Transcription mediated by NFAT is highly inducible in effector CD4+ T helper 2 (Th2) cells but not in Th1 cells

scientific article published on March 1997

Transcription mediated by NFAT is highly inducible in effector CD4+ T helper 2 (Th2) cells but not in Th1 cells is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1128/MCB.17.3.1522
P932PMC publication ID231878
P698PubMed publication ID9032280

P50authorRichard FlavellQ2149481
Mercedes RincónQ97069657
P2860cites workNFATx, a novel member of the nuclear factor of activated T cells family that is expressed predominantly in the thymusQ24316786
Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteinsQ24317724
Characterization of antigen receptor response elements within the interleukin-2 enhancerQ24632042
Activation and expression of the nuclear factors of activated T cells, NFATp and NFATc, in human natural killer cells: regulation upon CD16 ligand bindingQ24678802
Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cellsQ27860599
NF-AT components define a family of transcription factors targeted in T-cell activationQ28114991
The role of the CD28 receptor during T cell responses to antigenQ28263234
The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and JunQ28263918
B7, a new member of the Ig superfamily with unique expression on activated and neoplastic B cellsQ28279870
Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factorQ28288345
Purified transcription factor AP-1 interacts with TPA-inducible enhancer elementsQ28288355
Isolation of the cyclosporin-sensitive T cell transcription factor NFATpQ28511815
NFATc3, a Lymphoid-specific NFATc Family Member That Is Calcium-regulated and Exhibits Distinct DNA Binding SpecificityQ28591436
TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional propertiesQ29547848
Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophagesQ29618421
Identification of calcineurin as a key signalling enzyme in T-lymphocyte activationQ29620223
The mechanism of action of cyclosporin A and FK506Q30014847
Identification of a putative regulator of early T cell activation genesQ34171263
Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulationQ34591923
Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivoQ36353340
Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cellsQ36353430
Transcription of the interleukin 4 gene is regulated by multiple promoter elementsQ36361828
Two essential regulatory elements in the human interferon gamma promoter confer activation specific expression in T cellsQ36362494
Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouseQ36364541
Extent of T cell receptor ligation can determine the functional differentiation of naive CD4+ T cellsQ36365491
Regulation of AP-1 and NFAT transcription factors during thymic selection of T cellsQ36557490
Molecular dissection of the mouse interleukin-4 promoterQ36607974
Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such primingQ36638672
B70 antigen is a second ligand for CTLA-4 and CD28Q36697598
A common factor regulates both Th1- and Th2-specific cytokine gene expressionQ37628403
AP-1 transcriptional activity requires both T-cell receptor-mediated and co-stimulatory signals in primary T lymphocytes.Q37636349
Coordinate and cooperative roles for NF-AT and AP-1 in the regulation of the murine IL-4 geneQ38295828
Cyclosporin-A sensitive induction of NF-AT in murine B cellsQ38307826
Identification of cis-acting regulatory elements controlling interleukin-4 gene expression in T cells: roles for NF-Y and NF-ATcQ38317270
Comparative analysis of NFAT (nuclear factor of activated T cells) complex in human T and B lymphocytes.Q38317669
The NFAT-1 DNA binding complex in activated T cells contains Fra-1 and JunB.Q38321239
Characterization of the nuclear and cytoplasmic components of the lymphoid-specific nuclear factor of activated T cells (NF-AT) complex.Q38321848
Molecular basis for developmental changes in interleukin-2 gene inducibilityQ38322912
Cyclosporin A specifically inhibits function of nuclear proteins involved in T cell activationQ38342696
Hyperproliferation and dysregulation of IL-4 expression in NF-ATp-deficient miceQ38359933
Clonal expansion versus functional clonal inactivation: a costimulatory signalling pathway determines the outcome of T cell antigen receptor occupancyQ38624477
Multiple closely-linked NFAT/octamer and HMG I(Y) binding sites are part of the interleukin-4 promoterQ40412449
Lymphocyte responses and cytokinesQ40620203
Characterization of motifs which are critical for activity of the cyclic AMP-responsive transcription factor CREBQ40677556
NF-ATp: a transcription factor required for the co-ordinate induction of several cytokine genesQ40693171
Ubiquitous and lymphocyte-specific factors are involved in the induction of the mouse interleukin 2 gene in T lymphocytesQ40817161
An enhanced immune response in mice lacking the transcription factor NFAT1.Q41199166
Functional role and signal-induced modulation of proteins recognizing the conserved TCATTT-containing promoter elements in the murine IL-5 and GM-CSF genes in T lymphocytes.Q41435530
JNK is involved in signal integration during costimulation of T lymphocytes.Q41461688
Induction of NF-AT in normal B lymphocytes by anti-immunoglobulin or CD40 ligand in conjunction with IL-4.Q41465837
FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurinQ41618754
Cell type specificity and activation requirements for NFAT-1 (nuclear factor of activated T-cells) transcriptional activity determined by a new method using transgenic mice to assay transcriptional activity of an individual nuclear factorQ41721375
Altered peptide ligands can control CD4 T lymphocyte differentiation in vivoQ41761641
Murine B7-2, an alternative CTLA4 counter-receptor that costimulates T cell proliferation and interleukin 2 productionQ41853080
B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapyQ42675165
Effect of liposomal model membrane composition on immunogenicityQ44507627
Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptorQ46155874
Single cell assay of a transcription factor reveals a threshold in transcription activated by signals emanating from the T-cell antigen receptor.Q46195210
IL-4 directs the development of Th2-like helper effectorsQ46390956
Naive versus memory CD4 T cell response to antigen. Memory cells are less dependent on accessory cell costimulation and can respond to many antigen-presenting cell types including resting B cellsQ46681487
Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin AQ46979889
Establishment of stable, cell-mediated immunity that makes "susceptible" mice resistant to Leishmania major.Q54265963
Nuclear factor of activated T cells contains Fos and Jun.Q54271859
Human T cell activation through the activation-inducer molecule/CD69 enhances the activity of transcription factor AP-1Q58064746
Binding of a nuclear protein to the cyclic-AMP response element of the somatostatin geneQ59084755
The relationship of IL-4- and IFNγ-producing T cells studied by lineage ablation of IL-4-producing cellsQ63363245
Characterization of the constitutive and inducible components of a T cell IL-4 activation responsive elementQ72169111
P433issue3
P407language of work or nameEnglishQ1860
P304page(s)1522-1534
P577publication date1997-03-01
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleTranscription mediated by NFAT is highly inducible in effector CD4+ T helper 2 (Th2) cells but not in Th1 cells
P478volume17

Reverse relations

cites work (P2860)
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