Impairment of transforming growth factor beta signaling in caveolin-1-deficient hepatocytes: role in liver regeneration.

scientific article

Impairment of transforming growth factor beta signaling in caveolin-1-deficient hepatocytes: role in liver regeneration. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M109.072900
P8608Fatcat IDrelease_foyhv57h7rbazfroa6efvethx4
P932PMC publication ID2823504
P698PubMed publication ID19966340

P50authorAgueda Gonzalez-rodriguezQ42850261
Rafael MayoralQ57077986
Lisardo BoscaQ64410148
P2093author name stringPaloma Martín-Sanz
Angela M Valverde
Cristina Llorente Izquierdo
P2860cites workCytoplasmic SnoN in normal tissues and nonmalignant cells antagonizes TGF-beta signaling by sequestration of the Smad proteinsQ24316283
TGF beta signals through a heteromeric protein kinase receptor complexQ24337608
Requirement for the SnoN oncoprotein in transforming growth factor beta-induced oncogenic transformation of fibroblast cellsQ24534996
TGF-beta signalling from cell membrane to nucleus through SMAD proteinsQ28131770
Caveolin-1 regulates transforming growth factor (TGF)-beta/SMAD signaling through an interaction with the TGF-beta type I receptorQ28139202
Transforming growth factor-beta1 recruits histone deacetylase 1 to a p130 repressor complex in transgenic mice in vivoQ28145219
Escaping from the TGFbeta anti-proliferative controlQ28240031
Smad transcription factorsQ28284775
Changes in TGF-beta receptors of rat hepatocytes during primary culture and liver regeneration: increased expression of TGF-beta receptors associated with increased sensitivity to TGF-beta-mediated growth inhibitionQ28566763
Dynamic and regulated association of caveolin with lipid bodies: modulation of lipid body motility and function by a dominant negative mutantQ28581882
Phospho-caveolin-1 mediates integrin-regulated membrane domain internalization.Q30447025
Differential expression of Caveolin-1 in hepatocellular carcinoma: correlation with differentiation state, motility and invasionQ33411986
Caveolin-1 expression negatively regulates cell cycle progression by inducing G(0)/G(1) arrest via a p53/p21(WAF1/Cip1)-dependent mechanism.Q33944029
Caveolae: from basic trafficking mechanisms to targeting transcytosis for tissue-specific drug and gene delivery in vivoQ34365138
The fine structure of the gall bladder epithelium of the mouse.Q34537858
Caveolae: from cell biology to animal physiologyQ34838611
Endocytic regulation of TGF-beta signalingQ34892916
Expression of cyclooxygenase-2 in foetal rat hepatocytes stimulated with lipopolysaccharide and pro-inflammatory cytokines.Q35028167
Hepatocyte growth factor in kidney fibrosis: therapeutic potential and mechanisms of actionQ35794379
Caveolin-1 in oncogenic transformation, cancer, and metastasisQ36030347
Transforming Sloan-Kettering viruses generated from the cloned v-ski oncogene by in vitro and in vivo recombinationsQ36859994
Ski and SnoN, potent negative regulators of TGF-beta signalingQ37359949
Caveolin-1 negatively regulates TRAIL-induced apoptosis in human hepatocarcinoma cellsQ39919958
Caveolin-1 promotes the transformation and anti-apoptotic ability of mouse hepatoma cellsQ39962608
Caveolin-1 interacts and cooperates with the transforming growth factor-beta type I receptor ALK1 in endothelial caveolaeQ40038167
Caveolin-1 reduces osteosarcoma metastases by inhibiting c-Src activity and met signaling.Q40093820
Dispensability and dynamics of caveolin-1 during liver regeneration and in isolated hepatic cells.Q40102242
Molecular basis for the cell type specific induction of SnoN expression by hepatocyte growth factorQ40108341
Expression of caveolin-1 enhances cholesterol efflux in hepatic cellsQ40598222
Caveolins, a family of scaffolding proteins for organizing "preassembled signaling complexes" at the plasma membraneQ41715384
Caveolin-1 increases basal and TGF-beta1-induced expression of type I procollagen through PI-3 kinase/Akt/mTOR pathway in human dermal fibroblastsQ42435234
p42/44 MAP kinase-dependent and -independent signaling pathways regulate caveolin-1 gene expression. Activation of Ras-MAP kinase and protein kinase a signaling cascades transcriptionally down-regulates caveolin-1 promoter activityQ42809229
Expression of Caveolin-1 reduces cellular responses to TGF-beta1 through down-regulating the expression of TGF-beta type II receptor gene in NIH3T3 fibroblast cellsQ42827766
Morphologic and functional characterization of caveolae in rat liver hepatocytes.Q43601222
Distinct endocytic pathways regulate TGF-β receptor signalling and turnoverQ44419411
Molecular mechanisms of insulin resistance in IRS-2-deficient hepatocytesQ44564021
Caveolin and thrombospondin expression during hepatocellular carcinogenesisQ47713157
Caveolin-1 is essential for liver regeneration.Q52573584
Transforming growth factor-beta suppresses the ability of Ski to inhibit tumor metastasis by inducing its degradation.Q53321709
Liver regenerationQ63664803
Ski-related novel protein N (SnoN), a negative controller of transforming growth factor-beta signaling, is a prognostic marker in estrogen receptor-positive breast carcinomasQ73865005
Up-regulated transcriptional repressors SnoN and Ski bind Smad proteins to antagonize transforming growth factor-beta signals during liver regenerationQ74145184
Enhanced expression of endothelial nitric oxide synthase and caveolin-1 in human cirrhosisQ74168602
Factors of transforming growth factor beta signalling are co-regulated in human hepatocellular carcinomaQ80801494
P433issue6
P407language of work or nameEnglishQ1860
P304page(s)3633-3642
P577publication date2009-12-05
P1433published inJournal of Biological ChemistryQ867727
P1476titleImpairment of transforming growth factor beta signaling in caveolin-1-deficient hepatocytes: role in liver regeneration
P478volume285

Reverse relations

cites work (P2860)
Q585869083,5-Diethoxy-3'-Hydroxyresveratrol (DEHR) Ameliorates Liver Fibrosis via Caveolin-1 Activation in Hepatic Stellate Cells and in a Mouse Model of Bile Duct Ligation Injury
Q35573373Adipocyte SIRT1 knockout promotes PPARγ activity, adipogenesis and insulin sensitivity in chronic-HFD and obesity
Q38096319Caveolin and TGF-β entanglements
Q58605995Caveolin-1 Modulates Mechanotransduction Responses to Substrate Stiffness through Actin-Dependent Control of YAP
Q28576372Caveolin-1 and mitochondrial alterations in regenerating rat liver
Q34007771Caveolin-1 is required for TGF-β-induced transactivation of the EGF receptor pathway in hepatocytes through the activation of the metalloprotease TACE/ADAM17.
Q44107555Caveolin-1 orchestrates the balance between glucose and lipid-dependent energy metabolism: implications for liver regeneration
Q46604388Caveolin-1-dependent activation of the metalloprotease TACE/ADAM17 by TGF-β in hepatocytes requires activation of Src and the NADPH oxidase NOX1.
Q37899938Cholesterol: recapitulation of its active role during liver regeneration
Q42438492Eukaryotic elongation factor 2 controls TNF-α translation in LPS-induced hepatitis
Q36651774Increased caveolin-1 in intervertebral disc degeneration facilitates repair
Q35351530Plasminogen activator inhibitor-1 suppresses profibrotic responses in fibroblasts from fibrotic lungs
Q34805653Protein Tyrosine Phosphatase 1B (PTP1B) deficiency accelerates hepatic regeneration in mice
Q39377565Protein-tyrosine phosphatase 1B (PTP1B) deficiency confers resistance to transforming growth factor-β (TGF-β)-induced suppressor effects in hepatocytes
Q26779846Reciprocal regulation of TGF-β and reactive oxygen species: A perverse cycle for fibrosis
Q28512285Redox-induced Src kinase and caveolin-1 signaling in TGF-β1-initiated SMAD2/3 activation and PAI-1 expression
Q37498910SnoN activates p53 directly to regulate aging and tumorigenesis
Q35069771SnoN in mammalian development, function and diseases
Q37498907SnoN in regulation of embryonic development and tissue morphogenesis
Q92422748The TGF-β1/p53/PAI-1 Signaling Axis in Vascular Senescence: Role of Caveolin-1
Q38125298The less-often-traveled surface of stem cells: caveolin-1 and caveolae in stem cells, tissue repair and regeneration
Q62060038Transcriptional cofactors Ski and SnoN are major regulators of the TGF-β/Smad signaling pathway in health and disease
Q37970047Tyrosine phosphorylation and liver regeneration: A glance at intracellular transducers.

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