Chondroitin sulphate-modified neuropilin 1 is expressed in human tumour cells and modulates 3D invasion in the U87MG human glioblastoma cell line through a p130Cas-mediated pathway.

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Chondroitin sulphate-modified neuropilin 1 is expressed in human tumour cells and modulates 3D invasion in the U87MG human glioblastoma cell line through a p130Cas-mediated pathway. is …
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scholarly articleQ13442814

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P356DOI10.1038/EMBOR.2008.151
P932PMC publication ID2572126
P698PubMed publication ID18704117
P5875ResearchGate publication ID23171773

P50authorGiovanna Marisa D'abacoQ42797813
Caroline Pellet-ManyQ59680244
P2093author name stringIan C Zachary
Paul Frankel
Lili Cheng
Pauliina Lehtolainen
Michelle L Tickner
P2860cites workGlycosaminoglycan modification of neuropilin-1 modulates VEGFR2 signalingQ24292998
Blocking neuropilin-1 function has an additive effect with anti-VEGF to inhibit tumor growthQ24293042
Neuropilin is a receptor for the axonal chemorepellent Semaphorin IIIQ24310596
p130Cas mediates the transforming properties of the anaplastic lymphoma kinaseQ24315788
Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factorQ24321564
Core protein structure and sequence determine the site and presence of heparan sulfate and chondroitin sulfate on syndecan-1Q28252412
HEF1 is a necessary and specific downstream effector of FAK that promotes the migration of glioblastoma cellsQ28281874
p130Cas: a versatile scaffold in signaling networksQ28304929
Neuropilin-1 conveys semaphorin and VEGF signaling during neural and cardiovascular developmentQ28585676
Compensation mechanism in tumor cell migration: mesenchymal-amoeboid transition after blocking of pericellular proteolysisQ29615193
Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysisQ29616712
Neuropilins in neoplasms: expression, regulation, and function.Q30352740
Identification and synthesis of a recognition signal for the attachment of glycosaminoglycans to proteinsQ34622671
Mechanisms of cancer cell invasionQ36015535
Therapeutic value of glycosaminoglycans in cancerQ36598106
Chondroitin sulfate as a key molecule in the development of atherosclerosis and cancer progressionQ36713856
Proteoglycans: structures and interactionsQ37285263
Neuropilin-1 promotes human glioma progression through potentiating the activity of the HGF/SF autocrine pathwayQ39819576
Neuropilin-1 interacts with integrin beta1 and modulates pancreatic cancer cell growth, survival and invasionQ40088181
Expression of neuropilin-1 in high-grade dysplasia, invasive cancer, and metastases of the human gastrointestinal tractQ40563679
Heparan sulfate proteoglycans as adhesive and anti-invasive molecules. Syndecans and glypican have distinct functionsQ41014679
Vascular endothelial growth factor promotes breast carcinoma invasion in an autocrine manner by regulating the chemokine receptor CXCR4.Q42807023
Anti-chemorepulsive effects of vascular endothelial growth factor and placental growth factor-2 in dorsal root ganglion neurons are mediated via neuropilin-1 and cyclooxygenase-derived prostanoid productionQ44883177
Overexpression of the neuropilin 1 (NRP1) gene correlated with poor prognosis in human glioma.Q47435600
Doxorubicin-induced cell death in highly invasive human gliomasQ48187130
Characterization of a Bicyclic Peptide Neuropilin-1 (NP-1) Antagonist (EG3287) Reveals Importance of Vascular Endothelial Growth Factor Exon 8 for NP-1 Binding and Role of NP-1 in KDR SignalingQ58449597
Anti-tumor activities of chondroitinase AC and chondroitinase B: inhibition of angiogenesis, proliferation and invasionQ73719669
Effect of body temperature on chondroitinase ABC's ability to cleave chondroitin sulfate glycosaminoglycansQ79694980
P433issue10
P921main subjectglioblastomaQ282142
cell lineQ21014462
P304page(s)983-989
P577publication date2008-08-15
P1433published inEMBO ReportsQ5323356
P1476titleChondroitin sulphate-modified neuropilin 1 is expressed in human tumour cells and modulates 3D invasion in the U87MG human glioblastoma cell line through a p130Cas-mediated pathway
P478volume9

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cites work (P2860)
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Q38997374Detailed characterization of the O-linked glycosylation of the neuropilin-1 c/MAM-domain.
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Q41476713Glycosylation-dependent galectin-1/neuropilin-1 interactions promote liver fibrosis through activation of TGF-β- and PDGF-like signals in hepatic stellate cells
Q37958931How neuropilin-1 regulates receptor tyrosine kinase signalling: the knowns and known unknowns
Q36996552Imatinib and Nilotinib increase glioblastoma cell invasion via Abl-independent stimulation of p130Cas and FAK signalling
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