Evidence for in vitro and in vivo expression of the conserved VAR3 (type 3) plasmodium falciparum erythrocyte membrane protein 1.

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Evidence for in vitro and in vivo expression of the conserved VAR3 (type 3) plasmodium falciparum erythrocyte membrane protein 1. is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1050050927
P356DOI10.1186/1475-2875-11-129
P932PMC publication ID3407477
P698PubMed publication ID22533832
P5875ResearchGate publication ID224848584

P50authorPamela MagistradoQ114320963
Thor G. TheanderQ54802168
Michael AlifrangisQ54802182
Sanne S BergerQ55176215
Christian W. WangQ55182133
Andrea M MarquardQ56811381
Thomas LavstsenQ80377133
John LusinguQ90228924
Louise TurnerQ43240630
P2093author name stringDominique C Bengtsson
P2860cites workGenome sequence of the human malaria parasite Plasmodium falciparumQ22122524
Antigenic variation in malaria: in situ switching, relaxed and mutually exclusive transcription of var genes during intra-erythrocytic development in Plasmodium falciparumQ24533320
Malaria morbidity and immunity among residents of villages with different Plasmodium falciparum transmission intensity in North-Eastern TanzaniaQ24800714
Sub-grouping of Plasmodium falciparum 3D7 var genes based on sequence analysis of coding and non-coding regionsQ24804747
Plasmodium falciparum variant surface antigen expression patterns during malariaQ24811060
Mutually exclusive expression of virulence genes by malaria parasites is regulated independently of antigen productionQ25257163
Surface co-expression of two different PfEMP1 antigens on single plasmodium falciparum-infected erythrocytes facilitates binding to ICAM1 and PECAM1Q27313623
Selective upregulation of a single distinctly structured var gene in chondroitin sulphate A-adhering Plasmodium falciparum involved in pregnancy-associated malariaQ27976511
A semi-automated multiplex high-throughput assay for measuring IgG antibodies against Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) domains in small volumes of plasmaQ28384693
The large diverse gene family var encodes proteins involved in cytoadherence and antigenic variation of plasmodium falciparum-infected erythrocytesQ29393314
Cloning the P. falciparum gene encoding PfEMP1, a malarial variant antigen and adherence receptor on the surface of parasitized human erythrocytesQ29618254
Switches in expression of Plasmodium falciparum var genes correlate with changes in antigenic and cytoadherent phenotypes of infected erythrocytesQ29618991
A method for visualizing surface-exposed and internal PfEMP1 adhesion antigens in Plasmodium falciparum infected erythrocytesQ33340826
Multiple var2csa-type PfEMP1 genes located at different chromosomal loci occur in many Plasmodium falciparum isolatesQ33494832
Plasmodium falciparum erythrocyte membrane protein 1 diversity in seven genomes--divide and conquerQ33700519
A well-conserved Plasmodium falciparum var gene shows an unusual stage-specific transcript pattern.Q33849072
Virulence of malaria is associated with differential expression of Plasmodium falciparum var gene subgroups in a case-control studyQ33879876
Antibody recognition of Plasmodium falciparum erythrocyte surface antigens in Kenya: evidence for rare and prevalent variants.Q34000292
Detection of antibodies to variant antigens on Plasmodium falciparum-infected erythrocytes by flow cytometryQ77356524
An alternative to serum for cultivation of Plasmodium falciparum in vitroQ93899292
Full-length recombinant Plasmodium falciparum VAR2CSA binds specifically to CSPG and induces potent parasite adhesion-blocking antibodiesQ34095324
Antibodies against PfEMP1, RIFIN, MSP3 and GLURP are acquired during controlled Plasmodium falciparum malaria infections in naïve volunteersQ34103586
Plasmodium falciparum erythrocyte membrane protein 1 domain cassettes 8 and 13 are associated with severe malaria in childrenQ34276755
Antigenic variation at the infected red cell surface in malaria.Q34360835
Global genetic diversity and evolution of var genes associated with placental and severe childhood malariaQ34525362
A family affair: var genes, PfEMP1 binding, and malaria diseaseQ34543611
Differential var gene transcription in Plasmodium falciparum isolates from patients with cerebral malaria compared to hyperparasitaemiaQ34568283
Levels of plasma immunoglobulin G with specificity against the cysteine-rich interdomain regions of a semiconserved Plasmodium falciparum erythrocyte membrane protein 1, VAR4, predict protection against malarial anemia and febrile episodesQ34601747
Differential expression of var gene groups is associated with morbidity caused by Plasmodium falciparum infection in Tanzanian childrenQ34721291
The stability and complexity of antibody responses to the major surface antigen of Plasmodium falciparum are associated with age in a malaria endemic areaQ35579613
Immunoglobulin G antibody reactivity to a group A Plasmodium falciparum erythrocyte membrane protein 1 and protection from P. falciparum malariaQ35783951
Changes in var gene mRNA levels during erythrocytic development in two phenotypically distinct Plasmodium falciparum parasitesQ35865612
PfEMP1-DBL1alpha amino acid motifs in severe disease states of Plasmodium falciparum malariaQ36013437
Differential var gene expression in the organs of patients dying of falciparum malariaQ36318750
Plasmodium falciparum associated with severe childhood malaria preferentially expresses PfEMP1 encoded by group A var genesQ36399515
Chromatin associated sense and antisense noncoding RNAs are transcribed from the var gene family of virulence genes of the malaria parasite Plasmodium falciparumQ37034267
Parasite antigens on the infected red cell surface are targets for naturally acquired immunity to malaria.Q37331646
Plasmodium falciparum var gene expression is modified by host immunityQ37471820
High level of var2csa transcription by Plasmodium falciparum isolated from the placentaQ38324821
Analysis of Plasmodium falciparum var genes expressed in children from Papua New GuineaQ38998322
Malarial proteins at the membrane of Plasmodium falciparum-infected erythrocytes and their involvement in cytoadherence to endothelial cells.Q39515376
var gene transcription and PfEMP1 expression in the rosetting and cytoadhesive Plasmodium falciparum clone FCR3S1.2.Q41897345
Baculovirus expression of erythrovirus V9 capsids and screening by ELISA: serologic cross-reactivity with erythrovirus B19.Q42052491
Sequential, ordered acquisition of antibodies to Plasmodium falciparum erythrocyte membrane protein 1 domainsQ44605152
In vitro selection of Plasmodium falciparum 3D7 for expression of variant surface antigens associated with severe malaria in African childrenQ44691470
Antibodies to variable Plasmodium falciparum-infected erythrocyte surface antigens are associated with protection from novel malaria infectionsQ46184700
Identification of a conserved Plasmodium falciparum var gene implicated in malaria in pregnancyQ46586152
Plasmodium falciparum-infected erythrocytes: agglutination by diverse Kenyan plasma is associated with severe disease and young host age.Q46809348
Developmental selection of var gene expression in Plasmodium falciparumQ47741507
Biased distribution of msp1 and msp2 allelic variants in Plasmodium falciparum populations in ThailandQ47858805
Preferential transcription of conserved rif genes in two phenotypically distinct Plasmodium falciparum parasite linesQ47893123
Plasmodium falciparum variant surface antigen expression varies between isolates causing severe and nonsevere malaria and is modified by acquired immunityQ47901577
Evidence for the importance of genetic structuring to the structural and functional specialization of the Plasmodium falciparum var gene familyQ47971150
A var gene promoter controls allelic exclusion of virulence genes in Plasmodium falciparum malariaQ48021609
A sub-family of common and highly conserved Plasmodium falciparum var genes.Q48296993
P275copyright licenseCreative Commons Attribution 2.0 GenericQ19125117
P6216copyright statuscopyrightedQ50423863
P921main subjectPlasmodium falciparumQ311383
membrane proteinQ423042
P304page(s)129
P577publication date2012-04-25
P1433published inMalaria JournalQ15749954
P1476titleEvidence for in vitro and in vivo expression of the conserved VAR3 (type 3) plasmodium falciparum erythrocyte membrane protein 1.
P478volume11

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cites work (P2860)
Q28547338A Unique Virulence Gene Occupies a Principal Position in Immune Evasion by the Malaria Parasite Plasmodium falciparum
Q36938125Adhesion of Plasmodium falciparum infected erythrocytes in ex vivo perfused placental tissue: a novel model of placental malaria
Q36354336Beninese children with cerebral malaria do not develop humoral immunity against the IT4-VAR19-DC8 PfEMP1 variant linked to EPCR and brain endothelial binding
Q40219950Binding of Plasmodium falciparum to CD36 can be shielded by the glycocalyx.
Q54231990Children with cerebral malaria or severe malarial anaemia lack immunity to distinct variant surface antigen subsets.
Q39066692Comparison of functional assays used in the clinical development of a placental malaria vaccine
Q36189938Cytoadhesion to gC1qR through Plasmodium falciparum Erythrocyte Membrane Protein 1 in Severe Malaria
Q50104729Direct whole-genome sequencing of Plasmodium falciparum specimens from dried erythrocyte spots
Q89704858Evolutionary analysis of the most polymorphic gene family in falciparum malaria
Q46696354Immune evasion of Plasmodium falciparum by RIFIN via inhibitory receptors
Q98177092In vitro selection for adhesion of Plasmodium falciparum-infected erythrocytes to ABO antigens does not affect PfEMP1 and RIFIN expression
Q36053493Multiple Plasmodium falciparum Erythrocyte Membrane Protein 1 Variants per Genome Can Bind IgM via Its Fc Fragment Fcμ
Q34853037Plasmodium falciparum expressing domain cassette 5 type PfEMP1 (DC5-PfEMP1) bind PECAM1.
Q36177571Plasmodium falciparum-infected erythrocyte knob density is linked to the PfEMP1 variant expressed
Q35062854Seasonal changes in the antibody responses against Plasmodium falciparum merozoite surface antigens in areas of differing malaria endemicity in Indonesia
Q34348881Severe malaria is associated with parasite binding to endothelial protein C receptor
Q34416805The var3 genes of Plasmodium falciparum 3D7 strain are differentially expressed in infected erythrocytes

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