Dynamic regulation of neutrophil polarity and migration by the heterotrimeric G protein subunits Gαi-GTP and Gβγ.

scientific article

Dynamic regulation of neutrophil polarity and migration by the heterotrimeric G protein subunits Gαi-GTP and Gβγ. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1126/SCISIGNAL.AAD8163
P932PMC publication ID6364554
P698PubMed publication ID26905427
P5875ResearchGate publication ID295832775

P2093author name stringMinsoo Kim
Alan V Smrcka
Sundeep Malik
Chinmay R Surve
Jesi Y To
P2860cites workRoles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transductionQ22253158
P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for RacQ24294423
Cell migration: a physically integrated molecular processQ27860682
A cell's sense of directionQ28142672
The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101Q28678835
Random versus directionally persistent cell migrationQ29616686
How do receptors activate G proteins?Q30364607
Cell polarity: an examination of its behavioral expression and its consequences for polymorphonuclear leukocyte chemotaxisQ30442416
Spatial regulation of the cAMP-dependent protein kinase during chemotactic cell migrationQ30476244
Mice lacking the signaling molecule CalDAG-GEFI represent a model for leukocyte adhesion deficiency type III.Q30479426
Dynamics of a chemoattractant receptor in living neutrophils during chemotaxisQ30483206
Protein kinase A regulates 3-phosphatidylinositide dynamics during platelet-derived growth factor-induced membrane ruffling and chemotaxisQ30484908
Cells navigate with a local-excitation, global-inhibition-biased excitable network.Q30496894
mTORC2 regulates neutrophil chemotaxis in a cAMP- and RhoA-dependent fashionQ30499352
Uropod elongation is a common final step in leukocyte extravasation through inflamed vessels.Q30522340
PKCβII acts downstream of chemoattractant receptors and mTORC2 to regulate cAMP production and myosin II activity in neutrophilsQ30577302
Subcellular optogenetic inhibition of G proteins generates signaling gradients and cell migrationQ30585391
Differential targeting of Gbetagamma-subunit signaling with small moleculesQ33240532
Intracellular role of adenylyl cyclase in regulation of lateral pseudopod formation during Dictyostelium chemotaxisQ33770649
A chemical biology approach demonstrates G protein βγ subunits are sufficient to mediate directional neutrophil chemotaxisQ33793018
Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation.Q33889530
A Gβγ effector, ElmoE, transduces GPCR signaling to the actin network during chemotaxis.Q34134773
Mastoparan, a peptide toxin from wasp venom, mimics receptors by activating GTP-binding regulatory proteins (G proteins).Q34167134
Novel regulatory properties of human type 9 adenylate cyclaseQ34302709
Cellular expression of the carboxyl terminus of a G protein-coupled receptor kinase attenuates G beta gamma-mediated signaling.Q34336625
A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein beta gamma subunitsQ34339415
Regulation of cell polarity during eukaryotic chemotaxis: the chemotactic compassQ34560901
Signaling requirements for translocation of P-Rex1, a key Rac2 exchange factor involved in chemoattractant-stimulated human neutrophil functionQ34602721
Directional sensing in eukaryotic chemotaxis: a balanced inactivation modelQ34772718
A chemoattractant-mediated Gi-coupled pathway activates adenylyl cyclase in human neutrophilsQ35613540
Regulation of actin-based cell migration by cAMP/PKA.Q35832749
Conformational changes in the G protein Gs induced by the β2 adrenergic receptorQ36252945
Receptors induce chemotaxis by releasing the betagamma subunit of Gi, not by activating Gq or GsQ36821880
Navigating through models of chemotaxis.Q37061394
Galphai is not required for chemotaxis mediated by Gi-coupled receptorsQ40978871
Inhibition of Rac activation as a mechanism for negative regulation of actin cytoskeletal reorganization and cell motility by cAMPQ42101896
Chemokines and the signaling modules regulating integrin affinityQ42177472
Spatial distribution of protein kinase A activity during cell migration is mediated by A-kinase anchoring protein AKAP Lbc.Q42446982
Chemoattractant receptor-stimulated F-actin polymerization in the human neutrophil is signaled by 2 distinct pathwaysQ44189528
Asymmetrical protein kinase A activity establishes neutrophil cytoskeletal polarity and enables chemotaxis.Q44862134
Leading-edge research: PtdIns(3,4,5)P3 and directed migrationQ50336689
Directional sensing requires G beta gamma-mediated PAK1 and PIX alpha-dependent activation of Cdc42.Q52102307
P-Rex1 directly activates RhoG to regulate GPCR-driven Rac signalling and actin polarity in neutrophils.Q53240397
Inhibition of interleukin-8-activated human neutrophil chemotaxis by thapsigargin in a calcium- and cyclic AMP-dependent wayQ73375412
Localization of the G protein betagamma complex in living cells during chemotaxisQ73434802
P4510describes a project that usesImageJQ1659584
P433issue416
P304page(s)ra22
P577publication date2016-02-23
P1433published inScience SignalingQ7433604
P1476titleDynamic regulation of neutrophil polarity and migration by the heterotrimeric G protein subunits Gαi-GTP and Gβγ
P478volume9

Reverse relations

cites work (P2860)
Q47273282Activated Heterotrimeric G protein αi Subunits Inhibit Rap-Dependent Cell Adhesion and Promote Cell Migration
Q93183846Gβγ signaling to the chemotactic effector P-REX1 and mammalian cell migration is directly regulated by Gαq and Gα13 proteins
Q62567986Membrane Flow Drives an Adhesion-Independent Amoeboid Cell Migration Mode
Q36821853On the selectivity of the Gαq inhibitor UBO-QIC: A comparison with the Gαi inhibitor pertussis toxin.
Q37664759Regulation of Chemokine Signal Integration by Activator of G-Protein Signaling 4 (AGS4).
Q59358337Regulator of G protein signaling 5 restricts neutrophil chemotaxis and trafficking
Q91827049Targeting G protein-coupled receptor signalling by blocking G proteins

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