Valproic acid inhibits the growth of cervical cancer both in vitro and in vivo

scientific article

Valproic acid inhibits the growth of cervical cancer both in vitro and in vivo is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/JB/MVN074
P698PubMed publication ID18515856

P2093author name stringXiaofeng Huang
Han-Mei Xu
Zilong Shen
Naseruddin Höti
Siraj Sami
P2860cites workChronic administration of valproic acid inhibits prostate cancer cell growth in vitro and in vivoQ40253999
Role of hTERT in apoptosis of cervical cancer induced by histone deacetylase inhibitorQ40392211
Histone deacetylase inhibitor, Trichostatin A, activates p21WAF1/CIP1 expression through downregulation of c-myc and release of the repression of c-myc from the promoter in human cervical cancer cellsQ40506047
Triphenyl tin benzimidazolethiol, a novel antitumor agent, induces mitochondrial-mediated apoptosis in human cervical cancer cells via suppression of HPV-18 encoded E6.Q40618206
Functional interplay between modulation of histone deacetylase activity and its regulatory role in G2–M transitionQ40629817
Inhibitors of histone deacetylase arrest cell cycle and induce apoptosis in cervical carcinoma cells circumventing human papillomavirus oncogene expressionQ42657689
Histone deacetylase inhibitor trichostatin A induces cell-cycle arrest/apoptosis and hepatocyte differentiation in human hepatoma cellsQ44257942
Valproic acid inhibits angiogenesis in vitro and in vivoQ44772882
Effects of chronic administration of olanzapine, amitriptyline, haloperidol or sodium valproate in naive and anhedonic ratsQ46556776
Valproic acid induces extracellular signal-regulated kinase 1/2 activation and inhibits apoptosis in endothelial cellsQ46706734
Targeting the heat shock factor 1 by RNA interference: a potent tool to enhance hyperthermochemotherapy efficacy in cervical cancer.Q51792544
Carcinogenicity of human papillomavirusesQ58296516
Histone acetylation and histone deacetylase activity of magnesium valproate in tumor and peripheral blood of patients with cervical cancer. A phase I studyQ24810933
The global health burden of infection-associated cancers in the year 2002Q28290871
Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cellsQ28366303
Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogenQ29616224
Anticancer activities of histone deacetylase inhibitorsQ29616624
Angiogenesis inhibitors: perspectives for medical, surgical and radiation oncologyQ33250215
Valproate and valproate-analogues: potent tools to fight against cancer.Q34144072
Anti-tumor mechanisms of valproate: a novel role for an old drugQ34147644
Valproic acid modulates NCAM polysialylation and polysialyltransferase mRNA expression in human tumor cells.Q34394231
Evolving anticancer drug valproic acid: insights into the mechanism and clinical studies.Q36002354
Angiogenesis in gynecological oncology-mechanism of tumor progression and therapeutic targetsQ36262349
Metastasis: cell-autonomous mechanisms versus contributions by the tumor microenvironmentQ36369889
Role of angiogenesis in human tumor dormancy: animal models of the angiogenic switchQ36576720
Molecular biology of cervical cancerQ36862117
The mood stabilizer valproic acid activates mitogen-activated protein kinases and promotes neurite growthQ38299684
Sodium valproate exerts neuroprotective effects in vivo through CREB-binding protein-dependent mechanisms but does not improve survival in an amyotrophic lateral sclerosis mouse modelQ40128564
Valproic acid, a histone deacetylase inhibitor, is an antagonist for oncolytic adenoviral gene therapyQ40228873
Valproic Acid prolongs survival time of severe combined immunodeficient mice bearing intracerebellar orthotopic medulloblastoma xenograftsQ40245242
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectcervix uterine cancerQ160105
P304page(s)357-362
P577publication date2008-05-31
P1433published inJournal of BiochemistryQ6294839
P1476titleValproic acid inhibits the growth of cervical cancer both in vitro and in vivo
P478volume144

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cites work (P2860)
Q34113695Chromatin remodeling, cell proliferation and cell death in valproic acid-treated HeLa cells
Q36257542DNA Methylation Changes in Valproic Acid-Treated HeLa Cells as Assessed by Image Analysis, Immunofluorescence and Vibrational Microspectroscopy
Q34366588Effects of valproic acid on the cell cycle and apoptosis through acetylation of histone and tubulin in a scirrhous gastric cancer cell line
Q44014855Epilepsy, anti-epileptic medication use and risk of cancer
Q42703577Inhibitory effect of snake venom toxin on NF-κB activity prevents human cervical cancer cell growth via increase of death receptor 3 and 5 expression
Q97419293Metformin inhibits cervical cancer cell proliferation by modulating PI3K/Akt-induced major histocompatibility complex class I-related chain A gene expression
Q39435592Reduced glutamine concentration improves protein production in growth-arrested CHO-DG44 and HEK-293E cells
Q36524716Repurposing antipsychotics as glioblastoma therapeutics: Potentials and challenges
Q37110658Transcriptional regulation of E-cadherin and oncoprotein E7 by valproic acid in HPV positive cell lines
Q38849324Valproic acid induces NET cell growth arrest and enhances tumor suppression of the receptor-targeted peptide-drug conjugate via activating somatostatin receptor type II.
Q36335796Valproic acid inhibits proliferation of HER2-expressing breast cancer cells by inducing cell cycle arrest and apoptosis through Hsp70 acetylation
Q38788965Valproic acid inhibits the angiogenic potential of cervical cancer cells via HIF-1α/VEGF signals
Q39013397Valproic acid inhibits the proliferation of SHSY5Y neuroblastoma cancer cells by downregulating URG4/URGCP and CCND1 gene expression
Q45912062Valproic acid suppresses cervical cancer tumor progression possibly via activating Notch1 signaling and enhances receptor-targeted cancer chemotherapeutic via activating somatostatin receptor type II.
Q51742940miR-2861 as novel HDAC5 inhibitor in CHO cells enhances productivity while maintaining product quality.