Plasmodium falciparum associated with severe childhood malaria preferentially expresses PfEMP1 encoded by group A var genes

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Plasmodium falciparum associated with severe childhood malaria preferentially expresses PfEMP1 encoded by group A var genes is …
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scholarly articleQ13442814

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P356DOI10.1084/JEM.20040274
P932PMC publication ID2211911
P698PubMed publication ID15123742
P5875ResearchGate publication ID8581318

P50authorThor G. TheanderQ54802168
Ali SalantiQ55174835
Lars HviidQ55174838
Robert SauerweinQ72530989
Thomas LavstsenQ80377133
John LusinguQ90228924
Sarah SharpQ109797321
Lasse S VestergaardQ114320005
Pamela MagistradoQ114320963
Morten Agertoug NielsenQ44227553
P2093author name stringJesper Christensen
Anja T R Jensen
Colin Sutherland
Louise Joergensen
Rob Hermsen
Trine Staalsoe
Antonella Chiucchiuini
P2860cites workGenome sequence of the human malaria parasite Plasmodium falciparumQ22122524
Plasmodium falciparum variant surface antigen expression varies between isolates causing severe and nonsevere malaria and is modified by acquired immunityQ47901577
Widespread functional specialization of Plasmodium falciparum erythrocyte membrane protein 1 family members to bind CD36 analysed across a parasite genomeQ47923917
Gamma-globulin and acquired immunity to human malariaQ47957467
Evidence for the importance of genetic structuring to the structural and functional specialization of the Plasmodium falciparum var gene familyQ47971150
A sub-family of common and highly conserved Plasmodium falciparum var genes.Q48296993
Experimental procedure for the detection of a rare human mRNA with the DIG SystemQ73355514
Detection of antibodies to variant antigens on Plasmodium falciparum-infected erythrocytes by flow cytometryQ77356524
Antigenic variation in malaria: in situ switching, relaxed and mutually exclusive transcription of var genes during intra-erythrocytic development in Plasmodium falciparumQ24533320
Sub-grouping of Plasmodium falciparum 3D7 var genes based on sequence analysis of coding and non-coding regionsQ24804747
Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferaseQ27860571
Selective upregulation of a single distinctly structured var gene in chondroitin sulphate A-adhering Plasmodium falciparum involved in pregnancy-associated malariaQ27976511
Immunity to non-cerebral severe malaria is acquired after one or two infectionsQ28139257
The large diverse gene family var encodes proteins involved in cytoadherence and antigenic variation of plasmodium falciparum-infected erythrocytesQ29393314
Cloning the P. falciparum gene encoding PfEMP1, a malarial variant antigen and adherence receptor on the surface of parasitized human erythrocytesQ29618254
Switches in expression of Plasmodium falciparum var genes correlate with changes in antigenic and cytoadherent phenotypes of infected erythrocytesQ29618991
Geographical and temporal conservation of antibody recognition of Plasmodium falciparum variant surface antigensQ31064176
A well-conserved Plasmodium falciparum var gene shows an unusual stage-specific transcript pattern.Q33849072
Levels of antibody to conserved parts of Plasmodium falciparum merozoite surface protein 1 in Ghanaian children are not associated with protection from clinical malaria.Q33866742
Antibody recognition of Plasmodium falciparum erythrocyte surface antigens in Kenya: evidence for rare and prevalent variants.Q34000292
Antibodies to variant antigens on the surfaces of infected erythrocytes are associated with protection from malaria in Ghanaian children.Q34007707
Antigenic variation at the infected red cell surface in malaria.Q34360835
Lack of gender-specific antibody recognition of products from domains of a var gene implicated in pregnancy-associated Plasmodium falciparum malariaQ35106301
Malaria immunity in infants: a special case of a general phenomenon?Q35640581
Association of severe noncerebral Plasmodium falciparum malaria in Brazil with expressed PfEMP1 DBL1 alpha sequences lacking cysteine residuesQ36087903
Knob-independent cytoadherence of Plasmodium falciparum to the leukocyte differentiation antigen CD36.Q36351338
Cytoadherence by Plasmodium falciparum-infected erythrocytes is correlated with the expression of a family of variable proteins on infected erythrocytesQ36355465
Small, clonally variant antigens expressed on the surface of the Plasmodium falciparum-infected erythrocyte are encoded by the rif gene family and are the target of human immune responsesQ36375576
Parasite antigens on the infected red cell surface are targets for naturally acquired immunity to malaria.Q37331646
Plasmodium falciparum: analysis of transcribed var gene sequences in natural isolates from the Brazilian Amazon regionQ38861772
A model for sequestration of the transmission stages of Plasmodium falciparum: adhesion of gametocyte-infected erythrocytes to human bone marrow cells.Q39405774
Malaria-induced acquisition of antibodies to plasmodium falciparum variant surface antigensQ39655161
Specific T-cell recognition of the merozoite proteins rhoptry-associated protein 1 and erythrocyte-binding antigen 1 of plasmodium falciparumQ40373716
Tropical malaria contracted the natural way in the NetherlandsQ41136858
Characterization of a newly established human bone marrow endothelial cell line: distinct adhesive properties for hematopoietic progenitors compared with human umbilical vein endothelial cells.Q41142309
Rapid switching to multiple antigenic and adhesive phenotypes in malariaQ41904261
Effect of intermittent treatment with amodiaquine on anaemia and malarial fevers in infants in Tanzania: a randomised placebo-controlled trialQ41915799
Detection of Plasmodium falciparum malaria parasites in vivo by real-time quantitative PCR.Q44146886
In vitro selection of Plasmodium falciparum 3D7 for expression of variant surface antigens associated with severe malaria in African childrenQ44691470
Antibodies to variable Plasmodium falciparum-infected erythrocyte surface antigens are associated with protection from novel malaria infectionsQ46184700
Identification of a conserved Plasmodium falciparum var gene implicated in malaria in pregnancyQ46586152
Plasmodium falciparum-infected erythrocytes: agglutination by diverse Kenyan plasma is associated with severe disease and young host age.Q46809348
Developmental selection of var gene expression in Plasmodium falciparumQ47741507
Analysis of Plasmodium falciparum PfEMP-1/var genes suggests that recombination rearranges constrained sequencesQ47853007
Antigens induced on erythrocytes by P. falciparum: expression of diverse and conserved determinantsQ47886673
Antigenic variation and cytoadherence of PfEMP1 of Plasmodium falciparum-infected erythrocyte from malaria patients.Q47897156
P433issue9
P407language of work or nameEnglishQ1860
P921main subjectmalariaQ12156
Plasmodium falciparumQ311383
P304page(s)1179-1190
P577publication date2004-05-01
P1433published inJournal of Experimental MedicineQ3186912
P1476titlePlasmodium falciparum associated with severe childhood malaria preferentially expresses PfEMP1 encoded by group A var genes
P478volume199

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