MPP(+)-induced cytotoxicity in neuroblastoma cells: Antagonism and reversal by guanosine

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MPP(+)-induced cytotoxicity in neuroblastoma cells: Antagonism and reversal by guanosine is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S11302-007-9073-Z
P932PMC publication ID2072917
P698PubMed publication ID18404453
P5875ResearchGate publication ID5449170

P50authorPatrizia BalleriniQ114437495
Iolanda D'AlimonteQ114437533
Michel P RathboneQ114437541
Shucui JiangQ114437546
Eva S WerstiukQ114437797
P2093author name stringChristian Bau
Kathleen M Pettifer
P2860cites workIdentification of programmed cell death in situ via specific labeling of nuclear DNA fragmentationQ24642901
Parkinson-like syndrome induced by continuous MPTP infusion: convergent roles of the ubiquitin-proteasome system and alpha-synucleinQ26269955
Mutation in the alpha-synuclein gene identified in families with Parkinson's diseaseQ27860459
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machineryQ27860586
Alpha-synuclein in Lewy bodiesQ27860680
Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanismsQ28137802
Mechanisms of caspase activationQ28187994
Caspase-9 activation results in downstream caspase-8 activation and bid cleavage in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's diseaseQ28210040
Pertussis toxin and target eukaryotic cells: binding, entry, and activationQ28269020
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseasesQ28269333
Cell death in the nervous systemQ28269343
Classification of cell death: recommendations of the Nomenclature Committee on Cell DeathQ28278883
Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphateQ28301966
Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's diseaseQ28594269
Parkinson's disease: mechanisms and modelsQ29547424
Opposing effects of ERK and JNK-p38 MAP kinases on apoptosisQ29547567
Regulation of neuronal survival by the serine-threonine protein kinase AktQ29614185
Characterization and time course of MPP+ -induced apoptosis in human SH-SY5Y neuroblastoma cellsQ30303651
Rat brain guanosine binding site. Biological studies and pseudo-receptor construction.Q31029356
Low concentrations of 1-methyl-4-phenylpyridinium ion induce caspase-mediated apoptosis in human SH-SY5Y neuroblastoma cellsQ32063604
Etiology and pathogenesis of Parkinson's diseaseQ33593402
Nucleoside transporters: molecular biology and implications for therapeutic developmentQ33632764
Apoptotic DNA fragmentationQ33876750
Trophic effects of purines in neurons and glial cells.Q33939094
Akt/Protein kinase B inhibits cell death by preventing the release of cytochrome c from mitochondriaQ33959022
Cell death induced by MPTP, a substrate for monoamine oxidase B.Q34088858
DNA repair/pro-apoptotic dual-role proteins in five major DNA repair pathways: fail-safe protection against carcinogenesisQ34132208
Transcription-dependent and -independent control of neuronal survival by the PI3K-Akt signaling pathwayQ34278037
G-protein-coupled receptors and signaling networks: emerging paradigms.Q34296103
Caspase-independent cell deathQ34433759
Neuroprotection by propargylamines in Parkinson's disease: suppression of apoptosis and induction of prosurvival genesQ34802158
Caspase-3: A vulnerability factor and final effector in apoptotic death of dopaminergic neurons in Parkinson's disease.Q35083548
Targeting programmed cell death in neurodegenerative diseasesQ35120138
Apoptosis inducing factor and PARP-mediated injury in the MPTP mouse model of Parkinson's diseaseQ35171012
The 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model: a tool to explore the pathogenesis of Parkinson's diseaseQ35171029
Phosphoinositide 3-kinase signalling--which way to target?Q35181798
The role of alpha-synuclein in Parkinson's disease: insights from animal modelsQ35209957
Interrupting apoptosis in neurodegenerative disease: potential for effective therapy?Q35674384
Death without caspases, caspases without deathQ35739290
Mitogen-activated protein kinases in apoptosis regulationQ35743118
Neuroprotective strategies for Parkinson's disease: conceptual limits of animal models and clinical trials.Q35761616
Advances in protein kinase B signalling: AKTion on multiple frontsQ35766370
Role of extracellular signal regulated kinases 1 and 2 in neuronal survivalQ35778135
Adult neuron survival strategies--slamming on the brakesQ35868063
Caspases, IAPs and Smac/DIABLO: mechanisms from structural biologyQ35874476
DNA degradation in development and programmed cell deathQ36072468
The MPTP model of Parkinson's diseaseQ36080019
Molecular basis of programmed cell death involved in neurodegenerationQ36282417
Direct modification of the membrane adenylate cyclase system by islet-activating protein due to ADP-ribosylation of a membrane proteinQ36295605
Akt regulates cell survival and apoptosis at a postmitochondrial levelQ36342570
Heterotrimeric G-proteins: a short historyQ36364445
Caspase function in programmed cell deathQ36643566
Mechanisms of disease: DNA repair defects and neurological diseaseQ36753339
In situ detection of apoptotic nuclei in the substantia nigra compacta of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice using terminal deoxynucleotidyl transferase labelling and acridine orange stainingQ36857701
Salvianic acid A protects human neuroblastoma SH-SY5Y cells against MPP+-induced cytotoxicity.Q40463919
Guanosine protects SH-SY5Y cells against beta-amyloid-induced apoptosisQ40568471
Alpha-synuclein up-regulation and aggregation during MPP+-induced apoptosis in neuroblastoma cells: intermediacy of transferrin receptor iron and hydrogen peroxideQ40595894
Neuroprotective actions of Selegiline in inhibiting 1-methyl, 4-phenyl, pyridinium ion (MPP+)-induced apoptosis in SK-N-SH neuronsQ40599232
MPP+ increases alpha-synuclein expression and ERK/MAP-kinase phosphorylation in human neuroblastoma SH-SY5Y cellsQ40725645
Complexity and diversity of mammalian adenylyl cyclasesQ41048221
1-methyl-4-phenyl-pyridinium ion (MPP+) causes DNA fragmentation and increases the Bcl-2 expression in human neuroblastoma, SH-SY5Y cells, through different mechanismsQ41258866
Specific [(3)H]-guanosine binding sites in rat brain membranesQ42021948
The antiapoptotic effect of guanosine is mediated by the activation of the PI 3-kinase/AKT/PKB pathway in cultured rat astrocytes.Q42460494
Protective effect of harmalol and harmaline on MPTP neurotoxicity in the mouse and dopamine-induced damage of brain mitochondria and PC12 cellsQ42490786
Alpha-synuclein up-regulation in substantia nigra dopaminergic neurons following administration of the parkinsonian toxin MPTP.Q42617687
Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK.Q42800979
Is Bax a mitochondrial mediator in apoptotic death of dopaminergic neurons in Parkinson's disease?Q43548211
Release and aggregation of cytochrome c and alpha-synuclein are inhibited by the antiparkinsonian drugs, talipexole and pramipexoleQ43574350
Caspase-3 activation induced by inhibition of mitochondrial complex I is facilitated by glycogen synthase kinase-3beta and attenuated by lithiumQ43786473
Dopamine-dependent neurotoxicity of alpha-synuclein: a mechanism for selective neurodegeneration in Parkinson diseaseQ44013447
Do inducers of apoptosis trigger caspase-independent cell death?Q45267818
Involvement of 3-phosphoinositide-dependent protein kinase-1 in the MEK/MAPK signal transduction pathwayQ47400542
Protective effects of the antiparkinsonian drugs talipexole and pramipexole against 1-methyl-4-phenylpyridinium-induced apoptotic death in human neuroblastoma SH-SY5Y cells.Q55068180
Increased caspase 3 and Bax immunoreactivity accompany nuclear GAPDH translocation and neuronal apoptosis in Parkinson's diseaseQ64767727
Linkage of G protein-coupled receptors to the MAPK signaling pathway through PI 3-kinase gammaQ71970954
Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factorQ72121269
Signaling from G-protein-coupled receptors to mitogen-activated protein (MAP)-kinase cascadesQ77322545
P433issue4
P921main subjectcytotoxicityQ246181
neuroblastomaQ938205
P304page(s)399-409
P577publication date2007-09-01
P1433published inPurinergic SignallingQ15716545
P1476titleMPP(+)-induced cytotoxicity in neuroblastoma cells: Antagonism and reversal by guanosine
P478volume3

Reverse relations

cites work (P2860)
Q42372900Antiparkinsonian Efficacy of Guanosine in Rodent Models of Movement Disorder.
Q37447674Characterization of the endocannabinoid system in human neuronal cells and proteomic analysis of anandamide-induced apoptosis
Q47659411Curcumin affords neuroprotection and inhibits α-synuclein aggregation in lipopolysaccharide-induced Parkinson's disease model
Q33569173Curcumin reduces alpha-synuclein induced cytotoxicity in Parkinson's disease cell model
Q40466209Genetic modification of H2AX renders mesenchymal stromal cell-derived dopamine neurons more resistant to DNA damage and subsequent apoptosis.
Q46814683Guanosine Protects Against Cortical Focal Ischemia. Involvement of Inflammatory Response.
Q37256409Guanosine and its role in neuropathologies
Q48295676Guanosine protects against reperfusion injury in rat brains after ischemic stroke
Q28072158Guanosine: a Neuromodulator with Therapeutic Potential in Brain Disorders
Q35073154Inhibition of store-operated calcium entry attenuates MPP(+)-induced oxidative stress via preservation of mitochondrial function in PC12 cells: involvement of Homer1a
Q39437666Iridoids from the roots of Valeriana jatamansi and their biological activities
Q35759141Longitudinal Metabolomics Profiling of Parkinson's Disease-Related α-Synuclein A53T Transgenic Mice.
Q59127756Neuromodulatory Effects of Guanine-Based Purines in Health and Disease
Q54581993Neuroprotective effect of guanosine against glutamate-induced cell death in rat hippocampal slices is mediated by the phosphatidylinositol-3 kinase/Akt/ glycogen synthase kinase 3β pathway activation and inducible nitric oxide synthase inhibition.
Q95643364Novel Targets for Fast Antidepressant Responses: Possible Role of Endogenous Neuromodulators
Q38736125Sodium butyrate rescues dopaminergic cells from alpha-synuclein-induced transcriptional deregulation and DNA damage
Q35109170The potential therapeutic effect of guanosine after cortical focal ischemia in rats.

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