An ancestral retroviral protein identified as a therapeutic target in type-1 diabetes

scientific article published on 7 September 2017

An ancestral retroviral protein identified as a therapeutic target in type-1 diabetes is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1172/JCI.INSIGHT.94387
P932PMC publication ID5621895
P698PubMed publication ID28878130

P50authorJean-Louis TouraineQ12923
Hervé PerronQ110871612
P2093author name stringJacques Portoukalian
Raphaële Germi
Julie Medina
Marine Seffals
Thomas Piofczyk
Sandrine Levet
Julie Dimier
Amandine Demolder
Julie Joanou
Kevin Réant
Matthieu Normand
Nelly Queruel
P2860cites workImmunoproteomic Profiling of Antiviral Antibodies in New-Onset Type 1 Diabetes Using Protein ArraysQ21972778
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Abnormalities of the Exocrine Pancreas in Type 1 DiabetesQ28086876
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Multiple sclerosis-associated retrovirus particles cause T lymphocyte-dependent death with brain hemorrhage in humanized SCID mice modelQ48388046
A placebo randomized controlled study to test the efficacy and safety of GNbAC1, a monoclonal antibody for the treatment of multiple sclerosis - Rationale and designQ48505260
Detection of enterovirus in the islet cells of patients with type 1 diabetes: what do we learn from immunohistochemistry? Reply to Hansson SF, Korsgren S, Pontén F et al [letter].Q51852586
Circulating antibodies against an exocrine pancreatic enzyme in type 1 diabetesQ73224777
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Infrequency of detection of particle-associated MSRV/HERV-W RNA in the synovial fluid of patients with rheumatoid arthritisQ74312784
Multiple sclerosis retrovirus particles and recombinant envelope trigger an abnormal immune response in vitro, by inducing polyclonal Vbeta16 T-lymphocyte activationQ74449251
The IDDMK(1,2)22 retrovirus is not detectable in either mRNA or genomic DNA from patients with type 1 diabetesQ77804985
Dysregulated Toll-like receptor expression and signaling in bone marrow-derived macrophages at the onset of diabetes in the non-obese diabetic mouseQ83853916
The envelope protein of a human endogenous retrovirus-W family activates innate immunity through CD14/TLR4 and promotes Th1-like responsesQ83918234
Toll-like receptor 4 (TLR4) expression in human and murine pancreatic beta-cells affects cell viability and insulin homeostasisQ33830986
Demonstration of increased toll-like receptor 2 and toll-like receptor 4 expression in monocytes of type 1 diabetes mellitus patients with microvascular complicationsQ33937994
Lipopolysaccharides impair insulin gene expression in isolated islets of Langerhans via Toll-Like Receptor-4 and NF-κB signallingQ34257301
Increased immune cell infiltration of the exocrine pancreas: a possible contribution to the pathogenesis of type 1 diabetes.Q34393311
Blood and islet phenotypes indicate immunological heterogeneity in type 1 diabetesQ34393377
Expression and activation by Epstein Barr virus of human endogenous retroviruses-W in blood cells and astrocytes: inference for multiple sclerosisQ34427836
Human endogenous retrovirus protein activates innate immunity and promotes experimental allergic encephalomyelitis in miceQ35063712
Beta cell expression of endogenous xenotropic retrovirus distinguishes diabetes-susceptible NOD/Lt from resistant NON/Lt miceQ35612750
Toll-like receptor 4 on islet β cells senses expression changes in high-mobility group box 1 and contributes to the initiation of type 1 diabetesQ35952134
Inflammatory response of endothelial cells to a human endogenous retrovirus associated with multiple sclerosis is mediated by TLR4.Q36224032
Increased toll-like receptor (TLR) 2 and TLR4 expression in monocytes from patients with type 1 diabetes: further evidence of a proinflammatory stateQ36459935
The pathogenesis and natural history of type 1 diabetesQ36526611
Insulitis and β-Cell Mass in the Natural History of Type 1 Diabetes.Q36608775
Human endogenous retrovirus type W envelope expression in blood and brain cells provides new insights into multiple sclerosis disease.Q36613374
Molecular identification of a novel retrovirus repeatedly isolated from patients with multiple sclerosis. The Collaborative Research Group on Multiple SclerosisQ36661594
Human Endogenous Retrovirus and Neuroinflammation in Chronic Inflammatory Demyelinating Polyradiculoneuropathy.Q36869897
Type 1 diabetes as a relapsing-remitting disease?Q36992950
The role of the innate immune system in destruction of pancreatic beta cells in NOD mice and humans with type I diabetesQ36995532
The human endogenous retrovirus link between genes and environment in multiple sclerosis and in multifactorial diseases associating neuroinflammationQ37583679
Pathogenesis of type 1 diabetes mellitus: interplay between enterovirus and hostQ37721131
Immune cell crosstalk in type 1 diabetesQ37767586
CD4 T cell differentiation in type 1 diabetes.Q38535279
The potential role of retroviruses in autoimmunityQ38673415
The role of molecular mimicry and other factors in the association of Human Endogenous Retroviruses and autoimmunityQ38714224
Type 1 diabetes pathogenesis is modulated by spontaneous autoimmune responses to endogenous retrovirus antigens in NOD miceQ40382425
MSRV envelope protein is a potent, endogenous and pathogenic agonist of human toll-like receptor 4: Relevance of GNbAC1 in multiple sclerosis treatmentQ40921697
Human endogenous retrovirus-K contributes to motor neuron disease.Q40971963
Enterovirus infection and type 1 diabetes: closing in on a link?Q41290004
Human endogenous retrovirus W in brain lesions: Rationale for targeted therapy in multiple sclerosisQ42050724
Low HERV-K(C4) copy number is associated with type 1 diabetesQ42242979
Human cytomegalovirus (HCMV) induces human endogenous retrovirus (HERV) transcriptionQ42256195
Evaluation of the fidelity of immunolabelling obtained with clone 5D8/1, a monoclonal antibody directed against the enteroviral capsid protein, VP1, in human pancreas.Q42257763
Glucose Sensitivity and Metabolism-Secretion Coupling Studied during Two-Year Continuous Culture in INS-1E Insulinoma CellsQ42798453
Isolation of retrovirus from patients with multiple sclerosisQ44459265
No evidence for association between IDDMK(1,2)22, a novel isolated retrovirus, and IDDM.Q44834533
Human endogenous retrovirus type W envelope protein inhibits oligodendroglial precursor cell differentiationQ45193847
Regulation of human endogenous retrovirus W protein expression by herpes simplex virus type 1: implications for multiple sclerosisQ45418058
Detection of enterovirus in the islet cells of patients with type 1 diabetes: what do we learn from immunohistochemistry?Q46087400
Pancreas organ weight in individuals with disease-associated autoantibodies at risk for type 1 diabetes.Q47266966
Human endogenous retrovirus with a high genomic sequence homology with IDDMK(1,2)22 is not specific for Type I (insulin-dependent) diabetic patients but ubiquitousQ47967171
A human endogenous retroviral superantigen as candidate autoimmune gene in type I diabetesQ48047077
P433issue17
P921main subjecttype-1 diabetesQ124407
P577publication date2017-09-07
P1433published inJCI insightQ27727187
P1476titleAn ancestral retroviral protein identified as a therapeutic target in type-1 diabetes
P478volume2

Reverse relations

cites work (P2860)
Q64104092Anti-HERV-W antibodies are correlated with seroreactivity against Mycobacterium avium subsp. paratuberculosis in children and youths at T1D risk
Q91693298Endogenous Retroviruses Activity as a Molecular Signature of Neurodevelopmental Disorders
Q52338720HERV Envelope Proteins: Physiological Role and Pathogenic Potential in Cancer and Autoimmunity.
Q58610985HERV-W env regulates calcium influx via activating TRPC3 channel together with depressing DISC1 in human neuroblastoma cells
Q58754303Human Endogenous Retroviruses Are Ancient Acquired Elements Still Shaping Innate Immune Responses
Q52351424Human Endogenous Retroviruses in Neurological Diseases.
Q60046088Induction of Proinflammatory Multiple Sclerosis-Associated Retrovirus Envelope Protein by Human Herpesvirus-6A and CD46 Receptor Engagement
Q64078328Quantitative analysis of human endogenous retrovirus-K transcripts in postmortem premotor cortex fails to confirm elevated expression of HERV-K RNA in amyotrophic lateral sclerosis
Q58552569Rabbit models of human diseases for diagnostics and therapeutics development
Q60044236Variation in proviral content among human genomes mediated by LTR recombination

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