Combined inhibition of MEK and mTOR signaling inhibits initiation and progression of colorectal cancer

scientific article

Combined inhibition of MEK and mTOR signaling inhibits initiation and progression of colorectal cancer is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1080/07357900802314893
P698PubMed publication ID19194827
P5875ResearchGate publication ID23981226

P2093author name stringHua Xiong
Dan-Feng Sun
Jing-Yuan Fang
Xiao-Qing Tian
Yan-Jie Zhang
Shu-Liang Zhao
P2860cites workTOR signaling in growth and metabolismQ27860757
mTOR and cancer therapyQ28268516
Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancerQ29618155
Multiple signaling pathways must be targeted to overcome drug resistance in cell lines derived from melanoma metastasesQ34531564
The MAPK signalling pathways and colorectal cancerQ36111490
The Akt-mTOR tango and its relevance to cancerQ36260264
From Rapa Nui to rapamycin: targeting PI3K/Akt/mTOR for cancer therapyQ36352100
New paradigms in anticancer therapy: targeting multiple signaling pathways with kinase inhibitors.Q36557283
Therapeutic targets: MTOR and related pathwaysQ36592032
mTOR, translation initiation and cancerQ36623679
When translation meets transformation: the mTOR storyQ36623684
Targeting mammalian target of rapamycin (mTOR) for health and diseases.Q36727182
Small molecule signal transduction inhibitors for the treatment of solid tumorsQ36895413
PD98059 triggers G1 arrest and apoptosis in human leukemic U937 cells through downregulation of Akt signal pathwayQ38507712
Multipathway model enables prediction of kinase inhibitor cross-talk effects on migration of Her2-overexpressing mammary epithelial cellsQ40001089
Common effector processing mediates cell-specific responses to stimuliQ40105919
Mammalian target of rapamycin inhibitors as possible adjuvant therapy for microscopic residual disease in head and neck squamous cell cancerQ40164478
Inhibition of the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway decreases DNA methylation in colon cancer cellsQ40169850
Phosphorylation of ribosomal p70 S6 kinase and rapamycin sensitivity in human colorectal cancerQ40194215
Interferon-gamma-induced dephosphorylation of STAT3 and apoptosis are dependent on the mTOR pathwayQ40326784
Targeting protein translation in human non small cell lung cancer via combined MEK and mammalian target of rapamycin suppressionQ46868532
Identification of a highly effective rapamycin schedule that markedly reduces the size, multiplicity, and phenotypic progression of tobacco carcinogen-induced murine lung tumors.Q47294305
Human vascular endothelial growth factor protects axotomized retinal ganglion cells in vivo by activating ERK-1/2 and Akt pathways.Q48352796
P433issue3
P921main subjectcolorectal cancerQ188874
P304page(s)273-285
P577publication date2009-03-01
P1433published inCancer InvestigationQ325953
P1476titleCombined inhibition of MEK and mTOR signaling inhibits initiation and progression of colorectal cancer
P478volume27

Reverse relations

cites work (P2860)
Q38966079A combination of eicosapentaenoic acid-free fatty acid, epigallocatechin-3-gallate and proanthocyanidins has a strong effect on mTOR signaling in colorectal cancer cells.
Q39458515Adrenomedullin blockade suppresses sunitinib-resistant renal cell carcinoma growth by targeting the ERK/MAPK pathway
Q42437883Antitumor activity of pimasertib, a selective MEK 1/2 inhibitor, in combination with PI3K/mTOR inhibitors or with multi-targeted kinase inhibitors in pimasertib-resistant human lung and colorectal cancer cells
Q64111464Combination of cetuximab with met inhibitor in control of cetuximab-resistant oral squamous cell carcinoma
Q35798540Combined inhibition of MEK and mTOR has a synergic effect on angiosarcoma tumorgrafts
Q26781362Dual Inhibition of MEK and PI3K Pathway in KRAS and BRAF Mutated Colorectal Cancers
Q39831242Effective treatment of advanced colorectal cancer by rapamycin and 5-FU/oxaliplatin monitored by TIMP-1.
Q38081233Everolimus in colorectal cancer
Q35148085Induction of BCL2-Interacting Killer, BIK, is Mediated for Anti-Cancer Activity of Curcumin in Human Head and Neck Squamous Cell Carcinoma Cells
Q27851616KRAS, BRAF, PIK3CA, and PTEN mutations: implications for targeted therapies in metastatic colorectal cancer.
Q35157985Mammalian target of rapamycin: hitting the bull's-eye for neurological disorders
Q28074073Mechanisms of resistance to anti-EGFR therapy in colorectal cancer
Q28076490Mechanisms of resistance to anti-epidermal growth factor receptor inhibitors in metastatic colorectal cancer
Q90348651Multifunctional nanomedicines for targeting epidermal growth factor receptor in colorectal cancer
Q37349748Overcoming IGF1R/IR resistance through inhibition of MEK signaling in colorectal cancer models.
Q33439312Phase I trial of MEK 1/2 inhibitor pimasertib combined with mTOR inhibitor temsirolimus in patients with advanced solid tumors
Q38014668Prognostic and predictive biomarkers for epidermal growth factor receptor-targeted therapy in colorectal cancer: Beyond KRAS mutations
Q91644121Revisiting the Role of Exosomes in Colorectal Cancer: Where Are We Now?
Q38238743Strategies to overcome resistance to epidermal growth factor receptor monoclonal antibody therapy in metastatic colorectal cancer
Q53397945The Biological Activities of Oleocanthal from a Molecular Perspective.
Q38043507The promise of mTOR inhibitors in the treatment of colorectal cancer
Q84965476mTOR Signaling is Involved in Indomethacin and Nimesulide Suppression of Colorectal Cancer Cell Growth via a COX-2 Independent Pathway
Q27851707mTOR-independent 4E-BP1 phosphorylation is associated with cancer resistance to mTOR kinase inhibitors

Search more.