Defective RNA replication by poliovirus mutants deficient in 2A protease cleavage activity

scientific article published on January 1995

Defective RNA replication by poliovirus mutants deficient in 2A protease cleavage activity is …
instance of (P31):
scholarly articleQ13442814

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P932PMC publication ID188570
P698PubMed publication ID7983716

P2093author name stringS F Yu
R E Lloyd
M Bovee
P Benton
J Sessions
P2860cites workInhibition of translation in cells infected with a poliovirus 2Apro mutant correlates with phosphorylation of the alpha subunit of eucaryotic initiation factor 2Q24645301
Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform ExtractionQ25938986
Human immunodeficiency virus tat-activated expression of poliovirus protein 2A inhibits mRNA translationQ33846230
Eukaryotic initiation factor 3 is required for poliovirus 2A protease-induced cleavage of the p220 component of eukaryotic initiation factor 4F.Q33922083
Viral proteinasesQ34164183
Poliovirus polypeptide precursors: expression in vitro and processing by exogenous 3C and 2A proteinasesQ34630609
Direct cleavage of human TATA-binding protein by poliovirus protease 3C in vivo and in vitroQ36661993
trans rescue of a mutant poliovirus RNA polymerase functionQ36689121
Relationship of eukaryotic initiation factor 3 to poliovirus-induced p220 cleavage activityQ36697427
A transcriptionally active form of TFIIIC is modified in poliovirus-infected HeLa cellsQ36727339
Loss of a phosphorylated form of transcription factor CREB/ATF in poliovirus-infected cellsQ36783237
Characterization of poliovirus 2A proteinase by mutational analysis: residues required for autocatalytic activity are essential for induction of cleavage of eukaryotic initiation factor 4F polypeptide p220Q36797289
Relationship of p220 cleavage during picornavirus infection to 2A proteinase sequencingQ36882082
Restriction of translation of capped mRNA in vitro as a model for poliovirus-induced inhibition of host cell protein synthesis: relationship to p220 cleavageQ36916290
Poliovirus proteinase 2A induces cleavage of eucaryotic initiation factor 4F polypeptide p220.Q36918487
Poliovirus mutant that does not selectively inhibit host cell protein synthesisQ36950831
Translational enhancement of the poliovirus 5' noncoding region mediated by virus-encoded polypeptide 2AQ37274113
Role for poliovirus protease 2A in cap independent translationQ37628957
Poliovirus RNA synthesis utilizes an RNP complex formed around the 5'-end of viral RNA.Q38316546
Identification of essential amino acid residues in the functional activity of poliovirus 2A proteaseQ38335028
Identification of the cleavage site and determinants required for poliovirus 3CPro-catalyzed cleavage of human TATA-binding transcription factor TBP.Q40045340
Intracellular modifications induced by poliovirus reduce the requirement for structural motifs in the 5' noncoding region of the genome involved in internal initiation of protein synthesisQ40064632
RNA-binding properties of nonstructural polypeptide G of encephalomyocarditis virusQ40163157
In vitro molecular genetics as a tool for determining the differential cleavage specificities of the poliovirus 3C proteinaseQ40565594
Persistent infection of human erythroblastoid cells by poliovirusQ41556548
Characterization of persistent poliovirus mutants selected in human neuroblastoma cellsQ41697929
A second virus-encoded proteinase involved in proteolytic processing of poliovirus polyprotein.Q42028125
Purification of two picornaviral 2A proteinases: interaction with eIF-4 gamma and influence on in vitro translationQ43677793
A rabbit reticulocyte factor which stimulates protein synthesis in several mammalian cell-free systemsQ43866859
Protein 3CD is the major poliovirus proteinase responsible for cleavage of the P1 capsid precursorQ44133857
A functional ribonucleoprotein complex forms around the 5' end of poliovirus RNA.Q52483547
Characterization of the roles of conserved cysteine and histidine residues in poliovirus 2A proteaseQ67485788
Poliovirus protein 3CD is the active protease for processing of the precursor protein P1 in vitroQ69832090
Proteolytic processing of poliovirus polyprotein: elimination of 2Apro-mediated, alternative cleavage of polypeptide 3CD by in vitro mutagenesisQ69839884
Studies on dicistronic polioviruses implicate viral proteinase 2Apro in RNA replicationQ70475203
2A proteinases of coxsackie- and rhinovirus cleave peptides derived from eIF-4 gamma via a common recognition motifQ72731071
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectPoliovirusQ70923324
P304page(s)247-252
P577publication date1995-01-01
P1433published inJournal of VirologyQ1251128
P1476titleDefective RNA replication by poliovirus mutants deficient in 2A protease cleavage activity
P478volume69

Reverse relations

cites work (P2860)
Q39872049A poliovirus 2A(pro) mutant unable to cleave 3CD shows inefficient viral protein synthesis and transactivation defects.
Q34069651A protein linkage map of the P2 nonstructural proteins of poliovirus.
Q33799106A stable HeLa cell line that inducibly expresses poliovirus 2A(pro): effects on cellular and viral gene expression.
Q40269401Adaptive evolution and demographic history contribute to the divergent population genetic structure of Potato virus Y between China and Japan.
Q35851726Analysis of picornavirus 2A(pro) proteins: separation of proteinase from translation and replication functions
Q40471384Blockade of the poliovirus-induced cytopathic effect in neural cells by monoclonal antibody against poliovirus or the human poliovirus receptor.
Q39445022Cleavage of eukaryotic translation initiation factor 4G by exogenously added hybrid proteins containing poliovirus 2Apro in HeLa cells: effects on gene expression.
Q41191980Comparison of the replication of positive-stranded RNA viruses of plants and animals
Q40451342Cumulative mutations in the genome of Echovirus 6 during establishment of a chronic infection in precursors of glial cells.
Q27676341Deubiquitinase function of arterivirus papain-like protease 2 suppresses the innate immune response in infected host cells
Q35845842Hepatitis A viruses with deletions in the 2A gene are infectious in cultured cells and marmosets
Q24672016MDA-5 is cleaved in poliovirus-infected cells
Q36549022Protein 2A is not required for Theiler's virus replication
Q37344605RIG-I is cleaved during picornavirus infection
Q37060027Strand-Specific RNA Synthesis Defects in a Poliovirus with a Mutation in Protein 3A
Q53831376Structural view of the 2A protease from human rhinovirus C15.
Q39871495The foot-and-mouth disease virus leader proteinase gene is not required for viral replication
Q39754200The multifaceted poliovirus 2A protease: regulation of gene expression by picornavirus proteases.
Q37333907The porcine reproductive and respiratory syndrome virus nsp2 cysteine protease domain possesses both trans- and cis-cleavage activities
Q56897201Viral cysteine proteinases

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