Plasmodium knowlesi: a superb in vivo nonhuman primate model of antigenic variation in malaria

scientific article published on 17 July 2017

Plasmodium knowlesi: a superb in vivo nonhuman primate model of antigenic variation in malaria is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.1017/S0031182017001135
P932PMC publication ID5798396
P698PubMed publication ID28712361

P50authorLuis L. FonsecaQ41045675
P2093author name stringE O Voit
M R Galinski
C J Joyner
F Ay
K G LE Roch
M S Peterson
MAHPIC CONSORTIUM
S A Lapp
P2860cites workHow do antigenically varying pathogens avoid cross-reactive responses to invariant antigens?Q51396948
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The genome of the simian and human malaria parasite Plasmodium knowlesiQ22122203
Genome sequence of the human malaria parasite Plasmodium falciparumQ22122524
Antigenic variation in malaria: in situ switching, relaxed and mutually exclusive transcription of var genes during intra-erythrocytic development in Plasmodium falciparumQ24533320
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Plasmodium knowlesi malaria in humans is widely distributed and potentially life threateningQ24651907
Expression of Plasmodium falciparum erythrocyte membrane protein 1 in experimentally infected humansQ24804115
Translational regulation in blood stages of the malaria parasite Plasmodium spp.: systems-wide studies pave the wayQ26745676
Surface co-expression of two different PfEMP1 antigens on single plasmodium falciparum-infected erythrocytes facilitates binding to ICAM1 and PECAM1Q27313623
Genome regulation by long noncoding RNAs.Q27691812
PfSET10, a Plasmodium falciparum methyltransferase, maintains the active var gene in a poised state during parasite divisionQ27974692
PfSETvs methylation of histone H3K36 represses virulence genes in Plasmodium falciparumQ27976480
Comprehensive mapping of long-range interactions reveals folding principles of the human genomeQ28131819
A large focus of naturally acquired Plasmodium knowlesi infections in human beingsQ28253333
Transient cross-reactive immune responses can orchestrate antigenic variation in malariaQ28264776
Plasmodium malariae and P. ovale genomes provide insights into malaria parasite evolutionQ28529647
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The large diverse gene family var encodes proteins involved in cytoadherence and antigenic variation of plasmodium falciparum-infected erythrocytesQ29393314
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Cloning the P. falciparum gene encoding PfEMP1, a malarial variant antigen and adherence receptor on the surface of parasitized human erythrocytesQ29618254
Switches in expression of Plasmodium falciparum var genes correlate with changes in antigenic and cytoadherent phenotypes of infected erythrocytesQ29618991
Clinical and Laboratory Features of HumanPlasmodium knowlesiInfectionQ29999621
Genome-wide analysis of heterochromatin associates clonally variant gene regulation with perinuclear repressive centers in malaria parasitesQ30043920
Telomeric heterochromatin propagation and histone acetylation control mutually exclusive expression of antigenic variation genes in malaria parasitesQ30046041
Vector transmission regulates immune control of Plasmodium virulenceQ30445852
Robust 4C-seq data analysis to screen for regulatory DNA interactions.Q30563759
In vivo transcriptome of Plasmodium falciparum reveals overexpression of transcripts that encode surface proteinsQ30984141
Plasmodium falciparum var gene expression homogeneity as a marker of the host-parasite relationship under different levels of naturally acquired immunity to malariaQ31125954
Experimental infection of the olive baboon (Paplio anubis) with Plasmodium knowlesi: severe disease accompanied by cerebral involvementQ33189932
A SICAvar switching event in Plasmodium knowlesi is associated with the DNA rearrangement of conserved 3' non-coding sequencesQ33208154
Mathematical biology of HIV infections: antigenic variation and diversity thresholdQ33344856
Plasmodium cynomolgi infections in rhesus macaques display clinical and parasitological features pertinent to modelling vivax malaria pathology and relapse infectionsQ33435123
Genome-wide profiling of chromosome interactions in Plasmodium falciparum characterizes nuclear architecture and reconfigurations associated with antigenic variationQ41877614
Rapid switching to multiple antigenic and adhesive phenotypes in malariaQ41904261
A Study of Monkey-Malaria, and Its Experimental Transmission to Man.Q42255831
THE AGGLUTINATION OF PLASMODIUM KNOWLESI BY IMMUNE SERUMQ42800964
In vivo study of human Plasmodium knowlesi in Macaca fascicularisQ43274453
Protein antigens of Plasmodium knowlesi clones of different variant antigen phenotypeQ43433135
Adherence of infected erythrocytes to venular endothelium selects for antigenic variants of Plasmodium falciparumQ44461114
Plasmodium falciparum malaria in an asplenic man.Q44512854
Altered expression of Plasmodium knowlesi variant antigen on the erythrocyte membrane in splenectomized rhesus monkeysQ44591106
The detergent solubility properties of a malarial (Plasmodium knowlesi) variant antigen expressed on the surface of infected erythrocytesQ44723665
Solubilization and immunoprecipitation of 125I-labelled antigens from Plasmodium knowlesi schizont-infected erythrocytes using non-ionic, anionic and zwitterionic detergentsQ44827216
Heterochromatin silencing and locus repositioning linked to regulation of virulence genes in Plasmodium falciparumQ46429981
Developmental selection of var gene expression in Plasmodium falciparumQ47741507
Antigenic variation in malaria: a 3' genomic alteration associated with the expression of a P. knowlesi variant antigenQ47844441
Stability and bifurcations in a model of antigenic variation in malariaQ47874102
Malaria. Cooperative silencing elements in var genesQ47888988
The Plasmodium falciparum var gene transcription strategy at the onset of blood stage infection in a human volunteerQ47909162
Transgenic Plasmodium knowlesi: relieving a bottleneck in malaria research?Q47909753
Immunochemical analysis of surface membrane antigens on erythrocytes infected with non-cloned SICA[+] or cloned SICA[-] Plasmodium knowlesiQ47927863
Phylogenetic analysis of CSP and MSP-9 gene sequences demonstrates the close relationship of Plasmodium coatneyi to Plasmodium knowlesiQ47930294
Antigenic variation and immunity to Plasmodium knowlesi: antibodies which induce antigenic variation and antibodies which destroy parasitesQ47940080
Antibody Induced Variation in Malaria ParasitesQ47947088
Immunity to malaria: antigenic variation in chronic infections of Plasmodium knowlesiQ47953860
Deep vascular schizogony of Plasmodium knowlesi in Macaca mulatta. Distribution in organs and ultrastructure of parasitized red cells.Q47956598
Influence of the Spleen on the Expression of Surface Antigens on Parasitized ErythrocytesQ47976339
Proteomic studies of Plasmodium knowlesi SICA variant antigens demonstrate their relationship with P. falciparum EMP1.Q48021475
Absence of erythrocyte sequestration and lack of multicopy gene family expression in Plasmodium falciparum from a splenectomized malaria patientQ33510341
Three-dimensional modeling of the P. falciparum genome during the erythrocytic cycle reveals a strong connection between genome architecture and gene expressionQ33657762
Polysome profiling reveals translational control of gene expression in the human malaria parasite Plasmodium falciparumQ33741784
Knowlesi malaria: newly emergent and of public health importance?Q33746594
A Research Agenda to Underpin Malaria EradicationQ33818020
Antigenic variation in Plasmodium falciparum malaria involves a highly structured switching patternQ33847751
Classification of adhesive domains in the Plasmodium falciparum erythrocyte membrane protein 1 familyQ33924720
Plasmodium knowlesi provides a rapid in vitro and in vivo transfection system that enables double-crossover gene knockout studiesQ34117654
Evolution of the multi-domain structures of virulence genes in the human malaria parasite, Plasmodium falciparumQ34236544
Ordered appearance of antigenic variants of African trypanosomes explained in a mathematical model based on a stochastic switch process and immune-selection against putative switch intermediatesQ34324411
A statistically rigorous method for determining antigenic switching networksQ34326030
A new rhesus macaque assembly and annotation for next-generation sequencing analyses.Q34427961
Variant surface antigens of malaria parasites: functional and evolutionary insights from comparative gene family classification and analysisQ34785832
Spleen-dependent regulation of antigenic variation in malaria parasites: Plasmodium knowlesi SICAvar expression profiles in splenic and asplenic hosts.Q35035911
Dissecting the determinants of malaria chronicity: why within-host models struggle to reproduce infection dynamicsQ35134399
Redefining the expressed prototype SICAvar gene involved in Plasmodium knowlesi antigenic variationQ35154548
Antisense long noncoding RNAs regulate var gene activation in the malaria parasite Plasmodium falciparumQ35156901
Plasmodium knowlesi gene expression differs in ex vivo compared to in vitro blood-stage culturesQ35205219
Parasite accumulation in placenta of non-immune baboons during Plasmodium knowlesi infectionQ35212899
Multiple dimensions of epigenetic gene regulation in the malaria parasite Plasmodium falciparum: gene regulation via histone modifications, nucleosome positioning and nuclear architecture in P. falciparumQ35272932
Epigenetic memory at malaria virulence genesQ35574103
Variant antigen expression in malaria infections: posttranscriptional gene silencing, virulence and severe pathologyQ35640674
Admixture in Humans of Two Divergent Plasmodium knowlesi Populations Associated with Different Macaque Host SpeciesQ35645177
Stochastic differential equation models for ion channel noise in Hodgkin-Huxley neurons.Q35756015
Humans frequently exposed to a range of non-human primate malaria parasite species through the bites of Anopheles dirus mosquitoes in South-central VietnamQ35857150
Mosquito Passage Dramatically Changes var Gene Expression in Controlled Human Plasmodium falciparum InfectionsQ35987064
Mechanisms underlying mutually exclusive expression of virulence genes by malaria parasitesQ36029945
Co-infections of Plasmodium knowlesi, P. falciparum, and P. vivax among Humans and Anopheles dirus Mosquitoes, Southern VietnamQ36053110
Plasmodium falciparum malaria: association of knobs on the surface of infected erythrocytes with a histidine-rich protein and the erythrocyte skeletonQ36210516
Falciparum malaria after splenectomy: a prospective controlled study of 33 previously splenectomized Malawian adultsQ36229007
Surface alterations of erythrocytes in Plasmodium falciparum malaria. Antigenic variation, antigenic diversity, and the role of the spleenQ36347647
Splenic requirement for antigenic variation and expression of the variant antigen on the erythrocyte membrane in cloned Plasmodium knowlesi malariaQ36348229
Antigenic variation of cloned Plasmodium fragile in its natural host Macaca sinica. Sequential appearance of successive variant antigenic typesQ36352577
Transfection of the primate malaria parasite Plasmodium knowlesi using entirely heterologous constructsQ36377118
Patterns of antigenic diversity and the mechanisms that maintain themQ36671962
Active transcription is required for maintenance of epigenetic memory in the malaria parasite Plasmodium falciparumQ36734710
Variable switching rates of malaria virulence genes are associated with chromosomal positionQ36789305
Shared epigenetic mechanisms control virulence factors in protozoan parasitesQ37006999
Normocyte-binding protein required for human erythrocyte invasion by the zoonotic malaria parasite Plasmodium knowlesiQ37066743
The antigenic switching network of Plasmodium falciparum and its implications for the immuno-epidemiology of malariaQ37186212
Assessment of submicroscopic infections and gametocyte carriage of Plasmodium falciparum during peak malaria transmission season in a community-based cross-sectional survey in western Kenya, 2012.Q37192206
High-Quality Genome Assembly and Annotation for Plasmodium coatneyi, Generated Using Single-Molecule Real-Time PacBio TechnologyQ37229376
Parasite antigens on the infected red cell surface are targets for naturally acquired immunity to malaria.Q37331646
High-throughput genome scaffolding from in vivo DNA interaction frequencyQ37430742
Simultaneous transcription of duplicated var2csa gene copies in individual Plasmodium falciparum parasitesQ37442983
Antigenic variation of Plasmodium knowlesi malaria: identification of the variant antigen on infected erythrocytesQ37616694
Antigenic variation and the within-host dynamics of parasitesQ37726799
Antigenic Variation and the Genetics and Epigenetics of the PfEMP1 Erythrocyte Surface Antigens in Plasmodium falciparum MalariaQ37860638
Silence, activate, poise and switch! Mechanisms of antigenic variation in Plasmodium falciparum.Q38076799
Plasmodium knowlesi: a relevant, versatile experimental malaria modelQ38784765
Highly co-ordinated var gene expression and switching in clinical Plasmodium falciparum isolates from non-immune malaria patientsQ38886860
Cytoadherence and ultrastructure of Plasmodium falciparum-infected erythrocytes from a splenectomized patientQ39069200
Malaria EpigeneticsQ39188733
Anopheles dirus co-infection with human and monkey malaria parasites in VietnamQ39292619
How selection forces dictate the variant surface antigens used by malaria parasitesQ39932709
Antigenic variation of bloodstage malaria parasitesQ40096478
PacBio assembly of a Plasmodium knowlesi genome sequence with Hi-C correction and manual annotation of the SICAvar gene family.Q40129661
Roles of surface antigens on malaria-infected red blood cells in evasion of immunityQ40170210
Malaria Parasites Distribute Subversive Messages across Enemy LinesQ40434948
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P921main subjectmalariaQ12156
Plasmodium knowlesiQ241594
genetic variationQ349856
antigenic variationQ4774739
eukaryoteQ19088
protozoan proteinsQ76505803
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)85-100
P577publication date2017-07-17
2018-01-01
P1433published inParasitologyQ15753259
P1476titlePlasmodium knowlesi: a superb in vivo nonhuman primate model of antigenic variation in malaria
P478volume145

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cites work (P2860)
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Q57465375Nanomedicines for Malaria Chemotherapy: Encapsulation vs. Polymer Therapeutics
Q40129661PacBio assembly of a Plasmodium knowlesi genome sequence with Hi-C correction and manual annotation of the SICAvar gene family.
Q58608381Plasmodium genomics: an approach for learning about and ending human malaria
Q49967331Plasmodium knowlesi: experimental model, zoonotic pathogen and golden opportunity?

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