Myocardin-related transcription factors and SRF are required for cytoskeletal dynamics and experimental metastasis

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Myocardin-related transcription factors and SRF are required for cytoskeletal dynamics and experimental metastasis is …
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scholarly articleQ13442814

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P356DOI10.1038/NCB1833
P932PMC publication ID6089348
P698PubMed publication ID19198601

P50authorRichard TreismanQ21165478
Erik SahaiQ44050376
Cédric GaggioliQ56451904
P2093author name stringSouhila Medjkane
Cristina Perez-Sanchez
P2860cites workExpression profiling of serum inducible genes identifies a subset of SRF target genes that are MKL dependentQ21093352
Signal-regulated activation of serum response factor is mediated by changes in actin dynamicsQ22010445
Involvement of chemokine receptors in breast cancer metastasisQ24290909
RhoC is dispensable for embryogenesis and tumor initiation but essential for metastasisQ24531821
Megakaryoblastic leukemia 1, a potent transcriptional coactivator for serum response factor (SRF), is required for serum induction of SRF target genesQ24682874
Dual roles of myocardin-related transcription factors in epithelial mesenchymal transition via slug induction and actin remodelingQ24684909
Simultaneous imaging of GFP, CFP and collagen in tumors in vivo using multiphoton microscopyQ24811818
Genomic analysis of metastasis reveals an essential role for RhoCQ28144278
Conditional ROCK activation in vivo induces tumor cell dissemination and angiogenesisQ28298687
The SRF target gene Fhl2 antagonizes RhoA/MAL-dependent activation of SRFQ28299203
Nuclear movement regulated by Cdc42, MRCK, myosin, and actin flow establishes MTOC polarization in migrating cellsQ28508708
Neuronal migration in the murine rostral migratory stream requires serum response factorQ28585328
Actin dynamics control SRF activity by regulation of its coactivator MALQ28646140
Ca2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphataseQ29615195
RHO-GTPases and cancerQ29616099
Stromal fibroblasts in cancer initiation and progressionQ29618873
Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cellsQ29619848
Defining the mammalian CArGomeQ34338820
Assembly and mechanosensory function of focal contactsQ34360604
Differential expression of the CCN family members Cyr61, CTGF and Nov in human breast cancer.Q34378894
The Galpha13-Rho signaling axis is required for SDF-1-induced migration through CXCR4.Q34575941
Nuclear actin regulates dynamic subcellular localization and activity of the SRF cofactor MAL.Q34641302
Requirement of a myocardin-related transcription factor for development of mammary myoepithelial cellsQ35071026
A role for LIM kinase in cancer invasion.Q35163454
Myosin-IIA heavy-chain phosphorylation regulates the motility of MDA-MB-231 carcinoma cellsQ35942363
Rho family GTPases regulate mammary epithelium cell growth and metastasis through distinguishable pathwaysQ35944136
The activity status of cofilin is directly related to invasion, intravasation, and metastasis of mammary tumorsQ36117485
Overexpression of the rhoC gene correlates with progression of ductal adenocarcinoma of the pancreasQ36294989
Stromal fibroblasts in cancer: a novel tumor-promoting cell typeQ36553020
Regulation of the actin cytoskeleton in cancer cell migration and invasionQ36574131
Myosin II and mechanotransduction: a balancing act.Q36744365
A novel putative low-affinity insulin-like growth factor-binding protein, LIBC (lost in inflammatory breast cancer), and RhoC GTPase correlate with the inflammatory breast cancer phenotype.Q38467243
PDK1 regulates cancer cell motility by antagonising inhibition of ROCK1 by RhoE.Q40023259
ROCK- and myosin-dependent matrix deformation enables protease-independent tumor-cell invasion in vivoQ40247020
Inhibition of transendothelial migration and invasion of human breast cancer cells by preventing geranylgeranylation of Rho.Q40268151
Distinct roles of nonmuscle myosin II isoforms in the regulation of MDA-MB-231 breast cancer cell spreading and migrationQ40285029
Epidermal growth factor receptor overexpression results in increased tumor cell motility in vivo coordinately with enhanced intravasation and metastasisQ40333136
Galpha12/13 is essential for directed cell migration and localized Rho-Dia1 functionQ40357788
Overexpression of RhoA-GTP induces activation of the Epidermal Growth Factor Receptor, dephosphorylation of focal adhesion kinase and increased motility in breast cancer cellsQ40407870
Anti-RhoA and anti-RhoC siRNAs inhibit the proliferation and invasiveness of MDA-MB-231 breast cancer cells in vitro and in vivo.Q40466398
Effect of Wf-536, a novel ROCK inhibitor, against metastasis of B16 melanomaQ40642853
Specific inhibition of gene expression using a stably integrated, inducible small-interfering-RNA vectorQ40773079
RPEL motifs link the serum response factor cofactor MAL but not myocardin to Rho signaling via actin bindingQ41911107
Reorganization of the actin cytoskeleton via transcriptional regulation of cytoskeletal/focal adhesion genes by myocardin-related transcription factors (MRTFs/MAL/MKLs).Q42825349
Serum response factor is crucial for actin cytoskeletal organization and focal adhesion assembly in embryonic stem cellsQ42918539
Pentoxifylline impedes migration in B16F10 melanoma by modulating Rho GTPase activity and actin organisation.Q46582784
Serum response factor controls neuronal circuit assembly in the hippocampusQ46896180
Evidence for tension-based regulation of Drosophila MAL and SRF during invasive cell migrationQ47071318
c-fos is required for malignant progression of skin tumors.Q53461261
P4510describes a project that useslimmaQ112236343
P433issue3
P921main subjectcytoskeletonQ154626
P304page(s)257-268
P577publication date2009-02-08
P1433published inNature Cell BiologyQ1574111
P1476titleMyocardin-related transcription factors and SRF are required for cytoskeletal dynamics and experimental metastasis
P478volume11

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