Molecular mechanism of the TP53-MDM2-AR-AKT signalling network regulation by USP12

scientific article published on 14 May 2018

Molecular mechanism of the TP53-MDM2-AR-AKT signalling network regulation by USP12 is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1103931771
P356DOI10.1038/S41388-018-0283-3
P698PubMed publication ID29755129

P50authorUrszula L McClurgQ56427069
Arash NabbiQ57008801
Joanne EdwardsQ42315840
P2093author name stringCraig N Robson
Karl T Riabowol
Sirintra Nakjang
Mahsa Azizyan
Stuart R McCracken
Nay C T H Chit
P2860cites workPHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoformsQ24300933
SETD6 monomethylates H2AZ on lysine 7 and is required for the maintenance of embryonic stem cell self-renewalQ24309465
Defining the human deubiquitinating enzyme interaction landscapeQ24315885
Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptorQ24631156
Deubiquitinating enzymes as oncotargetsQ27026189
A conserved two-step binding for the UAF1 regulator to the USP12 deubiquitinating enzymeQ27728092
AR-V7 and resistance to enzalutamide and abiraterone in prostate cancerQ27853062
Role of Chemotherapy and Mechanisms of Resistance to Chemotherapy in Metastatic Castration-Resistant Prostate CancerQ28075965
WDR20 regulates activity of the USP12 x UAF1 deubiquitinating enzyme complexQ28115820
Allosteric Activation of Ubiquitin-Specific Proteases by β-Propeller Proteins UAF1 and WDR20Q28117407
Phosphorylation-dependent ubiquitylation and degradation of androgen receptor by Akt require Mdm2 E3 ligaseQ28511501
p53 coordinates base excision repair to prevent genomic instabilityQ28834500
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2Q29547403
HTSeq--a Python framework to work with high-throughput sequencing dataQ29614489
STAR: ultrafast universal RNA-seq alignerQ29615052
The development of androgen-independent prostate cancerQ29615650
Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancerQ29616218
Transcriptional control of human p53-regulated genesQ29617650
Pathview: an R/Bioconductor package for pathway-based data integration and visualizationQ30641811
Gene ontology analysis for RNA-seq: accounting for selection biasQ33861598
Small-molecule inhibitors of USP1 target ID1 degradation in leukemic cells.Q33873915
A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleusQ33944754
Synthesis and structure-activity relationship studies of N-benzyl-2-phenylpyrimidin-4-amine derivatives as potent USP1/UAF1 deubiquitinase inhibitors with anticancer activity against nonsmall cell lung cancerQ34313778
Identification of focally amplified lineage-specific super-enhancers in human epithelial cancersQ34504751
Awakening guardian angels: drugging the p53 pathwayQ35014385
Identification of PHLPP1 as a tumor suppressor reveals the role of feedback activation in PTEN-mutant prostate cancer progressionQ35223274
Cheminformatics models based on machine learning approaches for design of USP1/UAF1 abrogators as anticancer agentsQ35593976
Digital imaging in the immunohistochemical evaluation of the proliferation markers Ki67, MCM2 and Geminin, in early breast cancer, and their putative prognostic valueQ35709269
Selective and cell-active inhibitors of the USP1/ UAF1 deubiquitinase complex reverse cisplatin resistance in non-small cell lung cancer cellsQ35934305
USP1 targeting impedes GBM growth by inhibiting stem cell maintenance and radioresistanceQ36367391
Ubiquitin-specific protease 12 interacting partners Uaf-1 and WDR20 are potential therapeutic targets in prostate cancerQ38262067
Global transcriptional program of p53 target genes during the process of apoptosis and cell cycle progressionQ38353894
Gene amplifications associated with the development of hormone-resistant prostate cancerQ38450128
Gene silencing of USP1 by lentivirus effectively inhibits proliferation and invasion of human osteosarcoma cellsQ38731335
Divergent clonal evolution of castration-resistant neuroendocrine prostate cancerQ38768101
Translational regulation of the mRNA encoding the ubiquitin peptidase USP1 involved in the DNA damage response as a determinant of Cisplatin resistanceQ38798223
High Efficacy of Combination Therapy Using PI3K/AKT Inhibitors with Androgen Deprivation in Prostate Cancer Preclinical ModelsQ38956648
Deubiquitinating enzyme Usp12 regulates the interaction between the androgen receptor and the Akt pathway.Q38957082
Deubiquitinating enzyme Usp12 is a novel co-activator of the androgen receptor.Q39093258
USP1 regulates AKT phosphorylation by modulating the stability of PHLPP1 in lung cancer cellsQ39377739
The USP1/UAF1 complex promotes double-strand break repair through homologous recombinationQ39560571
FKBP51 affects cancer cell response to chemotherapy by negatively regulating Akt.Q39803380
Therapeutic potential of CDK inhibitor NU2058 in androgen-independent prostate cancer.Q40114067
Stabilization of Mdm2 via decreased ubiquitination is mediated by protein kinase B/Akt-dependent phosphorylationQ40550797
Androgen receptor phosphorylation at serine 515 by Cdk1 predicts biochemical relapse in prostate cancer patients.Q42146513
Identification of a novel K311 ubiquitination site critical for androgen receptor transcriptional activityQ42291797
Mdm2 association with p53 targets its ubiquitinationQ42824389
Pleckstrin Homology (PH) Domain Leucine-rich Repeat Protein Phosphatase Controls Cell Polarity by Negatively Regulating the Activity of Atypical Protein Kinase C.Q46874998
Observer variation in immunohistochemical analysis of protein expression, time for a change?Q53004389
Prostate cancer: AR aberrations and resistance to abiraterone or enzalutamide.Q53762730
P433issue34
P407language of work or nameEnglishQ1860
P304page(s)4679-4691
P577publication date2018-05-14
P1433published inOncogeneQ1568657
P1476titleMolecular mechanism of the TP53-MDM2-AR-AKT signalling network regulation by USP12
P478volume37

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cites work (P2860)
Q90113755Differential Expression of DUB Genes in Ovarian Cells Treated with Di-2-Ethylhexyl Phthalate
Q64076898Interaction of the Human Papillomavirus E1 Helicase with UAF1-USP1 Promotes Unidirectional Theta Replication of Viral Genomes
Q104142418Super-enhancer in prostate cancer: transcriptional disorders and therapeutic targets
Q90608540Targeting GRP78-dependent AR-V7 protein degradation overcomes castration-resistance in prostate cancer therapy
Q55129906The novel anti-androgen candidate galeterone targets deubiquitinating enzymes, USP12 and USP46, to control prostate cancer growth and survival.
Q103027967UAF1 deubiquitinase complexes facilitate NLRP3 inflammasome activation by promoting NLRP3 expression

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