Alanine mutagenesis of the primary antigenic escape residue cluster, c1, of apical membrane antigen 1.

scientific article published on 30 November 2009

Alanine mutagenesis of the primary antigenic escape residue cluster, c1, of apical membrane antigen 1. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/IAI.00866-09
P932PMC publication ID2812209
P698PubMed publication ID19948834

P2093author name stringSheetij Dutta
Robert A Gasser
J David Haynes
Adrian H Batchelor
Christopher D Pool
Lisa S Dlugosz
Joshua W Clayton
P2860cites workReduction of the inhibitory antibody response to human factor VIII in hemophilia A mice by mutagenesis of the A2 domain B-cell epitopeQ45874416
Allelic polymorphisms in apical membrane antigen-1 are responsible for evasion of antibody-mediated inhibition in Plasmodium falciparumQ47864459
Apical membrane antigen 1 plays a central role in erythrocyte invasion by Plasmodium speciesQ47874885
Crystal structure of the malaria vaccine candidate apical membrane antigen 1.Q48004368
The disulfide bond structure of Plasmodium apical membrane antigen-1.Q48033627
Fine mapping of an epitope recognized by an invasion-inhibitory monoclonal antibody on the malaria vaccine candidate apical membrane antigen 1.Q48037113
Quality and quantity of the humoral immune response in healthy elderly and young subjects after annually repeated influenza vaccination.Q50636460
Structural comparison of apical membrane antigen 1 orthologues and paralogues in apicomplexan parasitesQ56441125
A new method for determination of varicella-zoster virus immunoglobulin G avidity in serum and cerebrospinal fluidQ24799955
Structure of the Malaria Antigen AMA1 in Complex with a Growth-Inhibitory AntibodyQ27648686
High antibody titer against apical membrane antigen-1 is required to protect against malaria in the Aotus modelQ28749979
Erythrocytic malaria growth or invasion inhibition assays with emphasis on suspension culture GIA.Q33183956
Safety and immunogenicity of an AMA-1 malaria vaccine in Malian adults: results of a phase 1 randomized controlled trialQ33316023
Plasmodium falciparum: development and validation of a measure of intraerythrocytic growth using SYBR Green I in a flow cytometerQ33385396
An inhibitory antibody blocks interactions between components of the malarial invasion machineryQ33402457
Phase 1/2a study of the malaria vaccine candidate apical membrane antigen-1 (AMA-1) administered in adjuvant system AS01B or AS02A.Q33434412
Extreme polymorphism in a vaccine antigen and risk of clinical malaria: implications for vaccine developmentQ33654911
Structure of AMA1 from Plasmodium falciparum reveals a clustering of polymorphisms that surround a conserved hydrophobic pocketQ33943794
Comparing antigenicity and immunogenicity of engineered gp120.Q33984309
Specificity of the protective antibody response to apical membrane antigen 1Q34007362
Purification, characterization, and immunogenicity of the refolded ectodomain of the Plasmodium falciparum apical membrane antigen 1 expressed in Escherichia coliQ34122492
In vitro studies with recombinant Plasmodium falciparum apical membrane antigen 1 (AMA1): production and activity of an AMA1 vaccine and generation of a multiallelic responseQ34260615
Vaccination of monkeys with recombinant Plasmodium falciparum apical membrane antigen 1 confers protection against blood-stage malariaQ34260722
Identification of T-cell determinants in natural immune responses to the Plasmodium falciparum apical membrane antigen (AMA-1) in an adult population exposed to malariaQ35477854
Structural basis of antigenic escape of a malaria vaccine candidateQ35927982
Population structure of the genes encoding the polymorphic Plasmodium falciparum apical membrane antigen 1: implications for vaccine designQ36693957
Selective modification of variable loops alters tropism and enhances immunogenicity of human immunodeficiency virus type 1 envelopeQ37092741
A randomized controlled phase 2 trial of the blood stage AMA1-C1/Alhydrogel malaria vaccine in children in MaliQ37267850
Allele Frequency-Based Analyses Robustly Map Sequence Sites Under Balancing Selection in a Malaria Vaccine Candidate AntigenQ39362577
Phase I dose escalation safety and immunogenicity trial of Plasmodium falciparum apical membrane protein (AMA-1) FMP2.1, adjuvanted with AS02A, in malaria-naïve adults at the Walter Reed Army Institute of Research.Q40144102
Refocusing neutralizing antibody response by targeted dampening of an immunodominant epitope.Q41103077
Prediction of residues in discontinuous B-cell epitopes using protein 3D structuresQ41926924
Mode of action of invasion-inhibitory antibodies directed against apical membrane antigen 1 of Plasmodium falciparumQ42727356
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectL-alanineQ218642
P304page(s)661-671
P577publication date2009-11-30
P1433published inInfection and ImmunityQ6029193
P1476titleAlanine mutagenesis of the primary antigenic escape residue cluster, c1, of apical membrane antigen 1.
P478volume78

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cites work (P2860)
Q335452513D analysis of the TCR/pMHCII complex formation in monkeys vaccinated with the first peptide inducing sterilizing immunity against human malaria
Q36511421A full-length recombinant Plasmodium falciparum PfRH5 protein induces inhibitory antibodies that are effective across common PfRH5 genetic variants
Q34663978Blood stage vaccines for Plasmodium falciparum: current status and the way forward
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Q36514853Designing malaria vaccines to circumvent antigen variability
Q64110597Effect of low complexity regions within the PvMSP3α block II on the tertiary structure of the protein and implications to immune escape mechanisms
Q33828593Genetic mapping identifies novel highly protective antigens for an apicomplexan parasite
Q35037036Global Population Structure of the Genes Encoding the Malaria Vaccine Candidate, Plasmodium vivax Apical Membrane Antigen 1 (PvAMA1).
Q35683634Identification of an Immunogenic Mimic of a Conserved Epitope on the Plasmodium falciparum Blood Stage Antigen AMA1 Using Virus-Like Particle (VLP) Peptide Display
Q90009659Microarray analyses reveal strain-specific antibody responses to Plasmodium falciparum apical membrane antigen 1 variants following natural infection and vaccination
Q36509831Molecular basis of allele-specific efficacy of a blood-stage malaria vaccine: vaccine development implications
Q35079832Overcoming antigenic diversity by enhancing the immunogenicity of conserved epitopes on the malaria vaccine candidate apical membrane antigen-1.
Q36394182Recent advances in recombinant protein-based malaria vaccines
Q55429433Structural patterns of selection and diversity for Plasmodium vivax antigens DBP and AMA1.
Q34596157Use of immunodampening to overcome diversity in the malarial vaccine candidate apical membrane antigen 1.
Q27024344Vaccines for malaria: how close are we?

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