α2-Macroglobulin Can Crosslink Multiple Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) Molecules and May Facilitate Adhesion of Parasitized Erythrocytes

scientific article published on 2 July 2015

α2-Macroglobulin Can Crosslink Multiple Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) Molecules and May Facilitate Adhesion of Parasitized Erythrocytes is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PPAT.1005022
P2888exact matchhttp://ugspace.ug.edu.gh/handle/123456789/27550
P932PMC publication ID4489720
P698PubMed publication ID26134405
P5875ResearchGate publication ID279730553
P8602University of Ghana Digital Collections (UGSpace) ID27550

P50authorLars HviidQ55174838
Lea BarfodQ55174847
Graeme J CowanQ55176287
David CavanaghQ60648233
Gregers R. AndersenQ37383421
P2093author name stringErik Laursen
Liz Stevenson
Hviid, L.
Barfod, L.
Cavanagh, D.R.
Stevenson, L.
Betty Bandoh
Andersen, G.R.
Bandoh, B.
Cowan, G.J.
Laursen, E.
P2860cites workGlobal malaria mortality between 1980 and 2010: a systematic analysisQ20905423
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Surface co-expression of two different PfEMP1 antigens on single plasmodium falciparum-infected erythrocytes facilitates binding to ICAM1 and PECAM1Q27313623
Dimerization of Plasmodium vivax DBP is induced upon receptor binding and drives recognition of DARCQ27670749
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The crystal structure of human α2-macroglobulin reveals a unique molecular cageQ27676954
P. falciparum rosetting mediated by a parasite-variant erythrocyte membrane protein and complement-receptor 1Q27972544
The role of nanometer-scaled ligand patterns in polyvalent binding by large mannan-binding lectin oligomersQ28256721
Cloning the P. falciparum gene encoding PfEMP1, a malarial variant antigen and adherence receptor on the surface of parasitized human erythrocytesQ29618254
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Evasion of immunity to Plasmodium falciparum malaria by IgM masking of protective IgG epitopes in infected erythrocyte surface-exposed PfEMP1Q30502964
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Conserved role of a complement-like protein in phagocytosis revealed by dsRNA knockout in cultured cells of the mosquito, Anopheles gambiae.Q33938813
Full-length recombinant Plasmodium falciparum VAR2CSA binds specifically to CSPG and induces potent parasite adhesion-blocking antibodiesQ34095324
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A novel domain cassette identifies Plasmodium falciparum PfEMP1 proteins binding ICAM-1 and is a target of cross-reactive, adhesion-inhibitory antibodiesQ34315378
Severe malaria is associated with parasite binding to endothelial protein C receptorQ34348881
Alpha-macroglobulins: structure, shape, and mechanism of proteinase complex formationQ34415095
Screening trematodes for novel intervention targets: a proteomic and immunological comparison of Schistosoma haematobium, Schistosoma bovis and Echinostoma caproni.Q35230008
Crystallization and preliminary X-ray analysis of methylamine-treated alpha 2-macroglobulin and 3 alpha 2-macroglobulin-proteinase complexesQ67704994
Severe and complicated malaria. World Health Organization, Division of Control of Tropical DiseasesQ68570047
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Protein GRAB of streptococcus pyogenes regulates proteolysis at the bacterial surface by binding alpha2-macroglobulinQ77772105
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A human 88-kD membrane glycoprotein (CD36) functions in vitro as a receptor for a cytoadherence ligand on Plasmodium falciparum-infected erythrocytesQ35813897
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Plasmodium falciparum associated with severe childhood malaria preferentially expresses PfEMP1 encoded by group A var genesQ36399515
Normal and pathological serum levels of alpha2-macroglobulins in men and miceQ36587043
An in vivo and in vitro model of Plasmodium falciparum rosetting and autoagglutination mediated by varO, a group A var gene encoding a frequent serotypeQ36974515
Loss of endothelial protein C receptors links coagulation and inflammation to parasite sequestration in cerebral malaria in African childrenQ37065724
Identification of residues in the Cmu4 domain of polymeric IgM essential for interaction with Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1).Q37226958
Rosetting Plasmodium falciparum-infected erythrocytes bind to human brain microvascular endothelial cells in vitro, demonstrating a dual adhesion phenotype mediated by distinct P. falciparum erythrocyte membrane protein 1 domains.Q37643887
B-cell responses to pregnancy-restricted and -unrestricted Plasmodium falciparum erythrocyte membrane protein 1 antigens in Ghanaian women naturally exposed to malaria parasitesQ37713335
α-2-Macroglobulin: a physiological guardian.Q38053998
Identification of Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) as the rosetting ligand of the malaria parasite P. falciparumQ38340612
Clearance and binding of two electrophoretic "fast" forms of human alpha 2-macroglobulin.Q38356145
Plasmodium falciparum: the importance of IgM in the rosetting of parasite-infected erythrocytesQ38949087
Merozoite surface antigen 1 and 2 genotypes and rosetting of Plasmodium falciparum in severe and mild malaria in Lambaréné, GabonQ39152230
Multiple human serum components act as bridging molecules in rosette formation by Plasmodium falciparum-infected erythrocytesQ39477990
Investigating the function of Fc-specific binding of IgM to Plasmodium falciparum erythrocyte membrane protein 1 mediating erythrocyte rosettingQ39490520
Blood group A antigen is a coreceptor in Plasmodium falciparum rosettingQ39515750
Extensive immunoglobulin binding of Plasmodium falciparum-infected erythrocytes in a group of children with moderate anemia.Q39569704
Plasmodium falciparum rosetting is associated with malaria severity in KenyaQ39822248
Characterization of binding of human alpha 2-macroglobulin to group G streptococciQ40182982
Human cerebral malaria: association with erythrocyte rosetting and lack of anti-rosetting antibodiesQ41175606
Rapid switching to multiple antigenic and adhesive phenotypes in malariaQ41904261
Gametocyte-forming and non-gametocyte-forming clones of Plasmodium falciparum.Q41919000
Heparan sulphate identified on human erythrocytes: a Plasmodium falciparum receptorQ42156743
Plasmodium falciparum-infected erythrocytes form spontaneous erythrocyte rosettesQ42573749
Molecular architecture of a complex between an adhesion protein from the malaria parasite and intracellular adhesion molecule 1.Q43240550
Rosette formation in Plasmodium falciparum isolates and anti-rosette activity of sera from Gambians with cerebral or uncomplicated malaria.Q44327489
In vitro selection of Plasmodium falciparum 3D7 for expression of variant surface antigens associated with severe malaria in African childrenQ44691470
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Rosetting in Plasmodium falciparum: a cytoadherence phenotype with multiple actorsQ46453882
PECAM-1/CD31, an endothelial receptor for binding Plasmodium falciparum-infected erythrocytes.Q47824104
Disruption of Plasmodium falciparum erythrocyte rosettes by standard heparin and heparin devoid of anticoagulant activityQ47860538
The duffy-binding-like domain 1 of Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is a heparan sulfate ligand that requires 12 mers for binding.Q47866235
Intercellular adhesion molecule-1 is an endothelial cell adhesion receptor for Plasmodium falciparumQ47888568
Structural basis for the EBA-175 erythrocyte invasion pathway of the malaria parasite Plasmodium falciparumQ48013061
Novel fibrillar structure confers adhesive property to malaria-infected erythrocytesQ48025755
Evidence that the newly cloned low-density-lipoprotein receptor related protein (LRP) is the alpha 2-macroglobulin receptorQ48245025
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectPlasmodium falciparumQ311383
membrane proteinQ423042
Alpha-2-macroglobulinQ22680187
Plasmodium falciparum erythrocyte membrane protein 1, N-terminalQ24739102
Morphology of parasitized erythrocytes upon bovine (B. divergens) and canine (B. canis) babesioses (author's transl)Q67002728
P304page(s)e1005022
P577publication date2015-01-01
2015-07-02
P1433published inPLOS PathogensQ283209
P1476titleα2-Macroglobulin Can Crosslink Multiple Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) Molecules and May Facilitate Adhesion of Parasitized Erythrocytes
P478volume11

Reverse relations

cites work (P2860)
Q91900053Acquisition of IGG to ICAM-1-Binding DBLΒ Domains in the plasmodium falciparum erythrocyte membrane protein 1 antigen family varies between groups A, B, and C
Q27974543Binding of Plasmodium falciparum Merozoite Surface Proteins DBLMSP and DBLMSP2 to Human Immunoglobulin M Is Conserved among Broadly Diverged Sequence Variants
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Q40975795Early ovariectomy reveals the germline encoding of natural anti-A- and Tn-cross-reactive immunoglobulin M (IgM) arising from developmental O-GalNAc glycosylations. (Germline-encoded natural anti-A/Tn cross-reactive IgM).
Q36294168Effects of sevuparin on rosette formation and cytoadherence of Plasmodium falciparum infected erythrocytes
Q36469079Functional analysis of monoclonal antibodies against the Plasmodium falciparum PfEMP1-VarO adhesin
Q44169469Host immune evasion strategies of malaria blood stage parasite
Q98177092In vitro selection for adhesion of Plasmodium falciparum-infected erythrocytes to ABO antigens does not affect PfEMP1 and RIFIN expression
Q36053493Multiple Plasmodium falciparum Erythrocyte Membrane Protein 1 Variants per Genome Can Bind IgM via Its Fc Fragment Fcμ
Q50095537Natural and vaccine-induced acquisition of cross-reactive IgG inhibiting ICAM-1-specific binding of a PfEMP1 subtype associated specifically with cerebral malaria
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