Therapeutic potential of CDK inhibitor NU2058 in androgen-independent prostate cancer.

scientific article

Therapeutic potential of CDK inhibitor NU2058 in androgen-independent prostate cancer. is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1005376332
P356DOI10.1038/SJ.ONC.1210586
P698PubMed publication ID17599054
P5875ResearchGate publication ID6238635

P50authorNicola CurtinQ68388645
P2093author name stringC N Robson
A C Rigas
P2860cites workExpression of Tip60, an androgen receptor coactivator, and its role in prostate cancer developmentQ40651903
Androgen stimulated cellular proliferation in the human prostate cancer cell line LNCaP is associated with reduced retinoblastoma protein expressionQ40762889
Proliferation of cancer cells despite CDK2 inhibition.Q44391102
Cdc2-cyclin E complexes regulate the G1/S phase transitionQ46592665
Mutational analysis of the human cyclin-dependent kinase inhibitor p27kip1 in primary breast carcinomasQ70888925
N2-substituted O6-cyclohexylmethylguanine derivatives: potent inhibitors of cyclin-dependent kinases 1 and 2Q24298676
Expression profile of differentially-regulated genes during progression of androgen-independent growth in human prostate cancer cellsQ24300247
Identification of novel purine and pyrimidine cyclin-dependent kinase inhibitors with distinct molecular interactions and tumor cell growth inhibition profilesQ27626674
Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1Q28145116
Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formationQ28609667
New colorimetric cytotoxicity assay for anticancer-drug screeningQ29615418
The development of androgen-independent prostate cancerQ29615650
Role of p27 in prostate carcinogenesisQ33715175
S and G2 phase roles for Cdk2 revealed by inducible expression of a dominant-negative mutant in human cellsQ33941051
Bicalutamide functions as an androgen receptor antagonist by assembly of a transcriptionally inactive receptorQ34128784
Role of androgen receptor in the progression of human prostate tumor cells to androgen independence and insensitivityQ34433798
Dual mechanisms for the inhibition of E2F binding to RB by cyclin-dependent kinase-mediated RB phosphorylationQ36573000
Retinoblastoma tumor suppressor targets dNTP metabolism to regulate DNA replicationQ38363095
Combined depletion of cell cycle and transcriptional cyclin-dependent kinase activities induces apoptosis in cancer cellsQ40230424
Annual report to the nation on the status of cancer, 1975-2002, featuring population-based trends in cancer treatmentQ40383746
P433issue55
P407language of work or nameEnglishQ1860
P304page(s)7611-7619
P577publication date2007-06-18
P1433published inOncogeneQ1568657
P1476titleTherapeutic potential of CDK inhibitor NU2058 in androgen-independent prostate cancer
P478volume26

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cites work (P2860)
Q42006737A naturally derived small molecule disrupts ligand-dependent and ligand-independent androgen receptor signaling in human prostate cancer cells
Q35543453Androgen-regulation of the protein tyrosine phosphatase PTPRR activates ERK1/2 signalling in prostate cancer cells
Q53302883Cell‐cycle regulators cdk2ap1 and bicalutamide suppress malignant biological interactions between prostate cancer and bone cells
Q28484264Characterisation of a Tip60 specific inhibitor, NU9056, in prostate cancer
Q52637922Genomic alterations in plasma DNA from patients with metastasized prostate cancer receiving abiraterone or enzalutamide.
Q35722786Insights on Structural Characteristics and Ligand Binding Mechanisms of CDK2
Q38895320Intensified antineoplastic effect by combining an HDAC-inhibitor, an mTOR-inhibitor and low dosed interferon alpha in prostate cancer cells
Q62612784Molecular mechanism of the TP53-MDM2-AR-AKT signalling network regulation by USP12
Q38812632Nutlin-3 inhibits androgen receptor-driven c-FLIP expression, resulting in apoptosis of prostate cancer cells.
Q39673124Preferential induction of G1 arrest in androgen-responsive human prostate cancer cells by androgen receptor signaling antagonists DL3 and antiandrogen bicalutamide
Q35082989Protein-network modeling of prostate cancer gene signatures reveals essential pathways in disease recurrence.
Q58572503Synthesis and pharmacological evaluation of novel epidermal growth factor receptor inhibitors against prostate tumor cells
Q38259961The androgen receptor controls expression of the cancer-associated sTn antigen and cell adhesion through induction of ST6GalNAc1 in prostate cancer.
Q39189709The lysine demethylase, KDM4B, is a key molecule in androgen receptor signalling and turnover.
Q55129906The novel anti-androgen candidate galeterone targets deubiquitinating enzymes, USP12 and USP46, to control prostate cancer growth and survival.
Q38407976Upregulated FGFR1 expression is associated with the transition of hormone-naive to castrate-resistant prostate cancer.

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