Activation of FAK/PI3K/Rac1 signaling controls actin reorganization and inhibits cell motility in human cancer cells

scientific article published on January 2007

Activation of FAK/PI3K/Rac1 signaling controls actin reorganization and inhibits cell motility in human cancer cells is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1159/000110458
P8608Fatcat IDrelease_ggod4cw5vjhjfo27yzjzshrgqe
P698PubMed publication ID17982280

P50authorSofia AgelakiQ112876311
P2093author name stringVassilis Georgoulias
Christos Stournaras
Galatea Kallergi
Harris Markomanolaki
P2860cites workTyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinasesQ24306594
Evidence for in vivo phosphorylation of the Grb2 SH2-domain binding site on focal adhesion kinase by Src-family protein-tyrosine kinasesQ24336665
Control of motile and invasive cell phenotypes by focal adhesion kinase.Q35832728
The interaction of activated integrin lymphocyte function-associated antigen 1 with ligand intercellular adhesion molecule 1 induces activation and redistribution of focal adhesion kinase and proline-rich tyrosine kinase 2 in T lymphocytes.Q38611804
P433issue6
P304page(s)977-986
P577publication date2007-01-01
P1433published inCellular Physiology and BiochemistryQ2229420
P1476titleActivation of FAK/PI3K/Rac1 signaling controls actin reorganization and inhibits cell motility in human cancer cells
P478volume20

Reverse relations

cites work (P2860)
Q35372694A novel synthetic small molecule YH-306 suppresses colorectal tumour growth and metastasis via FAK pathway
Q37662920A proteomics approach to identifying novel protein targets involved in erinacine A-mediated inhibition of colorectal cancer cells' aggressiveness.
Q33698097A unified 35-gene signature for both subtype classification and survival prediction in diffuse large B-cell lymphomas
Q34500702Activation of Membrane Androgen Receptors in Colon Cancer Inhibits the Prosurvival Signals Akt/Bad In Vitro and In Vivo and Blocks Migration via Vinculin/Actin Signaling
Q42105697An anti-cancer WxxxE-containing azurin polypeptide inhibits Rac1-dependent STAT3 and ERK/GSK-3β signaling in breast cancer cells
Q47294328Computational modeling of single-cell mechanics and cytoskeletal mechanobiology.
Q37593372Coordinated cell motility is regulated by a combination of LKB1 farnesylation and kinase activity.
Q37229340Corticotropin Releasing Factor promotes breast cancer cell motility and invasiveness.
Q42150625Directing integrin-linked endocytosis of recombinant AAV enhances productive FAK-dependent transduction.
Q37587929Distraction-induced intestinal growth: the role of mechanotransduction mechanisms in a mouse model of short bowel syndrome
Q50660530Epigenetic silencing of miR-130a ameliorates hemangioma by targeting tissue factor pathway inhibitor 2 through FAK/PI3K/Rac1/mdm2 signaling.
Q64080545FHL2 mediates podocyte Rac1 activation and foot process effacement in hypertensive nephropathy
Q30315564Fibroblast growth factor (Fgf) 23 gene transcription depends on actin cytoskeleton reorganization.
Q37479712Functional membrane androgen receptors in colon tumors trigger pro-apoptotic responses in vitro and reduce drastically tumor incidence in vivo
Q35881151IRGM1 enhances B16 melanoma cell metastasis through PI3K-Rac1 mediated epithelial mesenchymal transition
Q36211321Inhibition of SGK1 enhances mAR-induced apoptosis in MCF-7 breast cancer cells
Q54124233Inhibition of cell migration by focal adhesion kinase: Time-dependent difference in integrin-induced signaling between endothelial and hepatoblastoma cells.
Q37185060Inhibitory effect of capsaicin on B16-F10 melanoma cell migration via the phosphatidylinositol 3-kinase/Akt/Rac1 signal pathway
Q52645434Interference with the contractile machinery of the fibroblastic chondrocyte cytoskeleton induces re-expression of the cartilage phenotype through involvement of PI3K, PKC and MAPKs.
Q48262506Intracellular nanoparticle dynamics affected by cytoskeletal integrity.
Q37087050LeftyA decreases Actin Polymerization and Stiffness in Human Endometrial Cancer Cells
Q50803364Matrix rigidity controls endothelial differentiation and morphogenesis of cardiac precursors.
Q38098147Mechanotransduction in cancer stem cells.
Q37069082Membrane androgen receptor activation triggers down-regulation of PI-3K/Akt/NF-kappaB activity and induces apoptotic responses via Bad, FasL and caspase-3 in DU145 prostate cancer cells.
Q39017471Membrane androgen receptor sensitive Na+/H+ exchanger activity in prostate cancer cells
Q38264264Membrane steroid receptor-mediated action of soy isoflavones: tip of the iceberg.
Q64253661Oleic acid induces migration through a FFAR1/4, EGFR and Akt-dependent pathway in breast cancer cells
Q37038658Phosphorylated EGFR and PI3K/Akt signaling kinases are expressed in circulating tumor cells of breast cancer patients
Q41626972Role of EHD2 in migration and invasion of human breast cancer cells
Q37354204Roles of integrins in tumor angiogenesis and lymphangiogenesis.
Q35738973SPARC Controls Melanoma Cell Plasticity through Rac1.
Q54531699Serum- and glucocorticoid-dependent kinase-1-induced cell migration is dependent on vinculin and regulated by the membrane androgen receptor.
Q33727986Signaling responses after exposure to 5 alpha-dihydrotestosterone or 17 beta-estradiol in norepinephrine-induced hypertrophy of neonatal rat ventricular myocytes
Q37176427Silencing of D4-GDI inhibits growth and invasive behavior in MDA-MB-231 cells by activation of Rac-dependent p38 and JNK signaling
Q22306017Targeting membrane androgen receptors in tumors
Q42364449Targeting the androgen receptor in triple-negative breast cancer: current perspectives
Q38453821Testosterone induced apoptosis in colon cancer cells is regulated by PI3K/Rac1 signaling
Q64253785The Crosstalk Between Cell Adhesion and Cancer Metabolism
Q38195010The actin cytoskeleton in rapid steroid hormone actions
Q90351225The histone demethylase KDM2B activates FAK and PI3K that control tumor cell motility
Q35117423Tumor mechanics and metabolic dysfunction
Q38804850Tyrosine 397 phosphorylation is critical for FAK-promoted Rac1 activation and invasive properties in oral squamous cell carcinoma cells.
Q35874513Up-regulation of Orai1 expression and store operated Ca(2+) entry following activation of membrane androgen receptors in MCF-7 breast tumor cells
Q34577302Vimentin regulates lung cancer cell adhesion through a VAV2-Rac1 pathway to control focal adhesion kinase activity
Q49500445shRNA-induced silencing of Ras-related C3 botulinum toxin substrate 1 inhibits the proliferation of colon cancer cells through upregulation of BAD and downregulation of cyclin D1.