Fatty acids do not activate UCP2 in pancreatic beta cells: comparison with UCP1.

scientific article

Fatty acids do not activate UCP2 in pancreatic beta cells: comparison with UCP1. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S00424-008-0548-8
P698PubMed publication ID18626658

P2093author name stringAlexandre Sarre
Patrick Muzzin
Nathalie Produit-Zengaffinen
Françoise Assimacopoulos-Jeannet
Hélène Perreten
Sandrine Galetti
P2860cites workUncoupling protein-3: a new member of the mitochondrial carrier family with tissue-specific expressionQ24309291
Coated Charcoal Immunoassay of InsulinQ71162157
Uncoupling protein 2, in vivo distribution, induction upon oxidative stress, and evidence for translational regulationQ73247191
A role for uncoupling protein-2 as a regulator of mitochondrial hydrogen peroxide generationQ73626811
Foxa1-deficient mice exhibit impaired insulin secretion due to uncoupled oxidative phosphorylationQ79143536
Uncoupling protein-2 contributes significantly to high mitochondrial proton leak in INS-1E insulinoma cells and attenuates glucose-stimulated insulin secretionQ81157112
Persistent nuclear factor-kappa B activation in Ucp2-/- mice leads to enhanced nitric oxide and inflammatory cytokine productionQ24541307
Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cellsQ24810302
Superoxide activates mitochondrial uncoupling proteinsQ28214829
Fatty acid activation of the uncoupling proteins requires the presence of the central matrix loop from UCP1Q28569542
Uncoupling proteins 2 and 3 are fundamental for mitochondrial Ca2+ uniportQ30580904
Uncoupling protein-2 prevents neuronal death and diminishes brain dysfunction after stroke and brain traumaQ31149457
Stable expression of functional mitochondrial uncoupling protein in Chinese hamster ovary cells.Q33666860
Mitochondria contribute to LPS-induced MAPK activation via uncoupling protein UCP2 in macrophagesQ34000569
Uncoupling protein 2 plays an important role in nitric oxide production of lipopolysaccharide-stimulated macrophagesQ34035403
The 'novel' 'uncoupling' proteins UCP2 and UCP3: what do they really do? Pros and cons for suggested functions.Q35044280
Modulation of glucose responsiveness of insulinoma beta-cells by graded overexpression of glucokinaseQ36131014
Mitochondrial uncoupling proteins in the CNS: in support of function and survival.Q36285974
Interaction of free fatty acids with mitochondria: coupling, uncoupling and permeability transitionQ36477187
Uncoupling proteins: a role in protection against reactive oxygen species--or not?Q36522086
UCP2, UCP3, avUCP, what do they do when proton transport is not stimulated? Possible relevance to pyruvate and glutamine metabolism.Q36548834
Uncoupling protein-3: clues in an ongoing mitochondrial mystery.Q36698779
Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes.Q38299277
Bioluminometric assay of ADP and ATP at high ATP/ADP ratios: assay of ADP after enzymatic removal of ATP.Q38569163
Glutamine stimulates translation of uncoupling protein 2mRNA.Q40130194
UCP2 is a mitochondrial transporter with an unusual very short half-lifeQ40180611
Increasing uncoupling protein-2 in pancreatic beta cells does not alter glucose-induced insulin secretion but decreases production of reactive oxygen species.Q40203702
Dexamethasone induces cell death in insulin-secreting cells, an effect reversed by exendin-4.Q40286548
Peroxisome proliferator-activated receptor alpha (PPARalpha) potentiates, whereas PPARgamma attenuates, glucose-stimulated insulin secretion in pancreatic beta-cellsQ40425673
PPARalpha suppresses insulin secretion and induces UCP2 in insulinoma cells.Q40729542
Uncoupling of protein-3 induces an uncontrolled uncoupling of mitochondria after expression in muscle derived L6 cellsQ40747524
UCP2-dependent proton leak in isolated mammalian mitochondriaQ40766544
Uncoupling protein 2: a possible link between fatty acid excess and impaired glucose-induced insulin secretion?Q40814727
Thermogenic responses in brown fat cells are fully UCP1-dependent. UCP2 or UCP3 do not substitute for UCP1 in adrenergically or fatty scid-induced thermogenesisQ42488444
Physiological levels of mammalian uncoupling protein 2 do not uncouple yeast mitochondriaQ42502013
Increased uncoupling protein-2 levels in beta-cells are associated with impaired glucose-stimulated insulin secretion: mechanism of actionQ42504879
No evidence for a basal, retinoic, or superoxide-induced uncoupling activity of the uncoupling protein 2 present in spleen or lung mitochondria.Q42521387
Induction and degradation of the uncoupling protein thermogenin in brown adipocytes in vitro and in vivo. Evidence for a rapidly degradable pool.Q42797470
Glucose Sensitivity and Metabolism-Secretion Coupling Studied during Two-Year Continuous Culture in INS-1E Insulinoma CellsQ42798453
Expression of UCP3 in CHO cells does not cause uncoupling, but controls mitochondrial activity in the presence of glucoseQ43226759
UCP1 muscle gene transfer and mitochondrial proton leak mediated thermogenesisQ44070751
Role of ATP production and uncoupling protein-2 in the insulin secretory defect induced by chronic exposure to high glucose or free fatty acids and effects of peroxisome proliferator-activated receptor-gamma inhibitionQ44114881
Increased glucose sensitivity of both triggering and amplifying pathways of insulin secretion in rat islets cultured for 1 wk in high glucoseQ44853229
PPAR-gamma overexpression selectively suppresses insulin secretory capacity in isolated pancreatic islets through induction of UCP-2 proteinQ45098447
Functional and morphological alterations of mitochondria in pancreatic beta cells from type 2 diabetic patients.Q45227245
Mitochondria from brown adipose tissue: uncoupling of respiratory chain phosphorylation by long fatty acids and recoupling by guanosine triphosphateQ46227500
Chronic hyperglycemia, independent of plasma lipid levels, is sufficient for the loss of beta-cell differentiation and secretory function in the db/db mouse model of diabetesQ46670137
A simple, rapid, and sensitive DNA assay procedureQ56879279
Polyunsaturated fatty acids activate human uncoupling proteins 1 and 2 in planar lipid bilayersQ63418348
Effects of adenoviral overexpression of uncoupling protein-2 and -3 on mitochondrial respiration in insulinoma cellsQ64380183
Fatty acids as acute regulators of the proton conductance of hamster brown-fat mitochondriaQ67255436
P433issue4
P921main subjectfatty acidQ61476
P304page(s)931-940
P577publication date2008-07-15
P1433published inPfluegers ArchivQ1091689
P1476titleFatty acids do not activate UCP2 in pancreatic beta cells: comparison with UCP1.
P478volume457

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cites work (P2860)
Q38880892H₂O₂-Activated Mitochondrial Phospholipase iPLA₂γ Prevents Lipotoxic Oxidative Stress in Synergy with UCP2, Amplifies Signaling via G-Protein-Coupled Receptor GPR40, and Regulates Insulin Secretion in Pancreatic β-Cells
Q34077042Mitochondrial uncoupling and lifespan.
Q47722955Mitochondrial uncoupling proteins: subtle regulators of cellular redox signaling
Q27021930Redox homeostasis in pancreatic β cells
Q35972265Test systems to study the structure and function of uncoupling protein 1: a critical overview.
Q38943061The Pancreatic β-Cell: A Bioenergetic Perspective
Q28565465Uncoupling protein-2 attenuates glucose-stimulated insulin secretion in INS-1E insulinoma cells by lowering mitochondrial reactive oxygen species

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