Thymic peptide hormones: basic properties and clinical applications in cancer

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Thymic peptide hormones: basic properties and clinical applications in cancer is …
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review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/S1040-8428(85)80035-4
P698PubMed publication ID3902261

P2093author name stringSchulof RS
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‘Nude’, a new hairless gene with pleiotropic effects in the mouseQ72951103
AN ELECTRON MICROSCOPIC STUDY OF THYMIC CORPUSCLES IN THE GUINEA PIG AND THE MOUSEQ76708495
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Prospective evaluation of thymosin fraction V immunotherapy in patients with non-small cell lung cancer receiving vindesine, doxorubicin, and cisplatin (VAP) chemotherapy.Q33477816
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Differentiation of population of peripheral blood lymphocytes into cells bearing sheep erythrocyte receptors in vitro by human thymic extractQ35074327
Identification of human and rodent thymic epithelium using tetanus toxin and monoclonal antibody A2B5Q35202102
Purification of thymus mRNA coding for a 16,000-dalton polypeptide containing the thymosin alpha 1 sequenceQ35302826
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Hormone-like activity of a thymus humoral factor on the induction of immune competence in lymphoid cellsQ36272835
Thymosins beta 8 and beta 9: two new peptides isolated from calf thymus homologous to thymosin beta 4.Q36286238
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Expression of receptors for tetanus toxin and monoclonal antibody A2B5 by pancreatic islet cellsQ36308727
Contribution of zinc and other metals to the biological activity of the serum thymic factorQ36310852
Monoclonal antibody against human T cell leukemia virus p19 defines a human thymic epithelial antigen acquired during ontogenyQ36347553
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Reduced gonadotropins in athymic mice: prevention by thymic transplantation.Q54163465
Solid-phase synthesis of thymosin alpha 1 using tert-butyloxycarbonylaminoacyl-4-(oxymethyl)phenylacetamidomethyl-resin.Q54543459
Amino-terminal sequence identity of ubiquitin and the nonhistone component of nuclear protein A24Q55066171
Reduction in the Incidence of Wasting Disease in Neonatally Thymectomized CBA/W Mice by the Injection of ThymosinQ56802907
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Evidence for the appearance of non-specific suppressor cells in the blood after local radiation therapyQ67318187
Thymosin-induced increase in E-rosette-forming capacity of lymphocytes in patients with malignant neoplasmsQ67323098
Severe combined immunodeficiency with cartilage-hair hypoplasa: in vitro response to thymosin and attempted reconstitutionQ67869749
Ultrastructure of the chick thymusQ68655198
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Peptide and amine producing endocrine-like cells in the chicken thymus. A chemical, histochemical and electron microscopic studyQ70019202
The Thymus-Adrenal Connection: Thymosin Has Corticotropin-Releasing Activity in PrimatesQ70182118
Increased circulation of T lymphocytes bearing surface thymosin 1 in patients with myasthenia gravis: Effect of thymectomyQ70239556
The in vivo effect of a thymic factor (thymostimulin) on immunologic parameters of patients with untreated Hodgkin's diseaseQ70245502
The thymus gland and reproduction: do thymic peptides influence the reproductive lifespan in females?Q70254898
The in vitro effect of a calf thymus extract (thymostimulin) on the immunologic parameters of patients with untreated Hodgkin's diseaseQ70265227
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Antigen recognition by T lymphocytes. II. Similar effects of azathioprine, antilymphocyte serum, and anti-theta serum on rosette-forming lymphocytes in normal and neonatally thymectomized miceQ70454315
The influence of adult thymectomy on immunological competence as measured by the mixed lymphocyte reactionQ70521894
Ability of thymosin to decrease in vivo and in vitro suppressor cell activity in tumor bearing mice and cancer patientsQ70546560
Human post-thymic precursor cells in health and disease. VI. Effect of serum thymic factor on the response of cells from patients with systemic lupus erythematosus or mixed connective tissue disease in autologous mixed lymphocyte reactionQ70549529
Multivariate analysis of T-cell functional defects and circulating serum factors in Hodgkin's diseaseQ70553828
Evidence of the presence in normal serum of a carrier of the serum thymic factor (FTS)Q70647830
Thymic hormonal effect on human peripheral blood lymphocytes in vitro. III. Conditions for mixed lymphocyte-tumor culture assayQ70656741
Structural requirement for the biological activity of serum thymic factorQ70667378
Circulating thymic hormone activity in patients with primary and secondary immunodeficiency diseasesQ70668032
Effects of the thymus lymphocytopoietic factorQ70886244
Thymostimulin therapy in melanoma patients: correlation of immunologic effects with clinical courseQ70991912
Complete amino acid sequences of bovine thymopoietins I, II, and III: closely homologous polypeptidesQ70997299
Early affect of adult thymectomyQ71054145
Isolation of thymosin alpha 1 from thymosin fraction 5 of different species by high-performance liquid chromatographyQ71071225
Automated solid phase synthesis of thymosin alpha 1Q71142800
Thymosin alpha 1 in myasthenia gravisQ71166812
Reflections on medical oncology: an appeal for better clinical trials and improved reporting of their resultsQ71186777
The in vivo effect of thymic factor (thymostimulin) administration on circulating immune complexes and serum lysozyme levels in untreated Hodgkin's disease patientsQ71186804
Thymosin therapy in the DiGeorge syndromeQ71215422
Low serum thymic hormone levels in patients with acquired immunodeficiency syndromeQ71231450
Improved radioimmunoassay technique for measuring serum thymopoietinQ71357015
The hormonal basis of reproductive defects in athymic mice: diminished gonadotropin concentrations in prepubertal femalesQ71533152
Epithelial cell components immunoreact with anti-serum thymic factor (FTS) antibodies: possible association with intermediate-sized filamentsQ71557018
Elevated serum thymosin alpha 1 levels associated with evidence of immune dysregulation in male homosexuals with a history of infectious diseases or Kaposi's sarcomaQ71726504
Effect of thymosin on T-lymphocyte rosette formation in children with kwashiorkorQ72073526
An inhibitor of thymic hormone activity in serum from patients with lymphoblastic leukemiaQ72074010
Serum thymic hormone activity with systemic lupus erythematosusQ72084556
Hypoparathyroidism with T-cell deficiency and hypoimmunoglobulinemia: response to thymosin therapyQ72091259
In vitro differentiation of human marrow T cell precursors by thymic factors in severe combined immunodeficiencyQ72102517
Treatment of cell-mediated immunodeficiency with calf thymic hormone (T.P.I.).Q72113065
Improvement of impaired leukocyte migration inhibition by thymosin in patients with head and neck squamous carcinomaQ72154996
Improvement of cellular immunity and IgA production in immunodeficient children after treatment with synthetic serum thymic factor (FTS)Q72530650
Selected phenotypic induction of null lymphocytes from mice with thymic and nonthymic agentsQ72541193
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The thymosins—preclinical and clinical studies with fraction V and alpha-iQ72817409
Immunologic studies of the acquired immune deficiency syndrome: relationship of immunodeficiency to extent of diseaseQ72839218
A thymus-dependent serum factor induces maturation of thymocytes as evaluated by graft-versus-host reactionQ72842377
Fine structure of the epithelial reticular cells of the medulla of the thymus in the golden hamsterQ72928609
Preparation, assay, and partial purification of a thymic lymphocytopoietic factor (thymosin)Q36381898
Specific receptors for the serum thymic factor (FTS) in lymphoblastoid cultured cell linesQ36389885
ENHANCEMENT OF IN VIVO INCORPORATION OF LABELED PRECURSORS INTO DNA AND TOTAL PROTEIN OF MOUSE LYMPH NODES AFTER ADMINISTRATION OF THYMIC EXTRACTSQ36397003
Keratin cytoskeletons in epithelial cells of internal organsQ37333405
Induction of T-cell differentiation in vitro by thymin, a purified polypeptide hormone of the thymus.Q37440454
Thymosin alpha 11: a peptide related to thymosin alpha 1 isolated from calf thymosin fraction 5Q37506962
Biochemical and biological properties of THF in animal and human modelsQ39299472
Circulating thymic-hormone activity in congenital immunodeficiencyQ39450626
Immunotherapy and immunopathologic studies in a patient with nucleoside phosphorylase deficiencyQ39606250
Use of Thymosin in the Treatment of Primary Immunodeficiency Diseases and CancerQ39769727
Increased reactivity of responding cells in the mixed lymphocyte reaction by a thymic humoral factorQ39788601
Adult thymectomy prevention of the appearance of suppressor T cells which depress contact sensitivity to picryl chloride and reversal of adult thymectomy effect by thymus extractQ39802098
The effect of thymosin on patients with disseminated malignancies.A phase I studyQ39820846
Effect of Thymic Humoral Factor on Cellular Immune Functions of Normal Children and of Pediatric Patients with Ataxia Telangiectasia and Down's SyndromeQ39894432
In vitro and in vivo enhancement of mixed lymphocyte culture reactivity by thymosin in patients with primary immunodeficiency diseaseQ39908323
The isolation of thymopoietin (thymin)Q39931201
Thymic factor in human sera demonstrable by a cyclic AMP assayQ39986606
Severe disseminated adenovirus infection successfully treated with a thymic humoral factor, THFQ40076546
The evolutionary origins of hormones, neurotransmitters, and other extracellular chemical messengers: implications for mammalian biologyQ40086299
The in vitro induction of differentiation of putative human stem cells by thymosin and agents that affect cyclic AMPQ40145152
Purification and properties of bovine thymosinQ40319653
Isolation and partial chemical characterization of THF, a thymus hormone involved in immune maturation of lymphoid cellsQ40346934
Age, Thymic Involution, and Circulating Thymic Hormone Activity*Q40469783
Thymosin reconstitution of T cell deficits in vitro in cancer patientsQ40641706
Induction of Suppressor T Cells in Systemic Lupus Erythematosus by Thymosin and Cultured Thymic EpitheliumQ40652709
The ultrastructure of the normal human thymus: A study of 36 casesQ40673182
Detection of human T-lymphocyte antigens (HTLA antigens) on thymosin-inducible T-cell precursorsQ40676360
Autologous rosette-forming T cells as the responding cells in human autologous mixed-lymphocyte reactionQ40687179
Decreased serum thymic factor activity in asthmatic childrenQ40693501
In Vivo and in Vitro Effects of Thymosin and Adenosine Deaminase on Adenosine-Deaminase-Deficient LymphocytesQ40699346
Thymosin-inducible 'null' cells in atopic eczemaQ40711236
In vitro thymosin effect on T lymphocytes in alcoholic liver diseaseQ40714771
Immunologic and Clinical Investigation on a Bovine Thymic Extract. Therapeutic Applications in Primary ImmunodeficienciesQ40721958
Effects of thymosin in vitro in cancer patients and correlation with clinical course after thymosin immunotherapyQ40734671
Presence of thymosin-like factors in human thymic epithelium conditioned mediumQ40739023
Circulating thymic factor, Facteur Thymique Serique (FTS), in mycosis fungoides and Sezary syndromeQ41105472
Clinical trials with thymosinQ41166424
Fine structural evidence for hormone secretion by the human thymusQ41260672
Myasthenia gravis, thymectomy and serum thymic hormone activityQ41531626
Thymosin in the early diagnosis and treatment of high risk homosexuals and hemophiliacs with AIDS-like immune dysfunctionQ41569271
Activity of synthetic thymosin alpha 1 C-terminal peptides in the azathioprine E-rosette inhibition assayQ41613283
A Synthetic Pentapeptide with Biological Activity Characteristic of the Thymic Hormone ThymopoietinQ41652706
Synthesis of a proposed thymic factorQ41692138
Ultrastructural studies on erythropoiesis in the avian thymus. I. Description of cell typesQ41730188
Thymic hormone-containing cells. Characterization and localization of serum thymic factor in young mouse thymus studied by monoclonal antibodiesQ41964818
Radioimmunoassays for the thymic hormone serum thymic factor (FTS).Q42258794
Thymopoietin-like Substance in Human SkinQ42454921
Isolation of bovine thymin: a polypeptide hormone of the thymusQ43735353
The effect of thymosin on human T-cells from cancer patientsQ43755223
Thymin: a thymic polypeptide causing the neuromuscular block of myasthenia gravisQ43813597
Synthesis of the nonatetracontapeptide corresponding to the sequence proposed for thymopoietin IIQ44293254
Influence of Thymosin on Immunological Competence of Lymphoid Cells from Thymectomized MiceQ44378141
Inverse correlation between age related abnormalities of T-cell immunity and circulating thymosin α1levels in haemophilia AQ44658140
Antibody to Human T-Cell Leukemia Virus Membrane Antigens, Beta_2-Microglobulin Levels, and Thymosin Alpha_1 Levels in Hemophiliacs and Their SpousesQ45797262
Sample size nomograms for interpreting negative clinical studiesQ47251269
Origin of immunoreactive lymphocytes in ratsQ47735301
Production of biologically active N alpha-desacetylthymosin alpha 1 in Escherichia coli through expression of a chemically synthesized geneQ48411482
P433issue4
P304page(s)309-376
P577publication date1985-01-01
P1433published inCritical Reviews in Oncology HematologyQ15724423
P1476titleThymic peptide hormones: basic properties and clinical applications in cancer
P478volume3

Reverse relations

cites work (P2860)
Q90292811A Reappraisal of Thymosin Alpha1 in Cancer Therapy
Q70378746A randomized trial to evaluate the immunorestorative properties of thymostimulin in patients with Hodgkin's disease in complete remission
Q33517999Aqueous extracts from dietary supplements influence the production of inflammatory cytokines in immortalized and primary T lymphocytes
Q69739688Development of thymocytes in organ culture: migrant cells with natural killer cell characteristics
Q69395979Growth hormone treatment stimulates thymulin production in aged dogs
Q43853516Involvement of mitogen-activated protein kinases in the signal transduction pathway of bone marrow-derived macrophage activation in response to in vitro treatment with thymosin alpha 1.
Q69616835Modulation of NK activity by thymic hormones: in vitro effects of thymostimulin
Q37395527Modulation of interleukin 2 receptor expression on normal human lymphocytes by thymic hormones
Q42805123Prothymosin alpha promotes cell proliferation in NIH3T3 cells.
Q37988329Prothymosin alpha: a ubiquitous polypeptide with potential use in cancer diagnosis and therapy
Q24628113The human prothymosin alpha gene is polymorphic and induced upon growth stimulation: evidence using a cloned cDNA
Q34452145Thymic hormones in cancer diagnostics and treatment
Q24236667Thymic peptides for treatment of cancer patients
Q38871798Thymosin alpha 1 suppresses proliferation and induces apoptosis in breast cancer cells through PTEN-mediated inhibition of PI3K/Akt/mTOR signaling pathway
Q44538537Thymostimulin treatment in AIDS-related complex