The role of PfEMP1 as targets of naturally acquired immunity to childhood malaria: prospects for a vaccine

scientific article

The role of PfEMP1 as targets of naturally acquired immunity to childhood malaria: prospects for a vaccine is …
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scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1017/S0031182015001274
P932PMC publication ID4825093
P698PubMed publication ID26741401

P50authorPeter C. BullQ47502958
Abdirahman AbdiQ43162269
P2093author name stringABDIRAHMAN I. ABDI
PETER C. BULL
P2860cites workImmunity to malaria: more questions than answersQ37194482
Identification of residues in the Cmu4 domain of polymeric IgM essential for interaction with Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1).Q37226958
Failure to respond to the surface of Plasmodium falciparum infected erythrocytes predicts susceptibility to clinical malaria amongst African childrenQ37229848
Parasite antigens on the infected red cell surface are targets for naturally acquired immunity to malaria.Q37331646
Immune selection and within-host competition can structure the repertoire of variant surface antigens in Plasmodium falciparum--a mathematical modelQ21562686
Genome sequence of the human malaria parasite Plasmodium falciparumQ22122524
Wagner-Jauregg and fever therapyQ24797148
Sub-grouping of Plasmodium falciparum 3D7 var genes based on sequence analysis of coding and non-coding regionsQ24804747
Plasmodium falciparum variant surface antigen expression patterns during malariaQ24811060
The role of PfEMP1 adhesion domain classification in Plasmodium falciparum pathogenesis researchQ26862567
The Cysteine-Rich Interdomain Region from the Highly Variable Plasmodium falciparum Erythrocyte Membrane Protein-1 Exhibits a Conserved StructureQ27651999
Structural Basis for the ABO Blood-Group Dependence of Plasmodium falciparum RosettingQ27670781
RIFINs are adhesins implicated in severe Plasmodium falciparum malariaQ27972159
Rifins: a second family of clonally variant proteins expressed on the surface of red cells infected with Plasmodium falciparumQ27972160
P. falciparum rosetting mediated by a parasite-variant erythrocyte membrane protein and complement-receptor 1Q27972544
STEVOR is a Plasmodium falciparum erythrocyte binding protein that mediates merozoite invasion and rosettingQ27972547
A Plasmodium falciparum histone deacetylase regulates antigenic variation and gametocyte conversionQ27974382
Heterochromatin protein 1 secures survival and transmission of malaria parasitesQ27974686
Selective upregulation of a single distinctly structured var gene in chondroitin sulphate A-adhering Plasmodium falciparum involved in pregnancy-associated malariaQ27976511
Immunity to non-cerebral severe malaria is acquired after one or two infectionsQ28139257
Expression of the domain cassette 8 Plasmodium falciparum erythrocyte membrane protein 1 is associated with cerebral malaria in BeninQ28534938
The large diverse gene family var encodes proteins involved in cytoadherence and antigenic variation of plasmodium falciparum-infected erythrocytesQ29393314
Cloning the P. falciparum gene encoding PfEMP1, a malarial variant antigen and adherence receptor on the surface of parasitized human erythrocytesQ29618254
Switches in expression of Plasmodium falciparum var genes correlate with changes in antigenic and cytoadherent phenotypes of infected erythrocytesQ29618991
A transcriptional switch underlies commitment to sexual development in malaria parasitesQ30041370
Genome sequencing of chimpanzee malaria parasites reveals possible pathways of adaptation to human hosts.Q30430428
Evasion of immunity to Plasmodium falciparum malaria by IgM masking of protective IgG epitopes in infected erythrocyte surface-exposed PfEMP1Q30502964
Antigen reversal identifies targets of opsonizing IgGs against pregnancy-associated malariaQ30603697
Geographical and temporal conservation of antibody recognition of Plasmodium falciparum variant surface antigensQ31064176
Plasmodium falciparum var gene expression homogeneity as a marker of the host-parasite relationship under different levels of naturally acquired immunity to malariaQ31125954
Epitope mapping and topographic analysis of VAR2CSA DBL3X involved in P. falciparum placental sequestrationQ33263953
Patterns of gene recombination shape var gene repertoires in Plasmodium falciparum: comparisons of geographically diverse isolatesQ33272663
Population genomics of the immune evasion (var) genes of Plasmodium falciparumQ33279159
Plasmodium falciparum erythrocyte membrane protein 1 diversity in seven genomes--divide and conquerQ33700519
The role of variant surface antigens on malaria-infected red blood cells.Q33746986
Age-related buildup of humoral immunity against epitopes for rosette formation and agglutination in African areas of malaria endemicityQ33765361
A var gene upstream element controls protein synthesis at the level of translation initiation in Plasmodium falciparumQ33769247
MHC polymorphism and parasites.Q54191001
Acquired immunity and postnatal clinical protection in childhood cerebral malariaQ56830923
Plasmodium falciparum parasitaemia described by a new mathematical model.Q47882129
Antigens induced on erythrocytes by P. falciparum: expression of diverse and conserved determinantsQ47886673
Plasmodium falciparum variant surface antigen expression varies between isolates causing severe and nonsevere malaria and is modified by acquired immunityQ47901577
The Plasmodium falciparum var gene transcription strategy at the onset of blood stage infection in a human volunteerQ47909162
Widespread functional specialization of Plasmodium falciparum erythrocyte membrane protein 1 family members to bind CD36 analysed across a parasite genomeQ47923917
Evidence for the importance of genetic structuring to the structural and functional specialization of the Plasmodium falciparum var gene familyQ47971150
Analysis of adhesive domains from the A4VAR Plasmodium falciparum erythrocyte membrane protein-1 identifies a CD36 binding domainQ47996636
Protection against clinical malaria by heterologous immunoglobulin G antibodies against malaria-infected erythrocyte variant surface antigens requires interaction with asymptomatic infectionsQ47997112
Identification of Id1-DBL2X of VAR2CSA as a key domain inducing highly inhibitory and cross-reactive antibodiesQ47999224
Plasmodium falciparum antigenic variation: relationships between in vivo selection, acquired antibody response, and disease severityQ48014091
Serological diversity of antigens expressed on the surface of erythrocytes infected with Plasmodium falciparumQ48018798
Gradual acquisition of immunity to severe malaria with increasing exposure.Q50983969
Immunogen design for HIV-1 and influenza.Q51846035
Plasmodium falciparum var gene expression is modified by host immunityQ37471820
Antigenic variation in Plasmodium falciparumQ37607771
Rosetting Plasmodium falciparum-infected erythrocytes bind to human brain microvascular endothelial cells in vitro, demonstrating a dual adhesion phenotype mediated by distinct P. falciparum erythrocyte membrane protein 1 domains.Q37643887
Llama immunization with full-length VAR2CSA generates cross-reactive and inhibitory single-domain antibodies against the DBL1X domainQ37734391
The age patterns of severe malaria syndromes in sub-Saharan Africa across a range of transmission intensities and seasonality settingsQ37799657
Sequence variation and structural conservation allows development of novel function and immune evasion in parasite surface protein familiesQ38180023
Conserved immunogens in prime-boost strategies for the next-generation HIV-1 vaccinesQ38184579
Immunization with PfEMP1-DBL1alpha generates antibodies that disrupt rosettes and protect against the sequestration of Plasmodium falciparum-infected erythrocytesQ38339089
Analysis of Plasmodium falciparum var genes expressed in children from Papua New GuineaQ38998322
Receptor-specific adhesion and clinical disease in Plasmodium falciparumQ39115353
Differential var gene expression in children with malaria and antidromic effects on host gene expressionQ39116665
Plasmodium falciparum infections are associated with agglutinating antibodies to parasite-infected erythrocyte surface antigens among healthy Kenyan childrenQ39123150
Recombinant Duffy binding-like-alpha domains of Plasmodium falciparum erythrocyte membrane protein 1 elicit antibodies in rats that recognise conserved epitopesQ39318009
Investigating the function of Fc-specific binding of IgM to Plasmodium falciparum erythrocyte membrane protein 1 mediating erythrocyte rosettingQ39490520
Low antibody responses to variant surface antigens of Plasmodium falciparum are associated with severe malaria and increased susceptibility to malaria attacks in Gabonese children.Q39515251
Fresh isolates from children with severe Plasmodium falciparum malaria bind to multiple receptors.Q39522091
Immunoglobulin G isotype responses to erythrocyte surface-expressed variant antigens of Plasmodium falciparum predict protection from malaria in African childrenQ39616918
Plasmodium falciparum rosetting is associated with malaria severity in KenyaQ39822248
How selection forces dictate the variant surface antigens used by malaria parasitesQ39932709
Julius Wagner-Jauregg (1857-1940): Introducing fever therapy in the treatment of neurosyphilisQ40229604
Determinant spreading and the dynamics of the autoimmune T-cell repertoire.Q40487702
Human cerebral malaria: association with erythrocyte rosetting and lack of anti-rosetting antibodiesQ41175606
Diversity of antigens expressed on the surface of erythrocytes infected with mature Plasmodium falciparum parasites in Papua New GuineaQ41298484
Prognostic indicators of life-threatening malaria are associated with distinct parasite variant antigen profilesQ41400361
Diversity of agglutinating phenotype, cytoadherence, and rosette-forming characteristics of Plasmodium falciparum isolates from Papua New Guinean children.Q41456213
var gene transcription and PfEMP1 expression in the rosetting and cytoadhesive Plasmodium falciparum clone FCR3S1.2.Q41897345
Rapid switching to multiple antigenic and adhesive phenotypes in malariaQ41904261
Sex: how malaria parasites get turned on.Q42216431
stevor and rif are Plasmodium falciparum multicopy gene families which potentially encode variant antigensQ42689345
3D7-Derived Plasmodium falciparum erythrocyte membrane protein 1 is a frequent target of naturally acquired antibodies recognizing protein domains in a particular pattern independent of malaria transmission intensityQ43946217
Agglutination of Plasmodium falciparum-infected erythrocytes from east and west African isolates by human sera from distant geographic regionsQ43955580
The sound of sexual commitment breaks the silencing of malaria parasitesQ44145958
Antibodies to blood stage antigens of Plasmodium falciparum in rural Gambians and their relation to protection against infectionQ44147641
Differential adhesion-inhibitory patterns of antibodies raised against two major variants of the NTS-DBL2X region of VAR2CSA.Q44227448
Sequential, ordered acquisition of antibodies to Plasmodium falciparum erythrocyte membrane protein 1 domainsQ44605152
Differentiating the pathologies of cerebral malaria by postmortem parasite countsQ44772302
Antibodies to variable Plasmodium falciparum-infected erythrocyte surface antigens are associated with protection from novel malaria infectionsQ46184700
Immunization of Aotus monkeys with recombinant cysteine-rich interdomain region 1 alpha protects against severe disease during Plasmodium falciparum reinfectionQ46226456
The NTS-DBL2X region of VAR2CSA induces cross-reactive antibodies that inhibit adhesion of several Plasmodium falciparum isolates to chondroitin sulfate A.Q46326711
Plasmodium falciparum-infected erythrocytes: agglutination by diverse Kenyan plasma is associated with severe disease and young host age.Q46809348
Allelic diversity of the Plasmodium falciparum erythrocyte membrane protein 1 entails variant-specific red cell surface epitopesQ33813188
Specific receptor usage in Plasmodium falciparum cytoadherence is associated with disease outcomeQ33842019
Virulence of malaria is associated with differential expression of Plasmodium falciparum var gene subgroups in a case-control studyQ33879876
Parasite burden and severity of malaria in Tanzanian childrenQ33882158
Adhesion of Plasmodium falciparum-infected erythrocytes to human cells: molecular mechanisms and therapeutic implications.Q33884983
Identification of a Plasmodium falciparum intercellular adhesion molecule-1 binding domain: a parasite adhesion trait implicated in cerebral malariaQ33890328
Investigating the host binding signature on the Plasmodium falciparum PfEMP1 protein familyQ33900642
Evidence of promiscuous endothelial binding by Plasmodium falciparum-infected erythrocytesQ33967171
Antibody recognition of Plasmodium falciparum erythrocyte surface antigens in Kenya: evidence for rare and prevalent variants.Q34000292
Antibodies to variant antigens on the surfaces of infected erythrocytes are associated with protection from malaria in Ghanaian children.Q34007707
Immunization of Aotus monkeys with a functional domain of the Plasmodium falciparum variant antigen induces protection against a lethal parasite lineQ34020876
Surface antigens of Plasmodium falciparum-infected erythrocytes as immune targets and malaria vaccine candidatesQ34161839
Evolution of the multi-domain structures of virulence genes in the human malaria parasite, Plasmodium falciparumQ34236544
Induction of strain-transcending antibodies against Group A PfEMP1 surface antigens from virulent malaria parasitesQ34244920
Plasmodium falciparum erythrocyte membrane protein 1 domain cassettes 8 and 13 are associated with severe malaria in childrenQ34276755
A restricted subset of var genes mediates adherence of Plasmodium falciparum-infected erythrocytes to brain endothelial cellsQ34276761
A subset of group A-like var genes encodes the malaria parasite ligands for binding to human brain endothelial cellsQ34276770
Hierarchical, domain type-specific acquisition of antibodies to Plasmodium falciparum erythrocyte membrane protein 1 in Tanzanian childrenQ34290645
A novel domain cassette identifies Plasmodium falciparum PfEMP1 proteins binding ICAM-1 and is a target of cross-reactive, adhesion-inhibitory antibodiesQ34315378
Severe malaria is associated with parasite binding to endothelial protein C receptorQ34348881
Identification of a region of PfEMP1 that mediates adherence of Plasmodium falciparum infected erythrocytes to CD36: conserved function with variant sequenceQ34443957
Structural conservation despite huge sequence diversity allows EPCR binding by the PfEMP1 family implicated in severe childhood malariaQ34452432
The surface variant antigens of Plasmodium falciparum contain cross-reactive epitopesQ34482933
Plasmodium falciparum rosetting epitopes converge in the SD3-loop of PfEMP1-DBL1α.Q34507076
A sequence in subdomain 2 of DBL1α of Plasmodium falciparum erythrocyte membrane protein 1 induces strain transcending antibodiesQ34555650
Differential var gene transcription in Plasmodium falciparum isolates from patients with cerebral malaria compared to hyperparasitaemiaQ34568283
B-cell epitopes in NTS-DBL1α of PfEMP1 recognized by human antibodies in Rosetting Plasmodium falciparumQ34599635
Differential PfEMP1 expression is associated with cerebral malaria pathologyQ34633859
Differences in gene transcriptomic pattern of Plasmodium falciparum in children with cerebral malaria and asymptomatic carriersQ34640524
Evaluating controlled human malaria infection in Kenyan adults with varying degrees of prior exposure to Plasmodium falciparum using sporozoites administered by intramuscular injectionQ34687174
Differential expression of var gene groups is associated with morbidity caused by Plasmodium falciparum infection in Tanzanian childrenQ34721291
Hypervariable antigen genes in malaria have ancient rootsQ34751031
Plasmodium falciparum expressing domain cassette 5 type PfEMP1 (DC5-PfEMP1) bind PECAM1.Q34853037
VAR2CSA signatures of high Plasmodium falciparum parasitemia in the placentaQ34921119
Diversity and virulence thresholds in AIDS.Q34983038
Using the PfEMP1 head structure binding motif to deal a blow at severe malariaQ35091763
Virulence and transmission success of the malarial parasite Plasmodium falciparumQ35132510
Virulence in malaria: an evolutionary viewpointQ35213982
Limited cross-reactivity among domains of the Plasmodium falciparum clone 3D7 erythrocyte membrane protein 1 familyQ35220304
Impact of malaria preexposure on antiparasite cellular and humoral immune responses after controlled human malaria infectionQ35439859
Generation of antigenic diversity in Plasmodium falciparum by structured rearrangement of Var genes during mitosisQ35529234
A review of hyperendemic malariaQ35654736
Generation of cross-protective antibodies against Plasmodium falciparum sequestration by immunization with an erythrocyte membrane protein 1-duffy binding-like 1 alpha domainQ35688950
Immunoglobulin G antibody reactivity to a group A Plasmodium falciparum erythrocyte membrane protein 1 and protection from P. falciparum malariaQ35783951
Why do some African children develop severe malaria?Q35907971
PfEMP1-DBL1alpha amino acid motifs in severe disease states of Plasmodium falciparum malariaQ36013437
Structural and functional insight into how the Plasmodium falciparum VAR2CSA protein mediates binding to chondroitin sulfate A in placental malaria.Q36078717
Association of severe noncerebral Plasmodium falciparum malaria in Brazil with expressed PfEMP1 DBL1 alpha sequences lacking cysteine residuesQ36087903
Malaria--a neglected disease?Q36127074
Epigenetic dysregulation of virulence gene expression in severe Plasmodium falciparum malariaQ36153793
Targets of antibodies against Plasmodium falciparum-infected erythrocytes in malaria immunityQ36190707
Antigenicity of the infected-erythrocyte and merozoite surfaces in Falciparum malariaQ36343017
Splenic requirement for antigenic variation and expression of the variant antigen on the erythrocyte membrane in cloned Plasmodium knowlesi malariaQ36348229
Small, clonally variant antigens expressed on the surface of the Plasmodium falciparum-infected erythrocyte are encoded by the rif gene family and are the target of human immune responsesQ36375576
Plasmodium falciparum associated with severe childhood malaria preferentially expresses PfEMP1 encoded by group A var genesQ36399515
Barriers to antigenic escape by pathogens: trade-off between reproductive rate and antigenic mutability.Q36412729
Induction of crossreactive antibodies against the Plasmodium falciparum variant proteinQ36690071
Plasmodium falciparum antigenic variation. Mapping mosaic var gene sequences onto a network of shared, highly polymorphic sequence blocksQ36737443
Plasmodium falciparum isolates from infected pregnant women and children are associated with distinct adhesive and antigenic propertiesQ37036123
Loss of endothelial protein C receptors links coagulation and inflammation to parasite sequestration in cerebral malaria in African childrenQ37065724
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectPlasmodium falciparumQ311383
malaria vaccineQ6741353
Plasmodium falciparum malariaQ18554672
protozoan proteinsQ76505803
malariaQ12156
eukaryoteQ19088
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)171-186
P577publication date2016-02-01
P1433published inParasitologyQ15753259
P1476titleThe role of PfEMP1 as targets of naturally acquired immunity to childhood malaria: prospects for a vaccine
P478volume143

Reverse relations

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