Sulfinosine enhances doxorubicin efficacy through synergism and by reversing multidrug resistance in the human non-small cell lung carcinoma cell line (NCI-H460/R).

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Sulfinosine enhances doxorubicin efficacy through synergism and by reversing multidrug resistance in the human non-small cell lung carcinoma cell line (NCI-H460/R). is …
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scholarly articleQ13442814

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P356DOI10.1007/S10637-008-9140-5
P698PubMed publication ID18493718

P50authorMilica PesicQ53475508
Ivanka MarkovićQ54165998
P2093author name stringSabera Ruzdijić
Jasna Banković
Ljubisa Rakić
Tijana Andjelković
P2860cites workConsequences of 6-thioguanine incorporation into DNA on polymerase, ligase, and endonuclease reactionsQ54671388
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Paradoxical behavior of 6-mercaptopurine as a cytotoxic agent: decreasing cell kill with increasing drug doseQ71230758
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The combination of sulfinosine and 8-Cl-cAMP induces synergistic cell growth inhibition of the human neuroblastoma cell line in vitro.Q40335896
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Sulfinosine-induced cell growth inhibition and apoptosis in human lung carcinomas in vitroQ40707959
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Altered expression of mRNAs for apoptosis-modulating proteins in a low level multidrug resistant variant of a human lung carcinoma cell line that also expresses mdr1 mRNA.Q40942841
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Verapamil and adriamycin in the treatment of drug-resistant ovarian cancer patientsQ41328786
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Cellular and biochemical characterization of thioxanthenes for reversal of multidrug resistance in human and murine cell linesQ41740569
Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents.Q42445479
Synthesis and in vivo antitumor activity of 2-amino-9H-purine-6-sulfenamide, -sulfinamide, and -sulfonamide and related purine ribonucleosidesQ46084000
Chemotherapeutic characterization in mice of 2-amino-9-beta-D-ribofuranosylpurine-6-sulfinamide (sulfinosine), a novel purine nucleoside with unique antitumor propertiesQ46731670
Cloning and sequence analysis of the promoter region of the MRP gene of HL60 cells isolated for resistance to adriamycinQ48079979
P433issue2
P921main subjectlung carcinomaQ18556110
cell lineQ21014462
doxorubicinQ18936
multiple drug resistanceQ643839
P304page(s)99-110
P577publication date2008-05-21
P1433published inInvestigational New DrugsQ2312231
P1476titleSulfinosine enhances doxorubicin efficacy through synergism and by reversing multidrug resistance in the human non-small cell lung carcinoma cell line (NCI-H460/R)
P478volume27

Reverse relations

cites work (P2860)
Q28478340Oleanolic acid initiates apoptosis in non-small cell lung cancer cell lines and reduces metastasis of a B16F10 melanoma model in vivo
Q39837066Purine analogs sensitize the multidrug resistant cell line (NCI-H460/R) to doxorubicin and stimulate the cell growth inhibitory effect of verapamil.
Q28484976Purine nucleoside analog--sulfinosine modulates diverse mechanisms of cancer progression in multi-drug resistant cancer cell lines
Q38950071Trametenolic acid B reverses multidrug resistance in breast cancer cells through regulating the expression level of P-glycoprotein