A novel role of ERK5 in integrin-mediated cell adhesion and motility in cancer cells via Fak signaling

scientific article

A novel role of ERK5 in integrin-mediated cell adhesion and motility in cancer cells via Fak signaling is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/JCP.21662
P932PMC publication ID7064882
P698PubMed publication ID19089993

P2093author name stringMichael G Brattain
Wensheng Liu
Rajinder S Sawhney
P2860cites workComponents of a new human protein kinase signal transduction pathwayQ24319086
Primary Structure of BMK1: A New Mammalian MAP KinaseQ24324142
BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2CQ24532869
FAK integrates growth-factor and integrin signals to promote cell migrationQ28144169
MEK5 overexpression is associated with metastatic prostate cancer, and stimulates proliferation, MMP-9 expression and invasionQ28180881
Identification of mitogen-activated protein kinase kinase as a chemoresistant pathway in MCF-7 cells by using gene expression microarrayQ28198214
Isolation of MEK5 and differential expression of alternatively spliced formsQ28285099
Bmk1/Erk5 is required for cell proliferation induced by epidermal growth factorQ28286729
Focal adhesion kinase: the first ten yearsQ28609173
Focal adhesion kinase: in command and control of cell motilityQ29615192
Integrating adhesion, protrusion, and contraction during cell migrationQ30440890
Focal adhesion kinase: targeting adhesion signaling pathways for therapeutic interventionQ30445536
Integrin cytoplasmic domain-binding proteinsQ34052642
Role of the BMK1/ERK5 signaling pathway: lessons from knockout miceQ34363614
Role of integrins in cell invasion and migrationQ35084782
Therapeutic antagonists and conformational regulation of integrin functionQ35209992
The activity status of cofilin is directly related to invasion, intravasation, and metastasis of mammary tumorsQ36117485
An inhibitory role for FAK in regulating proliferation: a link between limited adhesion and RhoA-ROCK signalingQ36118275
Monitoring fibroblast behavior in tissue culture with an applied electric fieldQ36262812
MAPK signalling: ERK5 versus ERK1/2.Q36553050
Specific induction of pp125 focal adhesion kinase in human breast cancerQ36615312
A morphological biosensor for mammalian cellsQ36757367
Cell-matrix adhesionQ36902965
Micromotion of mammalian cells measured electricallyQ37590362
Combination of integrin siRNA and irradiation for breast cancer therapyQ40211567
In vitro and in vivo characterization of 64Cu-labeled Abegrin, a humanized monoclonal antibody against integrin alpha v beta 3.Q40223991
Integrin alphaVbeta3 contains a receptor site for resveratrolQ40264413
Global gene expression analysis of ERK5 and ERK1/2 signaling reveals a role for HIF-1 in ERK5-mediated responses.Q40273686
Integrin alpha2-mediated ERK and calpain activation play a critical role in cell adhesion and motility via focal adhesion kinase signaling: identification of a novel signaling pathwayQ40319949
The unique C-terminal tail of the mitogen-activated protein kinase ERK5 regulates its activation and nuclear shuttling.Q40490843
Phase I trial of a monoclonal antibody specific for alphavbeta3 integrin (MEDI-522) in patients with advanced malignancies, including an assessment of effect on tumor perfusionQ40494312
Autocrine transforming growth factor alpha regulates cell adhesion by multiple signaling via specific phosphorylation sites of p70S6 kinase in colon cancer cells.Q40526630
Bimolecular interaction of insulin-like growth factor (IGF) binding protein-2 with alphavbeta3 negatively modulates IGF-I-mediated migration and tumor growth.Q40590800
A pilot trial of Vitaxin, a humanized anti-vitronectin receptor (anti alpha v beta 3) antibody in patients with metastatic cancerQ40704741
Integrin alpha(v)beta3 expression confers on tumor cells a greater propensity to metastasize to boneQ40713735
Prostatic carcinoma cell migration via alpha(v)beta3 integrin is modulated by a focal adhesion kinase pathwayQ40961756
Integrin alpha2 and extracellular signal-regulated kinase are functionally linked in highly malignant autocrine transforming growth factor-alpha-driven colon cancer cellsQ42438812
Differences in sensitivity of biological functions mediated by epidermal growth factor receptor activation with respect to endogenous and exogenous ligandsQ42512178
Activation of either ERK1/2 or ERK5 MAP kinase pathways can lead to disruption of the actin cytoskeletonQ42816454
Characterization of the MEK5-ERK5 module in human neutrophils and its relationship to ERK1/ERK2 in the chemotactic response.Q45069674
Breast adenocarcinoma cell adhesion to the vascular subendothelium in whole blood and under flow conditions: effects of alphavbeta3 and alphaIIbbeta3 antagonistsQ45243204
Vascular integrin alpha(v)beta3: a new prognostic indicator in breast cancerQ77603503
P433issue1
P921main subjectcell adhesionQ187640
P304page(s)152-161
P577publication date2009-04-01
P1433published inJournal of Cellular PhysiologyQ1524270
P1476titleA novel role of ERK5 in integrin-mediated cell adhesion and motility in cancer cells via Fak signaling
P478volume219

Reverse relations

cites work (P2860)
Q49798105Benzidine Induces Epithelial-Mesenchymal Transition of Human Bladder Cancer Cells through Activation of ERK5 Pathway
Q42117588Characterization of the role of RILP in cell migration
Q43811757Cytoskeletal reorganization mediates fluid shear stress-induced ERK5 activation in osteoblastic cells
Q21284312DIPSBC--data integration platform for systems biology collaborations
Q98771160ERK5 Is Required for Tumor Growth and Maintenance Through Regulation of the Extracellular Matrix in Triple Negative Breast Cancer
Q39418708ERK5 regulates invasiveness of osteosarcoma by inducing MMP-9.
Q37722089Effect of ART1 on the proliferation and migration of mouse colon carcinoma CT26 cells in vivo
Q37442141Extracellular signal regulated kinase 5 mediates signals triggered by the novel tumor promoter palytoxin
Q90122397Extracellular signal regulated kinase 5 promotes cell migration, invasion and lung metastasis in a FAK-dependent manner
Q61798865Focal adhesion kinase (FAK) activation by estrogens involves GPER in triple-negative breast cancer cells
Q33789414Focal adhesion kinase: a prominent determinant in breast cancer initiation, progression and metastasis
Q64065870Impact of ERK5 on the Hallmarks of Cancer
Q37467189Key signalling nodes in mammary gland development and cancer. Mitogen-activated protein kinase signalling in experimental models of breast cancer progression and in mammary gland development.
Q33917578Kinome profiling reveals breast cancer heterogeneity and identifies targeted therapeutic opportunities for triple negative breast cancer
Q38791344MAP Kinases and Prostate Cancer
Q38828361MAPK7 gene controls proliferation, migration and cell invasion in osteosarcoma
Q26866383MEK5/ERK5 pathway: the first fifteen years
Q37651604MEKK2 regulates focal adhesion stability and motility in invasive breast cancer cells.
Q38962538Modulation of ERK5 is a novel mechanism by which Cdc42 regulates migration of breast cancer cells.
Q92082570Mutations in the ND2 Subunit of Mitochondrial Complex I Are Sufficient to Confer Increased Tumorigenic and Metastatic Potential to Cancer Cells
Q39116456Oncogenic signaling of MEK5-ERK5.
Q51283531Optimal AraC-Cytotoxicity to AML Cells Requires ERK5 Activity.
Q24299360Pharmacological Inhibition of BMK1 Suppresses Tumor Growth through Promyelocytic Leukemia Protein
Q36502685Phosphorylation of BMK1 induces prostatic carcinoma cell proliferation by promoting entry into the S phase of the cell cycle
Q41905885Targeting the BMK1 MAP kinase pathway in cancer therapy.
Q54325437The mitogen-activated protein kinase ERK5 regulates the development and growth of hepatocellular carcinoma.
Q27023876The roles of PIKE in tumorigenesis
Q51337382The transcription factor FOXF1 promotes prostate cancer by stimulating the mitogen-activated protein kinase ERK5.

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