Reprogramming acyl carrier protein interactions of an Acyl-CoA promiscuous trans-acyltransferase

scientific article

Reprogramming acyl carrier protein interactions of an Acyl-CoA promiscuous trans-acyltransferase is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.CHEMBIOL.2014.02.019
P932PMC publication ID4035391
P698PubMed publication ID24726832
P5875ResearchGate publication ID261608118

P2093author name stringTilmann Weber
Gavin J Williams
Ewa M Musiol
Zhixia Ye
P2860cites workMolecular analysis of the kirromycin biosynthetic gene cluster revealed beta-alanine as precursor of the pyridone moietyQ46740696
Evidence for a protein-protein interaction motif on an acyl carrier protein domain from a modular polyketide synthaseQ48547204
Supramolecular templating in kirromycin biosynthesis: the acyltransferase KirCII loads ethylmalonyl-CoA extender onto a specific ACP of the trans-AT PKSQ83935895
PatchDock and SymmDock: servers for rigid and symmetric dockingQ24813335
Catalysis, specificity, and ACP docking site of Streptomyces coelicolor malonyl-CoA:ACP transacylaseQ27640455
Structural and Mechanistic Analysis of Protein Interactions in Module 3 of the 6-Deoxyerythronolide B SynthaseQ27647550
Structure and malonyl CoA-ACP transacylase binding of streptomyces coelicolor fatty acid synthase acyl carrier proteinQ27656251
Structure and Mechanism of the trans -Acting Acyltransferase from the Disorazole SynthaseQ27670570
Characterization of Molecular Interactions between ACP and Halogenase Domains in the Curacin A Polyketide SynthaseQ27675733
Structure of the Bifunctional Acyltransferase/Decarboxylase LnmK from the Leinamycin Biosynthetic Pathway Revealing Novel Activity for a Double-Hot-Dog FoldQ27675905
Crystal Structure of the Acyltransferase Domain of the Iterative Polyketide Synthase in Enediyne BiosynthesisQ27679103
A conserved motif flags acyl carrier proteins for β-branching in polyketide synthesisQ27680011
The SWISS-MODEL workspace: a web-based environment for protein structure homology modellingQ27860637
Chimera construction using multiple-template-based sequential PCRsQ30393306
Toward the estimation of the absolute quality of individual protein structure modelsQ30397038
Protein-protein recognition between acyltransferases and acyl carrier proteins in multimodular polyketide synthasesQ33584838
Expanding the fluorine chemistry of living systems using engineered polyketide synthase pathways.Q33753331
Oxazolomycin biosynthesis in Streptomyces albus JA3453 featuring an "acyltransferase-less" type I polyketide synthase that incorporates two distinct extender unitsQ33924378
Polyketide biosynthesis: a millennium reviewQ34362914
Molecular recognition between ketosynthase and acyl carrier protein domains of the 6-deoxyerythronolide B synthaseQ34438159
Type I polyketide synthase requiring a discrete acyltransferase for polyketide biosynthesisQ34867101
The 2.7-Angstrom crystal structure of a 194-kDa homodimeric fragment of the 6-deoxyerythronolide B synthase.Q35131209
Reprogramming a module of the 6-deoxyerythronolide B synthase for iterative chain elongationQ35837046
Bifunctional acyltransferase/decarboxylase LnmK as the missing link for beta-alkylation in polyketide biosynthesisQ37230944
How good is automated protein docking?Q37601847
Biosynthesis of polyketides by trans-AT polyketide synthasesQ37750498
Probing the selectivity and protein·protein interactions of a nonreducing fungal polyketide synthase using mechanism-based crosslinkers.Q39357904
Promiscuity of a modular polyketide synthase towards natural and non-natural extender units.Q39417729
Leinamycin biosynthesis revealing unprecedented architectural complexity for a hybrid polyketide synthase and nonribosomal peptide synthetaseQ42625933
Poly specific trans-acyltransferase machinery revealed via engineered acyl-CoA synthetasesQ44122119
The AT₂ domain of KirCI loads malonyl extender units to the ACPs of the kirromycin PKS.Q44144019
Enzyme-directed mutasynthesis: a combined experimental and theoretical approach to substrate recognition of a polyketide synthase.Q44595220
Enhancing the modularity of the modular polyketide synthases: transacylation in modular polyketide synthases catalyzed by malonyl-CoA:ACP transacylaseQ44660311
Fungal type I polyketide synthases.Q46052998
P433issue5
P304page(s)636-646
P577publication date2014-04-10
P1433published inChemistry and BiologyQ15758410
P1476titleReprogramming acyl carrier protein interactions of an Acyl-CoA promiscuous trans-acyltransferase
P478volume21

Reverse relations

cites work (P2860)
Q90242823A dual transacylation mechanism for polyketide synthase chain release in enacyloxin antibiotic biosynthesis
Q64897732Acyltransferases as Tools for Polyketide Synthase Engineering.
Q28828730Biochemical and Structural Basis for Controlling Chemical Modularity in Fungal Polyketide Biosynthesis
Q38675125Biosynthesis of polyketides by trans-AT polyketide synthases
Q57805449Branched late-steps of the cytosolic iron-sulphur cluster assembly machinery of Trypanosoma brucei
Q33792791Comparative analysis of the substrate specificity of trans- versus cis-acyltransferases of assembly line polyketide synthases
Q47215208Engineered polyketides: Synergy between protein and host level engineering.
Q46112896Engineering modular polyketide synthases for production of biofuels and industrial chemicals.
Q93363943Extender Unit Promiscuity and Orthogonal Protein Interactions of an Aminomalonyl-ACP Utilizing Trans-Acyltransferase from Zwittermicin Biosynthesis
Q36578763Harnessing natural product assembly lines: structure, promiscuity, and engineering
Q40967708Identification and activation of novel biosynthetic gene clusters by genome mining in the kirromycin producer Streptomyces collinus Tü 365.
Q94464362Out of the Abyss: Genome and Metagenome Mining Reveals Unexpected Environmental Distribution of Abyssomicins
Q40330330Polyketide Bioderivatization Using the Promiscuous Acyltransferase KirCII.
Q26766621Recent Advances in Understanding and Engineering Polyketide Synthesis
Q96155794Repurposing Modular Polyketide Synthases and Non-ribosomal Peptide Synthetases for Novel Chemical Biosynthesis
Q97425379Site directed mutagenesis as a precision tool to enable synthetic biology with engineered modular polyketide synthases
Q36607621Structure-based analysis of the molecular interactions between acyltransferase and acyl carrier protein in vicenistatin biosynthesis.
Q58797337Substrate Specificity of Acyltransferase Domains for Efficient Transfer of Acyl Groups
Q39024817The ClusPro web server for protein-protein docking
Q36535715The LINKS motif zippers trans-acyltransferase polyketide synthase assembly lines into a biosynthetic megacomplex.
Q47104996The secondary metabolite bioinformatics portal: Computational tools to facilitate synthetic biology of secondary metabolite production.

Search more.