Regulation of heat-induced apoptosis by Mcl-1 degradation and its inhibition by Hsp70.

scientific article

Regulation of heat-induced apoptosis by Mcl-1 degradation and its inhibition by Hsp70. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/CDD.2008.189
P698PubMed publication ID19148187
P5875ResearchGate publication ID23792083

P2093author name stringD D Mosser
N Mohseni
A M Livingstone
A R Stankiewicz
P2860cites workMCL-1S, a splicing variant of the antiapoptotic BCL-2 family member MCL-1, encodes a proapoptotic protein possessing only the BH3 domainQ22254196
Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic functionQ24293924
Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or BakQ24296478
Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteinsQ24302494
Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosisQ24306444
Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1Q24308005
Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family membersQ24337108
The Bcl-2 apoptotic switch in cancer development and therapyQ24620437
Structural insights into the degradation of Mcl-1 induced by BH3 domainsQ27644256
Seliciclib (CYC202, R-Roscovitine) induces cell death in multiple myeloma cells by inhibition of RNA polymerase II-dependent transcription and down-regulation of Mcl-1Q28256819
BH3-ligand regulates access of MCL-1 to its E3 ligaseQ28276218
The chaperone function of hsp70 is required for protection against stress-induced apoptosisQ28679271
Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and agingQ29614783
Apoptosis: controlled demolition at the cellular levelQ29620114
The multidomain proapoptotic molecules Bax and Bak are directly activated by heatQ34212713
DNA damage response and MCL-1 destruction initiate apoptosis in adenovirus-infected cellsQ34278532
Rapid degradation of Bim by the ubiquitin-proteasome pathway mediates short-term ischemic tolerance in cultured neuronsQ34446404
Mcl-1.Q35913618
Cooperation of molecular chaperones with the ubiquitin/proteasome systemQ35967558
Ultraviolet radiation triggers apoptosis of fibroblasts and skin keratinocytes mainly via the BH3-only protein Noxa.Q36117765
Regulating the regulators: control of protein ubiquitination and ubiquitin-like modifications by extracellular stimuliQ36246889
Bax and Bak coalesce into novel mitochondria-associated clusters during apoptosisQ36364894
Role of the human heat shock protein hsp70 in protection against stress-induced apoptosisQ36571858
Embedded together: the life and death consequences of interaction of the Bcl-2 family with membranesQ36799170
How do BCL-2 proteins induce mitochondrial outer membrane permeabilization?Q37100016
Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiationQ39895438
Mechanism of synergy of N-(4-hydroxyphenyl)retinamide and ABT-737 in acute lymphoblastic leukemia cell lines: Mcl-1 inactivation.Q39993903
A pivotal role for Mcl-1 in Bortezomib-induced apoptosisQ40102590
Acute acidification or amiloride treatment suppresses the ability of Hsp70 to inhibit heat-induced apoptosisQ40146133
Hsp70 inhibits heat-induced apoptosis upstream of mitochondria by preventing Bax translocationQ40371434
MCL1 is phosphorylated in the PEST region and stabilized upon ERK activation in viable cells, and at additional sites with cytotoxic okadaic acid or taxolQ40537978
Characterisation of Mcl-1 cleavage during apoptosis of haematopoietic cellsQ40555258
Phosphorylation and inactivation of myeloid cell leukemia 1 by JNK in response to oxidative stressQ40704873
Induced thermotolerance to apoptosis in a human T lymphocyte cell lineQ41623364
Bax is present as a high molecular weight oligomer/complex in the mitochondrial membrane of apoptotic cellsQ43514949
Degradation of Mcl-1 by granzyme B: implications for Bim-mediated mitochondrial apoptotic eventsQ44795441
Molecular chaperones and the stress of oncogenesisQ47785215
Antisense strategy shows that Mcl-1 rather than Bcl-2 or Bcl-x(L) is an essential survival protein of human myeloma cells.Q52546411
Hsp70 prevents activation of stress kinases. A novel pathway of cellular thermotoleranceQ73500626
Functional linkage between NOXA and Bim in mitochondrial apoptotic eventsQ79996271
Unraveling MCL-1 degradationQ83368258
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectapoptotic processQ14599311
P304page(s)638-647
P577publication date2009-01-16
P1433published inCell Death & DifferentiationQ2943974
P1476titleRegulation of heat-induced apoptosis by Mcl-1 degradation and its inhibition by Hsp70.
P478volume16

Reverse relations

cites work (P2860)
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Q89565902Blockade of HSP70 by VER-155008 synergistically enhances bortezomib-induced cytotoxicity in multiple myeloma
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