How selection forces dictate the variant surface antigens used by malaria parasites

scientific article published on 6 July 2011

How selection forces dictate the variant surface antigens used by malaria parasites is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1098/RSIF.2011.0239
P932PMC publication ID3243386
P698PubMed publication ID21733875
P5875ResearchGate publication ID51471843

P50authorDon KlinkenbergQ49655703
Hans HeesterbeekQ89022713
Maite SeverinsQ90313414
P2860cites workAntigenic variation in Plasmodium falciparum: gene organization and regulation of the var multigene familyQ24672872
Parasite-intrinsic factors can explain ordered progression of trypanosome antigenic variationQ24681812
Immunity promotes virulence evolution in a malaria modelQ24795264
Expression of Plasmodium falciparum erythrocyte membrane protein 1 in experimentally infected humansQ24804115
Molecules on the surface of the Plasmodium falciparum infected erythrocyte and their role in malaria pathogenesis and immune evasionQ27972541
Epidemiology and genetics in the coevolution of parasites and hostsQ28261345
Transient cross-reactive immune responses can orchestrate antigenic variation in malariaQ28264776
Coevolution of hosts and parasitesQ28273046
The pathogenic basis of malariaQ29615020
Cloning the P. falciparum gene encoding PfEMP1, a malarial variant antigen and adherence receptor on the surface of parasitized human erythrocytesQ29618254
Patterns of gene recombination shape var gene repertoires in Plasmodium falciparum: comparisons of geographically diverse isolatesQ33272663
Population genomics of the immune evasion (var) genes of Plasmodium falciparumQ33279159
Virulence of malaria is associated with differential expression of Plasmodium falciparum var gene subgroups in a case-control studyQ33879876
Revisiting the circulation time of Plasmodium falciparum gametocytes: molecular detection methods to estimate the duration of gametocyte carriage and the effect of gametocytocidal drugsQ33898575
Antibody recognition of Plasmodium falciparum erythrocyte surface antigens in Kenya: evidence for rare and prevalent variants.Q34000292
Two approximately 300 kilodalton Plasmodium falciparum proteins at the surface membrane of infected erythrocytesQ34171903
Do maternally acquired antibodies protect infants from malaria infection?Q34176239
Ordered appearance of antigenic variants of African trypanosomes explained in a mathematical model based on a stochastic switch process and immune-selection against putative switch intermediatesQ34324411
The role of antibodies to Plasmodium falciparum-infected-erythrocyte surface antigens in naturally acquired immunity to malariaQ34517598
A family affair: var genes, PfEMP1 binding, and malaria diseaseQ34543611
Differential expression of var gene groups is associated with morbidity caused by Plasmodium falciparum infection in Tanzanian childrenQ34721291
PfEMP1: an antigen that plays a key role in the pathogenicity and immune evasion of the malaria parasite Plasmodium falciparumQ34923699
The consequences of reducing transmission of Plasmodium falciparum in AfricaQ35042630
Virulence in malaria: an evolutionary viewpointQ35213982
Epigenetic memory at malaria virulence genesQ35574103
Malaria immunity in infants: a special case of a general phenomenon?Q35640581
Mechanisms underlying mutually exclusive expression of virulence genes by malaria parasitesQ36029945
Cytoadherence by Plasmodium falciparum-infected erythrocytes is correlated with the expression of a family of variable proteins on infected erythrocytesQ36355465
Plasmodium falciparum associated with severe childhood malaria preferentially expresses PfEMP1 encoded by group A var genesQ36399515
Activation, silencing and mutually exclusive expression within the var gene family of Plasmodium falciparumQ36517392
The epidemiology of Plasmodium falciparum gametocytes: weapons of mass dispersionQ36538665
Differences in human antibody reactivity to Plasmodium falciparum variant surface antigens are dependent on age and malaria transmission intensity in northeastern TanzaniaQ36710616
Plasmodium falciparum antigenic variation. Mapping mosaic var gene sequences onto a network of shared, highly polymorphic sequence blocksQ36737443
Frequent recombination events generate diversity within the multi-copy variant antigen gene families of Plasmodium falciparumQ36740593
The naturally acquired immunity in severe malaria and its implication for a PfEMP-1 based vaccineQ36775997
Origins and evolution of antigenic diversity in malaria parasitesQ36952261
Age patterns of severe paediatric malaria and their relationship to Plasmodium falciparum transmission intensityQ37073020
Sex in Plasmodium: a sign of commitmentQ37110637
Virulence evolution in response to vaccination: the case of malariaQ37145544
Immunity to malaria: more questions than answersQ37194482
Linking within- and between-host dynamics in the evolutionary epidemiology of infectious diseasesQ37227830
Acute or chronic? Within-host models with immune dynamics, infection outcome, and parasite evolutionQ37322465
The varieties of gene amplification, diversification and hypervariability in the human malaria parasite, Plasmodium falciparumQ37449650
The role of Plasmodium falciparum variant surface antigens in protective immunity and vaccine development.Q37613367
The selection landscape of malaria parasites.Q37751651
How many years of life could be saved if malaria were eliminated from a hyperendemic area of northern Ghana?Q38897628
PfEMP1, polymorphism and pathogenesisQ39115318
Relationships between host infectivity to mosquitoes and asexual parasite density in Plasmodium falciparum.Q39409657
Malaria-induced acquisition of antibodies to plasmodium falciparum variant surface antigensQ39655161
A retrospective examination of sporozoite- and trophozoite-induced infections with Plasmodium falciparum: development of parasitologic and clinical immunity during primary infectionQ40635110
Malaria pathogenesisQ40659853
The evolution of virulenceQ40739462
Antigenic variation in trypanosomes: a computer analysis of variant orderQ41599246
Acquisition of naturally occurring antibody responses to recombinant protein domains of Plasmodium falciparum erythrocyte membrane protein 1.Q41813370
Host life history and the evolution of parasite virulenceQ43474160
Relationship Between Altitude and Intensity of Malaria Transmission in the Usambara Mountains, TanzaniaQ43949141
Adherence of infected erythrocytes to venular endothelium selects for antigenic variants of Plasmodium falciparumQ44461114
Sequential, ordered acquisition of antibodies to Plasmodium falciparum erythrocyte membrane protein 1 domainsQ44605152
Developmental selection of var gene expression in Plasmodium falciparumQ47741507
Var gene diversity in Plasmodium falciparum is generated by frequent recombination eventsQ47815758
Antibody recognition of heterologous variant surface antigens after a single Plasmodium falciparum infection in previously naive adults.Q47832295
A retrospective examination of the patterns of recrudescence in patients infected with Plasmodium falciparumQ47850813
Understanding and predicting strain-specific patterns of pathogenesis in the rodent malaria Plasmodium chabaudiQ47879590
Imperfect vaccines and the evolution of pathogen virulenceQ47896350
The Plasmodium falciparum var gene transcription strategy at the onset of blood stage infection in a human volunteerQ47909162
Within-host competition in genetically diverse malaria infections: parasite virulence and competitive successQ48034646
On the evolution of reproductive restraint in malaria.Q51892155
Inferring malaria parasite population structure from serological networks.Q53528042
The relationship of variable antigen expression and population growth rates in Trypanosoma bruceiQ67984514
The evolution of parasite virulence, superinfection, and host resistanceQ81791485
P433issue67
P921main subjectmalariaQ12156
P304page(s)246-260
P577publication date2011-07-06
P1433published inJournal of the Royal Society InterfaceQ2492390
P1476titleHow selection forces dictate the variant surface antigens used by malaria parasites
P478volume9

Reverse relations

cites work (P2860)
Q48024447A modeller's perspective on infection dynamics within and between hosts
Q35134399Dissecting the determinants of malaria chronicity: why within-host models struggle to reproduce infection dynamics
Q51281704Linking the antigen archive structure to pathogen fitness in African trypanosomes.
Q40133225Plasmodium knowlesi: a superb in vivo nonhuman primate model of antigenic variation in malaria
Q36474042Population structuring of multi-copy, antigen-encoding genes in Plasmodium falciparum
Q28070246The role of PfEMP1 as targets of naturally acquired immunity to childhood malaria: prospects for a vaccine

Search more.