity in patients with advanced/metastatic colorectal cancer
Q37234171A phase II study of leucovorin, 5-FU and docetaxel combination chemotherapy in patients with inoperable or postoperative relapsed gastric cancer
Q36671560A phase II trial of capecitabine (Xeloda®) in recurrent ovarian cancer
Q53280262A prospective study of XELIRI plus bevacizumab as a first-line therapy in Japanese patients with unresectable or recurrent colorectal cancer (KSCC1101).
Q36778075A prospective study of XELOX plus bevacizumab as first-line therapy in Japanese patients with metastatic colorectal cancer (KSCC 0902).
Q44433166A randomised study of protracted venous infusion of 5-fluorouracil (5-FU) with or without bolus mitomycin C (MMC) in patients with carcinoma of unknown primary
Q36131174A randomized phase II study of weekly nab-paclitaxel plus gemcitabine or simplified LV5FU2 as first-line therapy in patients with metastatic pancreatic cancer: the AFUGEM GERCOR trial
Q45236679A randomized phase II trial of capecitabine and two different schedules of irinotecan in first-line treatment of metastatic colorectal cancer: efficacy, quality-of-life and toxicity
Q35113026A retrospective study of first-line combination chemotherapy in advanced colorectal cancer: a Korean single-center experience
Q47291560A review of capecitabine-based adjuvant therapy for gastric cancer in the Chinese population
Q36661290A review of the role of capecitabine in the treatment of colorectal cancer.
Q33342817A single-institution experience with concurrent capecitabine and radiation therapy in gastrointestinal malignancies
Q90115442A study of capecitabine metronomic chemotherapy is non-inferior to conventional chemotherapy as maintenance strategy in responders after induction therapy in metastatic colorectal cancer
Q37149160Accomplishments in 2007 in the management of localized gastric cancer
Q45936600Acquired Fanconi syndrome after treatment with capecitabine, irinotecan, and bevacizumab.
Q35111174Adjuvant therapy for colon cancer in the new millenium.
Q37462241Adjuvant therapy for rectal cancer
Q34999400Adjuvant therapy in colon cancer: current status and future directions
Q36257130Adjuvant treatment strategies for early colon cancer
Q35376573Advanced molecular design of biopolymers for transmucosal and intracellular delivery of chemotherapeutic agents and biological therapeutics
Q38222249Advances in the management of colorectal cancer: from biology to treatment
Q84972669Advances in the treatment of metastatic colorectal cancer
Q41180643Alteration of Drug Sensitivity in Human Colon Cancer Cells after Exposure to Heat: Implications for Liver Metastasis Therapy using RFA and Chemotherapy.
Q36024905Altered deoxyuridine and thymidine in plasma following capecitabine treatment in colorectal cancer patients.
Q50041173An Update on Randomized Clinical Trials in Metastatic Colorectal Carcinoma
Q31106341An individual patient data meta-analysis of adjuvant therapy with uracil-tegafur (UFT) in patients with curatively resected rectal cancer.
Q88867253Association Between Serum Folate Level and Toxicity of Capecitabine During Treatment for Colorectal Cancer
Q34343967Bevacizumab in combination with biweekly capecitabine and irinotecan, as first-line treatment for patients with metastatic colorectal cancer
Q38672496Bevacizumab plus FOLFOX or FOLFIRI regimens on patients with unresectable liver-only metastases of metastatic colorectal cancer
Q36521850Biological agents versus chemotherapy in the treatment of colorectal cancer
Q37114675Biomarker in Colorectal Cancer.
Q37609130Biomarkers in precision therapy in colorectal cancer.
Q37598890Breast cancer: beyond the cutting edge
Q80510550Cancers of the large bowel and hepatobiliary tract
Q81086290Cancers of the large bowel and hepatobiliary tract
Q33847848Capecitabine and bevacizumab as first-line treatment in elderly patients with metastatic colorectal cancer
Q37122339Capecitabine and irinotecan with and without bevacizumab for advanced colorectal cancer patients
Q36615283Capecitabine and mitomycin C as third-line therapy for patients with metastatic colorectal cancer resistant to fluorouracil and irinotecan
Q37077342Capecitabine and timing of radiotherapy during preoperative chemoradiation for rectal cancer.
Q30673291Capecitabine as first-line treatment in colorectal cancer. Pooled data from two large, phase III trials
Q44228128Capecitabine combinations in the treatment of advanced colorectal cancer
Q37821286Capecitabine for locally advanced and metastatic colorectal cancer: A review
Q33426732Capecitabine in combination with either cisplatin or weekly paclitaxel as a first-line treatment for metastatic esophageal squamous cell carcinoma: a randomized phase II study
Q37400585Capecitabine in combination with irinotecan (XELIRI), administered as a 2-weekly schedule, as first-line chemotherapy for patients with metastatic colorectal cancer: a phase II study of the Spanish GOTI group
Q36694859Capecitabine in hormone-resistant metastatic prostatic carcinoma - a phase II trial
Q24633039Capecitabine in the management of colorectal cancer
Q35920292Capecitabine in the routine first-line treatment of elderly patients with advanced colorectal cancer--results from a non-interventional observation study.
Q36616002Capecitabine plus docetaxel every 3 weeks in first- and second-line metastatic oesophageal cancer: final results of a phase II trial
Q46965894Capecitabine plus oxaliplatin (xelox) in the treatment of chemotherapy-naive patients with metastatic colorectal cancer.
Q34639725Capecitabine plus oxaliplatin compared with 5-fluorouracil plus oxaliplatin in metastatic colorectal cancer: Meta-analysis of randomized controlled trials
Q46538590Capecitabine plus oxaliplatin for the first-line treatment of elderly patients with metastatic colorectal carcinoma: final results of the Southern Italy Cooperative Oncology Group Trial 0108.
Q37085987Capecitabine plus oxaliplatin for the treatment of colorectal cancer.
Q37154737Capecitabine, alone and in combination, in the management of patients with colorectal cancer: a review of the evidence
Q85177862Capecitabine-based chemotherapy for metastatic colorectal cancer
Q53249399Capecitabine-induced, nonneutropenic enterocolitis.
Q36342796Capecitabine/Oxaliplatin combinations in advanced colorectal cancer: summary of recent randomized studies.
Q34481305Capecitabine: a review of its use in the treatment of advanced or metastatic colorectal cancer
Q37303878Capecitabine: have we got the dose right?
Q88682206Cardiotoxicity of 5-fluorouracil and capecitabine in Chinese patients: a prospective study
Q37735615Cetuximab strongly enhances immune cell infiltration into liver metastatic sites in colorectal cancer
Q38002127Chemoprevention, chemotherapy, and chemoresistance in colorectal cancer.
Q36189950Chemoradiotherapy for colorectal cancer
Q30436646Chemoradiotherapy for gastrointestinal cancers
Q35572017Chemotherapeutic and biologic agents as radiosensitizers in rectal cancer
Q78478993Chemotherapy for colorectal cancer
Q53855896Chemotherapy of Metastatic Colorectal Cancer.
Q37602291Chemotherapy, which drugs and when
Q48268736Clinical Features of Metastatic Hepatic Malignancies.
Q49791896Clinical characteristics and treatment propensity in elderly patients aged over 80 years with colorectal cancer
Q91638619Clinical factors related to severe enterocolitis after adjuvant CAPOX for colorectal cancer: a retrospective analysis
Q64892570Clinical implementation of pre-treatment DPYD genotyping in capecitabine-treated metastatic breast cancer patients.
Q35188403Clinical pharmacokinetic/pharmacodynamic and physiologically based pharmacokinetic modeling in new drug development: the capecitabine experience
Q31027996Clinical relevance of DPYD variants c.1679T>G, c.1236G>A/HapB3, and c.1601G>A as predictors of severe fluoropyrimidine-associated toxicity: a systematic review and meta-analysis of individual patient data
Q37092129Colon cancer and the elderly: from screening to treatment in management of GI disease in the elderly.
Q35039124Colorectal cancer in the elderly: is palliative chemotherapy of value?
Q37044732Colorectal cancer with multiple metachronous metastasis achieving complete remission 14 years after surgical resection: report of a case
Q33735234Colorectal cancer: from prevention to personalized medicine.
Q36613503Combination chemotherapy with carboplatin, capecitabine and epirubicin (ECarboX) as second- or third-line treatment in patients with relapsed ovarian cancer: a phase I/II trial.
Q36084353Combination therapies with oxaliplatin and oral capecitabine or intravenous 5-FU show similar toxicity profiles in gastrointestinal carcinoma patients if hand-food syndrome prophylaxis is performed continuously
Q45090159Combination therapy with capecitabine and interferon alfa-2A in patients with advanced renal cell carcinoma: a phase II study
Q35875388Combined modality therapy for rectal cancer.
Q36598736Comparative effectiveness of chemotherapy in elderly patients with metastatic colorectal cancer
Q41231221Comparison between three oxaliplatin-based regimens with bevacizumab in patients with metastatic colorectal cancer
Q42794358Comparison of neoadjuvant oral chemotherapy with UFT plus Folinic acid or Capecitabine concomitant with radiotherapy on locally advanced rectal cancer
Q37323827Comparison of the efficacy of oral capecitabine versus bolus 5-FU in preoperative radiotherapy of locally advanced rectal cancer
Q46098962Complete Response of Para-Aortic and Lateral Pelvic Lymph Node Recurrence of Rectal Cancer Treated to S-1 Monotherapy
Q39063211Concurrent capecitabine and upper abdominal radiation therapy is well tolerated
Q64936195Construction of Marker-Free Genetically Modified Maize Using a Heat-Inducible Auto-Excision Vector.
Q46132535Costs associated with complications are lower with capecitabine than with 5-fluorouracil in patients with colorectal cancer
Q42775518Current and Novel Treatment Options for Metastatic Colorectal Cancer: Emphasis on Aflibercept
Q38628257Current and advancing treatments for metastatic colorectal cancer
Q36960766Current and emerging trends in the treatment of early-stage colorectal cancer: importance of a multidisciplinary approach
Q36626785Current directions in chemotherapy for colorectal cancer
Q57812660DPYD genotype-guided dose individualisation of fluoropyrimidine therapy in patients with cancer: a prospective safety analysis
Q47768032DPYD genotype-guided dose individualization to improve patient safety of fluoropyrimidine therapy: call for a drug label update
Q30244769Decision-making in geriatric oncology: systemic treatment considerations for older adults with colon cancer
Q38673003Decreased gastrointestinal toxicity associated with a novel capecitabine schedule (7 days on and 7 days off): a systematic review
Q37116834Definitive chemoradiotherapy with capecitabine and cisplatin in patients with esophageal cancer: a pilot study
Q38236614Delayed Presentation of DPD Deficiency in Colorectal Cancer.
Q39041183Design of novel chemotherapeutic delivery systems for colon cancer therapy based on oral polymeric nanoparticles
Q36936972Dihydro pyrimidine dehydrogenase deficiency in patients treated with capecitabine based regimens: a tertiary care centre experience
Q34427755Disease management considerations: disease management considerations
Q44002046Dose adaptation of capecitabine based on individual prediction of limiting toxicity grade: evaluation by clinical trial simulation
Q36306269Drug Insight: Metastatic colorectal cancer--oral fluoropyrimidines and new perspectives in the adjuvant setting
Q36646598EORTC Early Clinical Studies Group early phase II trial of S-1 in patients with advanced or metastatic colorectal cancer
Q37729193Economic evaluation of capecitabine as adjuvant or metastatic therapy in colorectal cancer
Q28066866Effect of Neoadjuvant Chemoradiotherapy with Capecitabine versus Fluorouracil for Locally Advanced Rectal Cancer: A Meta-Analysis
Q33831232Effect of a structured, active, home-based cancer-treatment program for the management of patients on oral chemotherapy
Q26865057Efficacy of S-1 vs capecitabine for the treatment of gastric cancer: a meta-analysis
Q37270388Efficacy of the oral fluorouracil pro-drug capecitabine in cancer treatment: a review
Q35125667Elective Bowel Resection for Incurable Stage IV Colorectal Cancer: Prognostic Variables for Asymptomatic Patients
Q35581170Emerging drugs in colorectal cancer
Q92185841Evaluating the recent developments in palliative chemotherapy for metastatic colorectal cancer
Q26752747Evidence-based medical oncology and interventional radiology paradigms for liver-dominant colorectal cancer metastases
Q37372475Evolution of nonsurgical therapy for colorectal cancer
Q43289305Feasibility and efficacy of capecitabine and FOLFIRI in patients aged 65 years and older with advanced colorectal cancer: a retrospective analysis
Q48177237First-line bolus 5-fluorouracil plus leucovorin for peritoneally disseminated gastric cancer with massive ascites or inadequate oral intake
Q38555200First-line chemotherapy for mCRC—a review and evidence-based algorithm.
Q36104929First-line therapy for advanced colorectal cancer
Q36760297First-line treatment strategies for elderly patients with metastatic colorectal cancer
Q35629061First-line treatment strategies to improve survival in patients with advanced colorectal cancer
Q36610452First-line treatment with oxaliplatin and capecitabine in patients with advanced or metastatic oesophageal cancer: a phase II study
Q38817372Fluoropyrimidine-Induced Cardiotoxicity: Manifestations, Mechanisms, and Management.
Q100426629From Tissue-Agnostic to N-of-One Therapies: (R)Evolution of the Precision Paradigm
Q40660694Future treatment options with capecitabine in solid tumours
Q55040134Geographical Variations in the Clinical Management of Colorectal Cancer in Australia: A Systematic Review.
Q55668963Germline pharmacogenomics of DPYD*9A (c.85T>C) variant in patients with gastrointestinal malignancies treated with fluoropyrimidines.
Q45040987Hand-foot syndrome in patients treated with capecitabine-containing combination chemotherapy
Q41844636Hand-foot syndrome with scleroderma-like change induced by the oral capecitabine: a case report
Q37214290Higher capecitabine AUC in elderly patients with advanced colorectal cancer (SWOGS0030).
Q50790500Highlights from: 42nd Annual Meeting of the American Society of Clinical Oncology.
Q80408154Highlights from: 5-Fluorouracil Drug Management Pharmacokinetics and Pharmacogenomics Workshop; Orlando, Florida; January 2007
Q50577241Highlights from: XII European Cancer Conference, Copenhagen, Denmark, September 21-25, 2003.
Q35919188Hypokalemia secondary to capecitabine: a hidden toxicity?
Q36502358Identification of metastasis-associated genes in colorectal cancer using metaDE and survival analysis
Q90151718Identifying a Novel DPYD Polymorphism Associated with Severe Toxicity to 5-FU Chemotherapy in a Saudi Patient
Q40361727In vitro radiosensitization by oxaliplatin and 5-fluorouracil in a human colon cancer cell line
Q27028095Incidence and relative risk of grade 3 and 4 diarrhoea in patients treated with capecitabine or 5-fluorouracil: a meta-analysis of published trials
Q37355866Incidence and risk factors for capecitabine-induced symptomatic cardiotoxicity: a retrospective study of 452 consecutive patients with metastatic breast cancer.
Q33873230Increasing Access to Oral Anticancer Medicines in Middle-Income Countries: A Case Study of Private Health Insurance Coverage in Brazil.
Q100455599Individualized dosing of fluoropyrimidine-based chemotherapy to prevent severe fluoropyrimidine-related toxicity - What are the options?
Q44230410Inhibiting 5-fluorouracil breakdown: a broken down approach to 5-fluorouracil modulation
Q44217768Initial report of KSCC0803: feasibility study of capecitabine as adjuvant chemotherapy for stage III colon cancer in Japanese patients
Q34225660Integrating the oral fluoropyrimidines into the management of advanced colorectal cancer
Q92361660Integrative Gene Expression Profiling Analysis to Investigate Potential Prognostic Biomarkers for Colorectal Cancer
Q33344682Intermittent weekly high-dose capecitabine in combination with oxaliplatin: a phase I/II study in first-line treatment of patients with advanced colorectal cancer
Q73580657Intraoperative electron radiotherapy as a component of salvage therapy for patients with colorectal cancer and advanced nodal metastases
Q37394656Irinotecan as palliative chemotherapy for metastatic colorectal cancer: evolving tactics following initial treatment.
Q30470164Irinotecan-induced dysarthria.
Q48187299Is a nurse-led telephone intervention a viable alternative to nurse-led home care and standard care for patients receiving oral capecitabine? Results from a large prospective audit in patients with colorectal cancer
Q83305771Is oral tegafur with leucovorin equivalent to intravenous 5-fluorouracil and leucovorin in colorectal cancer?
Q36300533Japanese Society for Cancer of the Colon and Rectum (JSCCR) Guidelines 2014 for treatment of colorectal cancer
Q36324953Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2016 for the treatment of colorectal cancer.
Q92776508Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2019 for the treatment of colorectal cancer
Q37560984Laryngeal preservation in stage III/IV resectable laryngo-hypopharyngeal squamous cell carcinoma following concurrent chemoradiotherapy with capecitabine/cisplatin
Q44552839Lethal toxicity of capecitabine due to abusive folic acid prescription?
Q52765521Letter regarding Zhao et al. entitled " DPYD gene polymorphisms are associated with risk and chemotherapy prognosis in pediatric patients with acute lymphoblastic leukemia".
Q44228279Liquid chromatography-mass spectrometry method for the analysis of the anti-cancer agent capecitabine and its nucleoside metabolites in human plasma
Q37520492Long noncoding RNA GAPLINC promotes invasion in colorectal cancer by targeting SNAI2 through binding with PSF and NONO.
Q64257150Long-term survival of an elderly female with metastatic colon cancer after treated with capecitabine monotherapy
Q46765481Looking for the right drug for the right patient: a tale of old drugs and new pathways
Q35733020Low-dose capecitabine adjuvant chemotherapy in elderly stage II/III colorectal cancer patients (LC-ACEC): study protocol for a randomized controlled trial
Q33967458Maintenance therapy with capecitabine in patients with locally advanced unresectable pancreatic adenocarcinoma
Q34229432Maintenance therapy with capecitabine in patients with resected pancreatic adenocarcinoma after adjuvant therapy: a retrospective cohort study
Q38081864Management of advanced colorectal cancer, Part 1.
Q38057086Management of colon cancer: resource-stratified guidelines from the Asian Oncology Summit 2012.
Q35666090Management of colorectal cancer in elderly patients: focus on the cost of chemotherapy
Q34788235Management of colorectal cancer.
Q36615314Management of hand-foot syndrome induced by capecitabine
Q27026129Management of locally advanced and metastatic colon cancer in elderly patients
Q42661688Matuzumab plus epirubicin, cisplatin and capecitabine (ECX) compared with epirubicin, cisplatin and capecitabine alone as first-line treatment in patients with advanced oesophago-gastric cancer: a randomised, multicentre open-label phase II study.
Q42874419Medical oncology: A novel low-toxicity regimen for advanced colorectal cancer?
Q35076194Medical treatment of advanced colorectal cancer in 2009.
Q35532752Meta-analysis comparing the safety and efficacy of metastatic colorectal cancer treatment regimens, capecitabine plus irinotecan (CAPIRI) and 5-fluorouracil/leucovorin plus irinotecan (FOLFIRI).
Q34677913Metastatic colorectal cancer
Q35148795Metastatic colorectal cancer: systemic treatment in the new millennium
Q36607065Modern challenges in colorectal cancer.
Q83694425Modified FOLFOX6 with oxaliplatin stop-and-go strategy and oral S-1 maintenance therapy in advanced colorectal cancer: CCOG-0704 study
Q33440884Nab-paclitaxel plus either gemcitabine or simplified leucovorin and fluorouracil as first-line therapy for metastatic pancreatic adenocarcinoma (AFUGEM GERCOR): a non-comparative, multicentre, open-label, randomised phase 2 trial
Q36848090Neoadjuvant 5-FU or Capecitabine Plus Radiation With or Without Oxaliplatin in Rectal Cancer Patients: A Phase III Randomized Clinical Trial
Q88001745Neoadjuvant CapeOx therapy followed by sphincter-preserving surgery for lower rectal cancer
Q34006430Neoadjuvant capecitabine, radiotherapy, and bevacizumab (CRAB) in locally advanced rectal cancer: results of an open-label phase II study
Q35095353New developments in therapy for colorectal cancer
Q35875393New drugs for colorectal cancer.
Q35741932New systemic frontline treatment for metastatic colorectal carcinoma
Q48061495Novel Genetic Variants in Carboxylesterase 1 Predict Severe Early-Onset Capecitabine-Related Toxicity.
Q52599427Novel Therapeutic Targets in Cutaneous Squamous Cell Carcinoma.
Q35594038Novel chemotherapeutic and targeted agents in metastatic colorectal cancer: the time has arrived
Q35567292Nucleoside anticancer drugs: the role of nucleoside transporters in resistance to cancer chemotherapy
Q34530897Observations and hypothesis on an individual patient topically treated for capecitabine-induced Palmar-Plantar syndrome
Q37077204On the state of the art of adjuvant chemotherapy for colon cancer
Q37875058Optimal management of metastatic colorectal cancer: current status
Q37341676Optimal timing for the administration of capecitabine with preoperative chemoradiation for locally advanced rectal cancer
Q51046352Optimal use of adjuvant chemotherapy in stage II colorectal cancer.
Q44849722Oral 5-FU and digestive cancers
Q36822388Oral anticancer drugs in the elderly: an overview
Q30913489Oral capecitabine vs intravenous 5-fluorouracil and leucovorin: integrated efficacy data and novel analyses from two large, randomised, phase III trials
Q35055231Oral chemotherapy in colorectal cancer treatment: review of the literature.
Q30251387Oral drugs in the treatment of metastatic colorectal cancer
Q33442681Oral fluoropyrimidine versus intravenous 5-fluorouracil for the treatment of advanced gastric and colorectal cancer: meta-analysis
Q24239911Oral versus intravenous fluoropyrimidines for colorectal cancer
Q38650502Oral versus intravenous fluoropyrimidines for colorectal cancer.
Q35174812Oromandibular dystonia: a serious side effect of capecitabine.
Q39137546Overexpression of Lgr5 correlates with resistance to 5-FU-based chemotherapy in colorectal cancer
Q35201745Oxaliplatin and capecitabine chemotherapy for advanced colorectal cancer: a single institution's experience
Q33747440Oxaliplatin, irinotecan and capecitabine as first-line therapy in metastatic colorectal cancer (mCRC): a dose-finding study and pharmacogenomic analysis
Q35577933Oxaliplatin: A Novel Platinum Analog With Activity in Colorectal Cancer
Q34558173Palliative and adjuvant chemotherapy in colorectal cancer
Q34449797Panitumumab: the evidence of its therapeutic potential in metastatic colorectal cancer care.
Q38410725Paradoxical effect of capecitabine in 5-fluorouracil-induced cardiotoxicity: A case vignette and literature review.
Q42870250Patients With Locally Advanced and Metastatic Colorectal Cancer Treated With Capecitabine Versus 5-Fluorouracil as Monotherapy or Combination Therapy With Oxaliplatin: A Cost Comparison
Q39470148Patients homozygous for DPYD c.1129-5923C>G/haplotype B3 have partial DPD deficiency and require a dose reduction when treated with fluoropyrimidines
Q35444531Patients' self-reported adherence to capecitabine on XELOX treatment in metastatic colorectal cancer: findings from a retrospective cohort analysis
Q30227039Perceptions and Experiences of Patients Receiving Oral Chemotherapy
Q34731381Personalized colon cancer care in 2010.
Q38166233Personalizing colon cancer therapeutics: targeting old and new mechanisms of action.
Q79463052Pharmacokinetic and safety study of weekly irinotecan and oral capecitabine in patients with advanced solid cancers
Q26769850Pharmacologic resistance in colorectal cancer: a review
Q35182963Pharmacological factors influencing anticancer drug selection in the elderly
Q53641063Phase I clinical and pharmacokinetic study of S-1 plus oral leucovorin in patients with metastatic colorectal cancer.
Q36695872Phase I dose-escalation trial of irinotecan with continuous infusion 5-FU first line, in metastatic colorectal cancer
Q85026066Phase I dose-finding study of sorafenib in combination with capecitabine and cisplatin as a first-line treatment in patients with advanced gastric cancer
Q25256709Phase I study of intermittent and chronomodulated oral therapy with capecitabine in patients with advanced and/or metastatic cancer
Q34165276Phase I/II study of capecitabine plus oxaliplatin (XELOX) plus bevacizumab as first-line therapy in Japanese patients with metastatic colorectal cancer
Q46798803Phase I/II study of gefitinib and capecitabine in patients with colorectal cancer.
Q36201465Phase I/II trial of capecitabine, oxaliplatin, and irinotecan in combination with bevacizumab in first line treatment of metastatic colorectal cancer
Q41559464Phase I/II trial of dose-reduced capecitabine in elderly patients with advanced colorectal cancer.
Q36614888Phase II study of concurrent chemoradiotherapy with capecitabine and cisplatin in patients with locally advanced squamous cell carcinoma of the head and neck
Q44908377Phase II study of oral S-1 for treatment of metastatic colorectal carcinoma
Q46632523Phase II study of oral capecitabine in patients with hormone-refractory prostate cancer
Q34746009Phase II study of single agent capecitabine in the treatment of metastatic non-pancreatic neuroendocrine tumours
Q53476543Phase II trial of S-1 monotherapy in elderly or frail patients with metastatic colorectal cancer.
Q79508623Phase II trial of capecitabine and rHu-interferon-alpha-2a in patients with metastatic renal cell carcinoma, limited efficacy, and moderate toxicity
Q38775314Phase II trial of capecitabine plus erlotinib versus capecitabine alone in patients with advanced colorectal cancer
Q37386059Phase-II study of dose attenuated schedule of irinotecan, capecitabine, and celecoxib in advanced colorectal cancer
Q33370303Pilot study of postoperative adjuvant chemoradiation for advanced gastric cancer: adjuvant 5-FU/cisplatin and chemoradiation with capecitabine
Q52604710Plants and Surgery: The Protective Effects of Thymoquinone on Hepatic Injury-A Systematic Review of In Vivo Studies.
Q36671793Plasma concentrations of 5-fluorouracil and F-beta-alanine following oral administration of S-1, a dihydropyrimidine dehydrogenase inhibitory fluoropyrimidine, as compared with protracted venous infusion of 5-fluorouracil
Q35825206Population pharmacokinetics and concentration-effect relationships of capecitabine metabolites in colorectal cancer patients
Q35542484Postoperative Capecitabine with Concurrent Intensity-Modulated Radiotherapy or Three-Dimensional Conformal Radiotherapy for Patients with Stage II and III Rectal Cancer
Q36611129Postoperative chemoradiotherapy in gastric cancer -- a Phase I/II dose-finding study of radiotherapy with dose escalation of cisplatin and capecitabine chemotherapy
Q34569963Prediction of the response of colorectal cancer to systemic therapy
Q42722130Preferences of patients with advanced colorectal cancer for treatment with oral or intravenous chemotherapy
Q53662723Preliminary results of trial NPC-0501 evaluating the therapeutic gain by changing from concurrent-adjuvant to induction-concurrent chemoradiotherapy, changing from fluorouracil to capecitabine, and changing from conventional to accelerated radiother
Q37703496Preoperative chemoradiation in locally advanced rectal cancer: a comparison of bolus 5-fluorouracil/leucovorin and capecitabine
Q44146804Preoperative chemoradiation using oral capecitabine in locally advanced rectal cancer
Q37077330Preoperative chemoradiotherapy in the management of localized rectal cancer: the new standard.
Q33746816Prospective phase II study of preoperative chemoradiation with capecitabine in locally advanced rectal cancer
Q33620052Quality-of-life findings from a randomised phase-III study of XELOX vs FOLFOX-6 in metastatic colorectal cancer
Q35579304Radiotherapy and Oral Capecitabine in the Preoperative Treatment of Patients with Rectal Cancer: Rationale, Preliminary Results and Perspectives
Q44723860Randomized multicenter Phase II trial of two different schedules of irinotecan combined with capecitabine as first-line treatment in metastatic colorectal carcinoma
Q79846295Randomized trial of the efficacy of adjuvant chemotherapy for colon cancer with combination therapy incorporating the oral pyrimidine 1-hexylcarbamoyl-5-fluorouracil
Q42871713Randomized trial of two different doses of pyridoxine in the prevention of capecitabine‐associated palmar‐plantar erythrodysesthesia
Q34447526Recent advances in the management of colorectal cancer
Q36616519Recent advances in the systemic management of colorectal cancer
Q25257445Relationship between cyclooxygenase 8473T>C polymorphism and the risk of lung cancer: a case-control study
Q37573426Replacing 5-fluorouracil by capecitabine in localised squamous cell carcinoma of the anal canal: systematic review and meta-analysis
Q36615965Report of two protocol planned interim analyses in a randomised multicentre phase III study comparing capecitabine with fluorouracil and oxaliplatin with cisplatin in patients with advanced oesophagogastric cancer receiving ECF.
Q33455278Reporting of adverse events in randomized controlled trials of highly active antiretroviral therapy: systematic review
Q44700037Response of neoplastic meningitis from solid tumors to oral capecitabine
Q37009734Retrospective Analysis of Capecitabine and Radiation Therapy in the Treatment of Pancreatic Cancer
Q37560960Retrospective analysis of capecitabine and oxaliplatin (XELOX) plus bevacizumab as a first-line treatment for Japanese patients with metastatic colorectal cancer
Q97905332Retrospective study of preoperative chemoradiotherapy with capecitabine versus capecitabine plus oxaliplatin for locally advanced rectal cancer
Q27021105Review of systemic therapies for locally advanced and metastatic rectal cancer
Q64885950Revisiting the Clinical Importance of DPYD*9A (c.85T>C) Variant of Dihydropyrimidine Dehydrogenase (DPYD) Gene in Patients Treated with Fluoropyrimidine-Based Chemotherapy.
Q37692395Role of capecitabine in treating metastatic colorectal cancer in Chinese patients.
Q37113563Role of chemotherapy and novel biological agents in the treatment of elderly patients with colorectal cancer
Q37230238Role of oxaliplatin in the treatment of colorectal cancer
Q40068183Rs895819 in MIR27A improves the predictive value of DPYD variants to identify patients at risk of severe fluoropyrimidine-associated toxicity
Q33403790S-1 plus oxaliplatin versus capecitabine plus oxaliplatin for first-line treatment of patients with metastatic colorectal cancer: a randomised, non-inferiority phase 3 trial
Q89257709Second-Line Palliative Chemotherapy in Advanced Gall Bladder Cancer, CAP-IRI: Safe and Effective Option
Q45204578Second-line cetuximab/irinotecan versus oxaliplatin/fluoropyrimidines for metastatic colorectal cancer with wild-type KRAS.
Q37407092Second-look surgery following Hartmann's procedure for obstructive left-sided colorectal cancer
Q80871194Selective surgical treatment of patients with rectal carcinoma and unresectable synchronous metastases based on response to preoperative chemotherapy
Q24234461Sequential versus combination chemotherapy for advanced colorectal cancer
Q60629643Sequential versus combination chemotherapy for the treatment of advanced colorectal cancer (FFCD 2000–05): an open-label, randomised, phase 3 trial
Q34581085Sequential versus combination chemotherapy with capecitabine, irinotecan, and oxaliplatin in advanced colorectal cancer (CAIRO): a phase III randomised controlled trial
Q84453461Severe toxicity of capecitabine following uncomplicated treatment with 5-fluorouracil/leucovorin
Q38216008Should capecitabine replace 5-fluorouracil in the first-line treatment of metastatic colorectal cancer?
Q35584825Simplified prognostic model in patients with oxaliplatin-based or irinotecan-based first-line chemotherapy for metastatic colorectal cancer: a GERCOR study
Q53724796Simultaneous neoadjuvant radiochemotherapy with capecitabine and oxaliplatin for locally advanced rectal cancer. Treatment outcome outside clinical trials.
Q50872828Single-agent capecitabine as maintenance therapy after induction of XELOX (or FOLFOX) in first-line treatment of metastatic colorectal cancer: randomized clinical trial of efficacy and safety.
Q35103614Stage III colon cancer at Baylor University Medical Center at Dallas and the Baylor Sammons Cancer Center: experience from 2000 to 2004
Q57471266Survival outcome and prognostic model of patients with colorectal cancer on phase 1 trials
Q58614342Systemic Therapy for Patients with Colorectal Cancer: State of the Art
Q95806910Systemic chemotherapy with doxorubicin, cisplatin and capecitabine for metastatic hepatocellular carcinoma
Q46500265Systemic therapy for colorectal cancer
Q35572015Systemic therapy for colorectal cancer: focus on newer chemotherapy and novel agents
Q37109507Systemic therapy for metastatic colorectal cancer: current questions
Q81253030Systemic treatment of colorectal cancer
Q36217126Targeted drugs in metastatic colorectal cancer with special emphasis on guidelines for the use of bevacizumab and cetuximab: an Acta Oncologica expert report
Q37158228Targeted therapeutic agents for colorectal cancer
Q39233316The Role of Fluoropirimidines in Gastrointestinal Tumours: from the Bench to the Bed.
Q37328589The Value of Restaging With Chest and Abdominal CT/MRI Scan After Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Cancer.
Q24652904The clinical and economic benefits of capecitabine and tegafur with uracil in metastatic colorectal cancer
Q34980526The dual role of thymidine phosphorylase in cancer development and chemotherapy
Q39102953The effects of silencing of PI3K p85α on 5-FU-induced colorectal cancer cells apoptosis
Q41231669The efficacy and safety of capecitabine plus bevacizumab combination as first-line treatment in elderly metastatic colorectal cancer patients
Q34773758The efficacy of additional bevacizumab to cytotoxic chemotherapy regimens for the treatment of colorectal cancer: an updated meta-analysis for randomized trials
Q41083423The rapidly escalating cost of treating colorectal cancer in Australia.
Q36101808The role of chemotherapy in colon cancer.
Q33183187The use of oral cytotoxic and cytostatic drugs in cancer treatment
Q38842633Therapeutic drug monitoring of 5-fluorouracil.
Q26777679Therapeutic potential of TAS-102 in the treatment of gastrointestinal malignancies
Q80510490Thymidylate synthase inhibitors
Q37653406Tolerability of Capecitabine Monotherapy in Metastatic Colorectal Cancer: A Real-World Study
Q53622588Treatment of High-Grade Metastatic Pancreatic Neuroendocrine Carcinoma with FOLFIRINOX.
Q44457418Treatment of advanced colorectal carcinoma with oxaliplatin and capecitabine: a phase II trial
Q36276360Treatment of elderly cancer patients with chemotherapy
Q57071081Treatment of patients with metastatic colorectal cancer and poor performance status: current evidence and challenges
Q37649832Trends in treatment and survival in older patients presenting with stage IV colorectal cancer
Q37340518Twelve weeks of protracted venous infusion of fluorouracil (5-FU) is as effective as 6 months of bolus 5-FU and folinic acid as adjuvant treatment in colorectal cancer
Q40127619Uncommon dihydropyrimidine dehydrogenase mutations and toxicity by fluoropyrimidines: a lethal case with a new variant.
Q28085651Unresolved issues and controversies surrounding the management of colorectal cancer liver metastasis
Q93635367Upcoming articles
Q37815612Update on capecitabine alone and in combination regimens in colorectal cancer patients
Q34711507Which endpoints should we use in evaluating the use of novel fluoropyrimidine regimens in colorectal cancer?
Q33370632XELOX (capecitabine plus oxaliplatin) as first-line treatment for elderly patients over 70 years of age with advanced colorectal cancer
Q34630237XELOX vs FOLFOX-4 as first-line therapy for metastatic colorectal cancer: NO16966 updated results.
Q79769145[A review of chemotherapy for metastatic colon cancer]
Q45990468[Therapeutic use and profile of toxicity of the FOLFOX4 regimen].

Search more.