scholarly article | Q13442814 |
P2093 | author name string | Gijsbertus J Pronk | |
Anke Klippel | |||
Jörg Kaufmann | |||
Klaus Giese | |||
Hüseyin Aygün | |||
Frank Czauderna | |||
Melanie Fechtner | |||
Sibylle Dames | |||
P2860 | cites work | Stable suppression of gene expression by RNAi in mammalian cells | Q24533429 |
Stabilizing effects of the RNA 2'-substituent: crystal structure of an oligodeoxynucleotide duplex containing 2'-O-methylated adenosines | Q27748024 | ||
RNA interference is mediated by 21- and 22-nucleotide RNAs | Q27860764 | ||
Role for a bidentate ribonuclease in the initiation step of RNA interference | Q27860832 | ||
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans | Q27860867 | ||
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells | Q27860926 | ||
RNA interference | Q28131798 | ||
Single-stranded antisense siRNAs guide target RNA cleavage in RNAi | Q28201784 | ||
Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi | Q28218870 | ||
Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate | Q28365532 | ||
An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells | Q29547714 | ||
ATP requirements and small interfering RNA structure in the RNA interference pathway | Q29618384 | ||
Argonaute2, a link between genetic and biochemical analyses of RNAi | Q29618385 | ||
Specific interference with gene expression induced by long, double-stranded RNA in mouse embryonal teratocarcinoma cell lines. | Q33951914 | ||
Functional studies of the PI(3)-kinase signalling pathway employing synthetic and expressed siRNA. | Q34459792 | ||
Small interfering RNAs: a revolutionary tool for the analysis of gene function and gene therapy | Q35679433 | ||
The interaction of small domains between the subunits of phosphatidylinositol 3-kinase determines enzyme activity | Q36745695 | ||
Positional effects of short interfering RNAs targeting the human coagulation trigger Tissue Factor | Q39597818 | ||
Tolerance for mutations and chemical modifications in a siRNA. | Q39698017 | ||
GeneBlocs are powerful tools to study and delineate signal transduction processes that regulate cell growth and transformation | Q40712978 | ||
PKR--a protein kinase regulated by double-stranded RNA. | Q41647401 | ||
Establishment and maintenance of a heterochromatin domain | Q44128134 | ||
RNAi in human cells: basic structural and functional features of small interfering RNA. | Q44199577 | ||
Short 5'-phosphorylated double-stranded RNAs induce RNA interference in Drosophila. | Q52592619 | ||
Evidence that siRNAs function as guides, not primers, in the Drosophila and human RNAi pathways. | Q52600395 | ||
Chemical modification of hammerhead ribozymes. Catalytic activity and nuclease resistance | Q71823724 | ||
Metabolism of antisense oligonucleotides in rat liver homogenates | Q73289482 | ||
Expanding small RNA interference | Q78021693 | ||
P433 | issue | 11 | |
P407 | language of work or name | English | Q1860 |
P304 | page(s) | 2705-2716 | |
P577 | publication date | 2003-06-01 | |
P1433 | published in | Nucleic Acids Research | Q135122 |
P1476 | title | Structural variations and stabilising modifications of synthetic siRNAs in mammalian cells | |
P478 | volume | 31 |
Q34906848 | 8-Oxoguanosine switches modulate the activity of alkylated siRNAs by controlling steric effects in the major versus minor grooves |
Q37199509 | A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity |
Q40290076 | A novel siRNA-lipoplex technology for RNA interference in the mouse vascular endothelium |
Q45402073 | A post-synthetic approach for the synthesis of 2'-O-methyldithiomethyl-modified oligonucleotides responsive to a reducing environment |
Q57112729 | A potential treatment for pandemic influenza using siRNAs targeting conserved regions of influenza A |
Q35192409 | A single naturally occurring 2'-O-methylation converts a TLR7- and TLR8-activating RNA into a TLR8-specific ligand |
Q40285464 | A structural basis for discriminating between self and nonself double-stranded RNAs in mammalian cells. |
Q28571503 | ASPP1/2 regulate p53-dependent death of retinal ganglion cells through PUMA and Fas/CD95 activation in vivo |
Q33613316 | Advances in Systemic siRNA Delivery |
Q39250878 | Advances in siRNA delivery in cancer therapy |
Q38199518 | Advances in targeted delivery of small interfering RNA using simple bioconjugates |
Q46715836 | An ESI-MS method for characterization of native and modified oligonucleotides used for RNA interference and other biological applications |
Q99248466 | An artificial cationic oligosaccharide combined with phosphorothioate linkages strongly improves siRNA stability |
Q37030891 | Applying small RNA molecules to the directed treatment of human diseases: realizing the potential |
Q54633985 | Atu027 Prevents Pulmonary Metastasis in Experimental and Spontaneous Mouse Metastasis Models |
Q38301011 | Bioconjugates for targeted delivery of therapeutic oligonucleotides |
Q39859749 | Biological effects of hexitol and altritol-modified siRNAs targeting B-Raf |
Q34725471 | Branched RNA: A New Architecture for RNA Interference |
Q35529832 | Cell-penetrating and neurotargeting dendritic siRNA nanostructures. |
Q49408746 | Chemical Modification of the siRNA Seed Region Suppresses Off-Target Effects by Steric Hindrance to Base-Pairing with Targets |
Q36101387 | Chemical modification of gene silencing oligonucleotides for drug discovery and development |
Q37655882 | Chemical modification of siRNA. |
Q36970002 | Chemical modification patterns compatible with high potency dicer-substrate small interfering RNAs |
Q41814077 | Chemical modification resolves the asymmetry of siRNA strand degradation in human blood serum |
Q33308712 | Chemical modification: the key to clinical application of RNA interference? |
Q40244901 | Chemically modified short interfering hybrids (siHYBRIDS): nanoimmunoliposome delivery in vitro and in vivo for RNAi of HER-2. |
Q39121566 | Clinical and biological significance of hepatoma-derived growth factor in Ewing's sarcoma |
Q50061759 | Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo. |
Q39113952 | Competition for RISC binding predicts in vitro potency of siRNA. |
Q39664198 | Comprehensive analysis of sequence-specific stability of siRNA |
Q38768138 | Computing in mammalian cells with nucleic acid strand exchange |
Q37217876 | Concepts in in vivo siRNA delivery for cancer therapy |
Q37111373 | Confirming the RNAi-mediated mechanism of action of siRNA-based cancer therapeutics in mice |
Q35127967 | Controlling activation of the RNA-dependent protein kinase by siRNAs using site-specific chemical modification |
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Q92755701 | Current Aspects of siRNA Bioconjugate for In Vitro and In Vivo Delivery |
Q55383414 | Current Challenges in Delivery and Cytosolic Translocation of Therapeutic RNAs. |
Q64085262 | Current Development of siRNA Bioconjugates: From Research to the Clinic |
Q59358386 | Current Transport Systems and Clinical Applications for Small Interfering RNA (siRNA) Drugs |
Q28235733 | Current prospects for RNA interference-based therapies |
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Q35867148 | Degradation of nuclease-stabilized RNA oligonucleotides in Mycoplasma-contaminated cell culture media |
Q81255488 | Delivery of small interfering RNA to mammalian cells in culture by using cationic lipid/polymer-based transfection reagents |
Q38692510 | Delivery of therapeutic siRNA to the lung endothelium via novel Lipoplex formulation DACC. |
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Q37970644 | Deoxyribozymes and bioinformatics: complementary tools to investigate axon regeneration |
Q46847636 | Design of noninflammatory synthetic siRNA mediating potent gene silencing in vivo |
Q89910193 | Design, mechanism, delivery and therapeutics of canonical and Dicer-substrate siRNA |
Q47582195 | Designing Tyrosinase siRNAs by Multiple Prediction Algorithms and Evaluation of Their Anti-Melanogenic Effects |
Q36174842 | Development of Therapeutic-Grade Small Interfering RNAs by Chemical Engineering |
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Q37277394 | Disease-causing allele-specific silencing by RNA interference |
Q38811665 | Duplex end breathing determines serum stability and intracellular potency of siRNA-Au NPs. |
Q49850199 | Effect of Chemical Modifications on Aptamer Stability in Serum |
Q36935389 | Effect of asymmetric terminal structures of short RNA duplexes on the RNA interference activity and strand selection |
Q42046598 | Effect of base modifications on structure, thermodynamic stability, and gene silencing activity of short interfering RNA. |
Q34080079 | Effect of chemical modifications on modulation of gene expression by duplex antigene RNAs that are complementary to non-coding transcripts at gene promoters |
Q38291528 | Effect of lyophilization and freeze-thawing on the stability of siRNA-liposome complexes |
Q39765698 | Effect of north bicyclo[3.1.0]hexane 2'-deoxy-pseudosugars on RNA interference: a novel class of siRNA modification. |
Q46671810 | Effect of siRNA nuclease stability on the in vitro and in vivo kinetics of siRNA-mediated gene silencing |
Q41159509 | Effective inhibition of HIV-1 production by short hairpin RNAs and small interfering RNAs targeting a highly conserved site in HIV-1 Gag RNA is optimized by evaluating alternative length formats |
Q33572902 | Effects of chemical modification on the potency, serum stability, and immunostimulatory properties of short shRNAs |
Q36844506 | Effects of cholesterol-tagged small interfering RNAs targeting 12/15-lipoxygenase on parameters of diabetic nephropathy in a mouse model of type 1 diabetes |
Q39647908 | Effects of the knockdown of hypoxia inducible factor-1α expression by adenovirus-mediated shRNA on angiogenesis and tumor growth in hepatocellular carcinoma cell lines. |
Q95780509 | Efficient In Vivo Delivery of siRNA to the Liver by Conjugation of α-Tocopherol |
Q37520714 | Efficient RNA interference depends on global context of the target sequence: quantitative analysis of silencing efficiency using Eulerian graph representation of siRNA. |
Q34149828 | Efficient and targeted delivery of siRNA in vivo |
Q24806391 | Efficient delivery of small interfering RNA for inhibition of IL-12p40 expression in vivo |
Q54732681 | Enhancement of RNAi activity by improved siRNA duplexes. |
Q39277700 | Enhancement of gene silencing effect and membrane permeability by Peptide-conjugated 27-nucleotide small interfering RNA. |
Q36169056 | Epigenetic manipulation of gene expression: a toolkit for cell biologists |
Q37665372 | Exploring chemical modifications for siRNA therapeutics: a structural and functional outlook |
Q34520490 | Fabrication of stable and RNase-resistant RNA nanoparticles active in gearing the nanomotors for viral DNA packaging |
Q39521378 | Fluorescence cross-correlation spectroscopy reveals mechanistic insights into the effect of 2'-O-methyl modified siRNAs in living cells |
Q45011799 | Fluorescent tag is not a reliable marker for small RNA transfection in the presence of serum |
Q42979094 | Function and anatomy of plant siRNA pools derived from hairpin transgenes |
Q39202309 | Functionalization of the 3'-ends of DNA and RNA strands with N-ethyl-N-coupled nucleosides: a promising approach to avoid 3'-exonuclease-catalyzed hydrolysis of therapeutic oligonucleotides. |
Q37194010 | Functionalized gold nanoparticles for the binding, stabilization, and delivery of therapeutic DNA, RNA, and other biological macromolecules |
Q36658971 | Gene control of tyrosine kinase TIE2 and vascular manifestations of infections |
Q47578379 | Grand challenges in modulating the immune response with RNAi nanomedicines. |
Q33786171 | High-density lipoproteins for the systemic delivery of short interfering RNA. |
Q35813800 | Human Papillomavirus E6/E7-Specific siRNA Potentiates the Effect of Radiotherapy for Cervical Cancer in Vitro and in Vivo |
Q52582698 | Hyaluronic acid conjugated nanoparticle delivery of siRNA against TWIST reduces tumor burden and enhances sensitivity to cisplatin in ovarian cancer. |
Q35697443 | Hydrophobization and bioconjugation for enhanced siRNA delivery and targeting |
Q37775134 | Identifying HIV-1 host cell factors by genome-scale RNAi screening. |
Q29622905 | Illuminating the silence: understanding the structure and function of small RNAs |
Q35029184 | Improving gene silencing of siRNAs via tricyclo-DNA modification |
Q48093995 | In Vivo siRNA Delivery and Rebound of Renal LRP2 in Mice. |
Q25255776 | In situ fluorescence analysis demonstrates active siRNA exclusion from the nucleus by Exportin 5. |
Q34365687 | In vivo activity of nuclease-resistant siRNAs |
Q37974175 | In vivo imaging of the systemic delivery of small interfering RNA. |
Q36044790 | In vivo screening of modified siRNAs for non-specific antiviral effect in a small fish model: number and localization in the strands are important |
Q42113194 | Inhibition of MDR1 expression with altritol-modified siRNAs |
Q33778468 | Inhibition of lung tumor growth in nude mice by siRNA(CD31) targeting PECAM-1. |
Q90184104 | Innovative approaches for cancer treatment: current perspectives and new challenges |
Q34234252 | Interfering with disease: opportunities and roadblocks to harnessing RNA interference |
Q42216531 | Intracellular stability of 2'-OMe-4'-thioribonucleoside modified siRNA leads to long-term RNAi effect |
Q36540601 | Ligand-targeted delivery of therapeutic siRNA. |
Q37273669 | Light-activated RNA interference using double-stranded siRNA precursors modified using a remarkable regiospecificity of diazo-based photolabile groups |
Q24676555 | Light-dependent RNA interference with nucleobase-caged siRNAs |
Q38269555 | Lipid nanoparticles for gene delivery |
Q39183138 | Lipoplex mediated silencing of membrane regulators (CD46, CD55 and CD59) enhances complement-dependent anti-tumor activity of trastuzumab and pertuzumab |
Q53640671 | Liver-specific Fas silencing prevents galactosamine/lipopolysaccharide-induced liver injury. |
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Q33812404 | Logic integration of mRNA signals by an RNAi-based molecular computer |
Q39154770 | Long double-stranded multiplex siRNAs for dual genes silencing |
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Q33268852 | MALDI-TOF mass spectral analysis of siRNA degradation in serum confirms an RNAse A-like activity |
Q36050495 | Macrophage migration inhibitory factor as a potential prognostic factor in gastric cancer |
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Q38615221 | Mechanisms of immune system activation in mammalians by small interfering RNA (siRNA). |
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Q37338992 | Nucleic acids-based therapeutics in the battle against pathogenic viruses |
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Q51938052 | Overview of gene silencing by RNA interference. |
Q37873825 | Personalized cancer approach: using RNA interference technology |
Q38707859 | Photocrosslinkable, biodegradable hydrogels with controlled cell adhesivity for prolonged siRNA delivery to hMSCs to enhance their osteogenic differentiation |
Q37012046 | Polycation-based nanoparticle delivery for improved RNA interference therapeutics. |
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Q36557311 | Positive feedback loop of hepatoma-derived growth factor and β-catenin promotes carcinogenesis of colorectal cancer |
Q28085290 | Preclinical and clinical development of siRNA-based therapeutics |
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Q28255877 | Progress toward in vivo use of siRNAs-II |
Q28297652 | Progress towards in vivo use of siRNAs |
Q34370185 | Quantitative evaluation of siRNA delivery in vivo. |
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Q36944914 | RNA interference and antiviral therapy. |
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