Evidence that the newly cloned low-density-lipoprotein receptor related protein (LRP) is the alpha 2-macroglobulin receptor

scientific article published in December 1990

Evidence that the newly cloned low-density-lipoprotein receptor related protein (LRP) is the alpha 2-macroglobulin receptor is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/0014-5793(90)80530-V
P698PubMed publication ID1702392
P5875ResearchGate publication ID21454172

P50authorSøren Kragh MoestrupQ30510054
P2093author name stringKristensen T
Sottrup-Jensen L
Gliemann J
Bendtsen L
Sand O
P2860cites workThe LDL-receptor-related protein, LRP, is an apolipoprotein E-binding proteinQ24339570
Low density lipoprotein receptor-related protein mediates uptake of cholesteryl esters derived from apoprotein E-enriched lipoproteinsQ24609758
A comprehensive set of sequence analysis programs for the VAXQ26778432
Isolation of biologically active ribonucleic acid from sources enriched in ribonucleaseQ26778460
A simple and very efficient method for generating cDNA librariesQ27860461
Human apolipoprotein B: structure of carboxyl-terminal domains, sites of gene expression, and chromosomal localizationQ30403358
Lipoprotein binding and endosomal itinerary of the low density lipoprotein receptor-related protein in rat liverQ34322965
The human alpha 2-macroglobulin receptor: identification of a 420-kD cell surface glycoprotein specific for the activated conformation of alpha 2-macroglobulinQ36223019
pUEX, a bacterial expression vector related to pEX with universal host specificityQ40392157
Binding of alpha 2-macroglobulin to hepatocytes: mechanism of in vivo clearance.Q41774686
Characterization, size estimation and solubilization of alpha-macroglobulin complex receptors in liver membranesQ44370196
Second receptor verified?Q59046799
P433issue1-2
P407language of work or nameEnglishQ1860
P921main subjectlipoproteinQ28350
P304page(s)151-155
P577publication date1990-12-01
P1433published inFEBS LettersQ1388051
P1476titleEvidence that the newly cloned low-density-lipoprotein receptor related protein (LRP) is the alpha 2-macroglobulin receptor
P478volume276

Reverse relations

cites work (P2860)
Q282618513,400 new expressed sequence tags identify diversity of transcripts in human brain
Q2456825739 kDa receptor-associated protein is an ER resident protein and molecular chaperone for LDL receptor-related protein
Q2828063639-kDa protein modulates binding of ligands to low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor
Q30423035A gene for a low density lipoprotein receptor-related protein in the nematode Caenorhabditis elegans
Q28186647A novel mechanism for controlling the activity of alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein. Multiple regulatory sites for 39-kDa receptor-associated protein
Q67577150A physical map of a 1.3-Mb region on the long arm of chromosome 12, spanning the GLI and LRP loci
Q30464704Activated alpha 2-macroglobulin and transforming growth factor-beta 1 induce a synergistic smooth muscle cell proliferative response
Q36636420Acute phase proteins are major clients for the chaperone action of α₂-macroglobulin in human plasma
Q40674764Adipocyte low density lipoprotein receptor-related protein gene expression and function is regulated by peroxisome proliferator-activated receptor gamma
Q54048577Alpha 2-macroglobulin receptor mediates binding and cytotoxicity of plant ribosome-inactivating proteins.
Q46876133Alpha 2-macroglobulin-mediated clearance of proteases from the plasma of the American horseshoe crab, Limulus polyphemus
Q92713428Alpha-2-Macroglobulin, a Hypochlorite-Regulated Chaperone and Immune System Modulator
Q33699536Alpha2-macroglobulin: an evolutionarily conserved arm of the innate immune system
Q37352399Altered interaction of Cis-dichlorodiammineplatinum(II)--modified alpha 2-macroglobulin (alpha 2M) with the low density lipoprotein receptor-related protein/alpha 2M receptor but not the alpha 2M signaling receptor
Q48086927Amino acid sequence of hen ovomacroglobulin (ovostatin) deduced from cloned cDNA.
Q34208401Amyloid precursor protein (APP) and the biology of proteolytic processing: relevance to Alzheimer's disease
Q36685309An Antibody Fragment from a Phage Display Library Competes for Ligand Binding to the Low Density Lipoprotein Receptor Family and Inhibits Rhinovirus Infection
Q28367262Analysis of a two-domain binding site for the urokinase-type plasminogen activator-plasminogen activator inhibitor-1 complex in low-density-lipoprotein-receptor-related protein
Q38290559Analysis of ligand binding to the alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein. Evidence that lipoprotein lipase and the carboxyl-terminal domain of the receptor-associated protein bind to the same site.
Q36678418Analysis of the binding of pro-urokinase and urokinase-plasminogen activator inhibitor-1 complex to the low density lipoprotein receptor-related protein using a Fab fragment selected from a phage-displayed Fab library
Q39930551Analysis of the effect of LRP-1 silencing on the invasive potential of cancer cells by nanomechanical probing and adhesion force measurements using atomic force microscopy
Q40480072Animal models for disorders of hepatic lipoprotein metabolism
Q33938398Apolipoprotein E receptors: linking brain development and Alzheimer's disease
Q21562621Binding of alpha2ML1 to the low density lipoprotein receptor-related protein 1 (LRP1) reveals a new role for LRP1 in the human epidermis
Q41961333Binding of lipoprotein lipase to alpha 2-macroglobulin
Q59358865CD91 up-regulates upon immune stimulation in Xenopus adult but not larval peritoneal leukocytes
Q73615235CD91: a receptor for heat shock protein gp96
Q30438850Characterization and immunohistochemical localization of alpha 2-macroglobulin receptor (low-density lipoprotein receptor-related protein) in human brain
Q67538604Characterization of carbohydrates in the alpha 2-macroglobulin receptor
Q67487952Characterization of the chylomicron‐remnant‐recognition sites on parenchymal and Kupffer cells of rat liver Selective inhibition of parenchymal cell recognition by lactoferrin
Q72285749Characterization of the gene for apolipoprotein E5-Frankfurt (Gln81->Lys, Cys112->Arg) by polymerase chain reaction, restriction isotyping, and temperature gradient gel electrophoresis
Q61962818Characterization of α2-macroglobulin receptor low density lipoprotein receptor-related protein (α2MR/LRP) in White Carneau pigeon peritoneal macrophages: its role in lipoprotein metabolism
Q33705255Cholesterol pathways affected by small molecules that decrease sterol levels in Niemann-Pick type C mutant cells
Q48204455Cholesterol-mediated suppression of alpha 1-inhibitor III, a plasma alpha-macroglobulin family protein
Q24564351Complexes of tissue-type plasminogen activator and its serpin inhibitor plasminogen-activator inhibitor type 1 are internalized by means of the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor
Q27759036Crystal structure of the receptor-binding domain of alpha 2-macroglobulin
Q57796505Deletion of Macrophage Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1) Accelerates Atherosclerosis Regression and Increases C-C Chemokine Receptor Type 7 (CCR7) Expression in Plaque Macrophages
Q35833160Detection of two forms of GP330. Their role in Heymann nephritis.
Q64275820Developing LRP1 Agonists into a Therapeutic Strategy in Acute Myocardial Infarction
Q42280270Different molecular forms of rat kidney gp330, the dominant autoantigen of active Heymann nephritis
Q41370261Differential recognition of alpha 1-antitrypsin-elastase and alpha 1-antichymotrypsin-cathepsin G complexes by the low density lipoprotein receptor-related protein
Q24563934Direct isolation of genes encoded within a homogeneously staining region by chromosome microdissection
Q48437047Distribution of the alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein in human tissues
Q35181677Diverse role of LDL receptor-related protein in the clearance of proteases and in signaling
Q77942912Effect of dietary cholesterol on low density lipoprotein-receptor, 3-hydroxy-3-methylglutaryl-CoA reductase, and low density lipoprotein receptor-related protein mRNA expression in healthy humans
Q34002432Enhanced macrophage resistance to Pseudomonas exotoxin A is correlated with decreased expression of the low-density lipoprotein receptor-related protein.
Q48129584Evidence from sequence analysis that hen egg-white ovomacroglobulin (ovostatin) is devoid of an internal β-Cys-γ-Glu thiol ester
Q77747904Evolutionary conservation of circulating soluble low density lipoprotein receptor-related protein-like ("LRP-like") molecules
Q54601632Expression and refolding of a high‐affinity receptor binding domain from rat α1‐macroglobulin
Q54668700Expression of a functional alpha-macroglobulin receptor binding domain in Escherichia coli.
Q34143741Expression of alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein and scavenger receptor in human atherosclerotic lesions
Q35833423Expression of alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein and the 39-kd receptor-associated protein in human trophoblasts.
Q47726354Expression of lipoprotein receptors in atherosclerotic lesions
Q28287916Functional expression of low density lipoprotein receptor-related protein is controlled by receptor-associated protein in vivo
Q44795625Functional genomics of tick thioester-containing proteins reveal the ancient origin of the complement system
Q42801920Heparin binding protein-44 (HBP-44)/receptor-associated protein (RAP)mediates cell-substratum adhesion of mouse NIH/3T3 cells through its binding to low density lipoprotein (LDL) receptor-related protein (LRP).
Q24654232Human alpha2-macroglobulin is composed of multiple domains, as predicted by homology with complement component C3
Q47703446Human defensins activate monocyte-derived dendritic cells, promote the production of proinflammatory cytokines, and up-regulate the surface expression of CD91.
Q37312078Identification of a pathogenic epitope involved in initiation of Heymann nephritis
Q60405678Identification of the minimal functional unit in the low density lipoprotein receptor-related protein for binding the receptor-associated protein (RAP). A conserved acidic residue in the complement-type repeats is important for recognition of RAP.
Q77874760Incorporation of non-proteolytic proteins by murine alpha2-macroglobulin
Q39369735Inhibitors of kallikrein-related peptidases: An overview.
Q38061567Insights into the activity, differential expression, mutual regulation, and functions of matrix metalloproteinases and a disintegrin and metalloproteinases in hypertension and cardiac disease
Q72067397Insulin stimulates receptor-mediated uptake of apoE-enriched lipoproteins and activated alpha 2-macroglobulin in adipocytes
Q41508418Interaction of a 39 kDa protein with the low-density-lipoprotein-receptor-related protein (LRP) on rat hepatoma cells
Q28569336Interaction of lipoprotein lipase and receptor-associated protein
Q22254442Involvement of alpha-2-macroglobulin receptor in clearance of interleukin 8-alpha-2-macroglobulin complexes by human alveolar macrophages
Q33998653LDL receptor-related protein (LRP) in Alzheimer's disease: towards a unified theory of pathogenesis
Q37216064LDL receptor-related protein 1: unique tissue-specific functions revealed by selective gene knockout studies
Q21285122LRP-1: a checkpoint for the extracellular matrix proteolysis
Q34835060LRP-1: functions, signaling and implications in kidney and other diseases
Q35427475Level of receptor-associated protein moderates cellular susceptibility to pseudomonas exotoxin A
Q63915864Ligand-receptor interactions of the low density lipoprotein receptor-related protein, a multi-ligand endocytic receptor
Q24561866Lipoprotein lipase enhances the binding of chylomicrons to low density lipoprotein receptor-related protein
Q41606363Lipoprotein receptor mediated metabolism of [14C]arachidonic acid labeled chylomicron remnants by Hep G2 cells
Q36486210Lipoprotein receptors – an evolutionarily ancient multifunctional receptor family
Q33772665Lipoprotein receptors: new roles for ancient proteins.
Q40588222Lipoproteins and their functions
Q53900850Localisation of the major reactive lysine residue involved in the self-crosslinking of proteinase-activated Limulus alpha 2-macroglobulin.
Q42452094Localization of Low Density Lipoprotein Receptor-related Protein 1 to Caveolae in 3T3-L1 Adipocytes in Response to Insulin Treatment
Q42846215Localization of basic residues required for receptor binding to the single alpha-helix of the receptor binding domain of human alpha2-macroglobulin
Q41037701Low density lipoprotein receptor-related protein (LRP) expression varies among Hep G2 cell lines
Q40417173Low density lipoprotein receptor-related protein (LRP) interacts with presenilin 1 and is a competitive substrate of the amyloid precursor protein (APP) for gamma-secretase
Q34295583Low resolution X-ray structure of human methylamine-treated alpha 2-macroglobulin.
Q36535157Low-density lipoprotein receptor-related protein (LRP)-mediated clearance of activated blood coagulation co-factors and proteases: clearance mechanism or regulation?
Q38185972Low-density lipoprotein receptor-related protein-1: role in the regulation of vascular integrity.
Q73297617Metabolism of activated complement component C3 is mediated by the low density lipoprotein receptor-related protein/alpha(2)-macroglobulin receptor
Q39403705Methylamine-treated low density lipoproteins elicit different responses in HepG2 cells and macrophages
Q58883739Minireview
Q38991475Modulation of Systemic Metabolism by MMP-2: From MMP-2 Deficiency in Mice to MMP-2 Deficiency in Patients
Q35023109Modulation of beta-amyloid precursor protein trafficking and processing by the low density lipoprotein receptor family
Q42102287Modulation of the low-density-lipoprotein-receptor-related protein and its relevance to chylomicron-remnant metabolism
Q40393738Molecular Analysis of the Human and Mouse α2M Family
Q28570991Molecular characterization of an apical early endosomal glycoprotein from developing rat intestinal epithelial cells
Q36845286Molecular cloning of Limulus alpha 2-macroglobulin.
Q28207758Molecular genetics of the LDL receptor gene in familial hypercholesterolemia
Q42626877Nutrition support affects the distribution and organ uptake of cachectin/tumor necrosis factor in rats
Q34334896Placental heme receptor LRP1 correlates with the heme exporter FLVCR1 and neonatal iron status
Q41100535Plasminogen activation on tumor cell surface and its involvement in human leukemia.
Q24319788Primary structure of alpha 2-macroglobulin receptor-associated protein. Human homologue of a Heymann nephritis antigen
Q36862828Properties of human blood monocytes. I. CD91 expression and log orthogonal light scatter provide a robust method to identify monocytes that is more accurate than CD14 expression
Q36862833Properties of human blood monocytes. II. Monocytes from healthy adults are highly heterogeneous within and among individuals
Q48334078Proteome-wide Identification of Glycosylation-dependent Interactors of Galectin-1 and Galectin-3 on Mesenchymal Retinal Pigment Epithelial (RPE) Cells.
Q36535701Pseudomonas exotoxin-mediated selection yields cells with altered expression of low-density lipoprotein receptor-related protein
Q67490009Putative apolipoprotein receptor gene (LRP, A2MR) is not rearranged in either myxoid liposarcoma or lipomas with translocations in 12q13–14
Q24317297RAP, a specialized chaperone, prevents ligand-induced ER retention and degradation of LDL receptor-related endocytic receptors
Q48972430Receptor-associated protein and members of the low density lipoprotein receptor family share a common epitope. An extended model for the development of passive Heymann nephritis
Q54633352Receptor-binding domain of human alpha 2-macroglobulin. Expression, folding and biochemical characterization of a high-affinity recombinant derivative.
Q40814192Receptor-mediated endocytosis of plasminogen activators and activator/inhibitor complexes
Q33597635Receptor-mediated mechanisms of lipoprotein remnant catabolism
Q48163190Recombinant Expression of the Full-length Ectodomain of LDL Receptor-related Protein 1 (LRP1) Unravels pH-dependent Conformational Changes and the Stoichiometry of Binding with Receptor-associated Protein (RAP).
Q31442067Regulation of the ligand binding activity of the human very low density lipoprotein receptor by protein kinase C-dependent phosphorylation
Q46773921Role of heparan sulfate proteoglycans and the LDL receptor-related protein in remnant lipoprotein metabolism
Q46264980Role of receptor-associated 39/45 kD protein in active Heymann nephritis
Q35696767Secreted heat shock protein-90 (Hsp90) in wound healing and cancer
Q35295478Serpin-Enzyme Receptors LDL Receptor-Related Protein 1.
Q72083438Serum Prostate Specific Antigen Complexed toα1-Antichymotrypsin as an Indicator of Prostate Cancer
Q53980742Similar architectures of native and transformed human alpha2-macroglobulin suggest the transformation mechanism.
Q35677264Soluble low-density lipoprotein receptor-related protein
Q27695619Structure of a bacterial α2-macroglobulin reveals mimicry of eukaryotic innate immunity
Q47948186Sustained somatic gene inactivation by viral transfer of Cre recombinase.
Q37118416TGF beta2-induced changes in LRP-1/T beta R-V and the impact on lysosomal A beta uptake and neurotoxicity
Q72254130The LDL receptor and LRP are receptors for beta VLDL on pigeon monocyte-derived macrophages
Q71653797The Role of α2M Receptor/LRP in Chylomicron Remnant Metabolism
Q73575426The binding of receptor-recognized alpha2-macroglobulin to the low density lipoprotein receptor-related protein and the alpha2M signaling receptor is decoupled by oxidation
Q49089558The chicken LDL receptor-related protein/alpha 2-macroglobulin receptor family
Q49043259The chicken oocyte receptor for yolk precursors as a model for studying the action of receptor-associated protein and lactoferrin
Q24308738The complete amino acid sequence of human placental oxytocinase
Q42764602The low-density-lipoprotein receptor-related protein (LRP) is processed by furin in vivo and in vitro.
Q71246365The major subunit of the asialoglycoprotein receptor is expressed on the hepatocellular surface in mice lacking the minor receptor subunit
Q53314868The multiligand alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein (alpha 2MR/LRP). Binding and endocytosis of fluid phase and membrane-associated ligands.
Q28587803The primary sequence and the subunit structure of mouse α‐2‐macroglobulin, deduced from protein sequencing of the isolated subunits and from molecular cloning of the cDNA
Q34387393The roles of receptor-associated protein (RAP) as a molecular chaperone for members of the LDL receptor family
Q47592174Trafficking in Alzheimer's Disease: Modulation of APP Transport and Processing by the Transmembrane Proteins LRP1, SorLA, SorCS1c, Sortilin, and Calsyntenin.
Q35798254Transcription and translation of gp600 and receptor-associated protein (RAP) in active Heymann nephritis.
Q39024877Transforming growth factor alpha (TGFalpha)-stimulated secretion of HSP90alpha: using the receptor LRP-1/CD91 to promote human skin cell migration against a TGFbeta-rich environment during wound healing
Q31008087alpha 2-Macroglobulin: a new component in the insulin-like growth factor/insulin-like growth factor binding protein-1 axis.
Q35811289α2-Macroglobulin Can Crosslink Multiple Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) Molecules and May Facilitate Adhesion of Parasitized Erythrocytes
Q40393752α2‐Macroglobulin: A Sensor for Proteolysis

Search more.