Biochemical factors governing the steady-state estrone/estradiol ratios catalyzed by human 17beta-hydroxysteroid dehydrogenases types 1 and 2 in HEK-293 cells

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Biochemical factors governing the steady-state estrone/estradiol ratios catalyzed by human 17beta-hydroxysteroid dehydrogenases types 1 and 2 in HEK-293 cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1210/EN.2008-1817
P932PMC publication ID2736091
P698PubMed publication ID19556422

P2093author name stringRichard J Auchus
Dario Mizrachi
Daniel P Sherbet
Oleg L Guryev
Mahboubeh Papari-Zareei
Siayareh Rambally
Sharareh Akbar
P2860cites workExpression cloning and characterization of human 17 beta-hydroxysteroid dehydrogenase type 2, a microsomal enzyme possessing 20 alpha-hydroxysteroid dehydrogenase activityQ24321936
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Structure of human estrogenic 17β-hydroxysteroid dehydrogenase at 2.20 å resolutionQ27729862
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Purification, reconstitution, and steady-state kinetics of the trans-membrane 17 beta-hydroxysteroid dehydrogenase 2Q28213668
The key role of 17 beta-hydroxysteroid dehydrogenases in sex steroid biologyQ28303450
Glucose-6-phosphate dehydrogenase activity and NADPH/NADP+ ratio in liver and pancreas are dependent on the severity of hyperglycemia in ratQ28583459
Characteristics of human types 1, 2 and 3 17 beta-hydroxysteroid dehydrogenase activities: oxidation/reduction and inhibitionQ28646522
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Manipulating disulfide bond formation and protein folding in the endoplasmic reticulumQ33937712
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Cytochrome b5 augments the 17,20-lyase activity of human P450c17 without direct electron transferQ34454994
Characterization of cDNAs for human estradiol 17 beta-dehydrogenase and assignment of the gene to chromosome 17: evidence of two mRNA species with distinct 5'-termini in human placentaQ34543730
Complete amino acid sequence of human placental 17 beta-hydroxysteroid dehydrogenase deduced from cDNA.Q34556123
Differential binding of NAD+ and NADH allows the transcriptional corepressor carboxyl-terminal binding protein to serve as a metabolic sensorQ35234301
Minireview: cellular redox state regulates hydroxysteroid dehydrogenase activity and intracellular hormone potencyQ36073383
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Basic concepts and recent developments in human steroid hormone biosynthesisQ36966758
Separation of the glucose-stimulated cytoplasmic and mitochondrial NAD(P)H responses in pancreatic islet beta cellsQ36966837
CYP17 Mutation E305G Causes Isolated 17,20-Lyase Deficiency by Selectively Altering Substrate BindingQ38350188
Metabolic and morphological differences between rapidly proliferating cancerous and normal breast epithelial cellsQ40007880
17beta-hydroxysteroid dehydrogenase Type 1, and not Type 12, is a target for endocrine therapy of hormone-dependent breast cancer.Q40027067
Human 17beta-hydroxysteroid dehydrogenases types 1, 2, and 3 catalyze bi-directional equilibrium reactions, rather than unidirectional metabolism, in HEK-293 cellsQ40529567
Rational proteomics II: electrostatic nature of cofactor preference in the short-chain oxidoreductase (SCOR) enzyme familyQ41891997
Human 17 beta-hydroxysteroid dehydrogenase: overproduction using a baculovirus expression system and characterization.Q42067952
Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndromeQ42497234
The levels of nicotinamide nucleotides in liver microsomes and their possible significance to the function of hexose phosphate dehydrogenaseQ42856341
Critical residues for the specificity of cofactors and substrates in human estrogenic 17beta-hydroxysteroid dehydrogenase 1: variants designed from the three-dimensional structure of the enzymeQ43781525
Intracellular redox status affects transplasma membrane electron transport in pulmonary arterial endothelial cellsQ43821602
Glutamate-115 renders specificity of human 11beta-hydroxysteroid dehydrogenase type 2 for the cofactor NAD+.Q44410593
Rational proteomics I. Fingerprint identification and cofactor specificity in the short-chain oxidoreductase (SCOR) enzyme family.Q44667171
Dissection of the physiological interconversion of 5alpha-DHT and 3alpha-diol by rat 3alpha-HSD via transient kinetics shows that the chemical step is rate-determining: effect of mutating cofactor and substrate-binding pocket residues on catalysisQ45067218
Role of pentose phosphate pathway-derived NADPH in hypoxic pulmonary vasoconstrictionQ46734729
Arginine 276 controls the directional preference of AKR1C9 (rat liver 3alpha-hydroxysteroid dehydrogenase) in human embryonic kidney 293 cellsQ46853033
Adaptation of energy metabolism in breast cancer brain metastasesQ48269541
Mechanism-based inactivation of 17 beta,20 alpha-hydroxysteroid dehydrogenase by an acetylenic secoestradiolQ68748455
Isolation and sequencing of a complementary deoxyribonucleic acid clone encoding human placental 17 beta-estradiol dehydrogenase: identification of the putative cofactor binding siteQ69413747
The arginine 276 anchor for NADP(H) dictates fluorescence kinetic transients in 3 alpha-hydroxysteroid dehydrogenase, a representative aldo-keto reductaseQ77937499
Elucidation of a complete kinetic mechanism for a mammalian hydroxysteroid dehydrogenase (HSD) and identification of all enzyme forms on the reaction coordinate: the example of rat liver 3alpha-HSD (AKR1C9)Q81234512
P433issue9
P407language of work or nameEnglishQ1860
P921main subjecthydroxysteroidQ2157080
P304page(s)4154-4162
P577publication date2009-06-25
P1433published inEndocrinologyQ3054009
P1476titleBiochemical factors governing the steady-state estrone/estradiol ratios catalyzed by human 17beta-hydroxysteroid dehydrogenases types 1 and 2 in HEK-293 cells
P478volume150

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cites work (P2860)
Q50533271A validated and rapid high-performance liquid chromatography method for the quantification of conversion of radio-labelled sex steroids.
Q64226471Effect of Oxidative Stress on the Estrogen-NOS-NO-K Channel Pathway in Uteroplacental Dysfunction: Its Implication in Pregnancy Complications
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Q34130698The contribution of 17beta-hydroxysteroid dehydrogenase type 1 to the estradiol-estrone ratio in estrogen-sensitive breast cancer cells
Q27009283The structural biology of oestrogen metabolism

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