Metformin inhibits cervical cancer cell proliferation by modulating PI3K/Akt-induced major histocompatibility complex class I-related chain A gene expression

scientific article published on 06 July 2020

Metformin inhibits cervical cancer cell proliferation by modulating PI3K/Akt-induced major histocompatibility complex class I-related chain A gene expression is …
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scholarly articleQ13442814

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P356DOI10.1186/S13046-020-01627-6
P932PMC publication ID7336474
P698PubMed publication ID32631421

P50authorChenglai XiaQ97419290
P2093author name stringChang Liu
Yantao Cai
Zhihong He
Jinman Chen
P2860cites workHallmarks of Cancer: The Next GenerationQ22252312
p53 in the DNA-Damage-Repair ProcessQ28073944
Functions of natural killer cellsQ29614300
Targeting PI3K signalling in cancer: opportunities, challenges and limitationsQ29617685
Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesisQ33597162
Valproic acid sensitizes pancreatic cancer cells to natural killer cell-mediated lysis by upregulating MICA and MICB via the PI3K/Akt signaling pathwayQ33825014
Retracted: 3, 3'-Diindolylmethane Exhibits Antileukemic Activity In Vitro and In Vivo through a Akt-Dependent ProcessQ34171365
Expression of MICA, MICB and NKG2D in human leukemic myelomonocytic and cervical cancer cellsQ34855104
MICA/B and ULBP1 NKG2D ligands are independent predictors of good prognosis in cervical cancerQ34995302
AMPK-HDAC5 pathway facilitates nuclear accumulation of HIF-1α and functional activation of HIF-1 by deacetylating Hsp70 in the cytosolQ36186609
Metformin impairs the growth of liver kinase B1-intact cervical cancer cells.Q36205053
LY294002, a PI3K pathway inhibitor, prevents leptin-induced adverse effects on spermatozoa in Sprague-Dawley ratsQ93232976
Combining metformin and nelfinavir exhibits synergistic effects against the growth of human cervical cancer cells and xenograft in nude miceQ37676300
Is there a biological plausability for p53 codon 72 polymorphism influence on cervical cancer development?Q37889425
MICA polymorphism: biology and importance in cancerQ38261462
Metformin: A Novel but Controversial Drug in Cancer Prevention and TreatmentQ38597773
An Ancient, Unified Mechanism for Metformin Growth Inhibition in C. elegans and CancerQ38725828
Dual Role of p21 in the Progression of Cancer and Its Treatment.Q38856127
A hypoxia-induced decrease of either MICA/B or Hsp70 on the membrane of tumor cells mediates immune escape from NK cellsQ38967996
The endogenous danger signals HSP70 and MICA cooperate in the activation of cytotoxic effector functions of NK cells.Q39689690
Valproic acid inhibits the growth of cervical cancer both in vitro and in vivoQ39976555
Regulation of the expression of MHC class I-related chain A, B (MICA, MICB) via chromatin remodeling and its impact on the susceptibility of leukemic cells to the cytotoxicity of NKG2D-expressing cellsQ40108262
Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cellsQ40216291
Association between Metformin Use and Mortality after Cervical Cancer in Older Women with Diabetes.Q41006137
Constitutive release of IL6 by human papillomavirus type 16 (HPV16)-harboring keratinocytes: a mechanism augmenting the NK-cell-mediated lysis of HPV-bearing neoplastic cellsQ41673592
The HPV E6/E7 Oncogenes: Key Factors for Viral Carcinogenesis and Therapeutic Targets.Q41947880
Altered phenotype and function of NK cells infiltrating human papillomavirus (HPV)-associated genital warts during HIV infectionQ42232352
Efficacy of a quadrivalent prophylactic human papillomavirus (types 6, 11, 16, and 18) L1 virus-like-particle vaccine against high-grade vulval and vaginal lesions: a combined analysis of three randomised clinical trialsQ44634881
Evaluation of short- and long-term efficacy of chemoradiotherapy for advanced cervical cancer using HSP70 protein combined with multimodal MRI.Q47662747
Achieving ADA/ISPAD clinical guideline goals is associated with higher insulin sensitivity and cardiopulmonary fitness in adolescents with type 1 diabetes: Results from RESistance to InSulin in Type 1 ANd Type 2 diabetes (RESISTANT) and Effects of MQ47725249
The Potential Value of the PI3K/Akt/mTOR Signaling Pathway for Assessing Prognosis in Cervical Cancer and as a Target for TherapyQ48185689
Metformin as an anti-cancer agent: actions and mechanisms targeting cancer stem cells.Q50001260
HSP70 inhibitor combined with cisplatin suppresses the cervical cancer proliferation in vitro and transplanted tumor growth: An experimental study.Q51122640
Targeting the PI3K pathway in cancer: are we making headway?Q52672314
Metformin: Restraining Nucleocytoplasmic Shuttling to Fight Cancer and Aging.Q52812521
MHC class I chain-related gene A (MICA) polymorphism and the different histological types of cervical cancer.Q53657903
Metformin and Autoimmunity: A "New Deal" of an Old Drug.Q55240881
Vorinostat, a pan-HDAC inhibitor, abrogates productive HPV-18 DNA amplificationQ58576079
Hsp90 and Hsp70 chaperones: Collaborators in protein remodelingQ58607367
Roles of heat shock factor 1 beyond the heat shock responseQ60017544
High Glucose with Insulin Induces Cell Cycle Progression and Activation of Oncogenic Signaling of Bladder Epithelial Cells Cotreated with Metformin and PioglitazoneQ61799673
High glucose promotes pancreatic cancer cells to escape from immune surveillance via AMPK-Bmi1-GATA2-MICA/B pathwayQ64056215
Targeting Chemoresistant Tumors: Could TRIM Proteins-p53 Axis Be a Possible Answer?Q64059648
NKG2D/NKG2-Ligand Pathway Offers New Opportunities in Cancer TreatmentQ64102223
Targeting PI3K in cancer: mechanisms and advances in clinical trialsQ64254413
Up-regulation of proliferating cell nuclear antigen (PCNA) is closely associated with high-risk human papillomavirus (HPV) and progression of cervical intraepithelial neoplasia (CIN), but does not predict disease outcome in cervical cancerQ79349338
Surgery after concurrent chemoradiotherapy and brachytherapy for the treatment of advanced cervical cancer: morbidity and outcome: results of a multicenter study of the GCCLCC (Groupe des Chirurgiens de Centre de Lutte Contre le Cancer)Q82672660
Metformin, a first-line drug for type 2 diabetes mellitus, disrupts the MALAT1/miR-142-3p sponge to decrease invasion and migration in cervical cancer cellsQ88500195
The Effect of Metformin on Oncological Outcomes in Patients With Cervical Cancer With Type 2 Diabetes MellitusQ88813151
Recent Advances in Molecular Mechanisms of the NKG2D Pathway in Hepatocellular CarcinomaQ89782122
The Hsp70-Hsp90 Chaperone Cascade in Protein FoldingQ90019327
Cancer statistics, 2019Q90941571
NKT-like cells reveal higher than T lymphocytes expression of cellular protective proteins HSP70 and SOD2 and comparably increased expression of SIRT1 in the oldest seniorsQ91000072
Metformin combined with nelfinavir induces SIRT3/mROS-dependent autophagy in human cervical cancer cells and xenograft in nude miceQ91268385
HSP70/HSF1 axis, regulated via a PI3K/AKT pathway, is a druggable target in chronic lymphocytic leukemiaQ91682182
PI3K/AKT/mTOR Signaling Regulates the Virus/Host Cell Crosstalk in HPV-Positive Cervical Cancer CellsQ91783484
iTRAQ-based quantitative proteomic analysis of the inhibition of cervical cancer cell invasion and migration by metforminQ92171540
The relation between PI3K/AKT signalling pathway and cancerQ92230403
Receptor tyrosine kinases in PI3K signaling: The therapeutic targets in cancerQ92822761
Metformin Modulates Cyclin D1 and P53 Expression to Inhibit Cell Proliferation and to Induce Apoptosis in Cervical Cancer Cell LinesQ93059348
P433issue1
P921main subjectmetforminQ19484
P304page(s)127
P577publication date2020-07-06
P1433published inJournal of Experimental & Clinical Cancer ResearchQ13739415
P1476titleMetformin inhibits cervical cancer cell proliferation by modulating PI3K/Akt-induced major histocompatibility complex class I-related chain A gene expression
P478volume39

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