The mitogen-activated protein kinase ERK5 regulates the development and growth of hepatocellular carcinoma.

scientific article published on 2 September 2014

The mitogen-activated protein kinase ERK5 regulates the development and growth of hepatocellular carcinoma. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1136/GUTJNL-2014-306761
P698PubMed publication ID25183205
P5875ResearchGate publication ID265200539

P50authorNathanael GrayQ28112823
Elisabetta RovidaQ55834826
Azucena Esparís-OgandoQ57987677
Ignazia TusaQ63888737
Atanasio PandiellaQ83446572
Maurizio ParolaQ37841527
Fabio MarraQ37841541
Giovanni Di MairaQ39637977
P2093author name stringPersio Dello Sbarba
Xianming Deng
Elisa Vivoli
Ezio David
Nadia Navari
Stefania Cannito
Claudia Paternostro
P2860cites workPharmacological Inhibition of BMK1 Suppresses Tumor Growth through Promyelocytic Leukemia ProteinQ24299360
Components of a new human protein kinase signal transduction pathwayQ24319086
Primary Structure of BMK1: A New Mammalian MAP KinaseQ24324142
BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2CQ24532869
CDK inhibitors: positive and negative regulators of G1-phase progressionQ27860983
Sorafenib in advanced hepatocellular carcinomaQ27861075
Big mitogen-activated kinase regulates multiple members of the MEF2 protein familyQ28137985
ERK5 and ERK2 cooperate to regulate NF-kappaB and cell transformationQ28140491
Aberrant rel/nfkb genes and activity in human cancerQ28140722
ERK5 MAPK regulates embryonic angiogenesis and acts as a hypoxia-sensitive repressor of vascular endothelial growth factor expressionQ28591302
Canonical and kinase activity-independent mechanisms for extracellular signal-regulated kinase 5 (ERK5) nuclear translocation require dissociation of Hsp90 from the ERK5-Cdc37 complexQ28854310
Focal adhesion kinase: in command and control of cell motilityQ29615192
Hepatocellular carcinomaQ29615765
Human hepatocellular carcinoma cell lines secrete the major plasma proteins and hepatitis B surface antigenQ29617963
FOXO transcription factors at the interface between longevity and tumor suppressionQ29620472
Chromatin-associated CSF-1R binds to the promoter of proliferation-related genes in breast cancer cellsQ34077207
Impaired postnatal hepatocyte proliferation and liver regeneration in mice lacking c-jun in the liverQ34078580
Gene expression in fixed tissues and outcome in hepatocellular carcinoma.Q34235518
Tumour hypoxia, chemotherapeutic resistance and hypoxia-related therapies.Q35202899
Regulation of the G2-M cell cycle progression by the ERK5-NFkappaB signaling pathwayQ36118148
Gene expression profiles of hepatoma cell line HLE.Q36178624
Role of the microenvironment in the pathogenesis and treatment of hepatocellular carcinomaQ36625697
Cellular functions of FAK kinases: insight into molecular mechanisms and novel functionsQ37717830
Hypoxia and hypoxia inducible factors: diverse roles in liver diseasesQ37961603
ERK5 and its role in tumour developmentQ37977186
ERK5: structure, regulation and function.Q38026656
Targeting of FAK Ser910 by ERK5 and PP1delta in non-stimulated and phorbol ester-stimulated cellsQ39254626
The extracellular-regulated protein kinase 5 (ERK5) promotes cell proliferation through the down-regulation of inhibitors of cyclin dependent protein kinases (CDKs).Q39292142
Multisite phosphorylation of Erk5 in mitosisQ39663758
A novel role of ERK5 in integrin-mediated cell adhesion and motility in cancer cells via Fak signalingQ39904208
ERK5 is a target for gene amplification at 17p11 and promotes cell growth in hepatocellular carcinoma by regulating mitotic entryQ39923417
Redox mechanisms switch on hypoxia-dependent epithelial-mesenchymal transition in cancer cellsQ39939949
ERK5/MAPK is activated by TGFbeta in hepatocytes and required for the GSK-3beta-mediated Snail protein stabilization.Q39945102
ERK5/BMK1 is indispensable for optimal colony-stimulating factor 1 (CSF-1)-induced proliferation in macrophages in a Src-dependent fashion.Q40005436
Pharmacological inhibition of protein kinase CK2 reverts the multidrug resistance phenotype of a CEM cell line characterized by high CK2 level.Q40135888
Hepatitis C virus core protein induces expression of genes regulating immune evasion and anti-apoptosis in hepatocytesQ40250149
D-type cyclinsQ40443885
Time- and residue-specific differences in histone acetylation induced by VPA and SAHA in AML1/ETO-positive leukemia cellsQ41386062
The c-Rel subunit of nuclear factor-kappaB regulates murine liver inflammation, wound-healing, and hepatocyte proliferationQ42465515
Activation of extracellular signal-regulated protein kinase 5 downregulates FasL upon osmotic stressQ42495605
Roles played by a subset of integrin signaling molecules in cadherin-based cell-cell adhesionQ42915741
The biphasic nature of hypoxia-induced directional migration of activated human hepatic stellate cellsQ43495714
Signal transduction by the chemokine receptor CXCR3: activation of Ras/ERK, Src, and phosphatidylinositol 3-kinase/Akt controls cell migration and proliferation in human vascular pericytesQ43514940
Activation of cyclin D1 expression by the ERK5 cascadeQ47670094
Tyrosine phosphatases in the HER2-directed motility of ovarian cancer cells: Involvement of PTPN12, ERK5 and FAK.Q54021741
P433issue9
P407language of work or nameEnglishQ1860
P304page(s)1454-1465
P577publication date2014-09-02
P1433published inGutQ5621669
P1476titleThe mitogen-activated protein kinase ERK5 regulates the development and growth of hepatocellular carcinoma
P478volume64

Reverse relations

cites work (P2860)
Q49798105Benzidine Induces Epithelial-Mesenchymal Transition of Human Bladder Cancer Cells through Activation of ERK5 Pathway
Q89550782Beyond Kinase Activity: ERK5 Nucleo-Cytoplasmic Shuttling as a Novel Target for Anticancer Therapy
Q28078572ERK5 and Cell Proliferation: Nuclear Localization Is What Matters
Q52684307ERK5 is activated by oncogenic BRAF and promotes melanoma growth.
Q37369392ERK5 kinase activity is dispensable for cellular immune response and proliferation
Q90122397Extracellular signal regulated kinase 5 promotes cell migration, invasion and lung metastasis in a FAK-dependent manner
Q36244298Focal Adhesion Kinase: Insight into Molecular Roles and Functions in Hepatocellular Carcinoma
Q47136711Identification of cellular genes and pathways important for tumorigenicity of hepatocellular carcinoma cell lines by proteomic profiling.
Q64065870Impact of ERK5 on the Hallmarks of Cancer
Q47265464JNK, p38, ERK, and SGK1 Inhibitors in Cancer.
Q39116456Oncogenic signaling of MEK5-ERK5.
Q90316389Paradoxical activation of the protein kinase-transcription factor ERK5 by ERK5 kinase inhibitors
Q37580201Post-translational deregulation of YAP1 is genetically controlled in rat liver cancer and determines the fate and stem-like behavior of the human disease.
Q90631397SUMOylation Is Required for ERK5 Nuclear Translocation and ERK5-Mediated Cancer Cell Proliferation
Q57292631Targeting the Extracellular Signal-Regulated Kinase 5 Pathway to Suppress Human Chronic Myeloid Leukemia Stem Cells
Q90883692The protein kinase CK2 contributes to the malignant phenotype of cholangiocarcinoma cells
Q91967312The role of long noncoding RNAs in hepatocellular carcinoma

Search more.