Oroxylin A induces G2/M phase cell-cycle arrest via inhibiting Cdk7-mediated expression of Cdc2/p34 in human gastric carcinoma BGC-823 cells

scientific article published on November 2008

Oroxylin A induces G2/M phase cell-cycle arrest via inhibiting Cdk7-mediated expression of Cdc2/p34 in human gastric carcinoma BGC-823 cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1211/JPP.60.11.0006
P698PubMed publication ID18957166

P50authorQing-Long GuoQ88615113
P2093author name stringYong Yang
Wei Liu
Yang Hu
Li Zhao
Na Lu
Qi-Dong You
Qi Qi
Xiao-Tang Wang
Hong-Yan Gu
P2860cites workCdk-activating kinase complex is a component of human transcription factor TFIIHQ24306759
Principles of CDK regulationQ29547820
Universal control mechanism regulating onset of M-phaseQ29616481
The anticancer activities of wogonin in murine sarcoma S180 both in vitro and in vivoQ33245813
Wogonin and fisetin induce apoptosis in human promyeloleukemic cells, accompanied by a decrease of reactive oxygen species, and activation of caspase 3 and Ca(2+)-dependent endonucleaseQ33957385
Oroxylin A induced apoptosis of human hepatocellular carcinoma cell line HepG2 was involved in its antitumor activityQ40214864
Gambogic acid-induced G2/M phase cell-cycle arrest via disturbing CDK7-mediated phosphorylation of CDC2/p34 in human gastric carcinoma BGC-823 cellsQ40225492
Involvement of bax/bcl-2 in wogonin-induced apoptosis of human hepatoma cell line SMMC-7721.Q40240671
The dietary flavonoid apigenin sensitizes malignant tumor cells to tumor necrosis factor-related apoptosis-inducing ligandQ40285566
Inhibition of human telomerase reverse transcriptase gene expression by gambogic acid in human hepatoma SMMC-7721 cellsQ40356831
Anti-tumour effects of nobiletin, a citrus flavonoid, on gastric cancer include: antiproliferative effects, induction of apoptosis and cell cycle deregulationQ40527746
Flavonoid quercetin sensitizes a CD95-resistant cell line to apoptosis by activating protein kinase CalphaQ40645804
Role for the PP2A/B56delta phosphatase in regulating 14-3-3 release from Cdc25 to control mitosisQ41888954
Effects of the flavonoid baicalin and its metabolite baicalein on androgen receptor expression, cell cycle progression and apoptosis of prostate cancer cell linesQ43759636
Cytotoxic activities of flavonoids from two Scutellaria plants in Chinese medicineQ44809134
Isolation and purification of baicalein, wogonin and oroxylin A from the medicinal plant Scutellaria baicalensis by high-speed counter-current chromatographyQ46532320
P433issue11
P304page(s)1459-1463
P577publication date2008-11-01
P1433published inJournal of Pharmacy and PharmacologyQ10532762
P1476titleOroxylin A induces G2/M phase cell-cycle arrest via inhibiting Cdk7-mediated expression of Cdc2/p34 in human gastric carcinoma BGC-823 cells
P478volume60

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cites work (P2860)
Q38866753Anticancer Effect and Apoptosis Induction of Gambogic Acid in Human Leukemia Cell Line K562 In Vitro
Q35835756Aqueous extracts of Fructus Ligustri Lucide induce gastric carcinoma cell apoptosis and G2/M cycle arrest
Q64236878Blockade of glycolysis-dependent contraction by oroxylin a via inhibition of lactate dehydrogenase-a in hepatic stellate cells
Q38064457Cell cycle-related kinase in carcinogenesis
Q38858235Honokiol induces cell cycle arrest and apoptosis in human gastric carcinoma MGC-803 cell line.
Q64101523Long-Term Exposure to Oroxylin A Inhibits Metastasis by Suppressing CCL2 in Oral Squamous Cell Carcinoma Cells
Q26767372Novel Investigations of Flavonoids as Chemopreventive Agents for Hepatocellular Carcinoma
Q38957365Oroxylin A induces autophagy in human malignant glioma cells via the mTOR-STAT3-Notch signaling pathway
Q36809567Oroxylin A induces dissociation of hexokinase II from the mitochondria and inhibits glycolysis by SIRT3-mediated deacetylation of cyclophilin D in breast carcinoma
Q39779218Oroxylin A inhibits angiogenesis through blocking vascular endothelial growth factor-induced KDR/Flk-1 phosphorylation
Q35568870Oroxylin A promotes PTEN-mediated negative regulation of MDM2 transcription via SIRT3-mediated deacetylation to stabilize p53 and inhibit glycolysis in wt-p53 cancer cells
Q55129102VDAC1 as Pharmacological Target in Cancer and Neurodegeneration: Focus on Its Role in Apoptosis.

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