Characterization of neutralization epitopes in the V2 region of human immunodeficiency virus type 1 gp120: role of glycosylation in the correct folding of the V1/V2 domain.

scientific article published on April 1995

Characterization of neutralization epitopes in the V2 region of human immunodeficiency virus type 1 gp120: role of glycosylation in the correct folding of the V1/V2 domain. is …
instance of (P31):
scholarly articleQ13442814

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P932PMC publication ID188897
P698PubMed publication ID7533854

P2093author name stringH Chen
Z Wu
A Pinter
S C Kayman
C Shotton
S A Tilley
J McKeating
K Revesz
W Honnen
S Vijh-Warrier
P2860cites workSite-directed mutagenesis by overlap extension using the polymerase chain reactionQ27860503
Assignment of intrachain disulfide bonds and characterization of potential glycosylation sites of the type 1 recombinant human immunodeficiency virus envelope glycoprotein (gp120) expressed in Chinese hamster ovary cellsQ28288205
Nonrandom distribution of gp120 N-linked glycosylation sites important for infectivity of human immunodeficiency virus type 1Q28646731
Characterization of neutralizing monoclonal antibodies to linear and conformation-dependent epitopes within the first and second variable domains of human immunodeficiency virus type 1 gp120Q28646835
Antibodies that inhibit fusion of human immunodeficiency virus-infected cells bind a 24-amino acid sequence of the viral envelope, gp120Q33571605
Biosynthesis, cleavage, and degradation of the human immunodeficiency virus 1 envelope glycoprotein gp160.Q33685950
Discontinuous, conserved neutralization epitopes overlapping the CD4-binding region of human immunodeficiency virus type 1 gp120 envelope glycoproteinQ33937274
Temporal analysis of the antibody response to HIV envelope protein in HIV-infected laboratory workersQ34151491
Human anti-V2 monoclonal antibody that neutralizes primary but not laboratory isolates of human immunodeficiency virus type 1Q34292765
Principal neutralizing domain of the human immunodeficiency virus type 1 envelope proteinQ34301897
Presentation of native epitopes in the V1/V2 and V3 regions of human immunodeficiency virus type 1 gp120 by fusion glycoproteins containing isolated gp120 domainsQ36620087
Effect of amino acid changes in the V1/V2 region of the human immunodeficiency virus type 1 gp120 glycoprotein on subunit association, syncytium formation, and recognition by a neutralizing antibody.Q36649240
Functional and immunologic characterization of human immunodeficiency virus type 1 envelope glycoproteins containing deletions of the major variable regionsQ36650881
Probing the structure of the V2 domain of human immunodeficiency virus type 1 surface glycoprotein gp120 with a panel of eight monoclonal antibodies: human immune response to the V1 and V2 domainsQ36653730
Identification and characterization of a neutralization site within the second variable region of human immunodeficiency virus type 1 gp120Q36690500
Viral determinants of human immunodeficiency virus type 1 T-cell or macrophage tropism, cytopathogenicity, and CD4 antigen modulationQ36783052
Oligomeric structure of gp41, the transmembrane protein of human immunodeficiency virus type 1Q36828367
The role of the V3 loop of gp120 in HIV infection.Q37152307
Immunization of chimpanzees confers protection against challenge with human immunodeficiency virusQ37375345
Restricted neutralization of divergent human T-lymphotropic virus type III isolates by antibodies to the major envelope glycoproteinQ37412527
Another discontinuous epitope on glycoprotein gp120 that is important in human immunodeficiency virus type 1 neutralization is identified by a monoclonal antibodyQ37603996
Functional role of the V1/V2 region of human immunodeficiency virus type 1 envelope glycoprotein gp120 in infection of primary macrophages and soluble CD4 neutralization.Q39143639
A novel, glycan-dependent epitope in the V2 domain of human immunodeficiency virus type 1 gp120 is recognized by a highly potent, neutralizing chimpanzee monoclonal antibody.Q40038304
Conformational epitope on gp120 important in CD4 binding and human immunodeficiency virus type 1 neutralization identified by a human monoclonal antibodyQ40062738
Macrophage tropism determinants of human immunodeficiency virus type 1 in vivoQ40308974
HTLV-III-neutralizing antibodies in patients with AIDS and AIDS-related complexQ41379235
Truncated variants of gp120 bind CD4 with high affinity and suggest a minimum CD4 binding regionQ41516510
An IgG human monoclonal antibody that reacts with HIV-1/GP120, inhibits virus binding to cells, and neutralizes infectionQ41679452
Neutralization of Divergent HIV-1 Isolates by Conformation-Dependent Human Antibodies to Gp120Q42129803
A human monoclonal antibody against the CD4-binding site of HIV1 gp120 exhibits potent, broadly neutralizing activityQ44119196
Neutralization of human T-lymphotropic virus type III by sera of AIDS and AIDS-risk patientsQ44255828
A potent, neutralizing human monoclonal antibody against a unique epitope overlapping the CD4-binding site of HIV-1 gp120 that is broadly conserved across North American and African virus isolatesQ45790079
Amino acid residues of the human immunodeficiency virus type I gp120 critical for the binding of rat and human neutralizing antibodies that block the gp120-sCD4 interactionQ45872593
Novel mannosidase inhibitor blocking conversion of high mannose to complex oligosaccharides.Q55062424
Characteristics of a neutralizing monoclonal antibody to the HIV envelope glycoprotein.Q55242478
Relation of phenotype evolution of HIV-1 to envelope V2 configurationQ70739957
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectglycosylationQ898365
P304page(s)2271-2278
P577publication date1995-04-01
P1433published inJournal of VirologyQ1251128
P1476titleCharacterization of neutralization epitopes in the V2 region of human immunodeficiency virus type 1 gp120: role of glycosylation in the correct folding of the V1/V2 domain
P478volume69

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cites work (P2860)
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Q38631979Characterization of structural features and diversity of variable-region determinants of related quaternary epitopes recognized by human and rhesus macaque monoclonal antibodies possessing unusually potent neutralizing activities.
Q36978861Comparison of viral Env proteins from acute and chronic infections with subtype C human immunodeficiency virus type 1 identifies differences in glycosylation and CCR5 utilization and suggests a new strategy for immunogen design
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Q33648180Cyanovirin-N binds to gp120 to interfere with CD4-dependent human immunodeficiency virus type 1 virion binding, fusion, and infectivity but does not affect the CD4 binding site on gp120 or soluble CD4-induced conformational changes in gp120.
Q33796067Determinants of syncytium formation in microglia by human immunodeficiency virus type 1: role of the V1/V2 domains
Q33851094Differential CD4/CCR5 utilization, gp120 conformation, and neutralization sensitivity between envelopes from a microglia-adapted human immunodeficiency virus type 1 and its parental isolate
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Q35893538Improving immunogenicity of HIV-1 envelope gp120 by glycan removal and immune complex formation
Q39877884Length polymorphism within the second variable region of the human immunodeficiency virus type 1 envelope glycoprotein affects accessibility of the receptor binding site
Q39875204Location, exposure, and conservation of neutralizing and nonneutralizing epitopes on human immunodeficiency virus type 2 SU glycoprotein
Q33785035Location-specific, unequal contribution of the N glycans in simian immunodeficiency virus gp120 to viral infectivity and removal of multiple glycans without disturbing infectivity
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Q35677448Several N-Glycans on the HIV Envelope Glycoprotein gp120 Preferentially Locate Near Disulphide Bridges and Are Required for Efficient Infectivity and Virus Transmission
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Q36884458Specific N-linked and O-linked glycosylation modifications in the envelope V1 domain of simian immunodeficiency virus variants that evolve in the host alter recognition by neutralizing antibodies
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Q34583767Type-specific epitopes targeted by monoclonal antibodies with exceptionally potent neutralizing activities for selected strains of human immunodeficiency virus type 1 map to a common region of the V2 domain of gp120 and differ only at single positio

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