Potent and Orally Bioavailable GPR142 Agonists as Novel Insulin Secretagogues for the Treatment of Type 2 Diabetes.

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Potent and Orally Bioavailable GPR142 Agonists as Novel Insulin Secretagogues for the Treatment of Type 2 Diabetes. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1021/ML400186Z
P8608Fatcat IDrelease_regimxhbmvfzlpexosvyrvaml4
P932PMC publication ID4027368
P698PubMed publication ID24900747

P50authorRyo OkuyamaQ72967848
P2093author name stringMing Yu
Yi Chen
Leping Li
Xiaolin Hao
Satoshi Shibuya
Hui Tian
Run Zhuang
Futoshi Nara
Yasuyuki Ogawa
Yi-Jyun Lin
Yongjae Kim
Sarah Lively
Zice Fu
Masanori Izumi
Jeff D Reagan
Julio Medina
Nobuaki Watanabe
Qingxiang Liu
Alykhan Motani
Angela Fu
Yumei Xiong
Narihiro Toda
Peter Fan
Mike Lizarzaburu
Michiko Murakoshi
Kozo Oda
Shauna Lawlis
P2860cites workThe incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetesQ28273497
Sulphonylurea-induced hypoglycaemia in type 2 diabetes mellitus: a reviewQ34168385
The role of sulphonylureas in the management of type 2 diabetes mellitusQ35807254
Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitusQ37141727
Progress in the discovery and development of small-molecule modulators of G-protein-coupled receptor 40 (GPR40/FFA1/FFAR1): an emerging target for type 2 diabetesQ37481309
The therapeutic potential of GPR119 agonists for type 2 diabetesQ37980173
Lipophilicity in drug discoveryQ38028532
Novel metabolic bioactivation mechanism for a series of anti-inflammatory agents (2,5-diaminothiophene derivatives) mediated by cytochrome p450 enzymes.Q43041998
Risk of macrovascular and microvascular complications in Type 2 diabetes: results of longitudinal study designQ44070306
(2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine: a potent, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetesQ45212807
Phenylalanine derivatives as GPR142 agonists for the treatment of type II diabetes.Q48621489
Discovery and optimization of a novel series of GPR142 agonists for the treatment of type 2 diabetes mellitus.Q48628829
P433issue8
P921main subjecttype 2 diabetesQ3025883
P304page(s)790-794
P577publication date2013-06-17
P1433published inACS Medicinal Chemistry LettersQ2819061
P1476titlePotent and Orally Bioavailable GPR142 Agonists as Novel Insulin Secretagogues for the Treatment of Type 2 Diabetes
P478volume4

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cites work (P2860)
Q26830274Addressing unmet medical needs in type 2 diabetes: a narrative review of drugs under development
Q55262651Differential role of GPR142 in tryptophan-mediated enhancement of insulin secretion in obese and lean mice.
Q49598911Discovery and Optimization of a Novel Triazole Series of GPR142 Agonists for the Treatment of Type 2 Diabetes
Q35178871Discovery of DS-1558: A Potent and Orally Bioavailable GPR40 Agonist
Q35996954GPR142 Agonists Stimulate Glucose-Dependent Insulin Secretion via Gq-Dependent Signaling
Q36056936GPR142 Controls Tryptophan-Induced Insulin and Incretin Hormone Secretion to Improve Glucose Metabolism
Q52673362GPR142 prompts glucagon-like Peptide-1 release from islets to improve β cell function.
Q59548972Germline RAD51B truncating mutation in a family with cutaneous melanoma
Q90260620Glucagon-Like Peptide-1: Actions and Influence on Pancreatic Hormone Function
Q50964984Insights into unbound-bound states of GPR142 receptor in a membrane-aqueous system using molecular dynamics simulations.
Q90429528Leveraging the Gut to Treat Metabolic Disease
Q92948184Sustainable Synthetic Approach for (Pyrazol-4-ylidene)pyridines By Metal Catalyst-Free Aerobic C(sp2)-C(sp3) Coupling Reactions between 1-Amino-2-imino-pyridines and 1-Aryl-5-pyrazolones
Q48253186Synthesis and Pharmacological Activities of Pyrazole Derivatives: A Review
Q63379404The aromatic amino acid sensor GPR142 controls metabolism through balanced regulation of pancreatic and gut hormones
Q64280793The functional impact of G protein-coupled receptor 142 (Gpr142) on pancreatic β-cell in rodent

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