Recent advances in recombinant protein-based malaria vaccines

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Recent advances in recombinant protein-based malaria vaccines is …
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scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1016/J.VACCINE.2015.09.093
P932PMC publication ID4687528
P698PubMed publication ID26458807
P5875ResearchGate publication ID282875443

P50authorLouis H. MillerQ1646045
Michael TheisenQ58310143
Toshihiro HoriiQ62911332
Sumi BiswasQ91598971
Evelina AngovQ107291505
Simon J. DraperQ47576805
P2093author name stringPrakash Srinivasan
P2860cites workCloning and expression of the gene coding for the transmission blocking target antigen Pfs48/45 of Plasmodium falciparumQ48103837
Optimising the Drosophila S2 Expression System for Production of Therapeutic VaccinesQ56144357
Plasmodium falciparum apical membrane antigen 1 (PfAMA-1) is translocated within micronemes along subpellicular microtubules during merozoite developmentQ73764830
Vaccines against malariaQ17485685
The cellular and molecular basis for malaria parasite invasion of the human red blood cellQ21032502
A review of malaria vaccine clinical projects based on the WHO rainbow tableQ21034112
Algae-produced Pfs25 elicits antibodies that inhibit malaria transmissionQ21134576
Structure of malaria invasion protein RH5 with erythrocyte basigin and blocking antibodiesQ24289322
Basigin is a receptor essential for erythrocyte invasion by Plasmodium falciparumQ24297064
Multiprotein complex between the GPI-anchored CyRPA with PfRH5 and PfRipr is crucial for Plasmodium falciparum erythrocyte invasionQ27230042
Vaccination with Plasmodium knowlesi AMA1 formulated in the novel adjuvant co-vaccine HT™ protects against blood-stage challenge in rhesus macaquesQ27336448
Structure of the Malaria Antigen AMA1 in Complex with a Growth-Inhibitory AntibodyQ27648686
Host cell invasion by apicomplexan parasites: insights from the co-structure of AMA1 with a RON2 peptideQ27670931
Structure-Based Design of a Fusion Glycoprotein Vaccine for Respiratory Syncytial VirusQ27680499
Independent roles of apical membrane antigen 1 and rhoptry neck proteins during host cell invasion by apicomplexaQ27972557
Apical membrane antigen 1 mediates apicomplexan parasite attachment but is dispensable for host cell invasionQ27973517
A field trial to assess a blood-stage malaria vaccineQ35622737
Ad35.CS.01-RTS,S/AS01 Heterologous Prime Boost Vaccine Efficacy against Sporozoite Challenge in Healthy Malaria-Naïve AdultsQ35684141
Comparative assessment of vaccine vectors encoding ten malaria antigens identifies two protective liver-stage candidatesQ35813430
Update on the clinical development of candidate malaria vaccines.Q35872686
Association between protection against clinical malaria and antibodies to merozoite surface antigens in an area of hyperendemicity in Myanmar: complementarity between responses to merozoite surface protein 3 and the 220-kilodalton glutamate-rich proQ36227049
Evidence for a common role for the serine-type Plasmodium falciparum serine repeat antigen proteases: implications for vaccine and drug designQ36313967
Combination of protein and viral vaccines induces potent cellular and humoral immune responses and enhanced protection from murine malaria challengeQ36313990
Antimalarial immunity in Saimiri monkeys. Immunization with surface components of asexual blood stagesQ36349409
Sequential expression of antigens on sexual stages of Plasmodium falciparum accessible to transmission-blocking antibodies in the mosquitoQ36351262
Effects on immunogenicity by formulations of emulsion-based adjuvants for malaria vaccinesQ36362230
Proteolytic activation of the essential parasitophorous vacuole cysteine protease SERA6 accompanies malaria parasite egress from its host erythrocyteQ36368252
Enhancing blockade of Plasmodium falciparum erythrocyte invasion: assessing combinations of antibodies against PfRH5 and other merozoite antigensQ36384456
Humoral responses to plasmodium falciparum blood-stage antigens and association with incidence of clinical malaria in children living in an area of seasonal malaria transmission in Burkina Faso, West Africa.Q36421572
ChAd63-MVA-vectored blood-stage malaria vaccines targeting MSP1 and AMA1: assessment of efficacy against mosquito bite challenge in humansQ36460499
A full-length recombinant Plasmodium falciparum PfRH5 protein induces inhibitory antibodies that are effective across common PfRH5 genetic variantsQ36511421
Anti-Plasmodium falciparum invasion ligand antibodies in a low malaria transmission region, Loreto, PeruQ36531268
Wheat germ cell-free system-based production of malaria proteins for discovery of novel vaccine candidatesQ36539678
NF135.C10: a new Plasmodium falciparum clone for controlled human malaria infectionsQ36547334
Iron oxide nanoparticles as a clinically acceptable delivery platform for a recombinant blood-stage human malaria vaccineQ36615170
Results from tandem Phase 1 studies evaluating the safety, reactogenicity and immunogenicity of the vaccine candidate antigen Plasmodium falciparum FVO merozoite surface protein-1 (MSP1(42)) administered intramuscularly with adjuvant system AS01.Q36639261
Correctly folded Pfs48/45 protein of Plasmodium falciparum elicits malaria transmission-blocking immunity in miceQ36670217
Various PfRH5 polymorphisms can support Plasmodium falciparum invasion into the erythrocytes of owl monkeys and ratsQ36678022
Broadly neutralizing antibodies present new prospects to counter highly antigenically diverse virusesQ36693991
A diversity-covering approach to immunization with Plasmodium falciparum apical membrane antigen 1 induces broader allelic recognition and growth inhibition responses in rabbitsQ36710710
The oligomerization domain of C4-binding protein (C4bp) acts as an adjuvant, and the fusion protein comprised of the 19-kilodalton merozoite surface protein 1 fused with the murine C4bp domain protects mice against malaria.Q36804322
Overcoming allelic specificity by immunization with five allelic forms of Plasmodium falciparum apical membrane antigen 1.Q36826951
Diversity covering AMA1-MSP119 fusion proteins as malaria vaccinesQ36826984
Comparison of modeling methods to determine liver-to-blood inocula and parasite multiplication rates during controlled human malaria infectionQ36936348
Alga-produced cholera toxin-Pfs25 fusion proteins as oral vaccinesQ36970645
Apical membrane antigen 1: a malaria vaccine candidate in reviewQ37069649
Erythrocyte binding protein PfRH5 polymorphisms determine species-specific pathways of Plasmodium falciparum invasionQ37181802
Immunity to malaria: more questions than answersQ37194482
Plasmodium falciparum merozoite surface antigen, PfRH5, elicits detectable levels of invasion-inhibiting antibodies in humansQ37247459
A role for apical membrane antigen 1 during invasion of hepatocytes by Plasmodium falciparum sporozoitesQ27973519
A subset of Plasmodium falciparum SERA genes are expressed and appear to play an important role in the erythrocytic cycleQ27974188
The RTS,S malaria vaccineQ28285472
Inhibitory potential of prodomain of Plasmodium falciparum protease serine repeat antigen 5 for asexual blood stages of parasiteQ28479056
Immunogenicity of self-associated aggregates and chemically cross-linked conjugates of the 42 kDa Plasmodium falciparum merozoite surface protein-1Q28484081
The RON2-AMA1 interaction is a critical step in moving junction-dependent invasion by apicomplexan parasitesQ28742887
A phase 1 trial of MSP2-C1, a blood-stage malaria vaccine containing 2 isoforms of MSP2 formulated with Montanide® ISA 720Q28744696
Phase 1 trial of the Plasmodium falciparum blood stage vaccine MSP1(42)-C1/Alhydrogel with and without CPG 7909 in malaria naïve adultsQ28749215
Immunization with Pre-Erythrocytic Antigen CelTOS from Plasmodium falciparum Elicits Cross-Species Protection against Heterologous Challenge with Plasmodium bergheiQ28749621
High antibody titer against apical membrane antigen-1 is required to protect against malaria in the Aotus modelQ28749979
Monoclonal antibody characterization of Plasmodium falciparum antigens in immune complexes formed when schizonts rupture in the presence of immune serumQ30042480
An EGF-like protein forms a complex with PfRh5 and is required for invasion of human erythrocytes by Plasmodium falciparumQ30043132
Subcellular discharge of a serine protease mediates release of invasive malaria parasites from host erythrocytesQ30043441
CelTOS, a novel malarial protein that mediates transmission to mosquito and vertebrate hostsQ30045410
Passive immunoprotection of Plasmodium falciparum-infected mice designates the CyRPA as candidate malaria vaccine antigenQ30049113
PfRH5: a novel reticulocyte-binding family homolog of plasmodium falciparum that binds to the erythrocyte, and an investigation of its receptorQ30049204
RH5-Basigin interaction plays a major role in the host tropism of Plasmodium falciparum.Q30356310
Protective epitopes of the Plasmodium falciparum SERA5 malaria vaccine reside in intrinsically unstructured N-terminal repetitive sequences.Q30363119
Binding of Plasmodium merozoite proteins RON2 and AMA1 triggers commitment to invasionQ30503482
Identification of Plasmodium falciparum antigens by antigenic analysis of genomic and proteomic dataQ30814677
Identification of a major B-cell epitope of the Plasmodium falciparum glutamate-rich protein (GLURP), targeted by human antibodies mediating parasite killingQ30897109
Analysis of the Plasmodium and Anopheles transcriptomes during oocyst differentiationQ31027392
A Plasmodium falciparum GLURP-MSP3 chimeric protein; expression in Lactococcus lactis, immunogenicity and induction of biologically active antibodiesQ33198902
A randomized placebo-controlled phase Ia malaria vaccine trial of two virosome-formulated synthetic peptides in healthy adult volunteersQ33302116
Long-term clinical protection from falciparum malaria is strongly associated with IgG3 antibodies to merozoite surface protein 3.Q33305467
Identification of proteases that regulate erythrocyte rupture by the malaria parasite Plasmodium falciparumQ33317962
Phase 1 trial of malaria transmission blocking vaccine candidates Pfs25 and Pvs25 formulated with montanide ISA 51.Q33350210
An inhibitory antibody blocks interactions between components of the malarial invasion machineryQ33402457
Blood stage malaria vaccine eliciting high antigen-specific antibody concentrations confers no protection to young children in Western KenyaQ33415066
Phase 1/2a study of the malaria vaccine candidate apical membrane antigen-1 (AMA-1) administered in adjuvant system AS01B or AS02A.Q33434412
A potent malaria transmission blocking vaccine based on codon harmonized full length Pfs48/45 expressed in Escherichia coliQ33485233
Safety and immunogenicity of the malaria vaccine candidate MSP3 long synthetic peptide in 12-24 months-old Burkinabe childrenQ33512533
A bicomponent Plasmodium falciparum investigational vaccine composed of protein-peptide conjugates.Q33524699
Global identification of multiple substrates for Plasmodium falciparum SUB1, an essential malarial processing proteaseQ34739743
Phase 1b randomized trial and follow-up study in Uganda of the blood-stage malaria vaccine candidate BK-SE36.Q34749432
Optimising Controlled Human Malaria Infection Studies Using Cryopreserved P. falciparum Parasites Administered by Needle and SyringeQ34792326
A PfRH5-based vaccine is efficacious against heterologous strain blood-stage Plasmodium falciparum infection in aotus monkeysQ34978590
A library of functional recombinant cell-surface and secreted P. falciparum merozoite proteinsQ34991300
Extended safety, immunogenicity and efficacy of a blood-stage malaria vaccine in malian children: 24-month follow-up of a randomized, double-blinded phase 2 trialQ35048336
Overcoming antigenic diversity by enhancing the immunogenicity of conserved epitopes on the malaria vaccine candidate apical membrane antigen-1.Q35079832
Sustained high-titer antibody responses induced by conjugating a malarial vaccine candidate to outer-membrane protein complexQ35132063
Crystal structure of PfRh5, an essential P. falciparum ligand for invasion of human erythrocytesQ35167000
New antigens for a multicomponent blood-stage malaria vaccineQ35216634
A malaria vaccine candidate based on an epitope of the Plasmodium falciparum RH5 proteinQ35227478
Development of cultured Plasmodium falciparum blood-stage malaria cell banks for early phase in vivo clinical trial assessment of anti-malaria drugs and vaccinesQ35354508
Blood stage merozoite surface protein conjugated to nanoparticles induce potent parasite inhibitory antibodiesQ35456892
Long-lasting and transmission-blocking activity of antibodies to Plasmodium falciparum elicited in mice by protein conjugates of Pfs25.Q35575993
Naturally acquired immune responses to Plasmodium falciparum sexual stage antigens Pfs48/45 and Pfs230 in an area of seasonal transmissionQ35598030
Anti-apical-membrane-antigen-1 antibody is more effective than anti-42-kilodalton-merozoite-surface-protein-1 antibody in inhibiting plasmodium falciparum growth, as determined by the in vitro growth inhibition assayQ37256085
A chimeric Plasmodium falciparum merozoite surface protein vaccine induces high titers of parasite growth inhibitory antibodiesQ37264673
Inducing humoral and cellular responses to multiple sporozoite and liver-stage malaria antigens using exogenous plasmid DNA.Q37264722
TLR9 adjuvants enhance immunogenicity and protective efficacy of the SE36/AHG malaria vaccine in nonhuman primate modelsQ37384724
Neutralization of Plasmodium falciparum merozoites by antibodies against PfRH5.Q37412559
Experimentally induced blood-stage Plasmodium vivax infection in healthy volunteers.Q37463375
A novel malaria vaccine candidate antigen expressed in Tetrahymena thermophila.Q37529646
Challenges of assessing the clinical efficacy of asexual blood-stage Plasmodium falciparum malaria vaccinesQ37530299
Bacterially expressed full-length recombinant Plasmodium falciparum RH5 protein binds erythrocytes and elicits potent strain-transcending parasite-neutralizing antibodiesQ37548216
Naturally acquired antibodies specific for Plasmodium falciparum reticulocyte-binding protein homologue 5 inhibit parasite growth and predict protection from malariaQ37582331
The development of the RTS,S malaria vaccine candidate: challenges and lessonsQ37582422
Adjuvants for malaria vaccinesQ37582428
From the circumsporozoite protein to the RTS, S/AS candidate vaccineQ37608882
Potent malaria transmission-blocking antibody responses elicited by Plasmodium falciparum Pfs25 expressed in Escherichia coli after successful protein refoldingQ37713285
Blood-stage malaria vaccines - recent progress and future challengesQ37761208
Plasmodium falciparum serine repeat antigen 5 (SE36) as a malaria vaccine candidateQ37896256
Controlled human blood stage malaria infection: current status and potential applicationsQ38001604
Recent advances in antibody-inducing poxviral and adenoviral vectored vaccine delivery platforms for difficult disease targetsQ38096489
Phenotype and functions of memory Tfh cells in human bloodQ38226748
Insights and controversies into the role of the key apicomplexan invasion ligand, Apical Membrane Antigen 1.Q38243368
T follicular helper cell differentiation, function, and roles in diseaseQ38264816
Toward the development of effective transmission-blocking vaccines for malariaQ38322553
Serine repeat antigen (SERA5) is predominantly expressed among the SERA multigene family of Plasmodium falciparum, and the acquired antibody titers correlate with serum inhibition of the parasite growthQ38884020
Transmission-blocking effects of sera from malaria-exposed individuals on Plasmodium falciparum isolates from gametocyte carriersQ38977787
Safety and immunogenicity of GMZ2 - a MSP3-GLURP fusion protein malaria vaccine candidateQ38995083
Sequential Phase 1 and Phase 2 randomized, controlled trials of the safety, immunogenicity and efficacy of combined pre-erythrocytic vaccine antigens RTS,S and TRAP formulated with AS02 Adjuvant System in healthy, malaria naïve adultsQ39172614
A Plasmodium falciparum 48/45 single epitope R0.6C subunit protein elicits high levels of transmission blocking antibodiesQ39467691
Cytophilic immunoglobulin responses to Plasmodium falciparum glutamate-rich protein are correlated with protection against clinical malaria in Dielmo, SenegalQ39515540
A multi-stage malaria vaccine candidate targeting both transmission and asexual parasite life-cycle stagesQ39520295
The glutamate-rich protein (GLURP) of Plasmodium falciparum is a target for antibody-dependent monocyte-mediated inhibition of parasite growth in vitroQ39569469
Alanine mutagenesis of the primary antigenic escape residue cluster, c1, of apical membrane antigen 1.Q39924371
Safety and immunogenicity of a three-component blood-stage malaria vaccine (MSP1, MSP2, RESA) against Plasmodium falciparum in Papua New Guinean childrenQ40551098
Plasmodium falciparum: heterologous synthesis of the transmission-blocking vaccine candidate Pfs48/45 in recombinant vaccinia virus-infected cellsQ41003251
Safety and immunogenicity of the malaria vaccine candidate GMZ2 in malaria-exposed, adult individuals from Lambaréné, GabonQ41877888
Heterologous expression of the C-terminal antigenic domain of the malaria vaccine candidate Pfs48/45 in the green algae Chlamydomonas reinhardtiiQ43645737
Malaria vaccine technology roadmapQ43650366
Safety and immunogenicity of the Plasmodium falciparum merozoite surface protein-3 long synthetic peptide (MSP3-LSP) malaria vaccine in healthy, semi-immune adult males in Burkina Faso, West AfricaQ43932881
The relationship between anti-merozoite antibodies and incidence of Plasmodium falciparum malaria: A systematic review and meta-analysisQ33526349
Plasmodium falciparum merozoite surface protein 1 (MSP-1)-MSP-3 chimeric protein: immunogenicity determined with human-compatible adjuvants and induction of protective immune responseQ33613937
Association of antibodies to Plasmodium falciparum reticulocyte binding protein homolog 5 with protection from clinical malariaQ33820897
Clues to evolution of the SERA multigene family in 18 Plasmodium speciesQ33851402
Immunization of Saimiri sciureus monkeys with a recombinant hybrid protein derived from the Plasmodium falciparum antigen glutamate-rich protein and merozoite surface protein 3 can induce partial protection with Freund and Montanide ISA720 adjuvantsQ33858812
The Plasmodium serine-type SERA proteases display distinct expression patterns and non-essential in vivo roles during life cycle progression of the malaria parasiteQ33885507
The IC(50) of anti-Pfs25 antibody in membrane-feeding assay varies among speciesQ33892507
Immunization with a functional protein complex required for erythrocyte invasion protects against lethal malariaQ33925720
Structure of AMA1 from Plasmodium falciparum reveals a clustering of polymorphisms that surround a conserved hydrophobic pocketQ33943794
Impact on malaria parasite multiplication rates in infected volunteers of the protein-in-adjuvant vaccine AMA1-C1/Alhydrogel+CPG 7909.Q33974904
A randomized controlled phase Ib trial of the malaria vaccine candidate GMZ2 in African childrenQ33987686
Specificity of the protective antibody response to apical membrane antigen 1Q34007362
Lack of allele-specific efficacy of a bivalent AMA1 malaria vaccineQ34011922
Efficacy and safety of RTS,S/AS01 malaria vaccine with or without a booster dose in infants and children in Africa: final results of a phase 3, individually randomised, controlled trialQ34043843
Targeting sialic acid dependent and independent pathways of invasion in Plasmodium falciparumQ34131196
Sterile immunity to malaria after DNA prime/adenovirus boost immunization is associated with effector memory CD8+T cells targeting AMA1 class I epitopesQ34165879
Safety and immunogenicity of a recombinant nonglycosylated erythrocyte binding antigen 175 Region II malaria vaccine in healthy adults living in an area where malaria is not endemicQ34189972
A full-length Plasmodium falciparum recombinant circumsporozoite protein expressed by Pseudomonas fluorescens platform as a malaria vaccine candidateQ34232909
The blood-stage malaria antigen PfRH5 is susceptible to vaccine-inducible cross-strain neutralizing antibodyQ34241973
Assessment of humoral immune responses to blood-stage malaria antigens following ChAd63-MVA immunization, controlled human malaria infection and natural exposureQ34257253
In vitro studies with recombinant Plasmodium falciparum apical membrane antigen 1 (AMA1): production and activity of an AMA1 vaccine and generation of a multiallelic responseQ34260615
Vaccination of monkeys with recombinant Plasmodium falciparum apical membrane antigen 1 confers protection against blood-stage malariaQ34260722
Malaria vaccine R&D in the Decade of Vaccines: breakthroughs, challenges and opportunitiesQ34340186
Development of a Pfs25-EPA malaria transmission blocking vaccine as a chemically conjugated nanoparticleQ34341570
T cell responses induced by adenoviral vectored vaccines can be adjuvanted by fusion of antigen to the oligomerization domain of C4b-binding proteinQ34416263
Limited antigenic diversity of Plasmodium falciparum apical membrane antigen 1 supports the development of effective multi-allele vaccinesQ34416904
Phase 1 study in malaria naïve adults of BSAM2/Alhydrogel®+CPG 7909, a blood stage vaccine against P. falciparum malariaQ34441098
Phase I safety and immunogenicity trial of Plasmodium vivax CS derived long synthetic peptides adjuvanted with montanide ISA 720 or montanide ISA 51Q34546201
Saccharomyces cerevisiae recombinant Pfs25 adsorbed to alum elicits antibodies that block transmission of Plasmodium falciparum.Q34548828
Use of immunodampening to overcome diversity in the malarial vaccine candidate apical membrane antigen 1.Q34596157
Combining viral vectored and protein-in-adjuvant vaccines against the blood-stage malaria antigen AMA1: report on a phase 1a clinical trialQ34600955
DNA prime/Adenovirus boost malaria vaccine encoding P. falciparum CSP and AMA1 induces sterile protection associated with cell-mediated immunityQ34606356
Evaluating controlled human malaria infection in Kenyan adults with varying degrees of prior exposure to Plasmodium falciparum using sporozoites administered by intramuscular injectionQ34687174
A longitudinal study of immune responses to Plasmodium falciparum sexual stage antigens in Tanzanian adultsQ43945792
Expression of malaria transmission-blocking vaccine antigen Pfs25 in Pichia pastoris for use in human clinical trialsQ44150427
Experimental human challenge infections can accelerate clinical malaria vaccine developmentQ44156054
Antibodies to plant-produced Plasmodium falciparum sexual stage protein Pfs25 exhibit transmission blocking activityQ44156482
A comparison of transmission-blocking activity with reactivity in a Plasmodium falciparum 48/45-kD molecule-specific competition enzyme-linked immunosorbent assay.Q44169960
The malaria vaccine candidate GMZ2 elicits functional antibodies in individuals from malaria endemic and non-endemic areasQ44238175
Safety and immunogenicity of a three-component blood-stage malaria vaccine in adults living in an endemic area of Papua New GuineaQ44501476
Enzymic, phylogenetic, and structural characterization of the unusual papain-like protease domain of Plasmodium falciparum SERA5.Q44588572
Fc gamma receptor 3B (FCGR3B-c.233C>A-rs5030738) polymorphism modifies the protective effect of malaria specific antibodies in ghanaian childrenQ45172424
Naturally acquired antibodies to the glutamate-rich protein are associated with protection against plasmodium falciparum malariaQ46163143
A hypothesis about the chronicity of malaria infectionQ46833996
Ca(2+) -mediated exocytosis of subtilisin-like protease 1: a key step in egress of Plasmodium falciparum merozoitesQ46908547
Complement-mediated killing of Plasmodium falciparum erythrocytic schizont with antibodies to the recombinant serine repeat antigen (SERA).Q47773289
Conservation and heterogeneity of the glutamate-rich protein (GLURP) among field isolates and laboratory lines of Plasmodium falciparumQ47812641
Epitope analysis of the malaria surface antigen pfs48/45 identifies a subdomain that elicits transmission blocking antibodies.Q47829675
Immunological properties of recombinant proteins of the transmission blocking vaccine candidate, Pfs48/45, of the human malaria parasite Plasmodium falciparum produced in Escherichia coli.Q47837358
Assembly and expression of a synthetic gene encoding the antigen Pfs48/45 of the human malaria parasite Plasmodium falciparum in yeastQ47857505
Allelic polymorphisms in apical membrane antigen-1 are responsible for evasion of antibody-mediated inhibition in Plasmodium falciparumQ47864459
Synthetic peptides derived from the C-terminal 6kDa region of Plasmodium falciparum SERA5 inhibit the enzyme activity and malaria parasite developmentQ47864896
Malaria vaccine candidate antigen targeting the pre-erythrocytic stage of Plasmodium falciparum produced at high level in plantsQ47882452
Reticulocyte-binding protein homologue 5 - an essential adhesin involved in invasion of human erythrocytes by Plasmodium falciparumQ47887452
Vaccinating with the genome: a Sisyphean task?Q47899824
Immunogenic properties of a recombinant fusion protein containing the C-terminal 19 kDa of Plasmodium falciparum merozoite surface protein-1 and the innate immunity agonist FliC flagellin of Salmonella typhimurium.Q47928079
Immunogenicity and in vitro protective efficacy of recombinant Mycobacterium bovis bacille Calmette Guerin (rBCG) expressing the 19 kDa merozoite surface protein-1 (MSP-119) antigen of Plasmodium falciparumQ47964774
Production of non-glycosylated recombinant proteins in Nicotiana benthamiana plants by co-expressing bacterial PNGase F.Q48007592
Merozoite surface protein-3: a malaria protein inducing antibodies that promote Plasmodium falciparum killing by cooperation with blood monocytesQ48013154
The high immunogenicity induced by modified sporozoites' malarial peptides depends on their phi (ϕ) and psi (ψ) anglesQ48025225
Heterologous expression of proteins from Plasmodium falciparum: results from 1000 genesQ48028328
Diversity of the vaccine candidate AMA-1 of Plasmodium falciparumQ48065126
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue52
P407language of work or nameEnglishQ1860
P921main subjectmalariaQ12156
malaria vaccineQ6741353
recombinant proteinQ50209538
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)7433-7443
P577publication date2015-10-09
2015-12-22
P1433published inVaccineQ7907941
P1476titleRecent advances in recombinant protein-based malaria vaccines
P478volume33

Reverse relations

cites work (P2860)
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