Ikaros dominant negative isoform (Ik6) induces IL-3-independent survival of murine pro-B lymphocytes by activating JAK-STAT and up-regulating Bcl-xl levels

scientific article

Ikaros dominant negative isoform (Ik6) induces IL-3-independent survival of murine pro-B lymphocytes by activating JAK-STAT and up-regulating Bcl-xl levels is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1080/10428190801993462
P8608Fatcat IDrelease_4uypcb5wgfbufp4yvfb7vhmyku
P698PubMed publication ID18464116
P5875ResearchGate publication ID5387725

P2093author name stringAkira Morimoto
Shinsaku Imashuku
Tohru Sugimoto
Gen Kano
Tohru Inaba
Mami Takanashi
Shigeyoshi Hibi
Tomohito Yagi
P2860cites workCD45 is a JAK phosphatase and negatively regulates cytokine receptor signallingQ24290848
Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1Q24308005
A family of cytokine-inducible inhibitors of signallingQ24313168
Expression of dominant-negative and mutant isoforms of the antileukemic transcription factor Ikaros in infant acute lymphoblastic leukemiaQ24554417
The role of the Ikaros gene in lymphocyte development and homeostasisQ28237613
STATs and gene regulationQ29547796
STAT proteins as novel targets for cancer therapy. Signal transducer an activator of transcriptionQ33767810
Regulation of Bcl-xL: a little bit of this and a little bit of STAT.Q34086142
Ikaros, Aiolos and Helios: transcription regulators and lymphoid malignanciesQ34197736
Selective defects in the development of the fetal and adult lymphoid system in mice with an Ikaros null mutationQ34412659
Association of transcriptionally silent genes with Ikaros complexes at centromeric heterochromatinQ34450725
Haematopoietic cell-fate decisions, chromatin regulation and ikarosQ34576408
Defects in hemopoietic stem cell activity in Ikaros mutant miceQ36375493
Perturbation of Ikaros isoform selection by MLV integration is a cooperative event in Notch(IC)-induced T cell leukemogenesisQ38352939
BCR-ABL1 induces aberrant splicing of IKAROS and lineage infidelity in pre-B lymphoblastic leukemia cellsQ40365403
CD45-deficient mice accumulate Pro-B cells both in vivo and in vitroQ40528356
Role of the protein tyrosine phosphatase SHP-1 (Src homology phosphatase-1) in the regulation of interleukin-3-induced survival, proliferation and signallingQ40705311
Non-DNA-binding Ikaros isoform gene expressed in adult B-precursor acute lymphoblastic leukemiaQ40721250
High frequency of Ikaros isoform 6 expression in acute myelomonocytic and monocytic leukemias: implications for up-regulation of the antiapoptotic protein Bcl-XL in leukemogenesisQ40752507
Role of phosphatidylinositol 3-kinase and specific protein kinase B isoforms in the suppression of apoptosis mediated by the Abelson protein-tyrosine kinaseQ40884544
STAT5 interaction with the T cell receptor complex and stimulation of T cell proliferation.Q40982703
Activation of hematopoietic growth factor signal transduction pathways by the human oncogene BCR/ABL.Q41489968
Ikaros isoforms in human pituitary tumors: distinct localization, histone acetylation, and activation of the 5' fibroblast growth factor receptor-4 promoterQ41854991
Regulation of interleukin-3-induced substrate phosphorylation and cell survival by SHP-2 (Src-homology protein tyrosine phosphatase 2).Q42788780
Expression of the Ikaros gene family in childhood acute lymphoblastic leukaemiaQ44004531
Overexpression of dominant-negative Ikaros 6 protein is restricted to a subset of B common adult acute lymphoblastic leukemias that express high levels of the CD34 antigenQ44443472
Widespread failure of hematolymphoid differentiation caused by a recessive niche-filling allele of the Ikaros transcription factorQ44519043
Overexpression of the Ikaros 6 isoform is restricted to t(4;11) acute lymphoblastic leukaemia in children and infants and has a role in B-cell survivalQ44796463
Prognostic role of bcl-xL and p53 in childhood acute lymphoblastic leukemia (ALL).Q45246710
Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets.Q46001789
CD54 and CD62L expression by lymphoid cells in acute lymphoblastic leukaemia in childrenQ46599711
P433issue5
P304page(s)965-973
P577publication date2008-05-01
P1433published inLeukemia & LymphomaQ6534493
P1476titleIkaros dominant negative isoform (Ik6) induces IL-3-independent survival of murine pro-B lymphocytes by activating JAK-STAT and up-regulating Bcl-xl levels
P478volume49

Reverse relations

cites work (P2860)
Q34846643A novel, non-canonical splice variant of the Ikaros gene is aberrantly expressed in B-cell lymphoproliferative disorders.
Q39163794Adult T-cell leukemia cells are characterized by abnormalities of Helios expression that promote T cell growth
Q54426186Deletions of the transcription factor Ikaros in myeloproliferative neoplasms.
Q38066786Genetic and epigenetic alterations of myeloproliferative disorders
Q38159973Genetic basis of MPN: Beyond JAK2-V617F.
Q34358106IKAROS deletions dictate a unique gene expression signature in patients with adult B-cell acute lymphoblastic leukemia
Q90659924IKZF1 genetic variants rs4132601 and rs11978267 and acute lymphoblastic leukemia risk in Tunisian children: a case-control study
Q37157434Ikaros and acute leukemia
Q38371003Ikaros and leukaemia
Q37965798Ikaros and tumor suppression in acute lymphoblastic leukemia
Q37796303Ikaros in immune receptor signaling, lymphocyte differentiation, and function.
Q42057738Ikaros: master of hematopoiesis, agent of leukemia
Q42376333Overexpression of dominant-negative Ikaros 6 isoform is associated with resistance to TKIs in patients with Philadelphia chromosome positive acute lymphoblastic leukemia
Q30400144Programming the magnitude and persistence of antibody responses with innate immunity
Q35103926Regulator of myeloid differentiation and function: The secret life of Ikaros
Q37619813Targeting of heme oxygenase-1 attenuates the negative impact of Ikaros isoform 6 in adult BCR-ABL1-positive B-ALL.