Promoter Selective Transcriptional Synergy Mediated by Sterol Regulatory Element Binding Protein and Sp1: a Critical Role for the Btd Domain of Sp1

scientific article published on September 1, 1997

Promoter Selective Transcriptional Synergy Mediated by Sterol Regulatory Element Binding Protein and Sp1: a Critical Role for the Btd Domain of Sp1 is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1128/MCB.17.9.5193
P953full work available at URLhttp://mcb.asm.org/cgi/content/abstract/17/9/5193
https://europepmc.org/articles/PMC232370
https://europepmc.org/articles/pmc232370?pdf=render
https://europepmc.org/articles/PMC232370?pdf=render
https://journals.asm.org/doi/pdf/10.1128/MCB.17.9.5193
https://www.tandfonline.com/doi/pdf/10.1128/MCB.17.9.5193
P932PMC publication ID232370
P698PubMed publication ID9271397

P2093author name stringH. B. Sanchez
T. F. Osborne
J. N. Athanikar
P2860cites workSp1-mediated transcriptional activation is repressed by Sp3Q40792899
Transcriptional control mechanisms in the regulation of cholesterol balance.Q41133890
Hairpin orientation of sterol regulatory element-binding protein-2 in cell membranes as determined by protease protectionQ41260355
Cooperation by sterol regulatory element-binding protein and Sp1 in sterol regulation of low density lipoprotein receptor geneQ41379512
Identification of nucleotides responsible for enhancer activity of sterol regulatory element in low density lipoprotein receptor gene.Q41744326
A nuclear factor for interleukin-6 expression (NF-IL6) and the glucocorticoid receptor synergistically activate transcription of the rat alpha 1-acid glycoprotein gene via direct protein-protein interactionQ42127094
Negative regulation of Sp1 trans-activation is correlated with the binding of cellular proteins to the amino terminus of the Sp1 trans-activation domainQ42496209
ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolismQ42813608
Two tandem binding sites for sterol regulatory element binding proteins are required for sterol regulation of fatty-acid synthase promoterQ46133867
Different activation domains of Sp1 govern formation of multimers and mediate transcriptional synergismQ46405351
Role for sterol regulatory element binding protein in the regulation of farnesyl diphosphate synthase and in the control of cellular levels of cholesterol and triglyceride: evidence from sterol regulation-defective cells.Q46810732
Sp3 is a bifunctional transcription regulator with modular independent activation and repression domainsQ52552243
Promoter-specific activation of RNA polymerase II transcription by Sp1Q60017602
Sterol-dependent repression of low density lipoprotein receptor promoter mediated by 16-base pair sequence adjacent to binding site for transcription factor Sp1Q68127112
Three direct repeats and a TATA-like sequence are required for regulated expression of the human low density lipoprotein receptor geneQ69139568
NF-Y has a novel role in sterol-dependent transcription of two cholesterogenic genesQ72036717
SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysisQ24310555
SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory elementQ24318461
Cloning of GT box-binding proteins: a novel Sp1 multigene family regulating T-cell receptor gene expressionQ24337872
Functional analyses of the transcription factor Sp4 reveal properties distinct from Sp1 and Sp3Q28119159
The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factorQ28238069
Synergistic activation by the glutamine-rich domains of human transcription factor Sp1Q28245874
Nuclear protein that binds sterol regulatory element of low density lipoprotein receptor promoter. II. Purification and characterizationQ28259817
SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor geneQ28264180
Structure of the human gene encoding sterol regulatory element binding protein-1 (SREBF1) and localization of SREBF1 and SREBF2 to chromosomes 17p11.2 and 22q13Q28301916
Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segmentQ28644805
Sterol regulation of fatty acid synthase promoter. Coordinate feedback regulation of two major lipid pathwaysQ28646508
Regulation of the mevalonate pathwayQ29547763
Analysis of Sp1 in vivo reveals multiple transcriptional domains, including a novel glutamine-rich activation motifQ29620290
The promoter-specific transcription factor Sp1 binds to upstream sequences in the SV40 early promoterQ29620405
Domains of transcription factor Sp1 required for synergistic activation with sterol regulatory element binding protein 1 of low density lipoprotein receptor promoterQ34186131
Functional interactions between the retinoblastoma (Rb) protein and Sp-family members: superactivation by Rb requires amino acids necessary for growth suppressionQ34396889
Independent regulation of sterol regulatory element-binding proteins 1 and 2 in hamster liverQ34664294
An interaction between the DNA-binding domains of RelA(p65) and Sp1 mediates human immunodeficiency virus gene activationQ36666995
ADD1: a novel helix-loop-helix transcription factor associated with adipocyte determination and differentiationQ36694542
Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1aQ37360326
Sterol regulation of acetyl coenzyme A carboxylase: a mechanism for coordinate control of cellular lipidQ37728908
The retinoblastoma gene product RB stimulates Sp1-mediated transcription by liberating Sp1 from a negative regulatorQ38306731
A Drosophila homologue of human Sp1 is a head-specific segmentation gene.Q38313324
HTLV-I Tax protein stimulation of DNA binding of bZIP proteins by enhancing dimerizationQ38315223
Nuclear protein that binds sterol regulatory element of low density lipoprotein receptor promoter. I. Identification of the protein and delineation of its target nucleotide sequence.Q38317616
Antitumor promotion and antiinflammation: down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormoneQ38339139
P433issue9
P407language of work or nameEnglishQ1860
P921main subjecttranscriptionQ177900
promoterQ224093
CCAAT-enhancer-binding proteinsQ907967
Helix-Loop-Helix motifsQ70683285
Drosophila proteinsQ76518326
P304page(s)5193-5200
P577publication date1997-09-01
P1433published inMolecular and Cellular BiologyQ3319478
P1476titlePromoter Selective Transcriptional Synergy Mediated by Sterol Regulatory Element Binding Protein and Sp1: a Critical Role for the Btd Domain of Sp1
P478volume17

Reverse relations

cites work (P2860)
Q46816688A novel functional interaction between the Sp1-like protein KLF13 and SREBP-Sp1 activation complex underlies regulation of low density lipoprotein receptor promoter function
Q40508556A simple promoter containing two Sp1 sites controls the expression of sterol-regulatory-element-binding protein 1a (SREBP-1a).
Q47891691Acetyl-CoA carboxylase beta gene is regulated by sterol regulatory element-binding protein-1 in liver
Q40975184Activation of Sp1 and its functional co-operation with serum amyloid A-activating sequence binding factor in synoviocyte cells trigger synergistic action of interleukin-1 and interleukin-6 in serum amyloid A gene expression
Q28275445CBP Is Required for Sterol-regulated and Sterol Regulatory Element-binding Protein-regulated Transcription
Q44941998Characterization of human NLZ1/ZNF703 identifies conserved domains essential for proper subcellular localization and transcriptional repression
Q34101258Cholesterol and caveolae: structural and functional relationships
Q35210134Chromatin, TAFs, and a novel multiprotein coactivator are required for synergistic activation by Sp1 and SREBP-1a in vitro
Q28142804Co-stimulation of promoter for low density lipoprotein receptor gene by sterol regulatory element-binding protein and Sp1 is specifically disrupted by the yin yang 1 protein
Q37482957Curcumin inhibits srebp-2 expression in activated hepatic stellate cells in vitro by reducing the activity of specificity protein-1
Q54291501Dietary fat source alters hepatic gene expression profile and determines the type of liver pathology in rats overfed via total enteral nutrition
Q38315531Different sterol regulatory element-binding protein-1 isoforms utilize distinct co-regulatory factors to activate the promoter for fatty acid synthase.
Q28281340Direct interaction between USF and SREBP-1c mediates synergistic activation of the fatty-acid synthase promoter
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Q40142837Expression of the rat sterol regulatory element-binding protein-1c gene in response to insulin is mediated by increased transactivating capacity of specificity protein 1 (Sp1).
Q40963157FIRE3 in the promoter of the rat fatty acid synthase (FAS) gene binds the ubiquitous transcription factors CBF and USF but does not mediate an insulin response in a rat hepatoma cell line
Q35851299Gene regulation by Sp1 and Sp3.
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Q28506083Kr-pok increases FASN expression by modulating the DNA binding of SREBP-1c and Sp1 at the proximal promoter
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Q42454022Progesterone Regulates Transcription of the p21 Cyclindependent Kinase Inhibitor Gene through Sp1 and CBP/p300
Q43154975Proto-oncogene FBI-1 (Pokemon) and SREBP-1 synergistically activate transcription of fatty-acid synthase gene (FASN).
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Q34922462Regulation of the activity of Sp1-related transcription factors.
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Q39822654Sp1 coordinately regulates de novo lipogenesis and proliferation in cancer cells
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Q35666951Sterol regulation of human fatty acid synthase promoter I requires nuclear factor-Y- and Sp-1-binding sites
Q28511448Sterol regulatory element binding protein 1a regulates hepatic fatty acid partitioning by activating acetyl coenzyme A carboxylase 2
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Q28076855The Role of the Ubiquitously Expressed Transcription Factor Sp1 in Tissue-specific Transcriptional Regulation and in Disease
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Q26778594Transcriptional regulation of hepatic lipogenesis
Q28204504Transcriptional regulation of the murine acetyl-CoA synthetase 1 gene through multiple clustered binding sites for sterol regulatory element-binding proteins and a single neighboring site for Sp1

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